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市場調查報告書

全球細胞化驗分析市場

Cell-Based Assays

出版商 Global Industry Analysts, Inc. 商品編碼 236851
出版日期 內容資訊 英文 207 Pages
商品交期: 最快1-2個工作天內
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全球細胞化驗分析市場 Cell-Based Assays
出版日期: 2019年01月01日內容資訊: 英文 207 Pages
簡介

本報告提供全球細胞化驗分析市場相關調查,市場現狀與今後的成長預測,各地區趨勢,及加入此市場的主要企業的簡介等彙整資料。

第1章 簡介,調查方法,產品定義

第2章 產業概要

  • 全球急速成長
  • 藥物研發主導
  • 藥物篩檢的細胞為基礎HTS化驗的主要類型
  • 推動成長要素與市場課題
  • 已開發國家領導市場,發展中國家也急速成長
  • 製藥產業的研究開發投資的增加牽引市場
  • 中國與印度:投資的中心地 等

第3章 促進成長要素與市場趨勢

第4章 用途領域

  • 藥物研發
  • 藥物標的驗證
  • 領導鑑定
  • 先導藥物最適化
  • ADME實驗
  • 更佳模式的必要性:推動市場創新的要素

第5章 概要

  • 所謂細胞化驗分析的推動因素
  • 細胞培養的基礎
  • 細胞生物學概要
  • 基本的事實
  • 細胞化驗分析定義
  • 產品區隔
  • 化驗套件
  • 實驗室自動化

第6章 競爭環境

  • 全球主要企業
    • BD Biosciences
    • Beckman Coulter, Inc.
    • BioVision, Inc.
    • Cisbio Bioassays
    • Eurofins DiscoverX Corporation
    • Merck KgaA,
    • Enzo Life Sciences, Inc.
    • Evotec AG
    • GE Healthcare Life Sciences
    • New England Biolabs, Inc.
    • PerkinElmer, Inc.
    • Promega Corporation
    • ProQinase GmbH
    • Qiagen NV
    • Thermo Fisher Scientific, Inc.
    • Xenometrix AG
  • 近幾年的產業活動

第7章 全球市場預測

第8章 各地區市場趨勢

  • 美國
  • 日本
  • 歐洲
  • 亞太地區
  • 其他各國

第9章 企業簡介

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目錄
Product Code: MCP-6033

This report analyzes the worldwide markets for Cell-Based Assays in US$ Million by the following Applications: Drug Discovery, ADME Testing, and Basic Research. The report provides separate comprehensive analytics for the US, Japan, Europe, and Rest of World. Annual estimates and forecasts are provided for the period 2016 through 2024. Also, a five-year historic analysis is provided for these markets. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs. The report profiles 57 companies including many key and niche players such as -

BD Biosciences
Beckman Coulter, Inc.
BioVision, Inc.
Cisbio Bioassays
Eurofins DiscoverX Corporation
Merck KgaA

