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1378996

寡核苷酸合成市場：2023-2028 年全球產業趨勢、佔有率、規模、成長、機會與預測

Oligonucleotide Synthesis Market: Global Industry Trends, Share, Size, Growth, Opportunity and Forecast 2023-2028
出版日期: | 出版商: IMARC | 英文 149 Pages | 商品交期: 2-3個工作天內

價格

概要

2022年全球寡核苷酸合成市場規模達27億美元。展望未來， IMARC Group預計到2028年市場規模將達到55億美元，2022-2028年複合年成長率（CAGR）為12.6%。遺傳疾病在大眾中的日益流行、新型治療策略的開發以及使用小干擾 RNA (siRNA) 和反義寡核苷酸的療法的廣泛採用是推動市場的一些主要因素。

寡核苷酸合成是指依照預定序列建構短 DNA 或 RNA 分子（稱為寡核苷酸）的過程。它們的長度範圍可以從幾個鹼基到大約 200 個核苷酸。該過程是在受控實驗室環境中以化學方式完成的，通常使用固相亞磷醯胺化學。在這種方法中，核苷酸被順序添加到不斷成長的鏈中，每次添加都涉及一系列化學反應。該技術使科學家能夠產生用於各種應用的客製化寡核苷酸，包括基因合成、聚合酶鍊式反應 (PCR)、基因編輯工具（如 CRISPR-Cas9）和分子診斷測試。寡核苷酸合成的進步極大地加速了基因組學和分子生物學的研究，為醫學和生物學研究的許多突破奠定了基礎。

大眾遺傳疾病盛行率的上升主要推動了全球市場。這就需要開發新的治療策略，其中基於寡核苷酸的療法發揮重要作用。例如，正在研究使用小干擾 RNA (siRNA) 和反義寡核苷酸的療法，並將其用於治療遺傳性疾病，例如杜氏肌肉營養不良症和脊髓性肌肉萎縮症。因此，遺傳疾病的日益普及推動了全球範圍內的需求。同時，生物資訊學和資料科學的發展對寡核苷酸合成產業產生直接影響。分析大型基因組資料集的能力不斷增強也對市場產生了積極影響。因此，計算能力的提高正在推動對新型寡核苷酸合成的需求增加。此外，寡核苷酸，特別是反義寡核苷酸，已被證明是表觀遺傳學研究和治療的有效工具，有助於調節基因表達，從而創造了積極的市場前景。

寡核苷酸合成市場趨勢/促進因素：

醫療保健和製藥業的需求不斷成長

全球對個人化醫療和治療的需求正在迅速成長，導致寡核苷酸合成市場空前擴張。這些合成的序列是開發針對各種遺傳性疾病和疾病（包括癌症）的標靶療法的不可或缺的組成部分。同時，反義寡核苷酸、適體、siRNA 和免疫刺激寡核苷酸等治療性寡核苷酸的進步，透過特異性抑製或改變基因表達，正在徹底改變疾病治療。此外，客製化寡核苷酸的合成是疫苗生產的基礎，包括基於 mRNA 的 COVID-19 疫苗，該疫苗已被證明有效且現已廣泛使用。隨著製藥公司和研究人員不斷發現寡核苷酸在治療和預防疾病方面的新應用，寡核苷酸合成的需求即將上升。

技術進步與創新

寡核苷酸合成技術的穩定發展和完善正在推動市場成長。此外，合成製程的創新，包括高通量和自動化合成系統，提高了寡核苷酸生產的效率、準確性和可擴展性。此外，生物資訊學和合成生物學的發展，包括DNA定序和基因編輯（例如CRISPR-Cas9），在很大程度上依賴準確合成寡核苷酸的能力。這些進步允許創建具有更大複雜性和多樣性的客製化序列，並促進合成生物學中的快速原型測試，從而促進更有效的研究和開發。這些不斷的技術進步和發展也在為市場做出貢獻。

不斷加強的合作和夥伴關係

製藥公司、生技公司和研究機構之間的合作和夥伴關係已成為推動遺傳疾病寡核苷酸療法的開發和商業化的重要驅動力。這些合作匯集了不同的專業知識、資源和資金，創造了一個協同環境，加速將科學發現轉化為實際有效的治療方法。製藥公司在藥物開發、臨床試驗和監管流程方面擁有豐富的經驗，為此合作貢獻了重要的專業知識。他們擁有必要的基礎設施、知識和資源來應對藥物開發的複雜局面，並確保寡核苷酸療法符合安全性和有效性的監管標準。他們的參與有助於利用現有網路、製造能力和分銷管道簡化商業化之路。

寡核苷酸合成產業細分：

IMARC Group提供了全球寡核苷酸合成市場報告各細分市場主要趨勢的分析，以及 2023-2028 年全球、區域和國家層面的預測。我們的報告根據產品、應用和最終用途對市場進行了分類。

按產品分類：

合成寡核苷酸產品

試劑

裝置

服務

合成寡核苷酸產品主導市場

該報告根據產品提供了詳細的市場細分和分析。這包括合成的寡核苷酸產品、試劑、設備和服務。根據該報告，合成寡核苷酸產品代表了最大的部分。

製藥和生物技術公司對藥物發現和開發，特別是個人化醫療和標靶治療的需求不斷成長，推動了寡核苷酸合成產業中合成寡核苷酸產品的市場。同時，在次世代定序 (NGS) 和 CRISPR 基因編輯等技術的重大進步的推動下，基因組學和分子研究的興起，提高了合成寡核苷酸的需求。此外，寡核苷酸診斷應用的成長，例如遺傳性疾病和傳染病的 PCR 和微陣列檢測，正在推動市場向前發展。表觀遺傳學領域的不斷擴大也是一個關鍵促進因素，寡核苷酸在基因表現研究中發揮著至關重要的作用。此外，遺傳性疾病的日益普及以及由此產生的對涉及寡核苷酸的新型治療策略的需求進一步加速了合成寡核苷酸產品的市場成長。

