Product Code: GMDHC2044TDB
Summary
Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) pipeline Target constitutes close to 33 molecules. Out of which approximately 25 molecules are developed by companies and remaining by the universities/institutes. The latest report Histone Deacetylase 1 - Pipeline Review, H2 2019, outlays comprehensive information on the Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) - Histone deacetylase 1 is an enzyme encoded by the HDAC1 gene. The protein encoded by this gene belongs to the histone deacetylase family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis. It plays an important role in transcriptional regulation, cell cycle progression and developmental events. The molecules developed by companies in Phase III, Phase II, Preclinical and Discovery stages are 4, 5, 14 and 2 respectively. Similarly, the universities portfolio in Preclinical and Discovery stages comprises 7 and 1 molecules, respectively.
Report covers products from therapy areas Oncology, Central Nervous System, Hematological Disorders, Genetic Disorders, Gastrointestinal, Immunology, Infectious Disease and Musculoskeletal Disorders which include indications Breast Cancer, Acute Lymphocytic Leukemia (ALL, Acute Lymphoblastic Leukemia), Acute Myelocytic Leukemia (AML, Acute Myeloblastic Leukemia), Follicular Lymphoma, Diffuse Large B-Cell Lymphoma, Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma), Lymphoma, Melanoma, Mycosis Fungoides, Non-Small Cell Lung Cancer, Adenoid Cystic Carcinoma (ACC), B-Cell Non-Hodgkin Lymphoma, Burkitt Lymphoma, Colorectal Cancer, Cutaneous T-Cell Lymphoma, Epithelial Ovarian Cancer, Essential Thrombocythemia, Glioblastoma Multiforme (GBM), Lung Cancer, Mantle Cell Lymphoma, Marginal Zone B-cell Lymphoma, Metastatic Melanoma, Multiple Myeloma (Kahler Disease), Myelodysplastic Syndrome, Neuroblastoma, Pancreatic Cancer, Parkinson's Disease, Post-Polycythemia Vera Myelofibrosis (PPV-MF), Refractory Multiple Myeloma, Relapsed Acute Myeloid Leukemia, Relapsed Multiple Myeloma, Squamous Cell Carcinoma, Thalassemia, Triple-Negative Breast Cancer (TNBC), Adenocarcinoma Of The Gastroesophageal Junction, Alzheimer's Disease, Anaplastic Large Cell Lymphoma (ALCL), Angioimmunoblastic T-Cell Lymphoma (AITL)/Immunoblastic Lymphadenopathy, Basal Cell Carcinoma (Basal Cell Epithelioma), Becker Muscular Dystrophy, Bile Duct Cancer (Cholangiocarcinoma), Blood Cancer, Bone Disorders, Central Nervous System (CNS) Tumor, Charcot-Marie-Tooth Disease Type II, Chronic Lymphocytic Leukemia (CLL), CNS Lymphoma, Cognitive Disorders, Colon Cancer, Depression, Duchenne Muscular Dystrophy, Endometrial Cancer, Fallopian Tube Cancer, Gallbladder Cancer, Gastrointestinal Tract Cancer, Gliosarcoma, Hematological Tumor, Hemoglobinopathies, High-Grade Glioma, Human Immunodeficiency Virus (HIV) Infections (AIDS), Human Papillomavirus (HPV) Associated Cancer, Liver Cancer, Liver Fibrosis, Lung Adenocarcinoma, Merkel Cell Carcinoma, Metastatic Adenocarcinoma of The Pancreas, Metastatic Biliary Tract Cancer, Metastatic Breast Cancer, Metastatic Colorectal Cancer, Metastatic Renal Cell Carcinoma, Metastatic Uveal Melanoma, Multiple Sclerosis, Muscle Invasive Bladder Cancer (MIBC), Myelofibrosis, Natural Killer Cell Lymphomas, Neuroendocrine Cancer, Non-Hodgkin Lymphoma, NUT Midline Carcinoma (NMC or Nuclear Protein in Testis Midline Carcinoma), Pediatric Diffuse Intrinsic Pontine Glioma, Peripheral T-Cell Lymphomas (PTCL), Peritoneal Cancer, Polycythemia Vera, Post-Essential Thrombocythemia Myelofibrosis (Post-ET MF), Prostate Cancer, Recurrent Medulloblastoma, Refractory Acute Myeloid Leukemia, Refractory Chronic Lymphocytic Leukemia (CLL), Relapsed Chronic Lymphocytic Leukemia (CLL), Renal Cell Carcinoma, Sezary Syndrome, Sickle Cell Disease, Skin Cancer, Solid Tumor and Systemic Lupus Erythematosus.
Furthermore, this report also reviews key players involved in Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) targeted therapeutics development with respective active and dormant or discontinued projects. Driven by data and information sourced from proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources.
