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醫藥應用的新酵素技術

Novel Enzyme Technologies for Pharmaceutical Applications

出版商 Frost & Sullivan 商品編碼 921050
出版日期 內容資訊 英文 65 Pages
商品交期: 最快1-2個工作天內
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醫藥應用的新酵素技術 Novel Enzyme Technologies for Pharmaceutical Applications
出版日期: 2019年12月30日內容資訊: 英文 65 Pages
簡介

本報告研究醫藥應用的新酵素技術,討論酵素發現和改善,如定向突變、總體基因體學、人工智能與計算生物學、酵素突變體庫之高通量技術等。並分析醫學科學中的新興和潛在酵素應用,如癌症治療藥物、血栓溶解、API (原料藥) 製造、腸胃疾病治療藥物,彙整酵素表現系統、酵素製造製程、技術ROADMAP等內容。

第1章 摘要整理

第2章 產業概要

  • 酵素技術的進步
  • 生物催化技術開發浪潮

第3章 定向演化的酵素開發

  • 酵素的定向突變
  • 人工智能驅動的酵素定向突變
  • 透過計算生物學的定制酵素設計

第4章 酵素發現的總體基因體學方法

  • 無法培養微生物之總體基因體學方法
  • 定制酵素的開發和製造
  • 自動化網路基礎的總體基因體學軟體

第5章 醫藥品製造的酵素使用

  • API (原料藥) 製造的酵素
  • 透過酵素工程的抗瘧疾藥物的永續製造
  • 醫藥品酵素:印度的酵素製造商
  • 抗體標記的酵素基礎策略

第6章 作為治療藥物的重組酵素和合成酵素

  • 血栓的纖溶□應用
  • 酵素:酵素驅動的抗菌劑
  • 市售內溶素產品
  • 臨床開發中的酵素
  • 癌症治療的酵素
  • 代謝性抗癌症療法的潛在酵素標靶
  • 抗癌劑之改善生物有效性的酵素
  • 腸胃疾病的消化酵素補充劑
  • 乳糜瀉的新酵素療法
  • 乳糖不耐症和麩質過敏的酵素解決方案

第7章 疾病診斷和監控中的酵素

  • 電化學生物感測器的酵素
  • 葡萄糖氧化□ (GOx) 基礎的葡萄糖監控生物感測器
  • 使用ZnO奈米管的酵素固定化
  • 快速POC診斷之CRISPR/Cas應用
  • 分子診斷之CRISPR和合成生物學工具的結合

第8章 酵素替代療法

  • 罕見基因疾病的酵素替代療法
  • 市售酵素替代治療藥物

第9章 醫療清潔劑的酵素

  • 酵素醫療清潔劑之有機物高效降解
  • 優化的酵素清潔劑超過了髒污儀器清洗的臨床基準

第10章 酵素表現系統

  • 酵素製造的各種表現系統
  • 基於病毒載體的酵素製造
  • 無細胞酵素製造

第11章 酵素製造

  • 酵素製造的共通途徑
  • 下游製程的典型工作流程
  • 製程強化和連續製造
  • 製造過程中適用生物催化的關鍵元素

第12章 技術ROADMAP

第13章 產業聯絡資訊

目錄
Product Code: D8F6

A Review of Novel Enzyme Technologies and Enzyme Applications in API Production, Therapeutics, Diagnosis, Medical Detergents, and Enzyme Expression Systems, Including Enzyme Manufacturing for Pharmaceuticals

The current study discusses the novel enzyme technologies for enzyme discovery and improvement such as directed mutagenesis, metagenomics, artificial intelligence and computational biology approaches and highthroughput technologies used for generation of enzyme variant libraries. Additionally, novel enzyme applications and potential applications in medical sciences such as enzymes as cancer therapeutics, enzymes used to dissolve blood clots, enzyme used for production of active pharmaceutical ingredients, enzymes in digestive and gastrointestinal disease treatment, enzymes in diagnostics and enzyme based biosensors are covered. Enzyme replacement therapy and enzymes used in antibody-drug conjugates generation are also reviewed.

Bacteriophage endolysins are being developed as next generation antibacterials (enzybiotics) to counter antibiotic resistance make into this study. The later part of this study mostly deals with enzyme expression systems, cell based and cell-free enzyme expression, and production including continuous processing, process intensification as well as enzyme purification with brief introduction about enzymes in medical detergents.