按應用分類：

PCR引子

PCR 檢測與試劑盒

定序

DNA微陣列

螢光原位雜合技術 (FISH)

反義寡核苷酸

其他

PCR引子佔據市場主導地位

報告還提供了基於應用程式的詳細市場細分和分析。這包括 PCR 引子、PCR 檢測和組合、定序、DNA 微陣列、螢光原位雜合技術 (FISH)、反義寡核苷酸等。根據報告，PCR 引子代表了最大的片段。

持續的全球健康危機推動了寡核苷酸合成產業對 PCR 引子的需求，需要進行廣泛的病毒檢測，其中 PCR 是主要方法。此外，PCR 在醫學診斷、法醫學以及檢測基因突變和傳染病的研究中的應用日益增多，也推動了對引子的需求。在基因組學和分子生物學領域，PCR 被認為是 DNA 定序、克隆和基因操作的重要工具，這種廣泛的用途進一步推動了對 PCR 引子合成的需求。除此之外，即時PCR和數位PCR等PCR技術的進步也在刺激需求方面發揮作用。此外，醫療保健和生命科學研究領域的資金不斷增加，導致 PCR 的使用擴大，從而推動了整個產業對 PCR 引子的需求。

按最終用途細分：

製藥和生物技術公司

醫院和診斷實驗室

學術研究機構

學術研究機構主導市場

該報告根據產品提供了詳細的市場細分和分析。這包括製藥和生物技術公司、醫院和診斷實驗室以及學術研究機構。報告稱，學術研究機構佔比最大。

學術研究機構對寡核苷酸合成的需求是由基因組學和分子生物學研究的興起所推動的，特別是與基因表現、遺傳性疾病和新型治療策略的開發相關的研究。此外，依賴合成寡核苷酸的下一代定序 (NGS) 和 CRISPR 基因編輯等技術的進步正在刺激需求。此外，涉及生物資訊學和資料科學的跨學科研究的不斷成長趨勢，需要使用寡核苷酸進行資料驗證，進一步推動了這一需求。政府和機構對基因組學和生物技術研究的資助是另一個主要驅動力，使學術機構能夠投資於各種計畫的寡核苷酸合成。學術研究機構專注於基礎研究和發現，往往擁有前沿知識和創新理念。透過與業界合作，他們可以將科學發現轉化為實際應用和商業產品。

按地區分類：

北美洲

美國

加拿大

亞太

中國

日本

印度

韓國

澳洲

印尼

其他

歐洲

德國

法國

英國

義大利

西班牙

俄羅斯

其他

拉丁美洲

巴西

墨西哥

其他

中東和非洲

北美表現出明顯的主導地位，佔據最大的寡核苷酸合成市場佔有率

該報告還對所有主要區域市場進行了全面分析，其中包括北美（美國和加拿大）；亞太地區（中國、日本、印度、韓國、澳洲、印尼等）；歐洲（德國、法國、英國、義大利、西班牙、俄羅斯等）；拉丁美洲（巴西、墨西哥等）；以及中東和非洲。

北美寡核苷酸合成市場由強勁的製藥和生物技術產業推動，專注於藥物發現和開發。該地區對個人化醫療和標靶治療的重視進一步推動了這一需求。此外，北美複雜的醫療保健系統和先進的診斷能力增加了診斷分析中對寡核苷酸的需求。該地區還擁有許多頂級學術和研究機構，進行廣泛的基因組學和分子生物學研究，這需要寡核苷酸合成。此外，政府和私營部門對醫療保健和生命科學研究，特別是基因組學和個人化醫療的大力投資，推動了北美工業的成長。此外，北美基於寡核苷酸的療法的輸送系統和配方的進步表明該地區致力於突破該領域的創新界限。這些發展不僅有助於市場的成長，而且有可能徹底改變各種疾病的治療，包括遺傳性疾病、癌症和罕見疾病。

競爭格局：

由於開發新生產設施、升級現有設施以及實施更有效率的生產流程的投資不斷增加，全球寡核苷酸合成市場正在經歷顯著成長。因此，該公司正在大力投資研發以創新其產品，包括開發新的合成技術、提高合成的規模和準確性，以及創造新型寡核苷酸產品以支持診斷、治療和研究中的各種應用。同時，公司正進入策略合作、夥伴關係和收購，共同開發基於寡核苷酸的藥物、共享技術和專業知識或拓展新市場。此外，反義寡核苷酸、siRNA 和 miRNA 等療法的引入為治療包括遺傳性疾病和癌症在內的多種疾病提供了新途徑，對市場產生了積極影響。此外，主要參與者正在提供寡核苷酸的客製化合成服務。這使得研究人員和開發人員能夠根據自己的需求訂購特定的寡核苷酸序列，這在基因組學、分子生物學和個人化醫療等領域尤其重要。

該報告對全球寡核苷酸合成市場的競爭格局進行了全面分析。也提供了所有主要公司的詳細資料。市場上的一些主要參與者包括：

安捷倫科技公司

比奧萊吉奧有限公司

生物合成公司

歐陸基因公司

金斯瑞

地平線探索有限公司

Integrated DNA Technologies Inc（丹納赫公司）

鐘化 Eurogentec SA（鐘化株式會社）

LGC有限公司

Nitto Denko Avecia Inc（日東電工株式會社）

賽默飛世爾科技公司

最近的發展：

2023年5月，金斯瑞擴大了其位於中國江蘇鎮江的主要製造工廠的規模，用於生產寡核苷酸和勝肽。此次擴張建立在金斯瑞 20 年來為世界各地的科學家提供一流寡核苷酸和勝肽的歷史基礎上。

