Tyrosine Protein Kinase JAK1 - Pipeline Review, H2 2020
|出版商||Global Markets Direct||商品編碼||367826|
|出版日期||內容資訊||英文 273 Pages
|酪胺酸蛋白質激梅JAK1:開發中產品分析 Tyrosine Protein Kinase JAK1 - Pipeline Review, H2 2020|
|出版日期: 2020年07月31日||內容資訊: 英文 273 Pages||
Tyrosine Protein Kinase JAK1 (Janus Kinase 1 or JAK1 or EC 184.108.40.206) - JAK1 is a human tyrosine kinase protein essential for signaling for certain type I and type II cytokines. JAK1 plays a critical role in initiating responses to multiple major cytokine receptor families. Expression of JAK1 in cancer cells enables individual cells to contract, potentially allowing them to escape their tumor and metastasize to other parts of the body.
Tyrosine Protein Kinase JAK1 (Janus Kinase 1 or JAK1 or EC 220.127.116.11) pipeline Target constitutes close to 45 molecules. Out of which approximately 44 molecules are developed by companies and remaining by the universities/institutes. The molecules developed by companies in Pre-Registration, Phase III, Phase II, Phase I, IND/CTA Filed and Preclinical stages are 4, 6, 12, 5, 3 and 14 respectively. Similarly, the universities portfolio in Discovery stages comprises 1 molecules, respectively.
Report covers products from therapy areas Immunology, Dermatology, Gastrointestinal, Oncology, Musculoskeletal Disorders, Respiratory, Infectious Disease, Central Nervous System, Cardiovascular, Ophthalmology, Hematological Disorders and Women's Health which include indications Rheumatoid Arthritis, Atopic Dermatitis (Atopic Eczema), Alopecia Areata, Psoriasis, Ulcerative Colitis, Crohn's Disease (Regional Enteritis), Systemic Lupus Erythematosus, Coronavirus Disease 2019 (COVID-19), Vitiligo, Ankylosing Spondylitis (Bekhterev's Disease), Graft Versus Host Disease (GVHD), Inflammatory Bowel Disease, Asthma, Diffuse Large B-Cell Lymphoma, Hidradenitis Suppurativa, Inflammation, Multiple Sclerosis, Myelodysplastic Syndrome, Myelofibrosis, Peripheral T-Cell Lymphomas (PTCL), Psoriatic Arthritis, Triple-Negative Breast Cancer (TNBC), Anaplastic Large Cell Lymphoma (ALCL), B-Cell Non-Hodgkin Lymphoma, Bronchiolitis Obliterans, Chronic Lymphocytic Leukemia (CLL), Dermatitis (Eczema), Giant Cell Arteritis (Temporal Arteritis/Cranial Arteritis/Horton Disease), Head And Neck Cancer Squamous Cell Carcinoma, Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma), Lymphoma, Mantle Cell Lymphoma, Non-Small Cell Lung Cancer, Post-Polycythemia Vera Myelofibrosis (PPV-MF), Relapsed Multiple Myeloma, Systemic-Onset Juvenile Idiopathic Arthritis (Still Disease), T-Cell Acute Lymphocytic Leukemia (T-Cell Acute Lymphoblastic Leukaemia), Thrombocythemia Myelofibrosis, Waldenstrom Macroglobulinemia (Lymphoplasmacytic Lymphoma), Acute Lung Injury, Acute Lymphocytic Leukemia (ALL, Acute Lymphoblastic Leukemia), Acute Myelocytic Leukemia (AML, Acute Myeloblastic Leukemia), Androgenic Alopecia, Angioimmunoblastic T-Cell Lymphoma (AITL)/Immunoblastic Lymphadenopathy, Arthritis, Autoimmune Disorders, B-Cell Chronic Lymphocytic Leukemia, Breast Hyperplasia, Chronic Cutaneous Lupus Erythematosus (CCLE) / Discoid Lupus Erythematosus (DLE), Chronic Myelocytic Leukemia (CML, Chronic Myeloid Leukemia), Chronic Myelomonocytic Leukemia (CMML), Colon Cancer, Colorectal Cancer, Cutaneous Lupus Erythematosus, Cutaneous T-Cell Lymphoma, Cytokine Release Syndrome (Cytokine Storm), Endometrial Cancer, Epstein-Barr Virus (HHV-4) Infections, Essential Thrombocythemia, Follicular Lymphoma, Gastric Cancer, Hairy Cell Leukemia, Hepatocellular Carcinoma, Hypereosinophilic Syndrome, Hypopharyngeal Cancer, Juvenile Arthritis, Kidney Cancer (Renal Cell Cancer), Laryngeal Cancer, Leiomyosarcoma, Lupus Erythematosus, Lupus Nephritis, Marginal Zone B-cell Lymphoma, Melanoma, Metastatic Adenocarcinoma of The Pancreas, Metastatic Prostate Cancer, Multiple Myeloma (Kahler Disease), Myeloproliferative Disorders, Myxoid Liposarcoma, Non-Hodgkin Lymphoma, Oligoarticular Idiopathic Juvenile Arthritis, Oral Cavity (Mouth) Cancer, Oropharyngeal Cancer, Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma, Polyarticular Juvenile Idiopathic Arthritis (PJIA), Polycythemia Vera, Polymyalgia Rheumatica (PMR), Post-Essential Thrombocythemia Myelofibrosis (Post-ET MF), Primary Biliary Cholangitis (Primary Biliary Cirrhosis), Primary Myelofibrosis, Refractory Acute Myeloid Leukemia, Refractory Multiple Myeloma, Relapsed Acute Myeloid Leukemia, Renal Cell Carcinoma, Sicca Syndrome (Sjogren), Skin Cancer, Spondyloarthritis (Spondyloarthropathy), Synovial Sarcoma, Systemic Idiopathic Juvenile Arthritis, Takayasu Arteritis, Transitional Cell Cancer (Urothelial Cell Cancer), Transitional Cell Carcinoma (Urothelial Cell Carcinoma) and Uveitis.
The latest report Tyrosine Protein Kinase JAK1 - Pipeline Review, H2 2020, outlays comprehensive information on the Tyrosine Protein Kinase JAK1 (Janus Kinase 1 or JAK1 or EC 18.104.22.168) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. It also reviews key players involved in Tyrosine Protein Kinase JAK1 (Janus Kinase 1 or JAK1 or EC 22.214.171.124) targeted therapeutics development with respective active and dormant or discontinued projects.
Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.