Global Pre-packed Chromatography Columns Market - 2021-2028
The pre-packed chromatography columns market. The size was valued at US$ XX billion in 2020 and is estimated to reach US$ XX billion by 2028, growing at a CAGR of XX % during the forecast period (2021-2028).
Chromatography columns are critical factors to the successful separation of a valuable molecule. In addition, pre-packed columns help to manage the time-consuming, laborious process of packing chromatography columns, leaving more time for processing the product.
The pre-packed columns that include cost and time saving will drive the market
Pre-packed columns have not only seen growth due to the demand for alternative processing methods but for the myriad of advantages that such columns offer. As they are pre-packed, they are effortless to set up and clean by reducing the amount of labour, amount of time needed to be invested in their maintenance and use.
They have increased productivity and less downtime. Furthermore, outsourcing non-core work will no longer be necessary since they will come pre-packed and are designated for single-use only. Because of this, there will also be no need for expert specialists or specialized equipment, which is often a concern in smaller laboratories.
Research and development in the biotechnology as well as biopharmaceutical sector will drive the market in the forecast period
Research helps to uncover trends and the factors affecting pre-packed disposable chromatography columns market for downstream bioprocessing. The pre-packed, disposable chromatography columns market used for downstream bioprocessing is increasing rapidly.The greater productivity, efficiency and the move towards single-use and flexible facilities requirements are fuelling these changes.
Future integration of single-use technologies in the large-scale manufacturing is a primary driver. There has been a clear spike in interest among biopharmaceutical manufacturers for pre-packed disposable chromatography columns. An increase in demand for biopharmaceutical products such as vaccines and monoclonal bodies and the upcoming need for high-quality products will increase the market growth.
High-cost of resins will hamper the market
The resins used in pre-packed columns are very costly, and as such, very few columns are intended for single use. The cost of such resins is predicted to decrease in the coming years. If it does so, the convenience and practicality of single-use columns will see a rise in its use. The market for such columns is currently held back because commercially only smaller columns are available (typically under 30cm). However, with the price of resins, this problem is expected be a temporary concern as research into developing larger-scale columns progresses, and the production of them will become more widespread and commercially viable.
Column chromatography for flow-through or bind-elute ionic exchanger polishing steps operates at flow rates measured in centimeters/hour. This relatively slow passage demands rather large-diameter columns, upward of 1.0 meters, to achieve reasonable flow rates. At these diameters, fill volumes can require resin beads in the hundreds of liters, at substantial cost, these drawbacks of ionic exchange columns fueled the development and adoption of membrane adsorber chromatography, at first for contaminant reduction/removal (e.g., HCP, DNA, etc.) and subsequently for use in protein purification applications. The contaminants are directly bound to the membrane's charged ligands, eliminating the need for diffusive migration into resin beads.
COVID-19 Impact Analysis
Industries, markets, and businesses worldwide have been turned upside down by Covid-19, and this impact has been incredibly profound within the medical device sector. Massive increase in the demand for critical pieces of equipment such as PPE (personal protective equipment), ventilators and testing kits, along with subsequent shortages of these devices, has seen firms do everything they can to keep pace with the ever-growing needs of healthcare providers which put a halt on manufacturing of other devices. Hence, the manufacturing sector of pre-packed column chromatography got affected due to shut down of many industries during the COVID-19 crisis.
Pre-packed columns with more than 1L capacity have dominated the market
Future integration of single-use technologies into large-scale manufacturing is a primary driver for this segment. To follow the trend of single-use bioreactor capacity within the industry, a survey was done about the largest single-use bioreactor capacity in use at the site, in liters .The overall average largest size bioreactor at facilities is 755 L, while it was 659 L. The most significant total percentage indicated 2,000L, at 23.8%, a 40% increase from 16.9% in 2019. Nearly half of respondents (47.6%) reported ≥1,000 L single-use bioreactors at their facilities, i.e., working at a large scale by single-use standards, a 20% increase from 2019 (39.7%).
The proportion with the largest stainless steel bioreactors on-site with less than 1,000 L capacity decreased to 26.8%, down over 11 percentage points from 38.0% in 2019. Comparing the data reported for the largest in-house single-use vs. stainless steel bioreactors, 33.5% of facilities with stainless steel have ≥2,000 L bioreactors vs. 28.1% for single-use (compared to 35.7% and 21.0%, respectively, in 2019).
