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給藥微針的專利狀況

Microneedles for Drug Delivery Patent Landscape

出版商 KnowMade 商品編碼 953760
出版日期 內容資訊 英文 PDF >140 slides, Excel file > 2,450 patent families
商品交期: 最快1-2個工作天內
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給藥微針的專利狀況 Microneedles for Drug Delivery Patent Landscape
出版日期: 2020年08月06日內容資訊: 英文 PDF >140 slides, Excel file > 2,450 patent families
簡介

2018年,全球藥物輸送市場規模達到4050億美元。特別地,近來,使用微針輕鬆且安全地皮下注射而沒有疼痛的方法已經流行。結果,與該領域相關的研發(R&D)和專利申請變得活躍起來,許多公司正在產品開發上投入大量資金。在這種情況下,有必要瞭解各個公司的知識產權(IP)概述和使用策略,並努力開拓新的市場機會並增強其競爭力。

本報告分析了用於藥物輸送(藥物輸送)的微針相關專利的趨勢,提供了當前主要技術的概述,未來有希望的技術清單以及全球相關專利的申請/認證/認證。我們將收集諸如使用狀況,主要公司的知識產權(IP)組合,主要專利的概況(總計超過2450個)之類的信息。

目錄

簡介

分析方法

  • 專利搜索,專利選擇,專利分析
  • 搜索策略
  • 專利分析條款
  • 專利組合的實力和受阻的可能性

主要專利受讓人

執行摘要

專利狀況:概述

  • 專利公開
  • 專利申請國
  • 趨勢:按國家分類
  • 主要專利受讓人
  • 主要知識產權(IP)公司
  • 專利法律地位
  • 映射當前主要知識產權持有人
  • 主要知識產權公司的專利活動
  • 主要專利受讓人的變更
  • 知識產權部門的新進入公司
  • 知識產權部門的主要業務合作(合作)
  • 主要企業收購

主要專利申請人的IP職位

  • 數量和質量趨勢
  • 專利受讓人的IP領導
  • 使用常規技術進行堵塞的可能性
  • 強度指數

主要專利

  • 專利引用分析
  • 關鍵專利族
  • 對EP專利的主要反對

專利分類

  • 定義
  • 主要專利受讓人(按申請)
  • 按微針類型劃分的主要專利受讓人
  • 按IP位置和技術劃分的主要專利受讓人
  • 按應用/技術分類的矩陣

主要公司的IP檔案

結論

關於KnowMade

本報告中提到的公司

JOHNSON & JOHNSON、3M、BECTON DICKINSON、久光製藥、CORIUM、凸版印刷、ZEALAND PHARMA、PROCTER & GAMBLE、COSMED PHARMACEUTICAL、富士軟片、NANOPASS TECHNOLOGY、BIOSERENTACH、SORRENTO THERAPEUTICS、THERAJECT、KIMBERLY CLARK、SILICON MICRODEVICES、ALTEA、NITTO、RAPHAS、ZOSANO PHARMA、BOEHRINGER INGELHEIM、NISSHA、VAXXAS、NANOMED、CLEARSIDE BIOMEDICAL、LG HOUSEHOLD & HEALTH CARE、LTS LOHMANN THERAPY SYSTEMS等等

目錄
Product Code: KM20006

Report's Key Features:

  • PDF with > 140 slides
  • Excel file > 2,450 patent families
  • IP trends, including time-evolution of published patents, and countries of patent filings
  • Patents' legal status
  • Ranking of main patent assignees
  • Key players' IP position and relative strength of their patent portfolios
  • Summary of the IP related to applications: Cancer therapy, Cosmetic, Diabetes, Ophthalmic, Pain management and Vaccine.
  • Summary of the IP related to technologies: Applicators, housing, Coated, Hollow, Porous, Soluble, Hydrogel and Solid microneedles.
  • Analysis of patent oppositions (Europe) and review of key patents.
  • Excel database containing all patents analyzed in the report, including applications and technologies segmentations

Microneedles for drug delivery, a new way to deliver drugs through the stratum corneum

The global drug delivery market has been observed to be as large as USD 440.5 billion in 2018. Hypodermic needles are known to be very efficient and they have been used immensely in the delivery of biological macromolecules, insulin, vaccines, etc. However, their invasive nature, stability issues, and non-compliance have always been the issues of concern and led to the requirement of highly skilled medical practitioners for administration.

In this context, microneedles have shown immense potential, since they can easily, painlessly and safely deliver drugs without special storage infrastructure. Hence, they can be self-administered by anybody, thereby eliminating the need for a clinic visit and the assistance of skilled medical practitioners. This serves as an important advantage, especially in the emerging markets. Moreover, microneedles do not create sharp waste, thereby eliminating the problem of discarding needles and hazardous risks. Patients suffering from needle phobia can easily use microneedles. Indeed, according to a study published in Behavioral Neurology, 2014, around 3-4% of the world population faces needle phobia.

Microneedles for drug delivery are attracting interest from big companies and start-ups alike and show immense potential that could transform the global transdermal market. Furthermore, in the actual race to find a COVID-19 vaccine, numerous companies (e.g. Kindeva (3M), Debiotech, Verndari, NanoPass, Bioserentach, Sorrento Therapeutics, Merck, etc.) have developed or shared their microneedle delivery system and promising results have already been released. Other fields, like cosmetic, ophthalmic and diabetes showed important technological progress in the past few years that could disrupt the existing market and replace the current standard drug delivery system.

In this evolving context, it is crucial to understand the intellectual property position and strategy of these different players. Such knowledge can help detect business risks and opportunities, anticipate emerging technologies, and enable strategic decisions to strengthen one's market position.