Table of Contents

1. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

2. INDUSTRY OVERVIEW

  • Global Cell-based Assays Market Witnesses Rapid Growth
  • Drug Discovery Leads the Cell-based Assays Application
    • Table 1: Cell-based Assays Market by Application (2018): Percentage Share Breakdown of Value Sales for Drug Discovery, ADME Testing, and Basic Research (includes corresponding Graph/Chart)
  • Major Types of Cell-Based HTS Assays for Drug Screening
    • Table 2: Global Cell-based Assays Market by Segment (2018): Percentage Share Breakdown of Value Sales for Consumables, Instruments, Software, and Services(includes corresponding Graph/Chart)
    • Table 3: Global Market for Cell-based Assays by End-User (2018): Percentage Share Breakdown of Value Sales for Pharma & Biotech Companies, Government & Academic Institutes, CROs, and Others (includes corresponding Graph/Chart)
  • A Glance at Growth Drivers and Market Challenges
  • Growth Drivers
  • Market Challenges
  • Developed Regions Lead the Market, Developing Regions to Witness Fastest Growth
  • Increased Spending on Pharma R&D Spurs the Cell-based Assays Market
    • Table 4: Global Pharmaceutical R&D Spending (US$ Billion) for the Years 2010 through 2017 (includes corresponding Graph/Chart)
    • Table 5: Percentage Breakdown of Total Number of Compounds in Pipeline by Phase for Pre-Clinical, Phase I, Phase II and Phase III: 2017E (includes corresponding Graph/Chart)
    • Table 6: New FDA Approvals (2010-2016): Breakdown of Number of Approvals by Type for New Molecular Entity (NME) and Biologic License Application (BLA) Approvals (includes corresponding Graph/Chart)
  • China and India: Hot Spots for R&D Investment
    • Table 7: World R&D Market by Geographic Region (2015 & 2016): Percentage Breakdown of R&D Spending for Asia, Europe, Middle East & Africa, North America and South America (includes corresponding Graph/Chart)
  • Growing Prominence of Cell-based Assays in Drug Discovery
    • Table 8: Increasing Clinical Trial Failure Rate: 1990 and 2010 (includes corresponding Graph/Chart)
    • Table 9: Factors Leading to Failure of Drugs in Phase II Clinical Trials: Percentage Breakdown of Number of Cases for Efficacy, Pharmacokinetics, Toxicity and Others (includes corresponding Graph/Chart)
    • Table 10: Factors Leading to Failure of Drugs in Phase III Clinical Trials: Percentage Breakdown of Number of Cases for Efficacy, Pharmacokinetics, Toxicity and Others (includes corresponding Graph/Chart)
  • Cell-based Assays in HTS and UHTS
  • Resolving Technical Limitations: Cornerstone for Future Success of Cell-based HTS
  • High-Content Screening (HCS) - An Expanding Technology in Cell-Based Assays
  • High Content Screening - Key Application Areas
  • HCS Market Ripe with Growth Opportunity
  • HCS vs. HTS
  • Use of Cell-based Assays in ADME-Toxicity Testing Gains Traction
    • Table 11: Phase-I Clinical Trial Failures Before and After the Advent of Preclinical ADME/Pharmacokinetics (includes corresponding Graph/Chart)
    • Table 12: Drug Withdrawals Due to Toxicity Issues (1990-2010): Percentage Share Breakdown of Number of Drugs Withdrawn Due to Cardiotoxicity, Hepatotoxicity and Others (includes corresponding Graph/Chart)
  • Growing Inclination towards In-vitro Assays for Toxicology Studies
  • Hepatotoxicity Testing Occupies Largest Market Share
  • Cell-Based Assays Emerge as a Popular Tool in Basic Research

3. GROWTH DRIVERS AND MARKET TRENDS

  • Pharmaceutical Industry Leads the Way
  • Rising Number of Drug Targets Surge Demand for Cell-Based Assays
  • Rising Investment in Proteomics R&D Drive Cell-based Assays Market
  • Growing Focus on the Development of Reproducible and Robust Cell-based Assays
  • Shift towards High Throughput Research Builds Momentum for HTS
  • Stem Cells Exude Great Potential in Drug Toxicity Testing
  • Global Market for Stem Cell-Assays
  • Functional Assays: An Effective Way of Predicting Specific Toxic Effects
  • GPCR Targets to Drive Growth in Functional Cell Assay Market
  • Innovation in Screening Guarantees Success for Drug Discovery Programs
  • 3D Cell Culture Technology to Put a New Spin on In Vitro Cell Analyses
  • Automated Multiplexing Platforms Present Growth Opportunities
  • Miniaturized Cell-based Assays on the Horizon
  • Automation of Cell-based Assays: A Growing Trend
  • Technology Advances in Drug Discovery Processes Spurs Cell-Based Assay Market
  • Development of Label-free Cell-based Assays: A Recent Trend in Biological Assays
  • Microfluidics Systems in Cell-based Assays
  • Cell-Based Assays Likely to Gain from Microfluidic Devices
  • Other Trends
  • Raman Spectroscopy: An Attractive Analytical Tool for Pharmaceutical Industry
  • Fluorescence Spectroscopy for Cellular Imaging Analyses
  • Cell-based Immunoassays: Novel Assay Technology for Autoantibodies Detection
  • Shift Away from Established Cell Lines to Primary Cells
  • Role of Cell-based Assays in Personalized Medicine: A Research Focus
  • Select Innovations in Cell-based Assays Market
  • Cell-based Assays Featuring hPBMCs for Drug Discovery and Cell Therapy Applications
  • Thermo Fisher Develops Innovative Tools for Aiding Cell-based Assays in Cancer Research Studies
  • CROs - The Targeted Customers for Cell-based Assays
    • Table 13: Leading CROs Worldwide by Revenue: 2016 (includes corresponding Graph/Chart)
  • Outsourcing of R&D Projects to Propel CRO Market, Driving CTMS Demand
    • Noteworthy Contracts of Major CROs

