市場調查報告書

CRISPR Cas9 全球市場:臨床實驗、治療用途展望

Global CRISPR Cas9 Market, Clinical Trials & Therapeutic Application Outlook 2024

出版商 KuicK Research 商品編碼 913552
出版日期 內容資訊 英文 200 Pages
商品交期: 最快1-2個工作天內
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CRISPR Cas9 全球市場:臨床實驗、治療用途展望 Global CRISPR Cas9 Market, Clinical Trials & Therapeutic Application Outlook 2024
出版日期: 2019年10月09日內容資訊: 英文 200 Pages
簡介

本報告針對全球CRISPR-Cas9市場,聚焦於臨床實驗及治療用途進行調查,提供有關市場概要、臨床實驗趨勢、企業、適應症別的臨床實驗及從事臨床實驗的主要企業檔案等系統化資訊。

第1章 CRISPR-Cas9:簡介

第2章 作用機制

  • 單細胞微生物中CRISPR的免疫防禦
  • CRISPR技術

第3章 CRISPR-Cas9的輸遞方法

  • 經由物理方式的CRISPR-Cas9元件輸遞
  • 經由病毒載體的CRISPR-Cas9元件輸遞
  • 非病毒載體 (生物材料) 的CRISPR-Cas9元件輸遞

第4章 CRISPR-Cas9:各式各樣的用途

  • CRISPR-Cas9技術帶來的好處
  • 其他基因組編輯工具和CRISPR-Cas9的比較

第5章 全球CRISPR-Cas9臨床實驗:國家、適應症別

  • 研究
  • 臨床前
  • 階段I
  • 階段I/II
  • 階段II

第6章 全球CRISPR-Cas9市場:現況

  • 全球CRISPR市場分析
  • 全球CRISPR市場:地區全局

第7章 去除遺傳性疾病:以CRISPR-Cas9治療鐮刀型紅血球疾病

第8章 乙型地中海貧血治療的創新

第9章 對於癌症治療的可能性

第10章 CRISPR-Cas9:亨丁頓舞蹈症治療的第一步

第11章 CRISPR-Cas9:反轉肥胖蔓延的技術 (2型糖尿病)

第12章 CRISPR-Cas9:膽固醇治療

第13章 CRISPR-Cas9:瘧疾對策

第14章 CRISPR-Cas9:消滅囊狀纖維化

第15章 CRISPR-Cas9:去除B型肝炎

第16章 HIV/AIDS 的永久治療

第17章 CRISPR-Cas9:治癒阿茲海默症的一線曙光

第18章 CRISPR-Cas9:裘馨氏肌肉失養症 (DMD) 的矯正

第19章 CRISPR:擴大免疫療法的範圍

第20章 CRISPR-Cas9:在全球市場的動態

第21章 CRISPR-Cas9:全球市場未來展望

第22章 競爭情勢

  • Beam Therapeutics
  • Casebia Therapeutics
  • CRISPR Therapeutics
  • EdiGENE Corporation
  • Editas Medicine
  • Emendo Biotherapeutics
  • Intellia Therapeutics
  • Modalis Therapeutics
  • Neon Therapeutics
  • Refuge Biotechnologies
  • Sarepta Therapeutics
  • Vertex Pharmaceuticals
目錄

"Global CRISPR Cas9 Market, Clinical Trials & Therapeutic Application Outlook 2024" Report Highlight:

  • Report Focuses On Human Clinical Trials & Human Therapeutic Application
  • Global CRISPR Cas9 Market Overview
  • Global CRISPR Cas9 Clinical Trials: More Than 40 Trials
  • Global CRISPR Cas9 Clinical Trials by Company & Indication
  • Global CRISPR Cas9 Market Regional Scenario
  • Global CRISPR Cas9 Therapy Application by Multiple Indications
  • Key Companies Profile Involved In Clinical Trials: 12 Companies

CRISPR technology is one of the most advanced technology falling under the category of gene editing. It stands out as a mature existing system that can be used to engineer the genes with the desired ones. CRISPR contains innovative capabilities making its potential benefits endless. Till now, the theoretical knowledge about CRISPR has gained much attention and now it's the time for us to apply it for the practical use.

