市場調查報告書
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嗜睡症治療全球市場規模、份額和行業趨勢分析報告:2022-2028 年按類型、產品和地區劃分的展望和預測Global Narcolepsy Therapeutics Market Size, Share & Industry Trends Analysis Report By Type, By Product, By Regional Outlook and Forecast, 2022 - 2028 |
到 2028 年,全球嗜睡症藥物市場規模預計將達到 50 億美元,在預測期內以 10.5% 的複合年增長率增長。
最近在歐盟和美國批准用於治療與發作性睡病相關的 EDS 的藥物是多巴胺和去甲腎上腺素再攝取抑製劑 soliumfetol 和 H3R 拮抗劑pitrizant。許多新藥已被開發和測試用於治療與 EDS 和發作性睡病相關的猝倒,包括新型羥丁酸鹽低鈉製劑(FT218)、過夜製劑(JZP-258)和選擇性去甲腎上腺素再攝取抑製劑(AXS- 12)、莫達非尼和星形□□膠質細胞連接蛋白抑製劑(THN102)。
最近批准和研究的用於發作性睡病的藥物的作用機制、藥代動力學、療效、安全性/耐受性。嗜睡症是一種與過度嗜睡相關的慢性神經系統疾病,據認為全世界每 100,000 人中有 20-67 人患有嗜睡症。嗜睡症通常在二十多歲時開始,但通常在很晚才被診斷出來。
白天過度嗜睡 (EDS) 不是發作性睡病獨有的症狀,但應該在每個人身上看到以進行診斷。超過 60% 的患者有猝倒症。猝倒是清醒時肌肉張力的不自覺降低,通常由強烈的情緒引發。其他症狀包括不安的夜晚、入睡和醒來時的催眠和催眠幻覺,以及睡眠麻痺。
COVID-19 影響分析
在大流行期間,COVID-19 對嗜睡症藥物產生了負面影響。最大的問題是發作性睡病患者停止服藥,因為由於交通限制、家庭隔離和擔心醫院交叉感染,他們無法開出處方。此外,由於沒有針對 COVID-19 的有效治療方法,製造商和公司正在加大力度生產治療 COVID-19 所需的藥物和工具。
市場增長因素
醫療保健支出增加
推動市場增長的主要因素之一是政府對醫療保健行業的投資數量和規模不斷增加。這是因為由於發展中國家經濟的快速發展和醫療費用的上漲,高質量醫療保健的可及性預計將進一步擴大。這被視為嗜睡症藥物行業擴張的積極指標。由於這些國家的失眠問題日益嚴重,對各種治療方法和設備的需求猛增。
神經系統疾病的患病率增加
神經科醫生治療各種睡眠問題,包括發作性睡病、睡眠呼吸暫停、不寧腿綜合徵、失眠和睡眠呼吸暫停。內在的不規則是由幾種疾病引起的,會破壞規律的睡眠-覺醒週期。在接下來的幾年裡,隨著很大一部分人口老齡化,與神經睡眠相關的疾病預計會增加。美國國立衛生研究院 (NIH) 估計有 2000 萬美國人不時有睡眠問題,而估計有 4000 萬美國人患有神經系統疾病。
市場製約因素
診斷和治療嗜睡症的高昂費用
抑制嗜睡症市場的主要因素之一是嗜睡症診斷和治療的高成本。此外,“睡眠問題”一詞是指對個人健康產生嚴重不利影響並帶來巨大社會成本的一系列疾病。此外,2019年,嗜睡症市場的平穩運行將受到高額治療費用的阻礙。嗜睡症會擾亂日常功能,而且還會帶來巨大的經濟和醫療負擔——許多患者完全殘疾。
按類型劃分的前景
嗜睡症藥物市場按類型分為帶 cataplekey 的發作性睡病、不帶 cataplekey 的發作性睡病和繼發性發作性睡病。發作性睡病伴猝倒症細分市場將在 2021 年獲得發作性睡病治療市場最高的收入份額。這是因為猝倒症正在成為患者中更為常見和重要的症狀。預計在整個預測期間將保持其位置。
產品展望
根據產品,嗜睡症治療市場分為中樞神經系統興奮劑、羥丁酸鈉、選擇性血清素再攝取抑製劑、三環類抗抑鬱藥等。到 2021 年,中樞神經系統興奮劑部門將在嗜睡症治療市場中獲得可觀的收入份額。中樞神經系統藥物的數據分析,以評估成人發作性睡病患者對 Pitrisant 對白天過度嗜睡 (EDS) 和猝倒的反應開始時間。
區域展望
按地區分析了北美、歐洲、亞太地區和 LAMEA 的嗜睡症藥物市場。到 2021 年,亞太地區將在嗜睡症治療市場中獲得可觀的收入份額。這是由於經濟增長、公眾意識提高、可支配收入高、製藥和生物技術行業投資增加以及政府的慈善努力。在亞太國家中,日本被指出為嗜睡症的高發國家。
The Global Narcolepsy Therapeutics Market size is expected to reach $5 billion by 2028, rising at a market growth of 10.5% CAGR during the forecast period.
Chronic, incapacitating neurologic disease called narcolepsy is characterized by excessive daytime sleepiness (EDS). Modafinil, armodafinil, and stimulants are only a few of the medications used to treat narcolepsy. Others include sodium oxybate and venlafaxine, which are used to treat the symptoms of sleep paralysis and sleep-related hallucinations (e.g. sodium oxybate).
