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市場調查報告書

酪胺酸蛋白激酶JAK3:開發中產品分析

Tyrosine Protein Kinase JAK3 (Janus Kinase 3 or Leukocyte Janus Kinase or JAK3 or EC 2.7.10.2) - Pipeline Review, H1 2018

出版商 Global Markets Direct 商品編碼 367828
出版日期 內容資訊 英文 102 Pages
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酪胺酸蛋白激酶JAK3:開發中產品分析 Tyrosine Protein Kinase JAK3 (Janus Kinase 3 or Leukocyte Janus Kinase or JAK3 or EC 2.7.10.2) - Pipeline Review, H1 2018
出版日期: 2018年05月22日 內容資訊: 英文 102 Pages
簡介

本報告提供以酪胺酸蛋白激酶JAK3為標的治療藥之開發平台現狀及最新更新的各開發階段比較分析,提供您附最新的新聞和發表之企業和研究機關正在開發的治療藥,治療藥評估,後期階段及中止的計劃等相關資訊。

簡介

  • 調查範圍

酪胺酸蛋白激酶JAK3 概要

治療藥的開發

  • 開發中的產品:各開發階段
  • 開發中的產品:各治療領域
  • 開發中的產品:不同症狀

開發中產品概況

  • 後期階段的產品
  • 初期階段的產品

企業開發中的產品

治療藥的評估

  • 單劑/並用治療藥的情況
  • 各作用機制
  • 各給藥途徑
  • 各分子類型

治療藥開發企業

  • Aclaris Therapeutics, Inc.
  • Advinus Therapeutics Ltd
  • Arrien Pharmaceuticals, LLC
  • Astellas Pharma Inc.
  • Bristol-Myers Squibb Company
  • Chipscreen Biosciences Ltd
  • Creabilis SA
  • F. Hoffmann-La Roche Ltd.
  • Ligand Pharmaceuticals, Inc.
  • MYOS RENS Technology Inc.
  • Pfizer Inc.
  • Portola Pharmaceuticals, Inc.
  • Principia Biopharma Inc.
  • Rigel Pharmaceuticals, Inc.
  • Theravance Biopharma, Inc.
  • Vectura Group Plc

藥物簡介

暫停中的計劃

開發中止的產品

主要消息及新聞稿

附錄

圖表

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目錄
Product Code: GMDHC1459TDB

Summary

According to the recently published report 'Tyrosine Protein Kinase JAK3 - Pipeline Review, H1 2018'; Tyrosine Protein Kinase JAK3 (Janus Kinase 3 or Leukocyte Janus Kinase or JAK3 or EC 2.7.10.2) pipeline Target constitutes close to 24 molecules. Out of which approximately 24 molecules are developed by Companies.

Tyrosine Protein Kinase JAK3 (Janus Kinase 3 or Leukocyte Janus Kinase or JAK3 or EC 2.7.10.2) - Tyrosine-protein kinase JAK3 is an enzyme encoded by the JAK3 gene. It is involved in various processes such as cell growth, development, or differentiation. Mediates essential signaling events in both innate and adaptive immunity and plays a crucial role in hematopoiesis during T-cells development. It plays a pivotal role in signal transduction via its association with type I receptors sharing the common subunit gamma such as IL2R, IL4R, IL7R, IL9R, IL15R and IL21R. Following ligand binding to cell surface receptors phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins.

The report 'Tyrosine Protein Kinase JAK3 - Pipeline Review, H1 2018' outlays comprehensive information on the Tyrosine Protein Kinase JAK3 (Janus Kinase 3 or Leukocyte Janus Kinase or JAK3 or EC 2.7.10.2) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies / Universities.