CRISPR is one such technology that has totally revolutionized the working process in the scientific field. It has been only few years since its discovery and CRISPR has started dominating the research labs all over the world. Inspite of being a newly discovered technology, CRISPR has come out with latest methodologies of treating diseases with genetic or lifestyle inherited diseases.

Making targeted changes to the genome of an individual which was a long-standing goal for the researchers, has now become a dream come like true situation. The development of CRISPR technology has helped the bio-medical researchers to put out any experiment in an efficient way. CRISPR is not the first tool to get discovered for performing gene editing but it has made its way all to the top of the list in gene editing technologies.

CRISPR technology comes with a lot of potential in it. It is the most advanced technology for treating deadly diseases that the mankind is suffering from. CRISPR is successful in showing positive results in curing diseases such as: Sickle cell anemia, cancer, hepatitis B and cholesterol. CRISPR is used for producing alterations in the somatic cell lines as well as the germline (reproductive cells). With this application of CRISPR, it is possible to correct the mutation residing inside the genome of a fetus.

Clinical trials about the CRISPR components help in achieving the efficacy of the technology. More than 30 CRISPR-Cas9 clinical trials are going on, with a participation of more than 1,000 patients. Among all the countries, US and China are the most active countries that are running the maximum number of trials. CRISPR has not only marked its presence in the pharma sector, it has also come across a long path in gaining respect in the agriculture field. There is constant innovation going on in the laboratories for attaining maximum benefits from the CRISPR components.

The increasing potential benefits received from CRISPR are creating an unimaginable effect on the market of CRISPR across the globe. The market of CRISPR is going through a giant progress, as the benefits from CRISPR are increasing day by day. The market of CRISPR has shown a tremendous jump over the last few years. Researchers are also exploring different ways of utilizing CRISPR in both diagnostic as well as therapeutic development.

The successful commercialization of such development is likely to drive the market's revenue growth. The market of CRISPR is also driven by the increasing number of cancer cases, autoimmune diseases in the world. Inspite of the increasing cancer cases around the globe, other major factors driving the growth of CRISPR are the leading manufacturers of the pharmaceutical industry, technological advancements and the presence of skilled researchers.

Table of Contents

1. Introduction to CRISPR-Cas9

  • 1.1 Overview
  • 1.2 History of CRISPR-Cas9 Technology

2. Mechanism of Action

  • 2.1 Immune Defense with CRISPR in Single Celled Microorganisms
  • 2.2 CRISPR Technology

3. Delivery Methods for CRISPR-Cas9

  • 3.1 Delivery of CRISPR-Cas9 components through Physical Methods
    • 3.1.1 Microinjection
    • 3.1.2 Electroporation
    • 3.1.3 Hydrodynamic Delivery
  • 3.2 Delivery of CRISPR-Cas9 Components through Viral Vectors
    • 3.2.1 Adeno-Associated Virus (AAV)
    • 3.2.2 Lentivirus & Adenovirus
  • 3.3 Delivery of CRISPR-Cas9 Components through Non-Viral Vectors (Biomaterials)
    • 3.3.1 Liposomes
    • 3.3.2 Gold Nanoparticles
    • 3.3.3 DNA Nanoclew

4. CRISPR-Cas9: A Home to a Variety of Applications

  • 4.1 Advantages Accompanying CRISPR-Cas9 Technology
  • 4.2 CRISPR-Cas9 Comparison with other Genome Editing Tools

5. Global CRISPR-Cas9 Clinical Trials by Company & Indication

  • 5.1 Research
  • 5.2 Preclinical
  • 5.3 Phase-I
  • 5.4 Phase-I/II
  • 5.5 Phase-II

6. Global CRISPR-Cas9 Market Current Overview

  • 6.1 Global CRISPR Market Analysis
  • 6.2 Global CRISPR Market Regional Scenario

7. Elimination of Genetic Disease: Sickle-Cell Anemia through CRISPR-Cas9

  • 7.1 Overview
  • 7.2 Sickle Cell Treatment with CRISPR
  • 7.3 Clinical Trial for Testing CRISPR against Sickle Cell Anemia

