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市場調查報告書

纖維母細胞生長因子受體4:開發中產品分析

Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 2.7.10.1) - Pipeline Review, H1 2018

出版商 Global Markets Direct 商品編碼 367825
出版日期 內容資訊 英文 129 Pages
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纖維母細胞生長因子受體4:開發中產品分析 Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 2.7.10.1) - Pipeline Review, H1 2018
出版日期: 2018年05月16日 內容資訊: 英文 129 Pages
簡介

本報告提供以纖維母細胞生長因子受體4為標的治療藥之開發平台現狀及最新更新的各開發階段比較分析,提供您附最新的新聞和發表之企業和研究機關正在開發的治療藥,治療藥評估,後期階段及中止的計劃等相關資訊。

簡介

  • 調查範圍

纖維母細胞生長因子受體4 概要

治療藥的開發

  • 開發中的產品:各開發階段
  • 開發中的產品:各治療領域
  • 開發中的產品:不同症狀

開發中產品概況

  • 後期階段的產品
  • 初期階段的產品

企業開發中的產品

大學/機關開發中的產品

治療藥的評估

  • 單劑/並用治療藥的情況
  • 各作用機制
  • 各給藥途徑
  • 各分子類型

治療藥開發企業

  • Amgen Inc.
  • ArQule, Inc.
  • Astellas Pharma Inc.
  • AstraZeneca Plc
  • AVEO Pharmaceuticals, Inc.
  • Blueprint Medicines Corporation
  • Bristol-Myers Squibb Company
  • 第一三共
  • Eddingpharm
  • Eisai
  • Eli Lilly and Company
  • Genosco
  • H3 Biomedicine Inc.
  • Ionis Pharmaceuticals, Inc.
  • Johnson & Johnson
  • NGM Biopharmaceuticals, Inc.
  • Novartis AG
  • Principia Biopharma Inc.
  • Vichem Chemie Research Ltd.

藥物簡介

暫停中的計劃

開發中止的產品

主要消息及新聞稿

附錄

圖表

本網頁內容可能與最新版本有所差異。詳細情況請與我們聯繫。

目錄
Product Code: GMDHC1456TDB

Summary:

According to the recently published report 'Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 2.7.10.1) - Pipeline Review, H1 2018'; Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 2.7.10.1) pipeline Target constitutes close to 26 molecules. Out of which approximately 25 molecules are developed by companies and remaining by the universities/institutes.

Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 2.7.10.1) - Fibroblast growth factor receptor 4 is a protein encoded by the FGFR4 gene. It plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. It is required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. It phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades.

The report 'Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 2.7.10.1) - Pipeline Review, H1 2018' outlays comprehensive information on the Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 2.7.10.1) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies / Universities.

It also reviews key players involved in Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 2.7.10.1) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Pre-Registration, Phase III, Phase II, Phase I, IND/CTA Filed, Preclinical and Discovery stages are 1, 3, 6, 5, 1, 7 and 2 respectively. Similarly, the universities portfolio in Preclinical stages comprises 1 molecules, respectively. Report covers products from therapy areas Oncology, Metabolic Disorders, Central Nervous System, Gastrointestinal and Musculoskeletal Disorders which include indications Hepatocellular Carcinoma, Solid Tumor, Bile Duct Cancer (Cholangiocarcinoma), Breast Cancer, Type 2 Diabetes, Lung Adenocarcinoma, Ovarian Cancer, Bladder Cancer, Endometrial Cancer, Esophageal Cancer, Gastric Cancer, Head And Neck Cancer Squamous Cell Carcinoma, Melanoma, Metastatic Transitional (Urothelial) Tract Cancer, Non-Small Cell Lung Cancer, Obesity, Recurrent Glioblastoma Multiforme (GBM), Squamous Non-Small Cell Lung Cancer, Transitional Cell Carcinoma (Urothelial Cell Carcinoma), Achondroplasia, Adenoid Cystic Carcinoma (ACC), Adrenocortical Carcinoma (Adrenal Cortex Cancer), Constipation, Epithelial Ovarian Cancer, Ewing Sarcoma, Fallopian Tube Cancer, Glioblastoma Multiforme (GBM), Head And Neck Cancer, Hematological Tumor, High-Grade Glioma, Kidney Cancer (Renal Cell Cancer), Liver Cancer, Lung Cancer, Lymphoma, Metastatic Biliary Tract Cancer, Nasopharyngeal Cancer, Non-Alcoholic Steatohepatitis (NASH), Osteosarcoma, Peritoneal Cancer, Primary Biliary Cirrhosis, Primary Sclerosing Cholangitis, Primitive Neuroectodermal Tumor (PNET), Prostate Cancer, Refractory Acute Myeloid Leukemia, Relapsed Acute Myeloid Leukemia, Renal Cell Carcinoma, Rhabdomyosarcoma, Small-Cell Lung Cancer, Spinal Cord Injury, Thymic Carcinoma, Thyroid Cancer and Transitional Cell Cancer (Urothelial Cell Cancer).

Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope:

  • The report provides a snapshot of the global therapeutic landscape for Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 2.7.10.1)
  • The report reviews Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 2.7.10.1) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
  • The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
  • The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
  • The report reviews key players involved in Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 2.7.10.1) targeted therapeutics and enlists all their major and minor projects
  • The report assesses Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 2.7.10.1) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
  • The report summarizes all the dormant and discontinued pipeline projects
  • The report reviews latest news and deals related to Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 2.7.10.1) targeted therapeutics

Reasons to buy:

  • Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
  • Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
  • Identify and understand the targeted therapy areas and indications for Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 2.7.10.1)
  • Identify the use of drugs for target identification and drug repurposing
  • Identify potential new clients or partners in the target demographic
  • Develop strategic initiatives by understanding the focus areas of leading companies
  • Plan mergers and acquisitions effectively by identifying key players and it's most promising pipeline therapeutics
  • Devise corrective measures for pipeline projects by understanding Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 2.7.10.1) development landscape
  • Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Table of Contents

  • Table of Contents
    • List of Tables
    • List of Figures
  • Introduction
    • Global Markets Direct Report Coverage
  • Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 2.7.10.1) - Overview
    • Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 2.7.10.1) - Therapeutics Development
    • Products under Development by Stage of Development
    • Products under Development by Therapy Area
    • Products under Development by Indication
    • Products under Development by Companies
    • Products under Development by Universities/Institutes
  • Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 2.7.10.1) - Therapeutics Assessment
    • Assessment by Mechanism of Action
    • Assessment by Route of Administration
    • Assessment by Molecule Type
  • Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 2.7.10.1) - Companies Involved in Therapeutics Development
    • Abbisko Therapeutics Co Ltd
    • Amgen Inc
    • ArQule Inc
    • Bayer AG
    • Blueprint Medicines Corp
    • Eddingpharm Inc
    • Eisai Co Ltd
    • Eli Lilly and Co
    • Genosco Inc
    • H3 Biomedicine Inc
    • Hanmi Pharmaceuticals Co Ltd
    • Incyte Corp
    • Ionis Pharmaceuticals Inc
    • Johnson & Johnson
    • Merrimack Pharmaceuticals Inc
    • NGM Biopharmaceuticals Inc
    • Novartis AG
    • Principia Biopharma Inc
    • Tasly Pharmaceutical Group Co Ltd
    • Vichem Chemie Research Ltd
  • Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 2.7.10.1) - Drug Profiles
    • ABSK-011 - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • BLU-554 - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • BLU-9931 - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • derazantinib - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • EDP-317 - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • erdafitinib - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • ES-135 - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • FGF-401 - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • Fusion Protein to Agonize FGFR for Type 2 Diabetes - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • Fusion Proteins to Agonize FGFR for Metabolic Disorders - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • golvatinib tartrate + lenvatinib mesylate - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • H-3B6527 - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • HM-81442 - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • INCB-62079 - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • infigratinib - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • IONIS-463588 - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • lenvatinib mesylate - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • LY-2874455 - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • MM-161 - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • NGM-282 - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • PRN-1371 - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • rogaratinib - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • Small Molecule to Inhibit FGFR4 for Solid Tumors - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • Small Molecules to Antagonize FGFR4 for Hepatocellular Carcinoma - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • Small Molecules to Inhibit Pan FGFR for Oncology - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • TSLB-1344 - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
  • Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 2.7.10.1) - Dormant Products
  • Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 2.7.10.1) - Discontinued Products
  • Fibroblast Growth Factor Receptor 4 (CD334 or FGFR4 or EC 2.7.10.1) - Product Development Milestones
    • Featured News & Press Releases
      • Apr 14, 2018: NGM Bio Announces Results From Phase 2 Study Of NGM282 In Nash Patients Demonstrating Clinically Significant Improvements In Liver Histology After 12 Weeks
      • Apr 13, 2018: NGM Bio Announces Late-Breaking Plenary Presentation At International Liver Conference 2018 Of Detailed Results From Phase 2 Study Of NGM282 In Patients With Primary Sclerosing Cholangitis
      • Mar 23, 2018: Anticancer Agent LENVIMA (lenvatinib mesylate) Approved for Additional Indication of Unresectable Hepatocellular Carcinoma (HCC) in Japan, First Approval Worldwide for LENVIMA for HCC
      • Mar 15, 2018: Janssen Announces U.S. FDA Breakthrough Therapy Designation for Erdafitinib in the Treatment of Metastatic Urothelial Cancer
      • Mar 15, 2018: ArQule to Present Data on Derazantinib
      • Mar 12, 2018: Grupo Biotoscana Announces New Initiatives for LENVIMA
      • Mar 12, 2018: NGM Bio Announces Publication In The Lancet Of Phase 2 Study Of NGM282 In NASH Patients And Upcoming Presentations Of NGM282 NASH Histology Data And NGM282 PSC Data At The International Liver Congress 2018
      • Mar 08, 2018: Gastrointestinal Hormone Measurably Improved Symptoms of Non-Alcoholic Fatty Liver Disease
      • Feb 16, 2018: UK NICE Recommends Anticancer Agent Lenvima as Treatment for Thyroid Cancer
      • Feb 15, 2018: Positive Phase 3 Trial Results of Investigational Anticancer Agent Lenvatinib in Unresectable Hepatocellular Carcinoma (HCC) Published in The Lancet
      • Feb 10, 2018: Phase III Trial Results of Anticancer Agent Lenvatinib in Hepatocellular Carcinoma Published in the Lancet
      • Feb 05, 2018: NGM Reports Top-Line Results From Phase 2 Study Of NGM282 In Patients With Primary Sclerosing Cholangitis (PSC)
      • Jan 26, 2018: NICE Issues Technology Appraisal Guidance on Lenvatinib with Everolimus for Previously Treated Advanced RCC
      • Jan 25, 2018: Janssen to Present data on Erdafitinib at Prostate and Urothelial Cancers at ASCO GU 2018
      • Jan 22, 2018: Eisai Presents Results of Analysis of Phase III Trial of Lenvima (Lenvatinib) In Hepatocellular Carcinoma Based on Independent Imaging Review at ASCO-GI
  • Appendix
    • Methodology
    • Coverage
    • Secondary Research
    • Primary Research
    • Expert Panel Validation
    • Contact Us
  • Disclaimer