It also reviews key players involved in Tyrosine Protein Kinase JAK3 (Janus Kinase 3 or Leukocyte Janus Kinase or JAK3 or EC 2.7.10.2) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Pre-Registration, Phase III, Phase II, Phase I, Preclinical and Discovery stages are 2, 2, 4, 2, 10 and 4 respectively. Report covers products from therapy areas Immunology, Dermatology, Oncology, Gastrointestinal, Musculoskeletal Disorders and Ophthalmology which include indications Rheumatoid Arthritis, Alopecia, Psoriasis, Atopic Dermatitis, Ulcerative Colitis, Vitiligo, Crohn's Disease (Regional Enteritis), Diffuse Large B-Cell Lymphoma, Inflammation, Mantle Cell Lymphoma, Allergic Conjunctivitis, Androgenic Alopecia, Ankylosing Spondylitis (Bekhterev's Disease), Arthritis, Autoimmune Disorders, B-Cell Chronic Lymphocytic Leukemia, B-Cell Non-Hodgkin Lymphoma, Cachexia, Chronic Cutaneous Lupus Erythematosus (CCLE) / Discoid Lupus Erythematosus (DLE), Chronic Lymphocytic Leukemia (CLL), Cutaneous T-Cell Lymphoma, Dermatomyositis, Eczema, Follicular Lymphoma, Heart Transplant Rejection, Inflammatory Bowel Disease, Juvenile Rheumatoid Arthritis, Marginal Zone B-cell Lymphoma, Myeloproliferative Disorders, Peripheral T-Cell Lymphomas (PTCL), Pruritus, Psoriatic Arthritis, Sarcopenia, Systemic Lupus Erythematosus, Systemic Sclerosis (Scleroderma) and Waldenstrom Macroglobulinemia.

Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope

  • The report provides a snapshot of the global therapeutic landscape for Tyrosine Protein Kinase JAK3 (Janus Kinase 3 or Leukocyte Janus Kinase or JAK3 or EC 2.7.10.2)
  • The report reviews Tyrosine Protein Kinase JAK3 (Janus Kinase 3 or Leukocyte Janus Kinase or JAK3 or EC 2.7.10.2) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
  • The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
  • The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
  • The report reviews key players involved in Tyrosine Protein Kinase JAK3 (Janus Kinase 3 or Leukocyte Janus Kinase or JAK3 or EC 2.7.10.2) targeted therapeutics and enlists all their major and minor projects
  • The report assesses Tyrosine Protein Kinase JAK3 (Janus Kinase 3 or Leukocyte Janus Kinase or JAK3 or EC 2.7.10.2) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
  • The report summarizes all the dormant and discontinued pipeline projects
  • The report reviews latest news and deals related to Tyrosine Protein Kinase JAK3 (Janus Kinase 3 or Leukocyte Janus Kinase or JAK3 or EC 2.7.10.2) targeted therapeutics

Reasons to buy

  • Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
  • Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
  • Identify and understand the targeted therapy areas and indications for Tyrosine Protein Kinase JAK3 (Janus Kinase 3 or Leukocyte Janus Kinase or JAK3 or EC 2.7.10.2)
  • Identify the use of drugs for target identification and drug repurposing
  • Identify potential new clients or partners in the target demographic
  • Develop strategic initiatives by understanding the focus areas of leading companies
  • Plan mergers and acquisitions effectively by identifying key players and it's most promising pipeline therapeutics
  • Devise corrective measures for pipeline projects by understanding Tyrosine Protein Kinase JAK3 (Janus Kinase 3 or Leukocyte Janus Kinase or JAK3 or EC 2.7.10.2) development landscape
  • Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Table of Contents

