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市場調查報告書

坐骨神經痛:市場分析,流行病學,到2030年的市場預測

Sciatica - Market Insights, Epidemiology and Market Forecast-2030

出版商 DelveInsight Business Research LLP 商品編碼 960898
出版日期 按訂單生產 內容資訊 英文 188 Pages
商品交期: 10個工作天內
價格
坐骨神經痛:市場分析,流行病學,到2030年的市場預測 Sciatica - Market Insights, Epidemiology and Market Forecast-2030
出版日期: 按訂單生產內容資訊: 英文 188 Pages
簡介

坐骨神經痛是由坐骨神經刺激引起的下肢疼痛,通常從腰(腰部)到大腿後部感覺到,並可能擴散到膝蓋以下。坐骨神經是人體中最大的神經,從腰區的腰脊髓神經根開始,經過臀區,並延伸至下肢。術語坐骨神經痛僅限於L1至L4的神經根疼痛和刺激,但也可能包括相關區域。

坐骨神經痛主要影響老年人。通常對患者進行初級護理,但也可以進行手術。大多數坐骨神經痛是由椎間盤疝伴神經根受壓引起的,但也可能是由腰椎狹窄和腫瘤引起的。

本報告研究了到2030年美國,德國,法國,意大利,西班牙,英國和日本的七個主要國家的坐骨神經痛的流行情況。流行病學和患者人數,按國家/地區劃分的流行病,當前的治療方法,未解決的需求,新的療法,市場增長的驅動因素和障礙等等。

目錄

第1章主要調查結果

第2章執行摘要

第3章SWOT分析

第4章市場概述

第5章疾病背景和概述

  • 簡介
  • 坐骨神經痛和下背部疼痛的區別
  • 坐骨神經痛的症狀
  • 坐骨神經痛的原因
    • 椎間盤疝
    • 椎管狹窄
    • 懷孕
    • 梨肌綜合症
    • 退行性關節炎
    • 脊椎病和腰椎滑脫
    • 非椎間盤突出的原因
  • 椎間盤相關性坐骨神經痛的病理生理學
    • 臨床觀察
    • 坐骨神經痛的生理變化
  • 腸痛的病理生理機制
    • 炎症機制
    • 免疫學機制
    • 壓力機制
    • 腰椎管狹窄
    • 神經根損傷的骨骼原因
    • 腰或椎間盤突出症
  • 預後
  • 坐骨神經痛的生物標誌物
  • 坐骨神經痛的診斷
    • 坐骨神經痛指數
    • 診斷成像
    • 選擇性神經根阻滯(SRNB)
  • 鑑別診斷
  • 診斷的臨床指南
  • 診斷算法
  • 預防

第6章著名設施

第7章治療

  • 非手術治療
    • 物理療法
    • 心理療法
  • 外科治療

第8章,美國內科醫學會(ACP)的腰背痛治療指南

第9章,美國國家臨床研究所(NICE)的治療指南

第10章流行病學和患者人群

  • 主要發現
  • 流行病學調查方法
  • 7個主要國家的坐骨神經痛患病率

第11章國家流行病學

  • 美國
    • 假設和依據
    • 坐骨神經痛的患病率
    • 原因別的患病率
    • 性別別的患病率
    • 年齡別的患病率
    • 符合手術條件的患者人數
  • 5個歐洲國家
    • 德國
    • 法國
    • 意大利
    • 西班牙
    • 英國
  • 日本

第12章不受支持的需求

第13章新藥

  • 主要競爭對手
  • SP-102(Semdexa):Scilex Holding Company
  • Hernicore(SI-6603/Condoliase):Seikagaku Corporation
  • Clonidine Micropellets:Sollis Therapeutics
  • SX600:SpineThera
  • KLS-2031:Kolon Life Science
  • KTP-001:Teijin America

第14章七個主要國家的市場分析

  • 主要發現

第15章屬性分析

第16章主要市場前提條件

  • 7個主要國家/地區的市場規模
  • 7個主要國家/地區的治療方法市場規模
  • 7個主要國家/地區的市場前景
  • 美國
  • 德國
  • 法國
  • 意大利
  • 西班牙
  • 英國
  • 日本

第17章病例報告

  • 一名24歲男子的腰神經根症狀
  • 腰神經根疾病的物理療法康復
  • 骨質疏鬆性脊柱骨折後因孔狹窄引起的晚期腰椎神經根病變的內窺鏡檢查:一種新手術策略的病例報告

第18章市場增長的推動者

第19章市場壁壘

第20章附錄

第21章Delve Insight服務內容

第22章免責聲明

關於第23章Delve Insight

目錄
Product Code: DIMI0572

DelveInsight's 'Sciatica-Market Insights, Epidemiology and Market Forecast-2030' report delivers an in-depth understanding of the Sciatica, historical and forecasted epidemiology as well as the Sciatica market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan.