In general, drugs that boost norepinephrine or dopamine release or prevent their reuptake have wake-promoting effects and can help manage EDS, whereas drugs that block serotonin or norepinephrine reuptake have anti-cataplexy benefits. Both EDS and cataplexy are affected by the modification of either histamine H3 receptors (H3Rs) or -aminobutyric acid B (GABAB) receptors.
The most recent approved medications for EDS related to narcolepsy in the European Union and the USA are solriamfetol, a dopamine and norepinephrine reuptake inhibitor, and pitolisant, an H3R antagonist. Many new drugs are being developed and tested as potential treatments for EDS and cataplexy associated with narcolepsy (THN102), including novel Oxybate formulations of low sodium [FT218] and one-nightly [JZP-258], selective norepinephrine reuptake inhibitors (AXS-12), and modafinil and astroglial connexin inhibitors (THN102).
The mechanisms of action, pharmacokinetics, effectiveness, and safety/tolerability of recently authorized and developing therapies for narcolepsy. A chronic, incapacitating neurologic condition of hypersomnolence called narcolepsy is thought to affect 20-67 persons per 100,000 people across the world. Narcolepsy typically begins in the second decade of life; however, a diagnosis is frequently made much later.
Excessive daytime sleepiness (EDS), while not a specific symptom of narcolepsy, is a feature of the illness that must be present in all individuals to make the diagnosis. Up to 60% of patients have cataplexy, an involuntary decrease of muscle tone while awake that is generally brought on by intense emotions. Restless nights, hypnagogic and hypnopompic hallucinations that happen when the user falls asleep and wakes up, and sleep paralysis are other symptoms.
COVID-19 Impact Analysis
During the pandemic, COVID-19 had a detrimental effect on narcolepsy medications. The biggest problem is that patients with narcolepsy can stop taking their medication because they are unable to get their prescriptions filled because of transportation limitations, home quarantines, and hospital cross-infection fears. Additionally, because there is no effective treatment for COVID-19, manufacturers and companies are concentrating more on producing the pharmaceuticals and tools that are required for treating COVID-19.
Market Growth Factors
Growing Healthcare Expenditures
One of the main factors boosting the market's rise is the rising number and size of investments made in the healthcare sector by governments of various countries. It is anticipated that more developing nations would have greater access to high-quality healthcare as a result of their quick economic development and growing healthcare costs. This is viewed as a positive indicator of expansion for the narcolepsy therapeutics industry. The need for various treatment and apparatus has surged in these nations due to the rising insomnia problems.
Increasing Prevalence Of Neurological Conditions
Neurologists treat a wide variety of sleep problems, including narcolepsy, sleep apnea, restless legs syndrome, insomnia, and sleep apnea. Endogenous irregularities are brought on by several illnesses, which interfere with the regular sleep-wake cycle. In the upcoming years, neurological sleep-related diseases are predicted to rise as a significant section of the population ages. The National Institute of Health (NIH) estimates that 20 million Americans occasionally have sleep issues, whereas 40 million Americans suffer from neurological illnesses.
Market Restraining Factors
High Cost Of Narcolepsy Diagnosis & Treatment
One of the main factors holding back the narcolepsy market is the high cost of narcolepsy diagnosis and treatment. Additionally, the term "sleeping problem" refers to a broad range of illnesses with serious negative effects on the health of the individual and huge societal costs. Furthermore, in 2019 the smooth operation of the narcolepsy market is disrupted by the high cost of therapy. Daily functioning is hampered by narcolepsy, which is also connected with a significant financial and medical burden-many patients are fully disabled.
Type Outlook
On the basis of Type, the Narcolepsy Therapeutics Market is segmented into Narcolepsy with Cataplexy, Narcolepsy without Cataplexy, and Secondary Narcolepsy. The Narcolepsy with Cataplexy segment acquired the highest revenue share in the narcolepsy therapeutics market in 2021. It is because cataplexy is becoming a more common significant symptom among patients. Throughout the prediction, it is anticipated to hold onto its position.
Product Outlook
Based on the Product, the Narcolepsy Therapeutics Market is divided into Central Nervous System Stimulants, Sodium Oxybate, Selective Serotonin Reuptake inhibitors, Tricyclic Antidepressants, and Others. The Central Nervous System Stimulants segment recorded a substantial revenue share in the narcolepsy therapeutics market in 2021. It is because the data analysis of CNS Drugs assesses the time to onset of response to pitolisant for excessive daytime sleepiness (EDS) and cataplexy in adult narcolepsy patients.
Regional Outlook
Region-wise, the Narcolepsy Therapeutics Market is analyzed across North America, Europe, Asia Pacific, and LAMEA. The Asia Pacific region garnered a promising revenue share in the narcolepsy therapeutics market in 2021. It is due to economic growth, a rise in public awareness, high levels of disposable money, a rise in investments in the pharmaceutical and biotechnology industries, and benevolent government efforts. Among the Asia Pacific nations, Japan has been noted as having a high prevalence of narcolepsy.
The market research report covers the analysis of key stake holders of the market. Key companies profiled in the report include Jazz Pharmaceuticals plc, Shionogi & Co., Ltd., Teva Pharmaceuticals Industries Ltd., Pfizer, Inc. (Arena Pharmaceuticals, Inc.), Bioprojet, Takeda Pharmaceutical Company Limited, Ligand Pharmaceuticals, Inc., and Graymark Healthcare, Inc.
Market Segments covered in the Report:
By Type
By Product
By Geography
Companies Profiled
Unique Offerings from KBV Research
List of Figures