4. CELL-BASED ASSAYS - APPLICATION AREAS

  • Cell-Based Assays in Drug Discovery
  • Drug Target Validation
  • Lead Identification
  • Lead Optimization
    • Sources and Types of Cells Available for Drug Screening
  • Cell-Based Assays in ADME Testing
    • Table 14: Leading Causes of Failure During New Drug Development: Percentage Share Breakdown by ADME/Tox Issues, Insufficient Efficacy, Adverse Side Effects, and Commercial Viability (includes corresponding Graph/Chart)
  • Need for Better Models: A Major Factor Driving Innovation in the Market

5. CELL-BASED ASSAYS: AN OVERVIEW

  • What Drives Advances in Cell-based Assays?
  • Cell Culture Fundamentals
  • An Insight into Cell Biology
  • Cell-based Assays: Basic Facts
  • Defining Cell-based Assays
  • Assays
  • Biological Assays
  • Quantification of Biological Activity
  • Cell Based Assays: Prerequisites for Proof of Concept
  • List of Factors to be considered in Cell-Based Assays
  • Contamination with Mycoplasma: A Critical Factor
  • Modes of Contamination
  • Prevention
  • Uses of Cell-Based Assays
  • Challenges
  • Transient Transfection Cells
  • Limitations
  • Cell-based Assays: Product Segmentation
  • Assay Kits
    • Cell Function-Associated Assays
    • Cell Growth-Associated Assays
      • Select Methods of Evaluating Cell-Growth
      • Various Types of Cell Growth Associated Assays
    • Cell Death-Associated Assays
  • Lab Automation
    • MIACA

6. COMPETITIVE LANDSCAPE

  • 6.1 Focus on Select Global Players
  • BD Biosciences (USA)
  • Beckman Coulter, Inc. (USA)
  • BioVision, Inc. (USA)
  • Cisbio Bioassays (USA)
  • Eurofins DiscoverX Corporation (USA)
  • Merck KgaA, (Germany)
  • Enzo Life Sciences, Inc. (USA)
  • Evotec AG (Germany)
  • GE Healthcare Life Sciences (UK)
  • New England Biolabs, Inc. (USA)
  • PerkinElmer, Inc. (USA)
  • Promega Corporation (USA)
  • ProQinase GmbH (Germany)
  • Qiagen NV (The Netherlands)
  • Thermo Fisher Scientific, Inc. (USA)
  • Xenometrix AG (Switzerland)
  • 6.2 Recent Industry Activity
  • BioIVT Takes Over Ascendance Biotechnology
  • Agilent Acquires Luxcel Biosciences
  • Eurofins Acquires DiscoverX
  • IntelliCyt Introduces Cy-Clone Plus Assay System

7. GLOBAL MARKET PERSPECTIVE

    • Table 15: World Recent Past, Current and Future Analysis for Cell-Based Assays by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
    • Table 16: World Historic Review for Cell-Based Assays by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
    • Table 17: World 14-Year Perspective for Cell-Based Assays by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europe, and Rest of World Markets for Years 2011, 2018 and 2024 (includes corresponding Graph/Chart)
  • Cell-Based Assays Market by Application
    • Table 18: World Recent Past, Current and Future Analysis for Cell-Based Assays for Basic Research by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
    • Table 19: World Historic Review for Cell-Based Assays for Basic Research by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
    • Table 20: World 14-Year Perspective for Cell-Based Assays for Basic Research by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europe, and Rest of World Markets for Years 2011, 2018 and 2024(includes corresponding Graph/Chart)
    • Table 21: World Recent Past, Current and Future Analysis for Cell-Based Assays for ADME Testing by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
    • Table 22: World Historic Review for Cell-Based Assays for ADME Testing by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
    • Table 23: World 14-Year Perspective for Cell-Based Assays for ADME Testing by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europe, and Rest of World Markets for Years 2011, 2018 and 2024 (includes corresponding Graph/Chart)
    • Table 24: World Recent Past, Current and Future Analysis for Cell-Based Assays for Drug Discovery by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
    • Table 25: World Historic Review for Cell-Based Assays for Drug Discovery by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
    • Table 26: World 14-Year Perspective for Cell-Based Assays for Drug Discovery by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europe, and Rest of World Markets for Years 2011, 2018 and 2024 (includes corresponding Graph/Chart)
    • Table 27: World Recent Past, Current and Future Analysis for Cell-Based Assays Segment by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
    • Table 28: World Historic Review for Cell-Based Assays Segment by Geographic Region - US, Japan, Europe, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
    • Table 29: World 14-Year Perspective for Cell-Based Assays Segment by Geographic Region - Percentage Breakdown of Dollar Sales for US, Japan, Europe, and Rest of World Markets for Years 2011, 2018 and 2024 (includes corresponding Graph/Chart)