The Sciatica market report provides current treatment practices, emerging drugs, and market share of the individual therapies, current and forecasted 7MM Sciatica market size from 2017 to 2030. The report also covers current Sciatica treatment practice/algorithm, market drivers, market barriers and unmet medical needs to curate the best of the opportunities and assesses the underlying potential of the market.

Geography Covered:

  • The United States
  • EU5 (Germany, France, Italy, Spain, and the United Kingdom)
  • Japan

Study Period: 2017-2030

Sciatica Disease Understanding and Treatment Algorithm

Sciatica Overview

Sciatica is a pain in the lower extremity resulting from irritation of the sciatic nerve. The pain of Sciatica is typically felt from the low-back (lumbar area) to behind the thigh and can radiate down below the knee. The sciatic nerve is the largest nerve in the body and begins from nerve roots in the lumbar spinal cord in the low back and extends through the buttock area to send nerve endings down the lower limb. Radiculopathy is sometimes referred to as sciatic nerve pain. Sciatica is an unbearable condition in which the patient experiences pain and/or paresthesia in the supply of the sciatic nerve or linked lumbosacral nerve root. Sciatica is a specific pain that is a direct result of sciatic nerve or sciatic nerve root pathology. The term sciatica is limited to the pain and irritation in nerve roots from L1 to L4 and may also involve related areas. Many times patients and clinicians use Sciatica to describe any pain arising from the lower back and radiating down to the leg.

Sciatica affects mainly people of older age. The most important indications of pain arousal are radiating leg pain and related disabilities. Patients are commonly treated in primary care, but a small proportion is referred to secondary care, which may eventually end up in surgery. Synonyms for sciatica pain are lumbosacral radicular syndrome, ischias, nerve root pain, and nerve root entrapment. In maximum cases, it is caused by a herniated disc with nerve root compression, but lumbar stenosis and tumors are other possible causes. The diagnosis of Sciatica and its management is different from location to location as the surgery rates for lumbar discectomy vary widely between countries, large variation in disc surgery, even within countries can also be noticed. This may in part, be due to the scarcity of evidence on the value of diagnostic and therapeutic interventions and a lack of clear clinical guidelines reflect differences in healthcare and insurance systems.

Sciatica Diagnosis

Sciatica is mainly diagnosed by history taking and physical examination. By definition, patients mention burning pain in the leg. The patient is asked to report the distribution of the pain and whether it radiates below the knee and to draw or mark the area which may be used to evaluate the distribution. Sciatica is characterized by radiating pain that follows a dermatomal pattern. Patients may also report sensory symptoms.

Physical examination largely depends on neurological testing. The most applied investigation is the straight leg raising test or Lasegue's sign. Patients with Sciatica may also have slight back pain, but this is usually less severe than the leg pain. The diagnostic value of patient history and physical examination has not been well studied. No history examination or physical tests have both high sensitivity and high specificity. The sensitivity of the straight leg raising test is estimated to be very high with a corresponding specificity of being low. A thorough differential list is important in considering a diagnosis of Sciatica and should include- Herniated lumbosacral disc, muscle spasm, nerve root impingement, piriformis syndrome and others.

Sciatica Treatment

Currently, the market of Sciatica holds treatment options that are supportive in nature, such as conservative (nonsurgical) and surgical methods. Conservative treatment of Sciatica further includes physical therapy, behavioral therapies, or pharmacological therapies.

Patients are mostly benefited by physical therapy, which includes multiple options to get relief from the unbearable pain. Several types of deep massages, hot and cold therapies to release muscle tension and pressure thereby enabling the blood flow are preferred.

It covers the details of conventional and current medical therapies available in the Sciatica market for the treatment of the various types of Sciatica. Patients are also advised by the physicians to opt for certain behavioral therapies by which it is easy for them to diagnose and treat the disease efficiently. Talk sessions can help out the patients to exactly know the root cause of their pain. When physical therapy cannot help the patients from the intolerable pain of Sciatica, pharmacological therapies are the next mode of relief advised by the physicians. Several different classes of medications are used for sciatica treatment, such as pain killers, anti-inflammatories, antidepressants, muscle relaxants, calcium channel α2-帤 ligands, epidural steroids, topical pain medications, and opioids.