Scope
- The report provides a snapshot of the global therapeutic landscape for Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98)
- The report reviews Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
- The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
- The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
- The report reviews key players involved in Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) targeted therapeutics and enlists all their major and minor projects
- The report assesses Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
- The report summarizes all the dormant and discontinued pipeline projects
- The report reviews latest news and deals related to Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) targeted therapeutics
Reasons to buy
- Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
- Identify and understand the targeted therapy areas and indications for Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98)
- Identify the use of drugs for target identification and drug repurposing
- Identify potential new clients or partners in the target demographic
- Develop strategic initiatives by understanding the focus areas of leading companies
- Plan mergers and acquisitions effectively by identifying key players and it's most promising pipeline therapeutics
- Devise corrective measures for pipeline projects by understanding Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) development landscape
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
Table of Contents
List of Tables
List of Figures
- Introduction
- Global Markets Direct Report Coverage
- Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) - Overview
- Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) - Therapeutics Development
- Products under Development by Stage of Development
- Products under Development by Therapy Area
- Products under Development by Indication
- Products under Development by Companies
- Products under Development by Universities/Institutes
- Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) - Therapeutics Assessment
- Assessment by Mechanism of Action
- Assessment by Route of Administration
- Assessment by Molecule Type
- Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) - Companies Involved in Therapeutics Development
- 4D Pharma Plc
- 4SC AG
- Bristol-Myers Squibb Co
- Chipscreen Biosciences Ltd
- Curis Inc
- IRBM Science Park SpA
- Italfarmaco SpA
- Jubilant Biosys Ltd
- Medivir AB
- MEI Pharma Inc
- Merck & Co Inc
- Oceanyx Pharmaceuticals Inc
- Regenacy Pharmaceuticals LLC
- Shuttle Pharmaceuticals Inc
- Syndax Pharmaceuticals Inc
- Zhejiang Hisun Pharmaceutical Co Ltd
- Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) - Drug Profiles
- ACY-1035 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- ACY-1071 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- ACY-738 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) - Dormant Products
- Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) - Discontinued Products
- Histone Deacetylase 1 (HDAC1 or EC 3.5.1.98) - Product Development Milestones
- Featured News & Press Releases
- Appendix
- Methodology
- Coverage
- Secondary Research
- Primary Research
- Expert Panel Validation
- Contact Us
- Disclaimer
List of Tables
- Number of Products under Development by Stage of Development, H2 2019
- Number of Products under Development by Therapy Areas, H2 2019
- Number of Products under Development by Indications, H2 2019
- Number of Products under Development by Indications, H2 2019 (Contd..1), H2 2019
- Number of Products under Development by Indications, H2 2019 (Contd..2), H2 2019
- Number of Products under Development by Indications, H2 2019 (Contd..3), H2 2019
- Number of Products under Development by Indications, H2 2019 (Contd..4), H2 2019
- Number of Products under Development by Companies, H2 2019
- Products under Development by Companies, H2 2019
- Products under Development by Companies, H2 2019 (Contd..1), H2 2019
- Products under Development by Companies, H2 2019 (Contd..2), H2 2019
- Products under Development by Companies, H2 2019 (Contd..3), H2 2019
- Products under Development by Companies, H2 2019 (Contd..4), H2 2019
- Products under Development by Companies, H2 2019 (Contd..5), H2 2019
- Products under Development by Companies, H2 2019 (Contd..6), H2 2019
- Products under Development by Companies, H2 2019 (Contd..7), H2 2019
- Number of Products under Investigation by Universities/Institutes, H2 2019
- Products under Investigation by Universities/Institutes, H2 2019
- Number of Products by Stage and Mechanism of Actions, H2 2019
- Number of Products by Stage and Route of Administration, H2 2019
- Number of Products by Stage and Molecule Type, H2 2019
- Pipeline by 4D Pharma Plc, H2 2019
- Pipeline by 4SC AG, H2 2019
- Pipeline by Bristol-Myers Squibb Co, H2 2019
- Pipeline by Chipscreen Biosciences Ltd, H2 2019
- Pipeline by Curis Inc, H2 2019
- Pipeline by IRBM Science Park SpA, H2 2019
- Pipeline by Italfarmaco SpA, H2 2019
- Pipeline by Jubilant Biosys Ltd, H2 2019
- Pipeline by Medivir AB, H2 2019
- Pipeline by MEI Pharma Inc, H2 2019
- Pipeline by Merck & Co Inc, H2 2019
- Pipeline by Oceanyx Pharmaceuticals Inc, H2 2019
- Pipeline by Regenacy Pharmaceuticals LLC, H2 2019
- Pipeline by Shuttle Pharmaceuticals Inc, H2 2019
- Pipeline by Syndax Pharmaceuticals Inc, H2 2019
- Pipeline by Zhejiang Hisun Pharmaceutical Co Ltd, H2 2019
- Dormant Products, H2 2019
- Dormant Products, H2 2019 (Contd..1), H2 2019
- Dormant Products, H2 2019 (Contd..2), H2 2019
- Dormant Products, H2 2019 (Contd..3), H2 2019
- Dormant Products, H2 2019 (Contd..4), H2 2019
- Discontinued Products, H2 2019
List of Figures
- Number of Products under Development by Stage of Development, H2 2019
- Number of Products under Development by Therapy Areas, H2 2019
- Number of Products under Development by Top 10 Indications, H2 2019
- Number of Products by Stage and Mechanism of Actions, H2 2019
- Number of Products by Routes of Administration, H2 2019
- Number of Products by Stage and Routes of Administration, H2 2019
- Number of Products by Molecule Types, H2 2019
- Number of Products by Stage and Molecule Types, H2 2019
