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Zyprexa (Schizophrenia) - Forecast and Market Analysis to 2022

出版商 GlobalData 商品編碼 299177
出版日期 內容資訊 英文 45 Pages
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Zyprexa(精神分裂症治療藥):市場預測與分析 Zyprexa (Schizophrenia) - Forecast and Market Analysis to 2022
出版日期: 2014年02月28日 內容資訊: 英文 45 Pages



Eli Lilly所開發的olanzapine(商品名:Zyprexa),是第二代抗精神病藥,也具有D2/D3受體的拮抗劑作用。只是和同一代其他藥物不同,特徵是在D2/D3多巴胺受體激動劑的結合部位比較下,Zyprexa和血清素5-HT2A受體相對親合性高──僅有氯氮平和喹硫共有的功能──。但由於Zyprexa對M1/M3毒蕈鹼受體激動劑和H1組織胺受體激動劑的受體部位會強烈反應,業界內部認為可能有代謝調節不全的關聯性,進而產生接受度、安全性方面的疑慮。


第1章 目錄

第2章 簡介

  • 分析概要
  • 相關分析
  • 預定發行的相關分析

第3章 疾病概要

  • 病因與病情
    • 病因
    • 病理
  • 症狀

第4章 疾病的管理

  • 診斷
    • 主觀的評估
    • 疾病的分類
  • 治療方法概要
    • 治療精神分裂症相關的急性激越症狀
    • 精神分裂症的維持療法

第5章 競爭企業的評估

  • 概要
  • 競爭企業的策略性評估

第6章 關於Zyprexa(olanzapine)

  • 概要
  • 急性治療藥的功效
  • 維持治療藥的功效
  • 安全性
  • SWOT分析
  • 預測

第7章 附錄


Product Code: GDHC360DFR

Schizophrenia is a persistent long-term brain disorder that causes severe, debilitating psychotic episodes. Its core symptoms, auditory or visual hallucinations, are often accompanied by fixed, false, and often paranoid beliefs, called delusions. These two features are often combined with learning and cognitive deficits. WHO experts have estimated that roughly 24 million people are affected by schizophrenia worldwide. While the arrival of atypical antipsychotics has greatly expanded pharmacologic treatment options over the past two decades, the current drug market does not treat the negative and cognitive symptoms that are associated with the disease. GlobalData expects that the growing popularity of long-acting injectable (LAI) antipsychotics, along with the arrival of novel treatments that achieve higher efficacy in negative- and cognitive-predominant patients, will serve to stimulate growth in the marketplace over the forecast period. Country-specific treatment recommendations and policy implementation will be an essential metric for determining future mental health services in the 7MM.

Olanzapine (Zyprexa; Eli Lilly) is a second-generation antipsychotic that also acts as an antagonist at D2/D3 receptors. But unlike most agents in its class, Zyprexa has a higher relative affinity for serotonin 5-HT2A receptors in comparison to D2/D3 dopaminergic binding sites, a feature that it shares only with clozapine and quetiapine. However, Zyprexa's activity on M1 and M3 muscarinic and H1 histaminergic receptor sites imply an association with metabolic dysregulation and Zyprexa's industry reputation has led to tolerability and safety concerns.


  • Overview of Schizophrenia, including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.
  • Detailed information on Zyprexa including product description, safety and efficacy profiles as well as a SWOT analysis.
  • Sales forecast for Zyprexa for the top seven countries from 2012 to 2022.
  • Sales information covered for the US, France, Germany, Italy, Spain, the UK and Japan

Reasons to buy

  • Understand and capitalize by identifying products that are most likely to ensure a robust return
  • Stay ahead of the competition by understanding the changing competitive landscape for Schizophrenia
  • Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential
  • Make more informed business decisions from insightful and in-depth analysis of Zyprexa performance
  • Obtain sales forecast for Zyprexa from 2012-2022 in the top seven countries (the US, France, Germany, Italy, Spain, the UK and Japan)

Table of Contents

1. Table of Contents

  • 1.1. List of Tables

2. Introduction

  • 2.1. Catalyst
  • 2.2. Related Reports
  • 2.3. Upcoming Reports

3. Disease Overview

  • 3.1. Etiology and Pathophysiology
    • 3.1.1. Etiology
    • 3.1.2. Pathophysiology
  • 3.2. Symptoms

4. Disease Management

  • 4.1. Diagnosis
    • 4.1.1. Subjective Assessments
    • 4.1.2. Disease Subtypes
  • 4.2. Treatment Overview
    • 4.2.1. Treatment of Acute Agitation Associated with Schizophrenia
    • 4.2.2. Maintenance Treatment of Schizophrenia

5. Competitive Assessment

  • 5.1. Overview
  • 5.2. Strategic Competitor Assessment

6. Zyprexa (olanzapine)

  • 6.1. Overview
  • 6.2. Efficacy in Acute Treatment
  • 6.3. Efficacy in Maintenance Treatment
  • 6.4. Safety
  • 6.5. SWOT Analysis
  • 6.6. Forecast

7. Appendix

  • 7.1. Bibliography
  • 7.2. Abbreviations
  • 7.3. Methodology
  • 7.4. Forecasting Methodology
    • 7.4.1. Diagnosis and Treatment Rates
    • 7.4.2. Adherence Rates
    • 7.4.3. General Pricing Assumptions
    • 7.4.4. Drug Assumptions
    • 7.4.5. Generic Erosion
  • 7.5. Key Opinion Leaders
  • 7.6. About the Authors
    • 7.6.1. Author
    • 7.6.2. Reviewers
    • 7.6.3. Global Head of Healthcare
  • 7.7. About GlobalData
  • 7.8. Disclaimer

List of Tables

  • Table 1: Symptom Clusters of Schizophrenia
  • Table 2: Common Subjective Rating Scales Employed in Schizophrenia Diagnosis
  • Table 3: Development-Based Classification of Antipsychotic Drugs
  • Table 4: Receptor Binding Profiles of Atypical Antipsychotics
  • Table 5: Guidelines for the Treatment of Schizophrenia
  • Table 6: Leading Branded Treatments for Schizophrenia, 2013
  • Table 7: Strategic Competitor Assessment of the Marketed Products in Schizophrenia, 2014
  • Table 8: Product Profile - Zyprexa
  • Table 9: Zyprexa SWOT Analysis, 2014
  • Table 10: Global Sales Forecast ($m) for Zyprexa, 2012-2022
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