市場調查報告書
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1342642
外周血單核細胞市場 - 2018-2028 年全球行業規模、佔有率、趨勢、機會和預測,按產品、按應用、技術、來源、地區、競爭、預測和機會細分Peripheral Blood Mononuclear Cells Market - Global Industry Size, Share, Trends, Opportunity, and Forecast, 2018-2028 Segmented By Product, By Application, By Techniques, By Source, By Region, Competition, Forecast and Opportunities |
2022年,全球外周血單核細胞市場價值為2.3568億美元,由於細胞療法數量的成長、研究和開發的高需求,預計2023-2028年期間年複合成長率為10.39%對化合物的毒理學測試和反應機理負責新產品的穩定開發。例如,2023 年 6 月,國家醫學圖書館發表的一項研究評估了體外感染克氏錐蟲哥倫比亞株 (Col) 並用苯並硝唑治療的外周血單核細胞 (PBMC) 的免疫反應。
客戶對外周血單核細胞的認知不斷增強,以及對抗體開發的日益偏好,是該行業的兩個重要成長動力。 PBMC對於開展生物學和病理學相關研究以及與致命疾病、免疫學、疫苗開發等相關的臨床研究至關重要。例如,根據clinicaltirals.gov.in的數據,已針對外周血進行了972項研究單核細胞。 PBMC 提供有關前瞻性新型藥物分子對人類尤其是免疫系統影響的資訊。影響 PBMC 的藥物毒性可能會導致幾種嚴重的、有時甚至是致命的毒副作用,包括免疫系統抑制和中毒。毒理學研究旨在評估化學物質、藥物和環境因素對生物體的潛在有害影響。 PBMC 用於免疫毒性研究,以評估這些物質對免疫系統的影響。通過將 PBMC 暴露於不同的化合物並分析免疫反應,研究人員可以確定免疫毒性作用,包括免疫細胞群、細胞因子產生和免疫功能的改變。因此,免疫毒性研究對 PBMC 的需求不斷增加,促進了全球外周血單核細胞市場的成長。
相對於傳統的再生藥物,患者現在有了更好的細胞療法替代方案,但其副作用阻礙了它們在客戶中的使用。在這一產品類別中,北美和歐洲等已開發地區在促進人類福祉的細胞療法方面擁有強大的影響力。人們越來越認知到在細胞和基因治療中使用外周血單核細胞。因此,外周血單個核細胞的提取和使用被證明是市場擴張的關鍵驅動力。然而,急性心肌梗塞、慢性心力衰竭、脊髓損傷、中風和傷口癒合等致命疾病都已在臨床前研究中使用凋亡外周血單核細胞的分泌組成功治療,這推動了全球市場的成長。例如,根據美國疾病控制與預防中心的數據,美國每年約有 37,300 例新發 HPV+ 腫瘤病例,佔女性所有惡性腫瘤的 3%,佔男性所有癌症的 2%。隨著HPV在該國的流行率不斷上升,公司不斷致力於開發療法和藥物以進入美國市場。 PBMC 是細胞治療免疫細胞的寶貴來源。它們含有各種類型的免疫細胞,包括 T 細胞、B 細胞和自然殺傷 (NK) 細胞,在免疫反應和疾病靶向中發揮著至關重要的作用。 PBMC 提供了多種免疫細胞,可以在不同的細胞治療方法中分離、操作和利用它們。
此外,過繼細胞移植 (ACT) 是一種細胞療法,涉及將免疫細胞(通常是 T 細胞)轉移到患者體內,以靶向和消除癌症等疾病。 PBMC 通常用作分離和擴增特定 T 細胞亞群的起始材料,例如腫瘤浸潤淋巴細胞 (TIL)、腫瘤相關抗原特異性 T 細胞或基因工程 T 細胞。 PBMC 為 ACT 療法提供了便捷的 T 細胞來源。
隨著用於治療致命疾病的新型細胞/基因療法/藥物和新產品的開發,研發 (R&D) 實踐和活動的快速進步正在推動市場的成長。 PBMC 是從常規採集的血液樣本中獲取生理相關(免疫)蛋白質的合理方法,而且它們這樣做時,不會遇到天然人血漿中因高豐度蛋白質的存在而帶來的眾所周知的分析挑戰,從而推動市場的成長。此外,為了促進醫療保健領域的發展,各國政府正在為正在進行的外周血單核細胞研究提供資金。
此外,人們對 PBMC 在疾病研究中的潛力的認知不斷增強,導致研發活動增加,並促進了市場成長。 PBMC 在藥物發現和開發中發揮著至關重要的作用。它們用於早期研究,以評估潛在候選藥物的功效和安全性。 PBMC 提供了一個與人類相關的模型,用於研究免疫反應和評估新化合物對免疫細胞的影響。人們越來越認知到 PBMC 在藥物發現中的價值,導致對這些細胞的需求和利用增加,從而推動 PBMC 市場的成長。人們對基於細胞的療法的治療潛力的認知正在迅速增強。 PBMC 在細胞療法的開發和製造中至關重要,例如過繼細胞移植、CAR-T 細胞療法和免疫療法。這些先進療法的治療效果,加上人們對 PBMC 在其發育中的作用的認知不斷提高,導致了重大的研發工作和全球外周血單核細胞市場的成長。學術機構、研究組織和生物製藥行業之間的合作顯著增加。這種合作促進了知識交流、聯合研究項目和資助計劃,重點關注 PBMC 在各個研究領域的應用。人們對 PBMC 潛力的認知不斷增強以及研發方面的協作努力對全球外周血單核細胞市場的成長產生了積極影響。
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Global peripheral blood mononuclear cells market was valued at USD 235.68 million in 2022 and is anticipated to grow at a CAGR of 10.39% during the period 2023-2028 owing to the rising rate in the number of cell therapies, high demand of research, and development for toxicology testing and reaction mechanism of the compound responsible for new and stable development of products. For instance, in June 2023, a study published in the National Library of Medicine assessed the immune response of peripheral blood mononuclear cells (PBMC) that were infected in vitro with the Colombian strain (Col) of Trypanosoma cruzi and treated with Benzonidazole.