8. Revolutionizing the Treatment of Beta-Thalassemia

  • 8.1 Overview
  • 8.2 CRISPR Application in Treating Beta-Thalassemia
  • 8.3 CRISPR Clinical Trial for Beta-Thalassemia

9. Potential for Curing Cancer

  • 9.1 Overview
  • 9.2 CRISPR-Cas9 Fight for Cancer
  • 9.3 CRISPR Trial for Cancer Treatment Research

10. CRISPR-Cas9: A Step Closer to Treat Huntington's Disease

  • 10.1 Overview
  • 10.2 CRISPR-Cas9 Towards Huntington's Disease
  • 10.3 CRISPR Mediated Treatment of Huntington's Disease in Mouse Models

11. CRISPR-Cas9 Technique to Reverse Obesity Epidemic (Type 2 Diabetes)

  • 11.1 Overview
  • 11.2 CRISPR Treatment for Obesity
  • 11.3 Clinical Trials for Reducing Obesity Using CRISPR

12. CRISPR-Cas9 Treatment for Cholesterol

  • 12.1 Overview
  • 12.2 Expanding the Application of CRISPR for Cholesterol
  • 12.3 Lab Clinical Studies Reflecting the Positive Side of CRISPR

13. CRISPR-Cas9 Against Malaria

  • 13.1 Overview
  • 13.2 CRISPR-Cas9 Technology for Malaria Treatment
  • 13.3 Mosquitoes Carrying Parasites Eliminated using CRISPR-Cas9

14. CRISPR-Cas9 for Knocking Out Cystic Fibrosis

  • 14.1 Overview
  • 14.2 CRISPR-Cas9: A Versatile Tool for Deactivating CFTR
  • 14.3 Development & Research: CRISPR-Cas9

15. CRISPR-Cas9 for the Removal of Hepatitis B

  • 15.1 Overview
  • 15.2 CRISPR-Cas9 Rising against cccDNA
  • 15.3 Clinical Lab Studies Clears HBV cccDNA on Human Cell Lines

16. Permanent Cure for HIV/AIDS Treatment

  • 16.1 Overview
  • 16.2 CRISPR-Cas9 for Deleting CCR5 Gene
  • 16.3 Clinical Results Achieved Using CRISPR-Cas9 for HIV/AIDS
  • 16.4 Gene-Edited Babies: HIV resistant

17. CRISPR Hope for Alzheimer's Disease

  • 17.1 Overview
  • 17.2 CRISPR-Cas9 for Alzheimer's Disease
  • 17.3 Lab Clinical Studies for Eliminating Alzheimer's

18. CRISPR-Cas9 to Correct Duchenne Muscular Dystrophy (DMD)

  • 18.1 Overview
  • 18.2 CRISPR-Cas9 Technology Over-Powering DMD Gene
  • 18.3 CRISPR Success in Treating DMD in Mice Models

19. CRISPR Enhances the Reach of Immunotherapy

  • 19.1 CRISPR for Immunosuppressive Defects
  • 19.2 CRISPR Mediated Generation of CAR-T Cells

20. Global CRISPR-Cas9 Market Dynamics

  • 20.1 Market Drivers for CRISPR-Cas9 Therapy
  • 20.2 Challenges Overpowering CRISPR

21. Global CRISPR-Cas9 Market Future Outlook

22. Competitive Landscape

  • 22.1 Beam Therapeutics
  • 22.2 Casebia Therapeutics
  • 22.3 CRISPR Therapeutics
  • 22.4 EdiGENE Corporation
  • 22.5 Editas Medicine
  • 22.6 Emendo Biotherapeutics
  • 22.7 Intellia Therapeutics
  • 22.8 Modalis Therapeutics
  • 22.9 Neon Therapeutics
  • 22.10 Refuge Biotechnologies
  • 22.11 Sarepta Therapeutics
  • 22.12 Vertex Pharmaceuticals

