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市場調查報告書

下游生物處理市場 (層析管柱、樹脂,薄膜吸著設備、過濾系統、感測器)

Downstream Bioprocessing Markets (Chromatography Columns and Resins, Membrane Adsorbers, Filtration Systems, Sensors)

出版商 Kalorama Information 商品編碼 725972
出版日期 內容資訊 英文 179 Pages
商品交期: 最快1-2個工作天內
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下游生物處理市場 (層析管柱、樹脂,薄膜吸著設備、過濾系統、感測器) Downstream Bioprocessing Markets (Chromatography Columns and Resins, Membrane Adsorbers, Filtration Systems, Sensors)
出版日期: 2018年10月02日內容資訊: 英文 179 Pages
簡介

本報告提供全球下游生物處理市場調查,目前市場規模與未來的可能性,各地區的市場分析,各供應商的市場佔有率,市場成長的推動要素與課題,及主要企業簡介等彙整。

摘要整理

  • 概要
  • 調查手法

簡介

趨勢、促進因素

  • 蛋白質 A
  • 分子的課題
  • 層析法
  • 合理化、重新設計
  • 煉製
  • 委託製造業者的大規模利用
  • 製造效率
  • 國際
  • 癌症治療的促進
  • 合作、革新

課題

  • 層析法
  • 連續加工
  • 滴度、成分
  • 淨化、煉製策略的演進
  • 生產能力的障礙
  • 蛋白質的分離
  • 效率
  • 設計的品質
  • 人力資源不足

市場發展

  • 為了改善下游生物處理的合作
  • 新興企業的收購
  • 預注管柱的促進
  • 下一代管柱
  • 下一代親和配體
  • 免疫球蛋白設備
  • 生物處理服務、其他

市場形勢

  • 概要
  • 促進因素
  • 市場分析、預測
  • 全球下游生物處理零組件市場
    • 層析管柱、樹脂
    • 薄膜吸著設備
    • 過濾系統
    • 感測器

企業簡介

  • 3M Company
  • Abec
  • Alfa Laval
  • Avantor Performance Materials
  • BIA Separations
  • Boehringer Ingelheim Pharmaceuticals
  • Bosch
  • Dow
  • ESI Ultrapure
  • Finesse Solutions
  • FujiFilm Diosynth biotechnologies
  • GE Healthcare Life Sciences
  • GEA Germany Dusseldorf
  • Lonza Group
  • MilliporeSigma
  • Natrix Separations
  • Nordson Medical
  • Pall Biotech
  • Parker Hannifin
  • Repligen
  • Sartorius AG
  • Thermo Fisher Scientific
  • W. L. Gore & Associates, Inc.
  • Watson-Marlow Fluid Technology Group
目錄

Bioprocessing consists of two major processing steps: upstream and downstream processing. Upstream processing refers to the culturing of cells and microorganisms to create biologically active product for use in research and in the production of biopharmaceuticals. This processing is typically done through cell culture or fermentation. Downstream processing refers to the separation and refinement of bulk bioproduct into a form suitable for its end use. Typically, this processing includes separation, purification and sterilization. Downstream Bioprocessing Markets analyzes the current and potential world market for downstream bioprocessing and includes the following global market data for downstream bioprocessing components:

  • World Downstream Bioprocessing Markets, 2016-2021 ($ billions)
  • World Downstream Bioprocessing Markets by Geography, 2016-2021 ($ billions) (US, Western Europe, Eastern Europe, APAC [China, Japan, S. Korea, India, Others], Latin America, ROW)
  • World Downstream Bioprocessing Markets by Geography, 2017 (%) (US, Western EU, Eastern EU, APAC, ROW, SA)
  • Downstream Components Bioprocessing Market Share by Vendor 2018 (%)

Chromatography Columns and Resins:

The chromatography columns and resins segment of the downstream bioprocessing components market is a large segment. There are many issues driving this segment. The continuous need for new and different column and resin technologies continues to drive growth of this market segment as bioprocessors battle what they say is their biggest downstream bottleneck. The report includes the following global market data for downstream bioprocessing chromatography columns and resins markets:

  • World Downstream Bioprocessing Chromatography Columns and Resins Markets, 2016-2021 ($ billions)
  • World Downstream Bioprocessing Chromatography Columns and Resins Markets by Geography, 2016-2021 ($ billions) (US, Western Europe, Eastern Europe, APAC [China, Japan, S. Korea, India, Others], Latin America, ROW)
  • World Downstream Bioprocessing Chromatography Columns and Resins Markets by Geography, 2017 (%) (US, Western EU, Eastern EU, APAC, ROW, SA)

Membrane Adsorbers:

Membrane adsorbers are thin, synthetic, porous membranes modified with functional groups similar to those on equivalent resins. Membrane adsorbers are growing in use, finding more deployment in flexible manufacturing facilities in which speed of operations and robust performance are essential production criteria. The report includes the following global market data for downstream bioprocessing membrane adsorber markets:

  • World Downstream Bioprocessing Membrane Adsorber Market, 2016-2021 ($ millions)
  • World Downstream Bioprocessing Membrane Adsorber Market by Geography, 2016-2021 ($ millions) (US, Western Europe, Eastern Europe, APAC [China, Japan, S. Korea, India, Others], Latin America, ROW)
  • World Downstream Bioprocessing Membrane Adsorber Market by Geography, 2017 (%) (US, Western EU, Eastern EU, APAC, ROW, SA)

Filtration Systems:

The filtration segment of the downstream bioprocessing market includes microfiltration, ultrafiltration, nanofiltration, reverse osmosis, and ion-exchange filtration. Filtration is important for harvesting biologic actives from cell media and other downstream separations because biomolecules are highly sensitive to heat and chemicals. The segment is being spurred by the general increase in biodrug products. Downstream Bioprocessing Markets includes the following global market data for downstream bioprocessing filtration markets:

  • World Downstream Bioprocessing Filtration Market, 2016-2021 ($ billions)
  • World Downstream Bioprocessing Filtration Market by Geography, 2016-2021 ($ billions) (US, Western Europe, Eastern Europe, APAC [China, Japan, S. Korea, India, Others], Latin America, ROW)
  • World Downstream Bioprocessing Filtration Market by Geography, 2017 (%) (US, Western EU, Eastern EU, APAC, ROW, SA)

Sensors:

In a fast-paced production environment, in which the various processing steps must be closely monitored, bioprocessors must implement advanced control technologies. Many are applying novel automation and software systems to monitor and control bioprocessing. On-line technologies that can monitor, control, and improve downstream process steps significantly benefit bioprocessors. They can optimize the quality of their product by harnessing the timely data on critical operational and quality parameters available by implementing on-line monitoring systems, such as sensors. Sensor technology can help the industry better manage key challenges, such as having to comply with new regulations, and address cost control and risk issues during drug development and production. The report includes the following global market data for downstream bioprocessing sensor markets:

  • World Downstream Bioprocessing Sensor Market, 2016-2021 ($ billions)
  • World Downstream Bioprocessing Sensor Market by Geography, 2016-2021 ($ billions) (US, Western Europe, Eastern Europe, APAC [China, Japan, S. Korea, India, Others], Latin America, ROW)
  • World Downstream Bioprocessing Sensor Market by Geography, 2017 (%) (US, Western EU, Eastern EU, APAC, ROW, SA)

Market Trends and Drivers, Challenges, and Developments:

Even though bioprocessors and others in the industry have been in business for a number of years, they face a number of issues and challenges to their continued success and the development of future therapeutics. Advances in science and technology, as well as new demands from customers, present a continuous flow of issues to be addressed. Bioprocessors must innovate to be able to continue to command premium prices. For them, speed, process innovation, and operational excellence are must-win battles. Market trends and drivers, challenges, and developments are discussed in the report.

