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口服固體製劑 (OSDF) 的溶解性的提高:全球市場分析、機會

Solubility Enhancement in Pharmaceutial Oral Solid Dosage Forms: Global Market Analysis and Opportunities

出版商 Kline & Company, Inc. 商品編碼 358085
出版日期 內容資訊 英文 272 Pages
商品交期: 最快1-2個工作天內
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口服固體製劑 (OSDF) 的溶解性的提高:全球市場分析、機會 Solubility Enhancement in Pharmaceutial Oral Solid Dosage Forms: Global Market Analysis and Opportunities
出版日期: 2015年03月01日 內容資訊: 英文 272 Pages

在研發產品線的藥物候補整體的80%以上難溶於水,製藥產業面臨著藥物溶解性的巨大課題。這帶給醫藥品服用效率嚴重的問題,在OSDF (口服固體製劑) 很明顯。同時,整體上對可溶解技術來說,尤其是對提高溶解性所採用的賦形劑來說產生大幅成長機會。

本報告提供全球口服固體製劑 (OSDF) 的提高溶解性的市場相關調查,提高溶解性的競爭技術和目前利用,可利用的各技術的優點及缺點,各地區的提高溶解性賦形劑的銷售額,在市場活動的供應商與提供產品及相關市場佔有率,提高溶解性賦形劑的平均價格,技術形勢的發展預測,及提高溶解性賦形劑的消費預測等相關資料彙整。




  • 全球製藥產業:概要
  • 法規概要
  • 難吸收的活性成分的現狀


  • 細粉末化
  • 晶相的改良
  • 化學修飾
  • 環糊精形成的錯合
  • 使用界面活性劑的Micelle可溶解
  • 固溶體
  • 噴霧乾燥
  • 冷凍乾燥
  • 脂質可溶解
  • 自我乳化型藥物遞輸系統
  • 其他技術
  • 來的技術
  • 提高溶解性技術比較評估
  • 成為本章對象的各技術,提供以下的資訊
    • 可利用的技術
    • 優點及缺點
    • 賦形劑的利用
    • 展望






The pharmaceutical industry is facing a major challenge with drug solubility as more than 80% of the entire drug candidates in the R&D pipeline are reported to be poorly soluble in water. This leads to serious problems for the effi ciency of pharmaceutical doses and notably in the OSDF segment. At the same time, it is creating a sustainably growing market opportunity for solubilization technologies in general and for excipients used for solubility enhancement in particular.

This Report Will Help Answer the Following Questions:

  • What are the competing technologies for solubility enhancement and what is their current use?
  • What are the pros and cons of each technology available?
  • What are the sales of excipients for solubility enhancement by regions?
  • Which suppliers are active on the market, which products are they supplying, and what are their relative market shares?
  • What is the average price of various excipients for solubility enhancement?
  • How is the technological landscape expected to evolve?
  • What is the forecast consumption of excipients for solubility enhancement from 2014 to 2019?

This report assists suppliers of excipients in identifying opportunities within the global market of solubility enhancers. It also serves as an invaluable tool in the strategic planning process.

  • Develop business strategies by understanding the trends and developments that are driving the global solubility enhancement excipients market
  • Identify key growth drivers by product type, application, and geography to enable development of targeted sales and marketing strategies to exploit high growth areas
  • Develop market-entry and market expansion strategies
  • Identify the competition from alternative technologies
  • Competitive intelligence for use in benchmarking
  • Forecasting scenarios from which to base solid strategic business plans

Table of Contents


Executive Summary

Introduction to Solubility Enhancement

  • Global pharmaceutical industry: overview
  • Regulatory overview
  • Current situation of poorly bioavailable active ingredients

Solubility Enhancement Technologies

  • Particle size reduction
  • Modification of crystal habit
  • Chemical modification
  • Complexation with cyclodextrins
  • Micellar solubilization using surfactants
  • Solid dispersions
  • Spray drying
  • Hot-melt extrusion
  • Lyophilization
  • Lipid solubilization
  • Self-emulsifying drug delivery system
  • Other technologies
  • Upcoming technologies
  • Comparative assessment of solubility enhancement technologies

For each technology covered in this chapter, the following information is provided:

  • Technologies available
  • Pros and cons
  • Use of excipients
  • Outlook

Solubility Enhancement Excipients

Competitive Landscape

Appraisal and Outlook

List of Tables

Table 1: Products Covered

  • Cyclodextrins
  • Polyethylene Glycol (PEG)
  • Polyvinylpyrrolidone (PVP)
  • Polyvinyl alcohol (PVA)
  • Crospovidone
  • Poloxamers
  • Cellulose derivatives (HPMC, HPC, and CMEC)
  • Lipids and surfactants used in softgels

NOTE: This is a tentative scope, any excipients with significant consumption for solubility enhancement will be covered.

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