Table of Contents

1.0. Executive Summary

  • 1.1. Research Background: Enzyme Technologies for Pharmaceutical Applications
  • 1.2. Research Scope: Advances in Enzyme Technologies for Pharmaceutical Applications
  • 1.3. Analysis Framework: Frost & Sullivan Core Value
  • 1.4. Research Methodology: Five Steps Toward Success
  • 1.5. Key Findings of Novel Enzyme Technologies for Pharmaceutical Applications

2.0. Technology Snapshot

  • 2.1. Reported Advances in Enzyme Technologies
  • 2.2. Waves of Technological Developments in Biocatalysis

3.0. Enzyme Development Through Directed Evolution

  • 3.1. Directed Mutagenesis of Enzymes
  • 3.2. Artificial Intelligence-driven Directed Mutagenesis of Enzymes
  • 3.3. Designing Custom Enzymes Through Computational Biology

4.0. Metagenomics Approaches for Enzyme Discovery

  • 4.1. Metagenomics Approach for Unculturable Microorganisms
  • 4.2. Customized Enzyme Development and Manufacturing
  • 4.3. Automated Web-based Metagenomics Software

5.0. Enzymes Used for Production of Pharmaceuticals

  • 5.1. Enzymes in Active Pharmaceutical Ingredient Manufacturing
  • 5.2. Sustainable Production of Antimalarial Drugs Through Enzyme Engineering
  • 5.3. Pharmaceutical Enzyme Enzyme Manufacturers in India
  • 5.4. Enzyme-based Strategies for Antibody Labeling

6.0. Recombinant and Synthetic Enzymes as Therapeutics

  • 6.1. Applications of Fibrinolytic Enzymes in Thrombosis
  • 6.2. Enzybiotics: Enzyme-powered Antibacterials
  • 6.3. Commercialized Endolysin Products
  • 6.4. Enzybiotics Under Clinical Development
  • 6.5. Enzymes in Cancer Therapy
  • 6.6. Potential Enzyme Targets in Metabolic Anticancer Therapy
  • 6.7. Enzyme for Improved Bioavailability of Anticancer Drugs
  • 6.8. Digestive Enzyme Supplements for Gastrointestinal Disorders
  • 6.9. Novel Enzyme Therapy for Celiac Disease
  • 6.10. Enzymatic Solutions for Lactose Intolerance and Gluten Sensitivity

7.0. Enzymes in Disease Diagnosis and Monitoring

  • 7.1. Enzymes in Electrochemical Biosensors
  • 7.2. Glucose Oxidase-based Glucose Monitoring Biosensors
  • 7.3. Enzyme Immobilization Using ZnO Nanotubes
  • 7.4. Applying CRISPR/Cas for Rapid Point-of-Care Diagnosis
  • 7.5. Combination of CRISPR and Synthetic Biology Tools for Molecular Diagnostics

8.0. Enzyme Replacement Therapies

  • 8.1. Enzyme Replacement Therapies for Rare Genetic Diseases
  • 8.2. Commercially Available Enzyme Replacement Therapies

9.0. Enzymes in Medical Detergents

  • 9.1. Efficient Degradation of Organic Matter through Enzymatic Medical Detergents
  • 9.2. Optimized Enzymatic Detergents Exceed the Clinical Standard for Dirty Instruments Cleaning

10.0. Enzyme Expression Systems

  • 10.1. Various Expression Systems for Enzyme Production
  • 10.2. Viral Vector-based Enzyme Production
  • 10.3. Cell-free Enzyme Production

11.0. Enzyme Manufacturing

  • 11.1. Common Route of Enzyme Production
  • 11.2. Typical Workflow of Downstream Processing
  • 11.3. Process Intensification and Continuous Manufacturing
  • 11.4. Key Elements for Applying Biocatalysis in Pharmaceutical Processes

12.0. Technology Roadmap

  • 12.1. Enzyme Technology Roadmap for Pharmaceutical Applications

13.0. Key Industry Contacts

  • 13.1. Industry Interactions
  • 13.1. Industry Interactions (continued)
  • Legal Disclaimer