8. REGIONAL MARKET PERSPECTIVE

  • 8.1 The United States
  • A. Market Analysis
    • Cell-Based Assay Market to Witness Significant Growth
    • Functional Cell Assays - A Key Segment
    • Increased Usage Drives Growth of Cell-based Assays
    • Impact of Automation & High-Throughput Screening on CBA Market
    • HTS Assumes Critical Importance in Drug Discovery Projects
      • Spending on HTS Soars in Pharmaceutical Sector
      • HTS Outsourcing Gathers Steam
    • Custom Designed Assays to Drive the US Cell-based Assay Market
    • Clinical Trials Market in the US
    • Competitive Scenario
    • Increased Reliance on CROs by Drug Developers Drive the Cell-based Assays Market
  • B. Market Analytics
    • Table 30: The US Recent Past, Current and Future Analysis for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
    • Table 31: The US Historic Review for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
    • Table 32: The US 14-Year Perspective for Cell-Based Assays by Application - Percentage Breakdown of Dollar Sales for Basic Research, ADME Testing and Drug Discovery Markets for Years 2011, 2018 and 2024 (includes corresponding Graph/Chart)
  • 8.2 Japan
  • A. Market Analysis
    • Demographics Drive Market Growth
    • Table 33: Japanese Population by Age Group 2017E): Percentage Breakdown for 0-14 Years, 15-24 Years, 25-54 Years, 55-64 Years, 64 Years and Above (includes corresponding Graph/Chart)
  • B. Market Analytics
    • Table 34: Japanese Recent Past, Current and Future Analysis for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
    • Table 35: Japanese Historic Review for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
    • Table 36: Japanese 14-Year Perspective for Cell-Based Assays by Application - Percentage Breakdown of Dollar Sales for Basic Research, ADME Testing and Drug Discovery Markets for Years 2011, 2018 and 2024 (includes corresponding Graph/Chart)
  • 8.3 Europe
  • A. Market Analysis
    • Current and Future Analysis
    • HTS in European Pharmaceutical Sector
      • Innovations in Cell Culture Drive Adoption of Cell-based Assay HTS
      • Cell-based Assays Represent the Primary Drug Discovery Tool in HTS Laboratories
    • Pharmaceutical Companies Opt for Cell-Based Assays in Drug Discovery
    • Rising Number of Drug Targets Surge Demand for Cell-Based Assays
      • GPCR Targets to Drive Growth in Functional Cell Assay Market
    • Cell Growth-Based Assay Kits Market Makes Progress
    • Cell Death-Based Assays: Efficiency Improvements in Development Programs Favor Growth
    • Rising Cancer Incidence Propels the Need for Increased Research
    • Table 37: Number of New Cancer Cases in Europe (2012-2030) (in Million) (includes corresponding Graph/Chart)
    • Advances in Technology, Identification Methods, and Lab Disciplines in CBA Market
    • Regulatory Requirements in Cell-Based Assays Market
      • Validation Assays for Compliance with ICH Guidelines
    • Growth of European Drug Discovery CRO Market: Opportunities for CBA Market
    • Clinical Trials Market in Europe
    • Competitive Landscape
    • Clinical Trials Market in Select Regions
      • Spain
      • Garnering Investments from Multinational Pharma Companies
    • Table 38: Apportion of R & D Expenditure by Study Phase in Spain: 2015 (includes corresponding Graph/Chart)
      • Russia
    • Table 39: Russian Clinical Trials Market by Trial Type (2015): Percentage Breakdown of Number of Trials for Bioequivalence Studies (Foreign Sponsors), Bioequivalence Studies (Local Sponsors), Global Multi-Center Clinical Trials, Local Clinical Trials (Foreign Sponsors), and Local Clinical Trials (Local Sponsors) (includes corresponding Graph/Chart)
    • Table 40: Russian Clinical Trials Market Volume (2015): Percentage Breakdown of Trials by Hosting Country (includes corresponding Graph/Chart)
  • B. Market Analytics