It also provides the treatment guidelines and algorithms of the United States and Europe. DelveInsight's Sciatica market report gives a thorough understanding of Sciatica by including details such as disease definition, causes, pathophysiology, biomarkers, and diagnosis.

Sciatica Epidemiology

The disease epidemiology covered in the report provides historical as well as forecasted epidemiology (Prevalence of Sciatica, Diagnosed Prevalence of Sciatica, Cause-specific Diagnosed Prevalence of Sciatica, Gender-specific Diagnosed Prevalence of Sciatica, Age-specific Diagnosed Prevalence of Sciatica, Surgery eligible patient pool of Sciatica), scenario of Sciatica in the 7MM covering United States, EU5 countries (Germany, Spain, Italy, France, and the United Kingdom) and Japan from 2017 to 2030.

Key Findings

This section provides glimpses of the Sciatica epidemiology in the 7MM.

  • The total prevalent population of Sciatica in the seven major markets ranges was 27,022,660 in 2017
  • Delveinsight has also analyzed the diagnosed prevalent population of lumbar disc herniation. In 2017, the number of diagnosed prevalent cases of lumbar disc herniation was 7,358,250, which will increase in the forecast period.
  • In 2017, it was estimated that 4,802,485 males and 3,373,349 females were found with Sciatica in the United States.
  • In 2017, the surgery eligible patient pool in the US was 1,082,736, which is anticipated to increase in the forecast period.
  • The age-specific prevalence of Sciatica was maximum in the age group 45-54 with 2,043,958 cases in 2017 in the US while the lowest number of cases were found in 18-34 age group with 1,218,199 cases in 2017.
  • In 2017, it was estimated that 4,802,485 males and 3,373,349 females were found with Sciatica in the United States. On the other hand, a similar trend was not observed in EU5, and Japan wherein females are more predominant than males.

Country Wise-Sciatica Epidemiology

The epidemiology segment also provides the Sciatica epidemiology data and findings across the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom) and Japan.

Sciatica Drug Chapters

This segment of the Sciatica report encloses the detailed analysis of the mid- and late-stage (Phase-III and Phase-II) pipeline drugs. It also helps to understand the clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details of each included drug and the latest news and press releases.

Sciatica Emerging Drugs

SP-102 (Semdexa): Semnur Pharmaceuticals/Scilex Holding Company

SP-102 is the first nonopioid corticosteroid formulated as a viscous gel injection, which is under development for the treatment of lumbar radicular pain/sciatica, containing no neurotoxic preservatives, surfactants, solvents or particulates. The US Food and Drug Administration (FDA) has granted SP-102 Fast Track Designation for the treatment of lumbar radicular pain/sciatica. SP-102 is currently undergoing crucial Phase III trials with data readout expected in the first half of 2020

Condoliase (Hernicore): Seikagaku Corporation

Hernicore (Condoliase/SI-6603) is developed by Seikagaku Corporation and marketed in Japan which is used as a chemonucleolysis treatment to break down selected components of the IVD, primarily within the nucleus pulposus. This reduces its water content and volume, thereby relieving disc pressure and compression on the spinal nerve root. The treatment for lumbar disc herniation SI-6603, an injectable drug containing condoliase, an enzyme that selectively degrades glycosaminoglycan (GAG) in the herniated nucleus pulposus, and thus when injected directly into the intervertebral disc can reduce pressure on nerves (the source of pain) caused by the herniation, thereby providing relief from the pain. Glycosaminoglycans (GAG) are acidic mucopolysaccharides consisting of a repetitive disaccharide structure of amino sugar and uronic acid or galactose. SI-6603 does not break down proteins, so it does not affect surrounding tissue, such as blood vessels and nerves.

SX600: SpineThera

SX600, a nonopioid epidural steroid injection, a sustained-release, micro-suspension corticosteroid to address the unique requirements to treat back pain. The active ingredient in SX600 is dexamethasone acetate, which has been reformulated into an injectable micro-suspension containing microparticles that are smaller than the particles in a standard corticosteroid suspension and smaller than a red blood cell. The active drug is encapsulated within these tiny, biodegradable microparticles, which provide sustained release delivery of dexamethasone.

Clonidine Micropellets: Sollis Therapeutics

Clonidine is an alpha-2 agonist, an investigational extended-release form of a well-known analgesic and anti-inflammatory medication. The extended-release form is referred to as a "clonidine micropellet" and allows for localized delivery of clonidine to the affected nerves to reduce pain and inflammation via simple, one-time, epidural injection. Moreover, clonidine has been approved for systemic administration by the FDA for several uses because of its potent activity. The first product approved was introduced in 1974 as an orally administered pill for the treatment of hypertension. In 2010, clonidine was also approved for the treatment of attention deficit hyperactivity disorder and was usually administered with a patch.