List of Tables

  • Number of Products under Development by Stage of Development, H1 2018
  • Number of Products under Development by Therapy Areas, H1 2018
  • Number of Products under Development by Indications, H1 2018
  • Number of Products under Development by Indications, H1 2018 (Contd..1), H1 2018
  • Number of Products under Development by Indications, H1 2018 (Contd..2), H1 2018
  • Number of Products under Development by Companies, H1 2018
  • Number of Products under Development by Companies, H1 2018 (Contd..1)
  • Products under Development by Companies, H1 2018
  • Products under Development by Companies, H1 2018 (Contd..1), H1 2018
  • Products under Development by Companies, H1 2018 (Contd..2), H1 2018
  • Products under Development by Companies, H1 2018 (Contd..3), H1 2018
  • Products under Development by Companies, H1 2018 (Contd..4), H1 2018
  • Products under Development by Companies, H1 2018 (Contd..5), H1 2018
  • Products under Development by Companies, H1 2018 (Contd..6), H1 2018
  • Number of Products under Investigation by Universities/Institutes, H1 2018
  • Products under Investigation by Universities/Institutes, H1 2018
  • Number of Products by Stage and Mechanism of Actions, H1 2018
  • Number of Products by Stage and Route of Administration, H1 2018
  • Number of Products by Stage and Molecule Type, H1 2018
  • Pipeline by Abbisko Therapeutics Co Ltd, H1 2018
  • Pipeline by Amgen Inc, H1 2018
  • Pipeline by ArQule Inc, H1 2018
  • Pipeline by Bayer AG, H1 2018
  • Pipeline by Blueprint Medicines Corp, H1 2018
  • Pipeline by Eddingpharm Inc, H1 2018
  • Pipeline by Eisai Co Ltd, H1 2018
  • Pipeline by Eli Lilly and Co, H1 2018
  • Pipeline by Genosco Inc, H1 2018
  • Pipeline by H3 Biomedicine Inc, H1 2018
  • Pipeline by Hanmi Pharmaceuticals Co Ltd, H1 2018
  • Pipeline by Incyte Corp, H1 2018
  • Pipeline by Ionis Pharmaceuticals Inc, H1 2018
  • Pipeline by Johnson & Johnson, H1 2018
  • Pipeline by Merrimack Pharmaceuticals Inc, H1 2018
  • Pipeline by NGM Biopharmaceuticals Inc, H1 2018
  • Pipeline by Novartis AG, H1 2018
  • Pipeline by Principia Biopharma Inc, H1 2018
  • Pipeline by Tasly Pharmaceutical Group Co Ltd, H1 2018
  • Pipeline by Vichem Chemie Research Ltd, H1 2018
  • Dormant Products, H1 2018
  • Dormant Products, H1 2018 (Contd..1), H1 2018
  • Discontinued Products, H1 2018

List of Figures

  • Number of Products under Development by Stage of Development, H1 2018
  • Number of Products under Development by Therapy Areas, H1 2018
  • Number of Products under Development by Top 10 Indications, H1 2018
  • Number of Products by Mechanism of Actions, H1 2018
  • Number of Products by Stage and Mechanism of Actions, H1 2018
  • Number of Products by Routes of Administration, H1 2018
  • Number of Products by Stage and Routes of Administration, H1 2018
  • Number of Products by Molecule Types, H1 2018
  • Number of Products by Stage and Molecule Types, H1 2018
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