3D細胞培養全球市場 - 成長，趨勢，預測(2019年∼2024年)
3D Cell Culture Market - Growth, Trends, COVID-19 Impact, and Forecasts (2021 - 2026)
The 3D cell culture market is expected to register a CAGR of 12.5% during the forecast period of 2021-2026.
The COVID-19 pandemic is expected to have a significant impact on the market. Researchers working on COVID-19 with relevant matrices for 3D cell culture and suitable for air-liquid interface culture, need to investigate in vitro the mechanisms of the systemic consequences of cell cultures and to test potential therapies in a physiological microenvironment. This is the primary reason why 3D cell cultures are used in COVID-19 research. According to an article appearing in Frontiers Online in March 2021 titled, '3D Tissue Models as an Effective Tool for Studying Viruses and Vaccine Development', there are benefits of using 3D tissue culture techniques over 2D tissue culture when studying viral infections and the implications with regards to studying COVID-19. The study also found that techniques like organoids and spheroid cultures have been shown to replicate systems of viral infection more accurately than 2D cultures and to produce morphology and biochemical behaviors required to allow for viral infection in cases where 2D cultures do not.
The 3D cell culture market is witnessing stable growth due to the factors, like the use of 3D cell culture models as alternative tools for in vivo testing, development of automated large-scale cell culture systems, and rising need for organ transplantation. The 3D cell culture and co-culture models have huge benefits, since they not only enable drug safety and efficacy assessment in a more in vivo-like context than traditional 2D cell cultures, but they can eliminate the species differences that pose limitations in the interpretation of the preclinical outcomes, by allowing drug testing directly in human systems. Additionally, with the increase in demand for organ transplantation, there is likely to be a demand for 3D cell cultures as there is a need to recapitulate complex aspects of human physiology, pathology, and drug responses in vitro. According to the organdonor.gov websites of the United States Health Resources and Services Administration, 107,103 number of patients were on the national organ transplant waiting list in the year 2020. Data from the website also states that each year, 39,000 organ transplants are conducted in the United States. Thus, the increase in organ transplants is increasing demand for research models, where 3D cell cultures are used. This is expected to boost market growth.
Microchips are also called organ-on-a-chip or microsystems. Microchips can integrate microfluidic technologies with cells that are cultured within the micro fabricated 3D devices, using various techniques from the microchip industry. 2-dimensional (2D) culture models and animal models have been used for mechanism research and drug development. However, 2D models and animal models cannot mimic the physiology of human tissue, in terms of number of cell types and properties. Thus, conventional models cannot precisely reflect human and have not been able to accurately predict in vivo responses related to drug treatment. In this regard, many industries have been looking for, and developing a new platform, to replace animal models or flask cell-culture models, and recently, organs-on-a-chip (OoCs) emerged as an alternative candidate for cell experiments and drug screening. The main advantage of these chips is that they can be manufactured at low cost. Furthermore, they allow to test a wide range of concentrations in the dosage of medicine. This advantage is expected to drive the demand for microchips, primarily to considerably accelerate scientific research. In recent years, there has been innovative uses of the organ on a chip technology for drug discovery process. For example, in March 2019, the private space exploration company SpaceX announced that it plans to soon launch a Dragon cargo capsule that will contain four microchips embedded with living human cells designed to model various aspects of human physiology. This is expected to speed up analysis and glean insights on human physiology that can be used later for drug development. As a result, due to the aforementioned advantages and research in microchip 3D cell culture technologies are expected to drive the market's growth.
North America dominates the overall 3D cell culture market with the United States being the major contributor to the market. The United States is focusing on R&D and has been making significant investments in research on 3D cell culture, for the past few years. This has resulted in technological advancements in the country. Many American applicants feature among the main patent applicants for the 3D cell culture domain. American applicants tend to develop their technologies in the United States, as well as in Asia. There have also been huge investments in the bioengineering sector in the United States over the past few years. Bio engineering involves 3D cell culture research too. According to the National Institute of Health, in 2020, the total investment in various bio engineering technologies amounted to USD 5,646, an increase from USD 5,091 in 2019. These factors have augmented the US 3D cell culture market.
The 3D cell culture market is highly competitive and consists of several major players. In terms of market share, few of the major players currently dominate the market. The presence of major market players, such as Corning Incorporated, Lonza AG, Merck KGaA, and Thermo Fisher Scientific, is increasing the overall competitive rivalry in the market.