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iPS Cell Generation - Patent Landscape

出版商 France Innovation Scientifique et Transfert (FIST SA) 商品編碼 203954
出版日期 內容資訊 英文 152 Slides
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iPS細胞生成相關專利狀況:2011年 iPS Cell Generation - Patent Landscape
出版日期: 2013年04月30日 內容資訊: 英文 152 Slides



  • 技術概要:幹細胞的生成和來源
  • 技術概要:再編程技術
  • 全球iPS細胞相關專利·專利申請的搜尋方法


  • 專利申請趨勢
  • 優先申請趨勢與地圖
  • 專利擴展地圖


  • 主要的申請者轉變
  • 最初申請者10間公司擁有的投資組合
  • 主要的機關/產業的申請詳細內容
  • 申請者的共同申請
  • 申請者與相關公司


  • 主要發明者清單
  • 主要的研究團隊


  • 重新編程細胞的複製起點
  • 重新編程的細胞型
  • iPS細胞生成技術
  • 再編程因子1類型
  • 再編程因子2類型
  • 疫苗接種方法


  • 最常引用的專利·專利申請的清單
  • 最長的專利·專利申請的清單
  • 機關/產業申請者的申請授權許可·不受理專利:辦公室


  • 京都大學
  • Chinese Academy of Sciences
  • 美國政府
  • Harvard university
  • Korea university
  • 細胞動力學
  • Whitehead biomedical institute
  • Advanced Industrial Science and Technology
  • California university






Many diseases such as cardiovascular disorders, diabetes or neurodegenerative diseases are the consequences of dysfunction of specific cells. Strategies were developed to repair or regenerate the damaged tissues using differentiated cells out of stem cells. However, ethical and scientific issues are related to the use of embryonic stem cells. In this context, induced pluripotent stem cells (iPS) appear as a promising approach. The patient's somatic cells are first dedifferentiated into iPS cells and then redifferentiated into the cell of interest. This revolutionary technology represents major scientific, societal and economic challenges and was recently rewarded by a Nobel Prize in Physiology and Medicine to Prof. Shinya Yamanaka and Prof. John Gurdon.

With over 1000 patent families qualified and analyzed out of a pool of 3000 patent families, we have analysed:

The "iPS cells generation" patent landscape

The analysis of this patent landscape shows a strong complexity of the environment and demonstrates the ability of institutional players to develop a consistent IP strategy like the one from Kyoto university. Some major players already present in 2011 increased sharply their filings: the Kyoto university, the Chinese Academy of Sciences, the laboratories of US government. New entrants have filed numerous patent applications in the last years: Korea university, AIST, Cellular Dynamics, Salk Institute and A*STAR (SG).

The "iPS cells differentiation" patent landscape

As for the thematic "iPS cells generation", the main players are mainly institutional (23 institutional applicants in the top 30) with the university of Kyoto and the laboratories of the US government at the first two places. However, industrial applicants from all over the world clearly positioned themselves on the thematic such as Cellular Dynamics (US), Cellectis (FR) or Viacyte (US). The technological breakdowns presented in this study had shown specific positioning of the players through their patent applications notably regarding the type of cell obtained from the differentiation of iPS cells. Cardiovascular, neural, pancreatic cells are the most claimed by the applicants, this corresponding to the main pathologies observed nowadays. Hepatic cells are also often claimed notably for the establishment of toxicology studies.

The "iPS cells database"

Additionally, all patents dealing with iPS cells but who were concerning neither generation nor differentiation (thus all patents related to culture, selection, isolation, etc...) were grouped together in a database to get a full overview of the iPS landscape.

These patent landscapes provide you a comprehensive panorama of the intellectual property overview and help you:

  • Identify key inventors and players involved in the generation and differentiation of iPS cells
  • Understand their positioning, the collaboration networks and their dynamics
  • Analyze their IP strategy
  • Position your company's R&D and IP portfolio
  • Discover new trends and emerging topics

Table of Contents



  • Brief outline of the technology: generation and source of stem cells
  • Brief outline of the technology: reprogramming techniques
  • Global search strategy of patents and patent applications related to iPS cells

Evolution and location of patent filings

  • Evolution of patent filings (1999-2013)
  • Map and evolution of priority filings
  • Map of extensions

Analysis of patent applicants

  • Main applicants on the entire period (1999-2013)
  • Part of the portfolio hold by the first 10 applicants
  • Breakdown of filings of the main institutional/industrial applicants over time
  • Main co-filings between applicants
  • Applicants and their affiliates

Analysis of inventors

  • List of the main inventors
  • Main research teams

Breakdown of the patent portfolio

Breakdown of the portfolio (for each breakdown are presented the distribution of technologies, the evolution of fillings and the positioning of institutional applicants, industrial applicants and inventors)

Breakdown of the portfolio

  • 1 Origin of cell to be reprogrammed
  • 2 Type of cell to be reprogrammed
  • 3 iPS cells generation technique
  • 4 Type of reprogramming factor 1
  • 5 Type of reprogramming factor 2
  • 6 Method of delivery

Citation, extension & granted analysis

  • List of most cited patents and patent applications
  • List of the most extended patents & patent applications
  • Granted and not granted patents filed by institutional/industrial applicants by office

Applicant focuses

  • Kyoto university
  • Chinese Academy of Sciences
  • US government
  • Harvard university
  • Korea university
  • Cellular dynamics
  • Whitehead biomedical institute
  • Advanced Industrial Science and Technology
  • California university

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