List of Tables

List of Figures

  • Introduction
  • Global Markets Direct Report Coverage
  • Tyrosine Protein Kinase JAK3 (Janus Kinase 3 or Leukocyte Janus Kinase or JAK3 or EC 2.7.10.2) - Overview
  • Tyrosine Protein Kinase JAK3 (Janus Kinase 3 or Leukocyte Janus Kinase or JAK3 or EC 2.7.10.2) - Therapeutics Development
  • Products under Development by Stage of Development
  • Products under Development by Therapy Area
  • Products under Development by Indication
  • Products under Development by Companies
  • Tyrosine Protein Kinase JAK3 (Janus Kinase 3 or Leukocyte Janus Kinase or JAK3 or EC 2.7.10.2) - Therapeutics Assessment
  • Assessment by Mechanism of Action
  • Assessment by Route of Administration
  • Assessment by Molecule Type
  • Tyrosine Protein Kinase JAK3 (Janus Kinase 3 or Leukocyte Janus Kinase or JAK3 or EC 2.7.10.2) - Companies Involved in Therapeutics Development
  • Aclaris Therapeutics Inc
  • Arrien Pharmaceuticals LLC
  • Astellas Pharma Inc
  • Bristol-Myers Squibb Co
  • Chipscreen Biosciences Ltd
  • Clevexel Pharma SAS
  • Guangdong Zhongsheng Pharmaceutical Co Ltd
  • Japan Tobacco Inc
  • KBP BioSciences Co Ltd
  • LSK BioPartners Inc
  • Merck & Co Inc
  • MYOS RENS Technology Inc
  • Pfizer Inc
  • Portola Pharmaceuticals Inc
  • Sienna Biopharmaceuticals Inc
  • Simcere Pharmaceutical Group
  • Theravance Biopharma Inc
  • Tyrosine Protein Kinase JAK3 (Janus Kinase 3 or Leukocyte Janus Kinase or JAK3 or EC 2.7.10.2) - Drug Profiles
  • ARN-4079 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • ATI-501 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • ATI-502 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • cerdulatinib - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • CS-510 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • CVXL-0074 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • delgocitinib - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • KBP-7536 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • LSK-9985 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • OST-122 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • OST-246 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • peficitinib hydrobromide - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • PF-06651600 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • Small Molecule to Inhibit JAK3 for Heart Transplantation - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • Small Molecule to Inhibit JAK3 for Rheumatoid Arthritis - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • Small Molecules to Inhibit JAK1 and JAK3 for Inflammation - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • Small Molecules to Inhibit JAK2 and JAK3 for Immunology and Oncology - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • Small Molecules to Inhibit JAK3 for Rheumatoid Arthritis - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • Small Molecules to Inhibit JAK3 for Rheumatoid Arthritis - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • Small Molecules to Inhibit JAK3 for Rheumatoid Arthritis, Sarcopenia and Cachexia - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • SNA-125 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • TD-1473 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • tofacitinib citrate - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • tofacitinib citrate ER - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • Tyrosine Protein Kinase JAK3 (Janus Kinase 3 or Leukocyte Janus Kinase or JAK3 or EC 2.7.10.2) - Dormant Products
  • Tyrosine Protein Kinase JAK3 (Janus Kinase 3 or Leukocyte Janus Kinase or JAK3 or EC 2.7.10.2) - Discontinued Products
  • Tyrosine Protein Kinase JAK3 (Janus Kinase 3 or Leukocyte Janus Kinase or JAK3 or EC 2.7.10.2) - Product Development Milestones
  • Featured News & Press Releases
  • Apr 25, 2018: Portola Pharmaceuticals to Present New Interim Phase 2 Data for Cerdulatinib at the 2018 American Society of Clinical Oncology (ASCO) Annual Meeting
  • Apr 23, 2018: Aclaris Therapeutics Announces First Patient Dosed in a Pilot Study with ATI-502 Topical in Patients with Androgenetic Alopecia
  • Mar 12, 2018: Sienna Biopharmaceuticals Announces First Patient Dosed in Proof-of-Concept Trial of Topical by Design JAK Inhibitor SNA-125 for Atopic Dermatitis
  • Mar 08, 2018: Pfizer Announces Favorable Outcome of FDA Advisory Committee Meeting on XELJANZ (tofacitinib) for Moderately to Severely Active Ulcerative Colitis
  • Feb 14, 2018: Sienna Biopharmaceuticals Announces First Patient Dosed in First-in-Human Trial of Topical SNA-125
  • Feb 12, 2018: Xeljanz is accepted for restricted use within NHS Scotland
  • Feb 08, 2018: Astellas Announce Top-Line Results for Two Phase 3 Trials of Peficitinib in Rheumatoid Arthritis Patients with Inadequate Response to Existing Therapy
  • Jan 12, 2018: Top-line Results of the Topical JTE-052 JAK Inhibitor Phase 3 Clinical Study (Comparative Study) in Japan
  • Dec 19, 2017: Aclaris Therapeutics Initiates a Pilot Clinical Trial to Study ATI-50002 Topical in Patients with Vitiligo
  • Dec 14, 2017: Pfizer Announces FDA Approval Of Xeljanz (Tofacitinib) For The Treatment Of Active Psoriatic Arthritis
  • Dec 14, 2017: Pfizer Announces FDA Approval Of Xeljanz XR For The Treatment Of Active Psoriatic Arthritis
  • Dec 12, 2017: U.S. Food And Drug Administration Extends Action Date For XELJANZ (Tofacitinib) Supplemental New Drug Application In Ulcerative Colitis By Three Months
  • Nov 30, 2017: Portola Pharmaceuticals to Present New Data on Cerdulatinib at the 59th American Society of Hematology (ASH) Annual Meeting
  • Oct 16, 2017: New Ulcerative Colitis Data for XELJANZ (tofacitinib)at Upcoming Gastroenterology Congresses
  • Sep 08, 2017: NICE issues positive recommendation for XELJANZ (tofacitinib citrate) as a new treatment option for adults with severe rheumatoid arthritis
  • Appendix
  • Methodology
  • Coverage
  • Secondary Research
  • Primary Research
  • Expert Panel Validation
  • Contact Us
  • Disclaimer