    • Table 41: European Recent Past, Current and Future Analysis for Cell-Based Assays by Geographic Region - France, Germany, Italy, UK, Spain and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
    • Table 42: European Historic Review for Cell-Based Assays by Geographic Region - France, Germany, Italy, UK, Spain and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
    • Table 43: European 14-Year Perspective for Cell-Based Assays by Geographic Region - Percentage Breakdown of Dollar Sales for France, Germany, Italy, UK, Spain and Rest of Europe Markets for Years 2011, 2018 and 2024 (includes corresponding Graph/Chart)
    • Table 44: European Recent Past, Current and Future Analysis for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
    • Table 45: European Historic Review for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
    • Table 46: European 14-Year Perspective for Cell-Based Assays by Application - Percentage Breakdown of Dollar Sales for Basic Research, ADME Testing and Drug Discovery Markets for Years 2011, 2018 and 2024 (includes corresponding Graph/Chart)
  • 8.4 Asia-Pacific
  • A. Market Analysis
    • Current and Future Analysis
    • Asia-Pacific Emerges as Fastest Growing Market for HTS
    • Asia: The Most Preferred Destination for Clinical Trials
    • An Overview of Clinical Trials Market in Select Countries in the Region
      • China
      • Opportunities in Expanding in the Chinese Life Sciences Sector
      • Growing Drug Discovery Outsourcing Market Bodes Well for Market
      • Pharmaceutical Outsourcing Sector in China- An Overview .
      • Going Ahead....
      • India
      • A Thriving Clinical Trials Market
    • Table 47: Cost of Conducting Clinical Trials: India Vs. US (in US$ Thousand) (includes corresponding Graph/Chart)
      • Australia
      • Australia Makes Strong Pitch for Clinical Trials
      • Major Challenges Facing Australian Clinical Trials Market
  • B. Market Analytics
    • Table 48: Asia-Pacific Recent Past, Current and Future Analysis for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
    • Table 49: Asia-Pacific Historic Review for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
    • Table 50: Asia-Pacific 14-Year Perspective for Cell-Based Assays by Application - Percentage Breakdown of Dollar Sales for Basic Research, ADME Testing and Drug Discovery Markets for Years 2011, 2018 and 2024 (includes corresponding Graph/Chart)
  • 8.5 Rest of World
  • A. Market Analysis
    • Current and Future Analysis
    • Latin America: An Emerging Market for Clinical Trials
    • The Middle East - Brimming with Potential for Clinical Trials
    • Table 51: The Middle East Clinical Trial Market (2015): Percentage Breakdown of Registered Clinical Trials in Iran, Israel, Turkey and Rest of Middle East (includes corresponding Graph/Chart)
    • Emerging Nations Capitalize on the Outsourcing Trend
  • B. Market Analytics
    • Table 52: Rest of World Recent Past, Current and Future Analysis for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2016 through 2024 (includes corresponding Graph/Chart)
    • Table 53: Rest of World Historic Review for Cell-Based Assays by Application - Basic Research, ADME Testing and Drug Discovery Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2011 through 2015 (includes corresponding Graph/Chart)
    • Table 54: Rest of World 14-Year Perspective for Cell-Based Assays by Application - Percentage Breakdown of Dollar Sales for Basic Research, ADME Testing and Drug Discovery Markets for Years 2011, 2018 and 2024 (includes corresponding Graph/Chart)

9. COMPANY PROFILES Total Companies Profiled: 57 (including Divisions/Subsidiaries - 61) The United States (36) Japan (1) Europe (22) - France (3) - Germany (5) - The United Kingdom (7) - Italy (1) - Rest of Europe (6) Asia-Pacific (Excluding Japan) (1) Latin America (1)

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