List of Figures

  • Figure 1-1: Key Events in the History of CRISPR-Cas9 System Development
  • Figure 2-1: CRISPR Immune Mechanism in Bacteria
  • Figure 2-2: CRISPR Technology Working in Cell Lines
  • Figure 3-1: Delivery Methods for CRISPR-Cas9
  • Figure 3-2: Delivery Pathways for CRISPR-Cas9 Components
  • Figure 3-3: Physical Mode of Delivery for CRISPR-Cas9 Components
  • Figure 3-4: Viral Mode of Delivery for CRISPR-Cas9 Components
  • Figure 3-5: Non-Viral Mode of Delivery for CRISPR-Cas9 Components
  • Figure 4-1: Advantages of CRISPR-Cas9 Technology
  • Figure 4-2: Comparison between Different Genome Editing Tools
  • Figure 5-1: Global - CRISPR-Cas9 Clinical Trials by Phase (%), 2019 till 2024
  • Figure 5-2: Global - CRISPR-Cas9 Clinical Trials by Phase (Number), 2019 till 2024
  • Figure 6-1: Global - CRISPR Investments (US$ Million), 2011 & 2016
  • Figure 6-2: Global - Research Papers Published, 2011 & 2016
  • Figure 6-3: Global - CRISPR Market Size (US$ Million), 2018 - 2024
  • Figure 7-1: Normal RBCs VS Sickle Shaped RBCs
  • Figure 7-2: Treatment of Sickle Cell Anemia through CRISPR-Cas9
  • Figure 7-3: Phases Involved in a Clinical Trial of a Drug
  • Figure 8-1: Mutated Gene leading to Beta-Thalassemia
  • Figure 8-2: CRISPR-Cas9 Therapy for Beta-Thalassemia
  • Figure 9-1: Difference between Normal Cells & Cancer Cells
  • Figure 9-2: CRISPR-Cas9 Treatment for Cancer
  • Figure 9-3: Ongoing Clinical Trials on CRISPR in Different Types of Cancer
  • Figure 10-1: Defective Genes Leading to Huntington's Disease
  • Figure 10-2: CRISPR-Cas9 Technique for Huntington's Disease
  • Figure 10-3: Experiment Conducted to Test CRISPR-Cas9 Effect on Transgenic R6/2 Mouse Model
  • Figure 11-1: Obesity Related Health Issues
  • Figure 11-2: Mutations Leading to Obesity
  • Figure 11-3: CRISPR-Cas9 Controlling Obesity
  • Figure 12-1: Cholesterol Pathways Present in the Body
  • Figure 12-2: Mutation Leading to Clogging of Arteries
  • Figure 12-3: CRISPR-Cas9 against Cholesterol
  • Figure 12-4: Experiment Conducted to Test CRISPR-Cas9 on Cholesterol Level
  • Figure 13-1: Malaria Transmission Cycle
  • Figure 13-2: CRISPR Cas9 Machinery against Malaria
  • Figure 13-3: Experiment Conducted to Test CRISPR against Plasmodium
  • Figure 14-1: CRISPR-Cas9 Correcting Cystic Fibrosis
  • Figure 14-2: Experiment Conducted on CF Patient to Evaluate CRISPR
  • Figure 15-1: HBV Virus Infecting Healthy Liver Cells
  • Figure 15-2: CRISPR Activity against Hepatitis B Virus
  • Figure 15-3: Experiment Showing Reduction in HBV Viral Proteins due to CRISPR
  • Figure 16-1: HIV Infection Leading to AIDS
  • Figure 16-2: CRISPR Knocking Out CCR5 Gene
  • Figure 17-1: APP Gene Mutation Leading to Alzheimer's Disease
  • Figure 17-2: CRISPR-Cas9 Machinery for Alzheimer's Disease
  • Figure 17-3: Strategies Adopted by Researchers to Treat Alzheimer's Through CRISPR
  • Figure 17-4: Experiment Conducted to Test CRISPR for Alzheimer's
  • Figure 18-1: DMD Gene Mutation Leading to Duchenne muscular Dystrophy
  • Figure 18-2: CRISPR-Cas9 Editing DMD Gene
  • Figure 18-3: Experiment Showing the Success of CRISPR in Treating DMD in Mice
  • Figure 19-1: Cancer Cells Escaping Immune
  • Figure 19-2: CRISPR Potential Activities
  • Figure 20-1: Key Drivers Leading to the Development of CRISPR
  • Figure 21-1: Future of CRISPR-Cas9 Gene Editing Technology
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