Ion-exchange chromatography will dominate the market in the forecast period
Ion-exchange chromatography (IEC) is part of ion chromatography, an important analytical technique for separating and determining ionic compounds, together with ion-partition/interaction and ion-exclusion chromatography. In this ions from the mobile phase interact with the immobilized ions on the stationary phase, thus "shielding" the stationary phase from the protein and letting the protein elute. However, elution from ion-exchange columns can be sensitive to changes of a single charge- chromatofocusing.
The conventional method of packing ion-exchange resin into a chromatographic columns to make a slurry of the resin beads, introduce it into the column or a chamber attached to the column and then allow the resin particles to settle by gravity to form the packed bed.
The pharmaceutical biotechnology segment will dominate the market
Pharmaceutical biotechnology is a relatively new and growing field in which biotechnology principles are applied to the development of drugs. Most therapeutic drugs in the current market are bio formulations, such as antibodies, nucleic acid products and vaccines.
Tosoh Bioscience introduced the SkillPak 1 mL and 5 mL pre-packed columns for fast method development and resin screening of monoclonal antibodies, antibody constructs, oligonucleotides, proteins, and viruses. Tosoh Bioscience introduced the SkillPak 1 mL and 5 mL pre-packed columns for fast method development and resin screening of monoclonal antibodies, antibody constructs, oligonucleotides, proteins, and viruses. The columns come pre-packed with Toyopearl, TSKgel, or Ca++Pure-HA process chromatography media and are ready for use immediately. Additionally, the high-performance, scalable columns are available with short delivery times in affinity, anion and cation exchange, hydrophobic interaction, and size exclusion chromatographic modes. According to the company, peak performance is guaranteed, and the columns can be operated directly with low- or medium-pressure liquid chromatography systems.
North America will dominate the market
Traditionally, the United States has been viewed as the world leader in biotechnology innovation. Over 1,200 biotech companies employ almost 200,000 workers in fields ranging from human product development to food and agriculture services. Yet, as globalization becomes more prominent and technology spreads worldwide, other nations have also become the forefront of the biotech arena. The regions leading innovative biopharmaceutical research companies is represented by Pharmaceutical Research and Manufacturers of America (PhRMA),it is devoted to discovering and developing medicines that enable patients to live longer, healthier, and more productive lives. As a result, increased research and development in this region will drive the market.
Some prominent key players in the pre-packed chromatography columns market are Tosoh Corporation, Thermo Fisher Scientific Inc., Cole-Parmer Instrument Company, Purolite, Shimadzu Corporation, YMC Europe GMBH, F. Hoffmann-La Roche Ltd, Repligen Corporation, Bio-Rad Laboratories, Inc., Agilent Technologies, Inc., WATERS, Phenomenex Inc., GENERAL ELECTRIC, Merck & Co., Inc., Danaher, Halma plc.
Key Companies to Watch
Overview: Tosoh Corporation is the parent company of a Japanese chemical, specialty products and materials group comprising over 100 companies worldwide and a multiethnic workforce of more than 12,000 people. The parent company was established in 1935 and is listed on the First Section of the Tokyo Stock Exchange. In the more than 80 years that the company has been in business, it has built balanced product lines of commodity chemicals for industry and specialty products and materials for high technology and niche markets. Tosoh's markets include the chemical and petrochemical, construction, automotive, consumer electronics, information technology, bioscience, and environmental markets. It is a global chemical company that supplies manufacturers with the materials they need to produce the things that make modern life all that it is and everything it can be.
Product Portfolio: The Company offers chemical, specialty products and materials to produce the things that make modern life all that it is and everything it can be.
Key Development: Tosoh Bioscience GmbH launched a new affinity column - TSKgel FcR-IIIA-NPR - based on a recombinant FcγIIIa receptor ligand. The column is designed for rapid assessment of the biologic activity of mAbs. The FcγIIIa receptor plays a key role in antibody-dependent cell mediated cytotoxicity (ADCC) by interacting with the N-glycans of the Fc domain of immunoglobulins.
The pre-packed chromatography columns market. report would provide an access to an approx. 60 market data table, 53 figures and 200 pages.
Pre-packed Chromatography Columns Market. - By Type
Pre-packed Chromatography Columns Market. - By Techniques
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Pre-packed Chromatography Columns Market. - By Region
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