Peripheral blood mononuclear cells (PBMCs) are a type of blood cell that plays a crucial role in the immune system. PBMCs are a heterogeneous population of cells that are isolated from the peripheral blood, which is the blood circulating throughout the body. They are composed of lymphocytes, monocytes, and other immune cells. Lymphocytes are a type of white blood cell that includes T cells, B cells, and natural killer (NK) cells. T cells are responsible for cell-mediated immune responses, B cells produce antibodies for humoral immune responses, and NK cells are involved in the innate immune system and killing infected or cancerous cells. Monocytes are another type of white blood cell that circulates in the bloodstream and can differentiate into macrophages or dendritic cells when they migrate into tissues. Macrophages are responsible for engulfing and destroying foreign substances, dead cells, and cellular debris, while dendritic cells play a critical role in initiating and regulating immune responses by presenting antigens to T cells. The isolation and characterization of PBMCs have revolutionized the understanding of the immune system and have contributed to advancements in various fields, including cancer research, infectious diseases, autoimmune disorders, and transplantation medicine.
PBMCs are widely used in various research applications, including immunology, cell therapy, vaccine development, and drug discovery. They provide valuable insights into immune responses, allow researchers to study various immune cell populations, and serve as a source of cells for cell-based therapies. PBMCs can be isolated from peripheral blood using techniques such as density gradient centrifugation or specialized cell separation methods.
Additionally, the rise in number of cell therapies, expansion in research & development schemes, increasing focus of key players on R&D in peripheral blood mononuclear cells, increasing focus on regenerative medicine, as well as an increase in demand for cell operations among the population, increasing investigation of various aspects of immunology, infectious diseases, autoimmune disorders, transplantation, and vaccine development are projected to provide market players with lucrative prospects in the future.
The growing awareness of customers for peripheral blood mononuclear cells, as well as a growing preference for antibody development, are two important growth drivers for the industry. PBMC is crucial to carry out biology and pathology-related studies as well as in clinical research related to fatal diseases, immunology, vaccine development, etc. For instance, according to clinicaltirals.gov.in, 972 studies have been carried out for peripheral blood mononuclear cells. PBMCs provide information on the effects of prospective novel medication molecules on people, particularly on their immune systems. Drug toxicity that affects PBMCs can result in several serious, sometimes fatal toxic side effects, including immune system suppression and poisoning. Toxicology research aims to evaluate the potentially harmful effects of chemical substances, drugs, and environmental factors on living organisms. PBMCs are used in immunotoxicity studies to assess the impact of these substances on the immune system. By exposing PBMCs to different compounds and analyzing immune responses, researchers can determine the immunotoxic effects, including alterations in immune cell populations, cytokine production, and immune function. The demand for PBMCs in immunotoxicity research is thus increasing, contributing to the growth of the global peripheral blood mononuclear cells market.