2023 年 1 月，安捷倫科技公司宣布增加治療性核酸（也稱為寡核苷酸）的產量。該舉措是該行業為應對快速發展而進行的一系列投資中的最新舉措。安捷倫位於科羅拉多州弗雷德里克的工廠宣佈於 2020 年安裝一條生產線，預計今年稍後開始營運，該項目將增加兩條寡核苷酸生產線。

2022 年 2 月，Kaneka Eurogentec SA（鐘化株式會社）表示，為美國客戶批量生產的 25 g mRNA 已在其 mRNA 合成工廠成功生產。在其位於比利時的現有工廠中，Eurogentec 的 GMP mRNA 生產服務提供 GMP 材料的體外轉錄 (IVT)、純化、品質控制和批量放行，最大可達 25 g 規模。

本報告回答的關鍵問題

  • 2022年全球寡核苷酸合成市場規模是多少
  • 2023-2028年全球寡核苷酸合成市場的預期成長率是多少
  • 推動全球寡核苷酸合成市場的關鍵因素是什麼
  • COVID-19對全球寡核苷酸合成市場有何影響
  • 基於產品的全球寡核苷酸合成市場的細分是什麼
  • 基於應用的全球寡核苷酸合成市場區隔如何
  • 基於最終用途的全球寡核苷酸合成市場的細分是什麼
  • 全球寡核苷酸合成市場的重點區域有哪些
  • 誰是全球寡核苷酸合成市場的主要參與者/公司

本報告回答的關鍵問題

  • 2022年全球寡核苷酸合成市場規模有多大？
  • 2023-2028年全球寡核苷酸合成市場的預期成長率是多少？
  • 推動全球寡核苷酸合成市場的關鍵因素是什麼？
  • COVID-19對全球寡核苷酸合成市場有何影響？
  • 基於該產品的全球寡核苷酸合成市場的詳細情形如何？
  • 基於應用的全球寡核苷酸合成市場的詳細情形如何？
  • 根據最終用途，全球寡核苷酸合成市場的詳細情形如何？
  • 全球寡核苷酸合成市場的重點區域有哪些？
  • 全球寡核苷酸合成市場的主要參與者/公司有哪些？

目錄

第 1 章：前言

第 2 章：範圍與方法

  • 研究目的
  • 利害關係人
  • 資料來源
    • 主要資源
    • 二手資料
  • 市場預測
    • 自下而上的方法
    • 自上而下的方法
  • 預測方法

第 3 章：執行摘要

第 4 章：簡介

  • 概述
  • 主要行業趨勢

第 5 章：全球寡核苷酸合成市場

  • 市場概況
  • 市場業績
  • COVID-19 的影響
  • 市場預測

第 6 章：按產品分類的市場區隔

  • 合成寡核苷酸產品
    • 市場走向
    • 市場預測
  • 試劑
    • 市場走向
    • 市場預測
  • 裝置
    • 市場走向
    • 市場預測
  • 服務
    • 市場走向
    • 市場預測

第 7 章：按應用分類的市場區隔

  • PCR引子
    • 市場走向
    • 市場預測
  • PCR 檢測與試劑盒
    • 市場走向
    • 市場預測
  • 定序
    • 市場走向
    • 市場預測
  • DNA微陣列
    • 市場走向
    • 市場預測
  • 螢光原位雜合技術 (FISH)
    • 市場走向
    • 市場預測
  • 反義寡核苷酸
    • 市場走向
    • 市場預測
  • 其他
    • 市場走向
    • 市場預測

第 8 章：依最終用途分類的市場區隔

  • 製藥和生物技術公司
    • 市場走向
    • 市場預測
  • 醫院和診斷實驗室
    • 市場走向
    • 市場預測
  • 學術研究機構
    • 市場走向
    • 市場預測

第 9 章：按地區分類的市場區隔

  • 北美洲
    • 美國
      • 市場走向
      • 市場預測
    • 加拿大
      • 市場走向
      • 市場預測
  • 亞太
    • 中國
      • 市場走向
      • 市場預測
    • 日本
      • 市場走向
      • 市場預測
    • 印度
      • 市場走向
      • 市場預測
    • 韓國
      • 市場走向
      • 市場預測
    • 澳洲
      • 市場走向
      • 市場預測
    • 印尼
      • 市場走向
      • 市場預測
    • 其他
      • 市場走向
      • 市場預測
  • 歐洲
    • 德國
      • 市場走向
      • 市場預測
    • 法國
      • 市場走向
      • 市場預測
    • 英國
      • 市場走向
      • 市場預測
    • 義大利
      • 市場走向
      • 市場預測
    • 西班牙
      • 市場走向
      • 市場預測
    • 俄羅斯
      • 市場走向
      • 市場預測
    • 其他
      • 市場走向
      • 市場預測
  • 拉丁美洲
    • 巴西
      • 市場走向
      • 市場預測
    • 墨西哥
      • 市場走向
      • 市場預測
    • 其他
      • 市場走向
      • 市場預測
  • 中東和非洲
    • 市場走向
    • 按國家/地區分類的市場細分
    • 市場預測