The analysis of the time evolution of patent publications shows that using microneedles for drug delivery were first filed in the 1971 by ALZA corporation patent (US3964482). However, it was not possible to make such microstructure devices until the 1990s, with the advent of high-precision microelectronics industrial tools. Hence, no patent families were published until 1993 and publications increased from 2001/2002, mainly due to the patenting activity of ALZA Corporation and Becton and Dickinson. A stagnation phase was observed between 2007 and 2012, followed by a second acceleration phase related to the patenting activities of 3M, Toppan Printing and Hisamistu Pharmaceutical. Patent publications then accelerated from 2015 with the entry of numerous newcomers and the expansion of the cosmetic and soluble microneedles field. The main patent assignees are Asian industrial players that develop an international intellectual property strategy. Asia (CN, JP and KR) and US are the main territories of protection, which appear to be strategic territories for these applicants.

Analysis by segment

Microneedles for drug delivery can be applied to different fields and use different technologies (i.e. type of microneedles). Therefore, a technological segmentation was made for this IP landscape, as follows:

Applications:

  • Cancer therapy: microneedle patches present advantages in terms of controllability, easy applicability and predominant synergistic effect.
  • Cosmetic: microneedles make it possible to enhance skin permeation to deliver cosmeceuticals.
  • Diabetes: painless delivery of insulin transdermally into the stratum corneum through the miniature pores created by the microneedles.
  • Ophthalmic: microneedles make it possible to deliver drug formulations to the target ocular tissues with great precision.
  • Pain management: Injecting a vaccine strategically into the skin through microneedles can produce a significantly more intense immune response.

Technologies:

  • Applicators, housing & others: a key feature is the reliability that is required for applicators for consistent application/penetration of the microneedles.
  • Coated microneedles: the coated drug formulation of the microneedle dissolves and deposits in the skin.
  • Hollow microneedles: they make it possible to deliver continuously a large amount of drugs through the inserted hollow needles.
  • Porous microneedles: they are a single-unit-drug delivery system, containing either a liquid or a dry drug formulation.
  • Soluble microneedles: they dissolve upon contact with skin interstitial fluid and release the drug over time.
  • Hydrogel microneedles: Once inserted, hydrogel microneedles rapidly take up interstitial fluid from the tissue, thus inducing the diffusion of the drug.
  • Solid microneedles: they are creating transient aqueous microchannels through which the drug can be delivered through the stratum corneum.

Identifying the companies that have recently emerged in the IP landscape

Among the players that have filed patents related to microneedles for drug delivery, over 40 newcomers were identified. These companies are established companies and start-up firms developing their first products in the microneedle sector. Numerous IP newcomers are based in Asia and in the US with only a few in Europe. It is possible that one of these innovative companies could become one of the next healthcare unicorns that the big corporations will be tempted to acquire.

Key patent analysis

This IP study includes the selection and description of key patents. The key patent analysis includes the legal state of the family for each of the main territories, the number of received citations, the review of the main claim(s), the description of interesting features about the innovation disclosures and relevant figures illustrating how the innovation works. The description also contains information about the fact that the patent family was involved in patent litigation in the USA.

Moreover, the report also includes an Excel database with the >2450 patent families analyzed in this study. This useful patent database allows for multi-criteria searches and includes patent publication numbers, hyperlinks to the original documents, priority dates, titles, abstracts, patent assignees, each patent's current legal status and segmentation to which it belongs.

Companies mentioned in this report

JOHNSON & JOHNSON; 3M; BECTON DICKINSON; HISAMITSU PHARMACEUTICAL; CORIUM; TOPPAN PRINTING; ZEALAND PHARMA; PROCTER & GAMBLE; COSMED PHARMACEUTICAL; FUJIFILM; NANOPASS TECHNOLOGY; BIOSERENTACH; SORRENTO THERAPEUTICS; THERAJECT; KIMBERLY CLARK; SILICON MICRODEVICES; ALTEA; NITTO; RAPHAS; ZOSANO PHARMA; BOEHRINGER INGELHEIM; NISSHA; VAXXAS; NANOMED; CLEARSIDE BIOMEDICAL; LG HOUSEHOLD & HEALTH CARE; LTS LOHMANN THERAPY SYSTEMS (non-exhaustive list).

TABLE OF CONTENTS

INTRODUCTION

  • Definition of microneedle
  • Scope of the report
  • Key features of the report
  • Objectives of the report

METHODOLOGY

  • Patent search, patent selection and patent analysis
  • Search strategy
  • Terminologies for patent analysis
  • Strength and blocking potential of patent portfolio

MAIN PATENT ASSIGNEES

EXECUTIVE SUMMARY

PATENT LANDSCAPE OVERVIEW

  • Time evolution of patent publications
  • Countries of patent filings
  • Time evolution by country
  • Main Patent Assignees
  • Main IP Players
  • Patent legal status
  • Mapping of main current IP holders
  • Patenting activity of IP leading companies
  • Time evolution of main patent assignees
  • IP Newcomers
  • Main IP collaborations
  • Main acquisitions

IP POSITION OF MAIN PATENT APPLICANTS

  • Beyond Quantity Quantity Quality
  • IP leadership of patent assignees
  • Prior art blocking potential
  • Strength index

KEY PATENTS

  • Patent forward citation analysis
  • Key patent families
  • Main oppositions on EP patents

PATENT SEGMENTATION

  • Definition
  • Main assignees by application
  • Main assignees by type of microneedles
  • Main assignees by IP position and technology
  • Matrix applications vs technologies

IP PROFILE OF KEY PLAYERS

CONCLUSION

KNOWMADE PRESENTATION