List of Tables

  • Number of Products under Development by Stage of Development, H1 2018
  • Number of Products under Development by Therapy Areas, H1 2018
  • Number of Products under Development by Indications, H1 2018
  • Number of Products under Development by Indications, H1 2018 (Contd..1), H1 2018
  • Number of Products under Development by Companies, H1 2018
  • Products under Development by Companies, H1 2018
  • Products under Development by Companies, H1 2018 (Contd..1), H1 2018
  • Products under Development by Companies, H1 2018 (Contd..2), H1 2018
  • Products under Development by Companies, H1 2018 (Contd..3), H1 2018
  • Number of Products by Stage and Mechanism of Actions, H1 2018
  • Number of Products by Stage and Route of Administration, H1 2018
  • Number of Products by Stage and Molecule Type, H1 2018
  • Pipeline by Aclaris Therapeutics Inc, H1 2018
  • Pipeline by Arrien Pharmaceuticals LLC, H1 2018
  • Pipeline by Astellas Pharma Inc, H1 2018
  • Pipeline by Bristol-Myers Squibb Co, H1 2018
  • Pipeline by Chipscreen Biosciences Ltd, H1 2018
  • Pipeline by Clevexel Pharma SAS, H1 2018
  • Pipeline by Guangdong Zhongsheng Pharmaceutical Co Ltd, H1 2018
  • Pipeline by Japan Tobacco Inc, H1 2018
  • Pipeline by KBP BioSciences Co Ltd, H1 2018
  • Pipeline by LSK BioPartners Inc, H1 2018
  • Pipeline by Merck & Co Inc, H1 2018
  • Pipeline by MYOS RENS Technology Inc, H1 2018
  • Pipeline by Pfizer Inc, H1 2018
  • Pipeline by Portola Pharmaceuticals Inc, H1 2018
  • Pipeline by Sienna Biopharmaceuticals Inc, H1 2018
  • Pipeline by Simcere Pharmaceutical Group, H1 2018
  • Pipeline by Theravance Biopharma Inc, H1 2018
  • Dormant Products, H1 2018
  • Dormant Products, H1 2018 (Contd..1), H1 2018
  • Dormant Products, H1 2018 (Contd..2), H1 2018
  • Discontinued Products, H1 2018

List of Figures

  • Number of Products under Development by Stage of Development, H1 2018
  • Number of Products under Development by Therapy Areas, H1 2018
  • Number of Products under Development by Top 10 Indications, H1 2018
  • Number of Products by Stage and Mechanism of Actions, H1 2018
  • Number of Products by Routes of Administration, H1 2018
  • Number of Products by Stage and Routes of Administration, H1 2018
  • Number of Products by Molecule Type, H1 2018
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