The Market Landscape:

The report notes that advances in technology and bioprocessing equipment are making it possible to develop quality biologic drugs. This is increasing the use of bioprocessing equipment, which drives the biopharmaceutical market. The growing numbers of elderly, notably those suffering from chronic illnesses, will help generate a continuing need for novel biotherapeutic drugs. And as demand increases, bioprocessors will need processing technologies and components that will facilitate the production of high quality products. As a result, the significance of the downstream bioprocessing market will grow.

Competitive Analysis:

The report contains profiles of a wide range of companies. The downstream bioprocessing market players profiled in the report include:

  • 3M Company
  • Abec
  • Alfa Laval
  • Avantor Performance Materials
  • BIA Separations
  • Boehringer Ingelheim Pharmaceuticals
  • Bosch
  • Dow
  • ESI Ultrapure
  • Finesse Solutions
  • FujiFilm Diosynth biotechnologies
  • GE Healthcare Life Sciences
  • GEA Germany Düsseldorf
  • Lonza Group
  • MilliporeSigma
  • Natrix Separations
  • Nordson Medical
  • Pall Biotech
  • Parker Hannifin
  • Repligen
  • Sartorius AG
  • Thermo Fisher Scientific
  • W. L. Gore & Associates, Inc.
  • Watson-Marlow Fluid Technology Group

Market forecasts cover various segments and are based on an examination of current market conditions and on investigations into the development of new products by key companies. The market data provide multiple year forecasts for different product segments covered in the report. The information presented in this report is the result of data gathered from company product literature and other corporate brochures and documents, as well as information found in the scientific and trade press. In addition, interviews were conducted with company executives.

Table of Contents

Executive Summary

  • Overview
    • Focus on Cost Effectiveness
    • Outsourcing Popular
    • Flexibility and More Research Needed
      • Table: World Market for Downstream Bioprocessing Components, 2016-2021 ($ billions)
  • Methodology

Introduction

  • Downstream Processing
    • Table: The State of Downstream Bioprocessing
    • Important Roles
      • Table: Key Roles of Downstream Bioprocessing
    • Safety and Efficacy
  • Stages of Downstream Processing
    • Table: Stages of Downstream Bioprocessing
    • Solid-Liquid Separation
    • Intracellular Product Release
    • Product Concentration
    • Chromatography Purification
    • Formulation
  • Changes in Production Nature
    • Table: Current Biopharmaceutical Product Mix
    • Innovation Required
    • Globalization Continues
  • The Need for Operational Excellence
  • Competition Generating Cost Efficiencies
    • Downstream Resistance
    • Process Intensification
    • Higher Titers
    • New Technologies
    • Flexibility
    • Integration and Automation
    • Continuous Processing
  • Developing Research Areas
    • Chromatography
    • Resins
    • Alternative Processes for Purification
    • Spectroscopy
  • Filtration Technologies Advance
    • Tangential Flow
    • Automated
    • Gel Filtration Chromatography
    • Precipitation Alternative
    • Slow Adoption of New Technologies
  • Outsourcing
    • Core Competencies
    • Drivers
    • Issues
    • The Future

Trends and Drivers

  • Table: Key Trends in Downstream Bioprocessing
  • Protein A
  • Molecule Issues
  • Chromatography
    • Table: Application of Single Use Technology Downstream (percentage of overall use)
  • Streamlining and Redesigning
    • Streamlining Niches
  • Purification
  • Greater Use of Contract Manufacturers
  • Production Efficiency
  • International
  • Cancer Therapy Push
  • Collaborations and Innovation

Challenges

  • Chromatography
  • Continuous Processing
  • Titers and Composition
  • Evolving Clarification and Purification Strategies
  • Capacity Bottlenecks
  • Isolation of Proteins
  • Efficiencies
  • Quality by Design
  • Talent Shortage