Patients now have a better alternative to cell-based therapies with respect to traditional regenerative medicines, but their side effects have hindered their use among customers. In this product category, developed regions such as North America and Europe have a strong presence in cell therapies for human well-being. The population is gaining awareness regarding the use of peripheral blood mononuclear cells in cell and gene therapy. Hence, the extraction and usage of peripheral blood mononuclear cells prove to be the key driving force for market expansion. However, fatal diseases such as acute myocardial infarction, chronic heart failure, spinal cord injury, stroke, and wound healing have all been successfully treated in pre-clinical studies using the secretome of apoptotic peripheral blood mononuclear cells, which drives the market growth globally. For instance, according to the Centers for Disease Control and Prevention, around 37,300 new cases of HPV+ tumors occur each year in the U.S., accounting for 3% of all malignancies in women and 2% of all cancers in men. With the increasing prevalence of HPV in the country, companies are continuously focusing on the development of therapy and drugs to enter the US market. PBMCs serve as a valuable source of immune cells for cell therapy. They contain various types of immune cells, including T cells, B cells, and natural killer (NK) cells, which play crucial roles in immune responses and disease targeting. PBMCs provide a diverse population of immune cells that can be isolated, manipulated, and utilized in different cell therapy approaches.
Also, Adoptive Cell Transfer (ACT) is a type of cell therapy that involves the transfer of immune cells, typically T cells, into patients to target and eliminate diseases, such as cancers. PBMCs are often used as a starting material to isolate and expand specific subsets of T cells, such as tumor-infiltrating lymphocytes (TILs), tumor-associated antigen-specific T cells, or genetically engineered T cells. PBMCs provide a convenient source of T cells for ACT therapies.
Rapid advancements in research and development (R&D) practices and activities are propelling the growth of the market as novel cell/gene therapies/medications and new products are developed for the treatment of fatal diseases. PBMCs are a reasonable way to acquire physiologically relevant (immune) proteins from routinely collected blood samples, and they do so without the native human plasma's well-known analytical challenges brought on by the presence of highly abundant proteins for driving the growth of the market. Furthermore, the government of different countries, for their growth in the healthcare sector, are providing funds for the ongoing research of peripheral blood mononuclear cells.
Additionally, the growing awareness of the potential of PBMCs in disease research has led to increased R&D activities and contributed to market growth. PBMCs play a crucial role in drug discovery and development. They are utilized in early-stage research to assess the efficacy and safety of potential drug candidates. PBMCs provide a human-relevant model for studying immune responses and evaluating the effects of new compounds on immune cells. The growing awareness of the value of PBMCs in drug discovery has resulted in increased demand and utilization of these cells, driving the growth of the PBMCs market. The awareness of the therapeutic potential of cell-based therapies has been growing rapidly. PBMCs are essential in the development and manufacturing of cell-based therapies, such as adoptive cell transfer, CAR-T cell therapy, and immunotherapies. The therapeutic benefits of these advanced therapies, coupled with the increasing awareness of PBMCs' role in their development, have led to significant R&D efforts and the growth of global peripheral blood mononuclear cells market. There has been a notable increase in collaboration between academic institutions, research organizations, and the biopharmaceutical industry. This collaboration has fostered knowledge exchange, joint research projects, and funding initiatives focused on the application of PBMCs in various areas of research. The growing awareness of the potential of PBMCs and the collaborative efforts in R&D have positively impacted the growth of the global peripheral blood mononuclear cells market.
The global peripheral blood mononuclear cells market is segmented based on product, application, technique, source, region, and competitive landscape. Based on the product, the market can be split into cryopreserved or frozen PBMC, cultured or fresh PBMC, and peripheral blood mononuclear cell isolation & viability kits. Based on application, the market can be divided into immunology, hematology, infectious disease, and others. Based on techniques, the market is divided into density gradient centrifugation, leukapheresis, and others. In terms of sources, the market can be categorized into humans and animals.
Charles River Laboratories International, Inc., Lonza Group AG, Corning Inc, Bio-Rad Laboratories Inc, ABCAM, Biolegend Inc, ZEN-Bio Inc, DAPCEL, Inc., Creative Bioarray, iXCells Biotechnologies USA, LLC, Miltenyi Biotec B.V. & CO. KG, STEMCELL Technologies Inc., Precision Medicine Group, LLC, StemExpress, LLC, RayBiotech Life, Inc., REPROCELL Inc., Cytologics LLC, BioIVT LLC, Biopredic International, and Cell Applications, Inc. etc. are among the major players in the global peripheral blood mononuclear cells market.
In this report, Global Peripheral Blood Mononuclear Cells Market has been segmented into the following categories, in addition to the industry trends, which have also been detailed below:
Company Profiles: Detailed analysis of the major companies present in global peripheral blood mononuclear cells market.
With the given market data, TechSci Research offers customizations according to a company's specific needs. The following customization options are available for the report: