This report includes profiles of 40+ technologies which can be utilized to improve ocular delivery. Examples of technologies covered: punctal plugs, ocular inserts, long-acting injectables and implants, topical systems, nanoparticles, electroporation as well as novel administration devices.
Each profile will contain the following information:
- Company summary
- Technology description
- Patents/Publications
- Development Status/Pipeline
- Competitive Advantages
- Partnering Opportunities
- Company Contact Information
Table of Contents
Introduction
Chapter I: Eye Diseases
- Age-Related Macular Degeneration (AMD)
- Macular Edema and Diabetic Retinopathy
- Glaucoma
- Inflammatory Conditions
- Dry Eye Disease
Chapter II: Market Overview
Chapter III: Ophthalmic Drug Delivery Landscape
- Non-Invasive Delivery Technologies
- Invasive Delivery Technologies
- Approved Ocular DDS Products
- Ocular DDS Pipeline
- Glaucoma
- Uveitis and Macular Edema
- Ocular Inflammation
- Age-Related Macular Degeneration
- Dry Eye Disease
- Novel Therapies & Indications
- Development Opportunities
- Future Perspectives
Chapter IV: Technology Profiles
- Novel Aerosol & Eye Drop Devices
- Aero Pump
- CIS Pharma
- Eyenovia
- Kedalion Therapeutics
- Nemera
- Zeteo Biomedical
- Punctal Plugs & Ocular Inserts
- AesculaTech
- Amorphex Therapeutics
- BioLight Life Sciences
- Eximore
- Mati Therapeutics
- Ocular Therapeutix
- Topical Delivery Systems
- 20/20 OptimEyes
- Aciont
- EyeCRO
- EyeGate Pharma
- Integral Ophthalmics
- iView Therapeutics
- Kala Pharmaceuticals
- Nanomerics
- Novaliq
- Oculis
- MC2 Therapeutics
- MuPharma
- Santen Pharmaceuticals
- Sun Ophthalmics
- Surface Pharmaceuticals
- TALLC
- TearClear
- Injectables & Implants
- 3T Ophthalmics
- Abbvie
- Aerie Pharmaceuticals
- Clearside Biomedical
- Congruence Medical
- DelSiTech
- EyePoint Pharmaceuticals
- Eyevensys
- Glaukos
- Graybug Vision
- iVeena Delivery Systems
- Kodiak Biosciences
- LayerBio
- Nanogenics
- Neurotech Pharmaceuticals
- OcuJect
- PolyActiva
- Re-Vana Therapeutics
- Roche
- TLC Bio
- VisusNano
- Drug Eluting Lenses
- Glint Pharmaceuticals
- Leo Lens Pharma
- OcuMedic
Chapter V: University Technologies
- Johns Hopkins University: Retinal Implantation Device
- Johns Hopkins University: Canalicular Delivery System
- Ohio State University: Bi-layered Capsule
- Stanford University: Injectable Deformable Hydrogels
- University of Colorado: Nanogel Ophthalmic Delivery Devices
- University of Florida: Oleogel Technology
- University of Michigan: PLGA-Coated Ocular Implants
- University of North Carolina: Ceria Nanoparticles
- University of Pittsburgh: CyteSolutions Lens
- University of Pittsburgh: Reverse Thermal Gels
Table & Figures
- Figure 1: Eye Disease Prevalence, US
- Table 1: Wet AMD Therapeutics
- Table 2: Injectable Steroids for Macular Edema
- Table 3: Topical Glaucoma Products
- Table 4: Ocular Anti-inflammatory Products
- Table 5: Prescription Dry Eye Treatments
- Figure 2: US Ophthalmic Market by Product Type, 2019
- Table 6: Top-Selling Prescription Ophthalmic Products, 2019
- Figure 3: Ophthalmic Revenues of Key Players, 2019
- Figure 4: Key Players with Ocular DDS Products
- Table 7: Comparison of Non-Invasive Ocular DDS
- Figure 5: Durysta® Injector and Implant
- Table 8: Comparison of Invasive Ocular DDS
- Table 9: Approved Ophthalmic DDS Products, US
- Figure 6: Timeline for Approved SR Ocular Implants in the US
- Table 10: Topical Glaucoma DDS Pipeline
- Table 11: Sustained Release Glaucoma Pipeline
- Figure 7: Clearside Bio SCS Microinjector
- Table 12: Uveitis and Macular Edema DDS Pipeline
- Table 13: Ocular Pain and Inflammation DDS Pipeline
- Table 14: Macular Degeneration DDS Pipeline
- Table 15: Dry Eye DDS Pipeline
- Table 16: Novel Therapies Pipeline
- Table 17: Examples of Ophthalmic Candidates for Long-Acting Delivery
- Figure 8: Medspray Spray Nozzle Unit
- Figure 9: CIS Pharma Connected Dispenser
- Figure 10: Eyenovia Microdose Dispenser
- Table 18: Eyenovia Pipeline
- Table 19: Optejet vs. Standard Eye Dropper
- Figure 11: Depiction of AcuStream Patient Administration
- Table 20: Kedalion Pipeline
- Figure 12: e-Novelia Smart Add-On
- Figure 13: AquilaMD Ophthalmic Device
- Figure 14: AesculaGel and Applicator
- Figure 15: TODDD matrix
- Figure 16: TODDD drug depots
- Table 21: Amorphex Pipeline
- Table 22: TODDD Competitive Comparison
- Figure 17: Eximore punctal plug
- Table 23: Eximore Pipeline
- Figure 18: Inserting the Evolute plug
- Table 24: Mati Therapeutics Pipeline
- Figure 19: Punctum Plug Depot
- Table 25: Ocular Therapeutix Pipeline
- Figure 20: Visulex-P Applicator
- Figure 21: Visulex-I Platform and General Visulex Process
- Figure 22: Aciont MRI study
- Table 26: Aciont Pipeline
- Figure 23: MiDROPS illustration
- Figure 24: CMHA-S composition
- Table 27: EyeGate Pipeline
- Table 28: iView Pipeline
- Figure 25: Proprietary Attributes of AMMPLIFY Technology
- Table 29: Kala Pipeline
- Figure 26: MET Design and Process
- Table 30: Novaliq Pipeline
- Table 31: Santen Ophthalmic DDS Pipeline
- Table 32: Sun Ophthalmic DDS Products
- Table 33: Surface Pharmaceuticals Pipeline
- Figure 27: SmartCelle Delivery Schematic
- Table 34: TALLC Pipeline
- Figure 28: Diagram of Common Ocular Drug Delivery Systems
- Figure 29: Visual of the Episcleral System
- Table 35: 3T Product Pipeline
- Figure 30: Photographs of the Sustained Release Bimatoprost SR Implant
- Figure 31: PRINT technology
- Table 36: Aerie Pipeline
- Figure 32: SCS Microinjector
- Table 37: Clearside Biomedical Pipeline
- Figure 33: MDS Shown with Various 1 mL Long Prefillable Syringes
- Figure 34: Durasert Implant
- Table 38: EyePoint Pipeline
- Table 39: Eyevensys Pipeline
- Figure 35: Two Generations of iDose Implants
- Table 40: Glaukos Pipeline
- Figure 36: Graybug Microparticle Depot
- Table 41: Graybug Pipeline
- Figure 37: iVeena Bioerodible Implant
- Figure 38: Kodiak ABC Platform
- Figure 39: Molecular Properties of KSI-301
- Table 42: Kodiak ABC Pipeline
- Figure 40: LayerForm Assembly
- Figure 41: PolyNet Illustration
- Table 43: LayerBio Pipeline
- Figure 42: ECT Platform Schematic
- Table 44: Neurotech Pipeline
- Figure 43: Classes of Therapeutics Supported by ECT Technology
- Figure 44: SteriCap Mini Needle
- Table 45: PolyActiva Ophthalmic Pipeline
- Figure 45: EyeLief Mechanism of Drug Release
- Table 46: Benefits of Re-Vana Delivery Systems
- Figure 46: The PDS Implant in Position
- Figure 47: Injection Demonstration for TLC399
- Figure 48: Schematic of Leo Lens MediPrint Process
- Table 47: Leo Lens Pipeline
- Table 48: Leo Lens Technology Advantages
- Figure 49: OcuMedic Novel Lens Technology
- Table 49: OcuMedic Pipeline