Market Developments

  • Collaboration to Improve Downstream Bioprocessing
  • Start-up Acquisition
  • Promoting Pre-Packed Columns
  • Next Generation Columns
  • Next Generation Affinity Ligands
  • Immunoglobulin Facility
  • Bioprocessing Services
  • Expansion
  • Acquisition
  • Supply Deal
  • Bioconjugation Process
  • New Structured Substrates
  • New Protein A Chromatography Resin
  • Enterprise Software Increases Throughput and Quality
  • Investing in Protein Expression Platform

Market Landscape

  • Overview
  • Drivers
    • Table: Key Drivers of Downstream Bioprocessing
    • Expanding Therapies and Markets
  • Market Analysis and Forecasts
    • Biosimilars
    • Growth and Emerging Markets
    • Continuous Processing
  • Global Market for Downstream Bioprocessing Components
    • Table: Downstream Components Bioprocessing Market Share by Vendor 2018 (%)
    • Table: World Downstream Bioprocessing Markets, 2016-2021 ($ billions)
    • Table: World Downstream Bioprocessing Markets by Geography, 2016-2021 ($ billions)
    • Table: World Downstream Bioprocessing Markets by Geography, 2017 (%)
    • Chromatography Columns and Resins
      • Table: World Downstream Bioprocessing Chromatography Columns and Resins Markets, 2016-2021 ($ billions)
      • Table: World Downstream Bioprocessing Chromatography Columns and Resins Markets by Geography, 2016-2021 ($ billions)
      • Table: World Downstream Bioprocessing Chromatography Columns and Resins Markets by Geography, 2017 (%)
    • Membrane Adsorbers
      • Table: World Downstream Bioprocessing Membrane Adsorber Market, 2016-2021 ($ millions)
      • Table: World Downstream Bioprocessing Membrane Adsorber Market by Geography, 2016-2021 ($ millions)
      • Table: World Downstream Bioprocessing Membrane Adsorber Market by Geography, 2017 (%)
    • Filtration Systems
      • Table: World Downstream Bioprocessing Filtration Market, 2016-2021 ($ billions)
      • Table: World Downstream Bioprocessing Filtration Market by Geography, 2016-2021 ($ billions)
      • Table: World Downstream Bioprocessing Filtration Market by Geography, 2017 (%)
    • Sensors
      • Table: World Downstream Bioprocessing Sensor Market, 2016-2021 ($ billions)
      • Table: World Downstream Bioprocessing Sensor Market by Geography, 2016-2021 ($ billions)
      • Table: World Downstream Bioprocessing Sensor Market by Geography, 2017 (%)

Corporate Profiles

  • 3M Company, St. Paul, MN 55144
  • Abec, Bethlehem, PA 18017
  • Alfa Laval, Lund, Sweden
  • Avantor Performance Materials, Center Valley, PA 18034
  • BIA Separations, AjdovSèina, Slovenia
  • Boehringer Ingelheim Pharmaceuticals, Ridgefield, CT 06877
  • Bosch, Stuttgart, Germany
  • Dow, Midland, MI
  • ESI Ultrapure, Cwmbran, Torfaen, NP44 3XS, UK
  • Finesse Solutions, Santa Clara, CA 95054
  • FujiFilm Diosynth biotechnologies, College Station, TX 77845
  • GE Healthcare Life Sciences, Marlborough, MA 01752,
  • GEA Germany Düsseldorf, 40468 Düsseldorf, Germany
  • Lonza Group, Basel, Switzerland
  • Millipore, Millipore Sigma, Burlington, MA 01803
  • Natrix Separations, Burlington, Ontario, L7L 6A8 Canada
  • Nordson Medical, Marlborough, MA 01752
  • Pall Biotech, Port Washington, NY 11050
  • Parker Hannifin, Cleveland, OH 44124
  • Repligen, Waltham, MA 02453
  • Sartorius AG, Goettingen, Germany
  • Thermo Fisher Scientific, Waltham, MA 02451
  • W. L. Gore & Associates, Inc., Newark, DE 19711
  • Watson-Marlow Fluid Technology Group, Falmouth, TR11 4SZ UK
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