第 10 章：SWOT 分析

  • 概述
  • 優勢
  • 弱點
  • 機會
  • 威脅

第 11 章：價值鏈分析

第 12 章：波特五力分析

  • 概述
  • 買家的議價能力
  • 供應商的議價能力
  • 競爭程度
  • 新進入者的威脅
  • 替代品的威脅

第 13 章：價格分析

第14章：競爭格局

  • 市場結構
  • 關鍵參與者
  • 關鍵參與者簡介
    • Agilent Technologies Inc.
    • Biolegio BV
    • Bio-Synthesis Inc
    • Eurofins Genomics
    • GenScript
    • Horizon Discovery Ltd
    • Integrated DNA Technologies Inc (Danaher Corporation)
    • Kaneka Eurogentec SA (Kaneka Corporation)
    • LGC Limited
    • Nitto Denko Avecia Inc (Nitto Denko Corporation)
    • Thermo Fisher Scientific Inc.
Product Code: SR112023A3812

Abstract

The global oligonucleotide synthesis market size reached US$ 2.7 Billion in 2022. Looking forward, IMARC Group expects the market to reach US$ 5.5 Billion by 2028, exhibiting a growth rate (CAGR) of 12.6% during 2022-2028. The growing prevalence of genetic diseases among the masses, the development of novel therapeutic strategies, and the widespread adoption of therapies using small interfering RNAs (siRNAs), and antisense oligonucleotides are some of the major factors propelling the market.

Oligonucleotide synthesis refers to the process of constructing short DNA or RNA molecules, called oligonucleotides, in a predetermined sequence. These can range from just a few bases to around 200 nucleotides in length. The process is accomplished chemically in a controlled laboratory environment, typically using solid phase phosphoramidite chemistry. In this method, nucleotides are sequentially added to a growing chain, each addition involving a series of chemical reactions. This technology enables scientists to generate custom-made oligonucleotides for various applications including gene synthesis, polymerase chain reaction (PCR), gene editing tools, such as CRISPR-Cas9, and molecular diagnostic tests. Advances in oligonucleotide synthesis have dramatically accelerated research in genomics and molecular biology, underpinning many breakthroughs in medical and biological research.

The rising prevalence of genetic diseases among the masses majorly drives the global market. This necessitates the development of novel therapeutic strategies, where oligonucleotide-based therapies play a significant role. For instance, therapies using small interfering RNAs (siRNAs) and antisense oligonucleotides are being investigated and utilized in the treatment of genetic disorders, such as Duchenne muscular dystrophy and spinal muscular atrophy. As such, the growing prevalence of genetic diseases drives the demand on the global level. Along with this, the growth of bioinformatics and data science has a direct impact on the oligonucleotide synthesis industry. The escalating capacity to analyze large genomic datasets is also positively influencing the market. Therefore, the rising computational capability is driving an increased demand for the synthesis of novel oligonucleotides. Furthermore, oligonucleotides particularly antisense oligonucleotides, have been shown to be effective tools in epigenetic research and therapy, helping to modulate gene expression, which is creating a positive market outlook.

Oligonucleotide Synthesis Market Trends/Drivers:

Rising Demand in the Healthcare and Pharmaceutical Industries

The global demand for personalized medicine and therapeutics is rapidly increasing, leading to an unprecedented expansion in the oligonucleotide synthesis market. These synthesized sequences are integral components in developing targeted therapies for various genetic disorders and diseases, including cancer. Along with this, the advancement of therapeutic oligonucleotides, such as antisense oligonucleotides, aptamers, siRNAs, and immunostimulatory oligonucleotides, is revolutionizing disease treatment by specifically inhibiting or altering gene expression. Furthermore, the synthesis of custom oligonucleotides is fundamental to the production of vaccines, including mRNA-based COVID-19 vaccines, which have proven effective and are now widely used. As pharmaceutical companies and researchers continue to discover novel applications for oligonucleotides in the treatment and prevention of diseases, the demand for oligonucleotide synthesis is poised to rise.

Technological Advancements and Innovation

The steady development and refinement of oligonucleotide synthesis technologies are driving market growth. In addition, innovations in the synthesis process, including high-throughput and automated synthesis systems, have increased the efficiency, accuracy, and scalability of oligonucleotide production. Moreover, developments in bioinformatics and synthetic biology, including DNA sequencing and gene editing (e.g., CRISPR-Cas9), heavily rely on the ability to synthesize oligonucleotides accurately. These advancements allow for the creation of custom sequences with greater complexity and diversity and facilitate rapid prototype testing in synthetic biology, thereby fostering more efficient research and development. These continuous technological advancements and developments are also contributing to the market.

Growing Collaborations and Partnerships

Collaborations and partnerships between pharmaceutical companies, biotechnology firms, and research institutions have become essential drivers in advancing the development and commercialization of oligonucleotide therapies for genetic diseases. These collaborations bring together diverse expertise, resources, and funding, creating a synergistic environment that accelerates the translation of scientific discoveries into practical and effective treatments. Pharmaceutical companies, with their experience in drug development, clinical trials, and regulatory processes, contribute vital expertise to the collaboration. They have the infrastructure, knowledge, and resources necessary to navigate the complex landscape of drug development and ensure that oligonucleotide therapies meet regulatory standards for safety and efficacy. Their involvement helps streamline the path to commercialization by leveraging existing networks, manufacturing capabilities, and distribution channels.

Oligonucleotide Synthesis Industry Segmentation:

IMARC Group provides an analysis of the key trends in each segment of the global oligonucleotide synthesis market report, along with forecasts at the global, regional and country levels from 2023-2028. Our report has categorized the market based on product, application and end use.

Breakup by Product:

Synthesized Oligonucleotide Products

Reagents

Equipment

Services

Synthesized oligonucleotide products dominate the market

The report has provided a detailed breakup and analysis of the market based on the product. This includes synthesized oligonucleotide products, reagents, equipment, and services. According to the report, synthesized oligonucleotide products represented the largest segment.

The market for synthesized oligonucleotide products in the oligonucleotide synthesis industry is being driven by the ever-increasing demand from pharmaceutical and biotechnological companies for drug discovery and development, especially for personalized medicine and targeted therapeutics. Along with this, the rise in genomics and molecular research, fueled by significant advancements in technologies such as Next Generation Sequencing (NGS) and CRISPR gene-editing, is enhancing the requirement for synthesized oligonucleotides. Additionally, the growth in diagnostic applications of oligonucleotides, such as in PCR and microarray assays for genetic and infectious diseases, is propelling the market forward. The expanding field of epigenetics also represents a key driver, with oligonucleotides playing a crucial role in gene expression studies. Moreover, the increasing prevalence of genetic disorders and the resultant demand for novel therapeutic strategies involving oligonucleotides further accelerates the market growth for synthesized oligonucleotide products.

Breakup by Application:

PCR Primers

PCR Assays and Panels

Sequencing

DNA Microarrays

Fluorescence In-Situ Hybridization (FISH)

Antisense Oligonucleotides

Others

PCR primers dominate the market

A detailed breakup and analysis of the market based on the application has also been provided in the report. This includes PCR primers, PCR assays and panels, sequencing, DNA microarrays, Fluorescence In-Situ Hybridization (FISH), antisense oligonucleotides, and others. According to the report, the PCR primers represented the largest segment.

The demand for PCR primers in the oligonucleotide synthesis industry is driven by the ongoing global health crisis necessitating extensive viral testing, in which PCR is a primary method. Furthermore, the increasing application of PCR in medical diagnostics, forensics, and research to detect genetic mutations and infectious diseases fuels the demand for primers. In the field of genomics and molecular biology, PCR is considered a crucial tool for DNA sequencing, cloning, and genetic manipulation, and this broad utilization further drives the need for PCR primer synthesis. Apart from this, technological advancements in PCR techniques, such as real-time PCR and digital PCR, are also playing a role in boosting demand. Moreoevr, the growing funding for research in healthcare and life sciences has resulted in expanded use of PCR, thus driving the demand for PCR primers in the overall industry.

Breakup by End Use:

Pharmaceutical and Biotechnology Companies

Hospital and Diagnostic Laboratories

Academic Research Institutes

Academic research institutes dominate the market

The report has provided a detailed breakup and analysis of the market based on the product. This includes pharmaceutical and biotechnology companies, hospital and diagnostic laboratories, and academic research institutes. According to the report, academic research institutes represented the largest segment.

The demand for oligonucleotide synthesis in academic research institutes is driven by a rise in genomics and molecular biology research, particularly studies related to gene expression, genetic disorders, and the development of novel therapeutic strategies. Additionally, advancements in technologies such as Next-Generation Sequencing (NGS) and CRISPR gene-editing, which rely on synthesized oligonucleotides, are stimulating demand. In addition, the rising trend of interdisciplinary studies involving bioinformatics and data science, which necessitate the use of oligonucleotides for data validation, further drives the need. Governmental and institutional funding for genomics and biotechnology research is another major driver, enabling academic institutes to invest in oligonucleotide synthesis for various projects. Academic research institutes, with their focus on fundamental research and discovery, often possess cutting-edge knowledge and innovative ideas. By partnering with industry, they can translate their scientific findings into practical applications and commercial products.

Breakup by Region:

North America

United States

Canada

Asia-Pacific

China

Japan

India

South Korea

Australia

Indonesia

Others

Europe

Germany

France

United Kingdom

Italy

Spain

Russia

Others

Latin America

Brazil

Mexico

Others

Middle East and Africa

North America exhibits a clear dominance, accounting for the largest oligonucleotide synthesis market share

The report has also provided a comprehensive analysis of all the major regional markets, which include North America (the United States and Canada); Asia Pacific (China, Japan, India, South Korea, Australia, Indonesia, and others); Europe (Germany, France, the United Kingdom, Italy, Spain, Russia, and others); Latin America (Brazil, Mexico, and others); and the Middle East and Africa.

The North American market for oligonucleotide synthesis is propelled by a robust pharmaceutical and biotech industry, with a strong focus on drug discovery and development. The region's emphasis on personalized medicine and targeted therapies further propels this need. Additionally, North America's sophisticated healthcare system with advanced diagnostic capabilities increases the demand for oligonucleotides in diagnostic assays. The region also hosts numerous top-tier academic and research institutes conducting extensive genomics and molecular biology research, which necessitates oligonucleotide synthesis. Moreover, strong governmental and private sector investment in healthcare and life sciences research, particularly in genomics and personalized medicine, fuels the growth of industry in North America. Moreover, the advancements in delivery systems and formulations for oligonucleotide-based therapeutics in North America demonstrate the region's commitment to pushing the boundaries of innovation in this field. These developments not only contribute to the growth of the market but also have the potential to revolutionize the treatment of various diseases, including genetic disorders, cancers, and rare diseases.

Competitive Landscape:

The global oligonucleotide synthesis market is experiencing significant growth due to the escalating investments in the development of new production facilities, upgrading existing ones, and implementing more efficient production processes. Therefore, Companies are heavily investing in research and development to innovate their offerings, including developing new synthesis techniques, improving the scale and accuracy of synthesis, and creating new types of oligonucleotide products to support various applications in diagnostics, therapeutics, and research. Along with this, companies are entering into strategic collaborations, partnerships, and acquisitions to co-develop oligonucleotide-based drugs, share technology and expertise, or expand into new markets. In addition, the introduction of therapeutics, such as antisense oligonucleotides, siRNAs, and miRNAs, offer new avenues for treating a wide range of diseases, including genetic disorders and cancers is positively influencing the market. Furthermore, key players are offering services for the custom synthesis of oligonucleotides. This allows researchers and developers to order specific oligonucleotide sequences tailored to their needs, which is particularly important in fields like genomics, molecular biology, and personalized medicine.

The report has provided a comprehensive analysis of the competitive landscape in the global oligonucleotide synthesis market. Detailed profiles of all major companies have also been provided. Some of the key players in the market include:

Agilent Technologies Inc.

Biolegio B.V.

Bio-Synthesis Inc

Eurofins Genomics

GenScript

Horizon Discovery Ltd

Integrated DNA Technologies Inc (Danaher Corporation)

Kaneka Eurogentec S.A. (Kaneka Corporation)

LGC Limited

Nitto Denko Avecia Inc (Nitto Denko Corporation)

Thermo Fisher Scientific Inc.

Recent Developments:

In May 2023, GenScript increased the size of its principal manufacturing plant in Zhenjiang, Jiangsu, China for the manufacture of oligonucleotides and peptides. The expansion builds on GenScript's history of providing top-notch oligo and peptides to scientists all across the world for 20 years.

In January 2023, Agilent Technologies Inc. announced to increase its production of therapeutic nucleic acids, also known as oligonucleotides. The initiative is the most recent in a series of investments done by the sector in response to rapid development. At Agilent's plant in Frederick, Colorado, where the installation of a line announced in 2020 is slated to commence operating later this year, the project will add two oligonucleotide production lines.

In February 2022, Kaneka Eurogentec S.A. (Kaneka Corporation) stated that a 25 g batch of mRNA for a US customer had been successfully manufactured at its mRNA synthesis facility. In its present facility in Belgium, Eurogentec's GMP mRNA production service provides in vitro transcription (IVT), purification, quality control, and batch release of GMP material up to 25 g scale.

Key Questions Answered in This Report

  • 1. What was the size of the global oligonucleotide synthesis market in 2022?
  • 2. What is the expected growth rate of the global oligonucleotide synthesis market during 2023-2028?
  • 3. What are the key factors driving the global oligonucleotide synthesis market?
  • 4. What has been the impact of COVID-19 on the global oligonucleotide synthesis market?
  • 5. What is the breakup of the global oligonucleotide synthesis market based on the product?
  • 6. What is the breakup of the global oligonucleotide synthesis market based on the application?
  • 7. What is the breakup of the global oligonucleotide synthesis market based on end use?
  • 8. What are the key regions in the global oligonucleotide synthesis market?
  • 9. Who are the key players/companies in the global oligonucleotide synthesis market?

Table of Contents

1 Preface

2 Scope and Methodology

  • 2.1 Objectives of the Study
  • 2.2 Stakeholders
  • 2.3 Data Sources
    • 2.3.1 Primary Sources
    • 2.3.2 Secondary Sources
  • 2.4 Market Estimation
    • 2.4.1 Bottom-Up Approach
    • 2.4.2 Top-Down Approach
  • 2.5 Forecasting Methodology

3 Executive Summary

4 Introduction

  • 4.1 Overview
  • 4.2 Key Industry Trends

5 Global Oligonucleotide Synthesis Market

  • 5.1 Market Overview
  • 5.2 Market Performance
  • 5.3 Impact of COVID-19
  • 5.4 Market Forecast

6 Market Breakup by Product

  • 6.1 Synthesized Oligonucleotide Products
    • 6.1.1 Market Trends
    • 6.1.2 Market Forecast
  • 6.2 Reagents
    • 6.2.1 Market Trends
    • 6.2.2 Market Forecast
  • 6.3 Equipment
    • 6.3.1 Market Trends
    • 6.3.2 Market Forecast
  • 6.4 Services
    • 6.4.1 Market Trends
    • 6.4.2 Market Forecast

7 Market Breakup by Application

  • 7.1 PCR Primers
    • 7.1.1 Market Trends
    • 7.1.2 Market Forecast
  • 7.2 PCR Assays and Panels
    • 7.2.1 Market Trends
    • 7.2.2 Market Forecast
  • 7.3 Sequencing
    • 7.3.1 Market Trends
    • 7.3.2 Market Forecast
  • 7.4 DNA Microarrays
    • 7.4.1 Market Trends
    • 7.4.2 Market Forecast
  • 7.5 Fluorescence In-Situ Hybridization (FISH)
    • 7.5.1 Market Trends
    • 7.5.2 Market Forecast
  • 7.6 Antisense Oligonucleotides
    • 7.6.1 Market Trends
    • 7.6.2 Market Forecast
  • 7.7 Others
    • 7.7.1 Market Trends
    • 7.7.2 Market Forecast

8 Market Breakup by End Use

  • 8.1 Pharmaceutical and Biotechnology Companies
    • 8.1.1 Market Trends
    • 8.1.2 Market Forecast
  • 8.2 Hospital and Diagnostic Laboratories
    • 8.2.1 Market Trends
    • 8.2.2 Market Forecast
  • 8.3 Academic Research Institutes
    • 8.3.1 Market Trends
    • 8.3.2 Market Forecast

9 Market Breakup by Region

  • 9.1 North America
    • 9.1.1 United States
      • 9.1.1.1 Market Trends
      • 9.1.1.2 Market Forecast
    • 9.1.2 Canada
      • 9.1.2.1 Market Trends
      • 9.1.2.2 Market Forecast
  • 9.2 Asia-Pacific
    • 9.2.1 China
      • 9.2.1.1 Market Trends
      • 9.2.1.2 Market Forecast
    • 9.2.2 Japan
      • 9.2.2.1 Market Trends
      • 9.2.2.2 Market Forecast
    • 9.2.3 India
      • 9.2.3.1 Market Trends
      • 9.2.3.2 Market Forecast
    • 9.2.4 South Korea
      • 9.2.4.1 Market Trends
      • 9.2.4.2 Market Forecast
    • 9.2.5 Australia
      • 9.2.5.1 Market Trends
      • 9.2.5.2 Market Forecast
    • 9.2.6 Indonesia
      • 9.2.6.1 Market Trends
      • 9.2.6.2 Market Forecast
    • 9.2.7 Others
      • 9.2.7.1 Market Trends
      • 9.2.7.2 Market Forecast
  • 9.3 Europe
    • 9.3.1 Germany
      • 9.3.1.1 Market Trends
      • 9.3.1.2 Market Forecast
    • 9.3.2 France
      • 9.3.2.1 Market Trends
      • 9.3.2.2 Market Forecast
    • 9.3.3 United Kingdom
      • 9.3.3.1 Market Trends
      • 9.3.3.2 Market Forecast
    • 9.3.4 Italy
      • 9.3.4.1 Market Trends
      • 9.3.4.2 Market Forecast
    • 9.3.5 Spain
      • 9.3.5.1 Market Trends
      • 9.3.5.2 Market Forecast
    • 9.3.6 Russia
      • 9.3.6.1 Market Trends
      • 9.3.6.2 Market Forecast
    • 9.3.7 Others
      • 9.3.7.1 Market Trends
      • 9.3.7.2 Market Forecast
  • 9.4 Latin America
    • 9.4.1 Brazil
      • 9.4.1.1 Market Trends
      • 9.4.1.2 Market Forecast
    • 9.4.2 Mexico
      • 9.4.2.1 Market Trends
      • 9.4.2.2 Market Forecast
    • 9.4.3 Others
      • 9.4.3.1 Market Trends
      • 9.4.3.2 Market Forecast
  • 9.5 Middle East and Africa
    • 9.5.1 Market Trends
    • 9.5.2 Market Breakup by Country
    • 9.5.3 Market Forecast

10 SWOT Analysis

  • 10.1 Overview
  • 10.2 Strengths
  • 10.3 Weaknesses
  • 10.4 Opportunities
  • 10.5 Threats

11 Value Chain Analysis

12 Porters Five Forces Analysis

  • 12.1 Overview
  • 12.2 Bargaining Power of Buyers
  • 12.3 Bargaining Power of Suppliers
  • 12.4 Degree of Competition
  • 12.5 Threat of New Entrants
  • 12.6 Threat of Substitutes

13 Price Analysis

14 Competitive Landscape

  • 14.1 Market Structure
  • 14.2 Key Players
  • 14.3 Profiles of Key Players
    • 14.3.1 Agilent Technologies Inc.
      • 14.3.1.1 Company Overview
      • 14.3.1.2 Product Portfolio
      • 14.3.1.3 Financials
      • 14.3.1.4 SWOT Analysis
    • 14.3.2 Biolegio B.V.
      • 14.3.2.1 Company Overview
      • 14.3.2.2 Product Portfolio
    • 14.3.3 Bio-Synthesis Inc
      • 14.3.3.1 Company Overview
      • 14.3.3.2 Product Portfolio
    • 14.3.4 Eurofins Genomics
      • 14.3.4.1 Company Overview
      • 14.3.4.2 Product Portfolio
    • 14.3.5 GenScript
      • 14.3.5.1 Company Overview
      • 14.3.5.2 Product Portfolio
    • 14.3.6 Horizon Discovery Ltd
      • 14.3.6.1 Company Overview
      • 14.3.6.2 Product Portfolio
    • 14.3.7 Integrated DNA Technologies Inc (Danaher Corporation)
      • 14.3.7.1 Company Overview
      • 14.3.7.2 Product Portfolio
    • 14.3.8 Kaneka Eurogentec S.A. (Kaneka Corporation)
      • 14.3.8.1 Company Overview
      • 14.3.8.2 Product Portfolio
    • 14.3.9 LGC Limited
      • 14.3.9.1 Company Overview
      • 14.3.9.2 Product Portfolio
    • 14.3.10 Nitto Denko Avecia Inc (Nitto Denko Corporation)
      • 14.3.10.1 Company Overview
      • 14.3.10.2 Product Portfolio
    • 14.3.11 Thermo Fisher Scientific Inc.
      • 14.3.11.1 Company Overview
      • 14.3.11.2 Product Portfolio
      • 14.3.11.3 Financials
      • 14.3.11.4 SWOT Analysis

List of Figures

  • Figure 1: Global: Oligonucleotide Synthesis Market: Major Drivers and Challenges
  • Figure 2: Global: Oligonucleotide Synthesis Market: Sales Value (in Billion US$), 2017-2022
  • Figure 3: Global: Oligonucleotide Synthesis Market Forecast: Sales Value (in Billion US$), 2023-2028
  • Figure 4: Global: Oligonucleotide Synthesis Market: Breakup by Product (in %), 2022
  • Figure 5: Global: Oligonucleotide Synthesis Market: Breakup by Application (in %), 2022
  • Figure 6: Global: Oligonucleotide Synthesis Market: Breakup by End Use (in %), 2022
  • Figure 7: Global: Oligonucleotide Synthesis Market: Breakup by Region (in %), 2022
  • Figure 8: Global: Oligonucleotide Synthesis (Synthesized Oligonucleotide Products) Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 9: Global: Oligonucleotide Synthesis (Synthesized Oligonucleotide Products) Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 10: Global: Oligonucleotide Synthesis (Reagents) Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 11: Global: Oligonucleotide Synthesis (Reagents) Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 12: Global: Oligonucleotide Synthesis (Equipment) Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 13: Global: Oligonucleotide Synthesis (Equipment) Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 14: Global: Oligonucleotide Synthesis (Services) Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 15: Global: Oligonucleotide Synthesis (Services) Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 16: Global: Oligonucleotide Synthesis (PCR Primers) Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 17: Global: Oligonucleotide Synthesis (PCR Primers) Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 18: Global: Oligonucleotide Synthesis (PCR Assays and Panels) Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 19: Global: Oligonucleotide Synthesis (PCR Assays and Panels) Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 20: Global: Oligonucleotide Synthesis (Sequencing) Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 21: Global: Oligonucleotide Synthesis (Sequencing) Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 22: Global: Oligonucleotide Synthesis (DNA Microarrays) Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 23: Global: Oligonucleotide Synthesis (DNA Microarrays) Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 24: Global: Oligonucleotide Synthesis (Fluorescence In-Situ Hybridization (FISH)) Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 25: Global: Oligonucleotide Synthesis (Fluorescence In-Situ Hybridization (FISH)) Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 26: Global: Oligonucleotide Synthesis (Antisense Oligonucleotides) Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 27: Global: Oligonucleotide Synthesis (Antisense Oligonucleotides) Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 28: Global: Oligonucleotide Synthesis (Other Applications) Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 29: Global: Oligonucleotide Synthesis (Other Applications) Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 30: Global: Oligonucleotide Synthesis (Pharmaceutical and Biotechnology Companies) Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 31: Global: Oligonucleotide Synthesis (Pharmaceutical and Biotechnology Companies) Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 32: Global: Oligonucleotide Synthesis (Hospital and Diagnostic Laboratories) Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 33: Global: Oligonucleotide Synthesis (Hospital and Diagnostic Laboratories) Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 34: Global: Oligonucleotide Synthesis (Academic Research Institutes) Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 35: Global: Oligonucleotide Synthesis (Academic Research Institutes) Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 36: North America: Oligonucleotide Synthesis Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 37: North America: Oligonucleotide Synthesis Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 38: United States: Oligonucleotide Synthesis Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 39: United States: Oligonucleotide Synthesis Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 40: Canada: Oligonucleotide Synthesis Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 41: Canada: Oligonucleotide Synthesis Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 42: Asia-Pacific: Oligonucleotide Synthesis Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 43: Asia-Pacific: Oligonucleotide Synthesis Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 44: China: Oligonucleotide Synthesis Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 45: China: Oligonucleotide Synthesis Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 46: Japan: Oligonucleotide Synthesis Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 47: Japan: Oligonucleotide Synthesis Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 48: India: Oligonucleotide Synthesis Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 49: India: Oligonucleotide Synthesis Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 50: South Korea: Oligonucleotide Synthesis Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 51: South Korea: Oligonucleotide Synthesis Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 52: Australia: Oligonucleotide Synthesis Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 53: Australia: Oligonucleotide Synthesis Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 54: Indonesia: Oligonucleotide Synthesis Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 55: Indonesia: Oligonucleotide Synthesis Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 56: Others: Oligonucleotide Synthesis Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 57: Others: Oligonucleotide Synthesis Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 58: Europe: Oligonucleotide Synthesis Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 59: Europe: Oligonucleotide Synthesis Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 60: Germany: Oligonucleotide Synthesis Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 61: Germany: Oligonucleotide Synthesis Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 62: France: Oligonucleotide Synthesis Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 63: France: Oligonucleotide Synthesis Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 64: United Kingdom: Oligonucleotide Synthesis Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 65: United Kingdom: Oligonucleotide Synthesis Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 66: Italy: Oligonucleotide Synthesis Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 67: Italy: Oligonucleotide Synthesis Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 68: Spain: Oligonucleotide Synthesis Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 69: Spain: Oligonucleotide Synthesis Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 70: Russia: Oligonucleotide Synthesis Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 71: Russia: Oligonucleotide Synthesis Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 72: Others: Oligonucleotide Synthesis Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 73: Others: Oligonucleotide Synthesis Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 74: Latin America: Oligonucleotide Synthesis Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 75: Latin America: Oligonucleotide Synthesis Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 76: Brazil: Oligonucleotide Synthesis Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 77: Brazil: Oligonucleotide Synthesis Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 78: Mexico: Oligonucleotide Synthesis Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 79: Mexico: Oligonucleotide Synthesis Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 80: Others: Oligonucleotide Synthesis Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 81: Others: Oligonucleotide Synthesis Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 82: Middle East and Africa: Oligonucleotide Synthesis Market: Sales Value (in Million US$), 2017 & 2022
  • Figure 83: Middle East and Africa: Oligonucleotide Synthesis Market: Breakup by Country (in %), 2022
  • Figure 84: Middle East and Africa: Oligonucleotide Synthesis Market Forecast: Sales Value (in Million US$), 2023-2028
  • Figure 85: Global: Oligonucleotide Synthesis Industry: SWOT Analysis
  • Figure 86: Global: Oligonucleotide Synthesis Industry: Value Chain Analysis
  • Figure 87: Global: Oligonucleotide Synthesis Industry: Porter's Five Forces Analysis

List of Tables

  • Table 1: Global: Oligonucleotide Synthesis Market: Key Industry Highlights, 2022 and 2028
  • Table 2: Global: Oligonucleotide Synthesis Market Forecast: Breakup by Product (in Million US$), 2023-2028
  • Table 3: Global: Oligonucleotide Synthesis Market Forecast: Breakup by Application (in Million US$), 2023-2028
  • Table 4: Global: Oligonucleotide Synthesis Market Forecast: Breakup by End Use (in Million US$), 2023-2028
  • Table 5: Global: Oligonucleotide Synthesis Market Forecast: Breakup by Region (in Million US$), 2023-2028
  • Table 6: Global: Oligonucleotide Synthesis Market: Competitive Structure
  • Table 7: Global: Oligonucleotide Synthesis Market: Key Players