Products detail in the report…

Sciatica Market Outlook

Patients who have Sciatica are best aided by a treatment plan that is individualized based on the patient's symptoms, diagnosis, and response to various treatments. Many cases of Sciatica go away within a few weeks using conservative treatment methods. However, this is not the case for all patients. For some, Sciatica can last much longer, even for several months.

Currently, the market of Sciatica holds treatment options that are supportive in nature, such as conservative (nonsurgical) and surgical methods. Conservative treatment of Sciatica further includes physical therapy, behavioral therapies, or pharmacological therapies.

Patients are mostly benefited by physical therapy, which includes multiple options to get relief from the unbearable pain. Several types of deep massages, hot and cold therapies to release muscle tension and pressure thereby enabling the blood flow are preferred. It covers the details of conventional and current medical therapies available in the Sciatica market for the treatment of the various types of Sciatica. Patients are also advised by the physicians to opt for certain behavioral therapies by which it is easy for them to diagnose and treat the disease efficiently. Talk sessions can help out the patients to exactly know the root cause of their pain. When physical therapy cannot help the patients from the intolerable pain of Sciatica, pharmacological therapies are the next mode of relief advised by the physicians. Several different classes of medications are used for sciatica treatment, such as pain killers, anti-inflammatories, antidepressants, muscle relaxants, calcium channel α2-帤 ligands, epidural steroids, topical pain medications, and opioids. The market of Sciatica exhibit a critical unmet need to improve the quality of life of the patients since there are no FDA approved therapies to treat the indication and the off-label therapies have several side effects.

The Sciatica market outlook of the report helps to build a detailed comprehension of the historic, current and forecasted Sciatica market trends by analyzing the impact of current therapies on the market, unmet needs, drivers and barriers, and demand of better technology.

This segment gives a thorough detail of Sciatica market trend of each marketed drug and late-stage pipeline therapy by evaluating their impact based on the annual cost of therapy, inclusion and exclusion criteria's, mechanism of action, compliance rate, growing need of the market, increasing patient pool, covered patient segment, expected launch year, competition with other therapies, brand value, their impact on the market and view of the key opinion leaders. The calculated market data are presented with relevant tables and graphs to give a clear view of the market at first sight.

According to DelveInsight, Sciatica 7MM market is expected to change in the study period 2017-2030.

Key Findings

This section includes a glimpse of the Sciatica 7 MM market.

  • According to Delveinsight estimates, the United States accounts for the largest market size of Sciatica, in comparison to Japan and EU5 (the United Kingdom, Germany, Italy, France, and Spain).
  • The market size of Sciatica in the seven major markets is USD 2,047.28 Million in 2017.
  • Japan accounts for the least market size in 7MM during the forecast period 2017-2030, at a CAGR of 4.24% for the study period (2017-2030)
  • Among the EU5 countries, Germany had the highest market size, with USD 158.45 Million in 2017, while Spain had the smallest market size of Sciatica with USD 91.82 Million.
  • Expected Launch of potential therapies may increase market size in the coming years, assisted by an increase in the diagnosed prevalent population of Sciatica. Owing to the positive outcomes of the upcoming products during the developmental stage by key players such as Scilex Holdings, Seikagaku Corporation have the potential to create a significant positive shift in the Sciatica Market Size

Sciatica Drugs Uptake

This section focusses on the rate of uptake of the potential drugs that are expected to get launched in the market during the study period 2017-2030. The analysis covers Sciatica market uptake by drugs; patient uptake by therapies; and sales of each drug.

This helps in understanding the drugs with the most rapid uptake, reasons behind the maximal use of new drugs and allow the comparison of the drugs based on market share and size which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.

Sciatica Development Activities

The report provides insights into different therapeutic candidates in phase II, and phase III stage. It also analyzes key players involved in developing targeted therapeutics.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition and merger, licensing and patent details for Sciatica emerging therapies.

Competitive Intelligence Analysis

We perform competitive and market Intelligence analysis of the Sciatica market by using various competitive intelligence tools that include-SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies, etc. The inclusion of the analysis entirely depends upon the data availability.

Scope of the Report:

  • The report covers the descriptive overview of Sciatica, explaining its causes, signs and symptoms, pathogenesis and currently available therapies.
  • Comprehensive insight has been provided into the Sciatica epidemiology and treatment.
  • Additionally, an all-inclusive account of both the current and emerging therapies for Sciatica is provided, along with the assessment of new therapies, which will have an impact on the current treatment landscape.
  • A detailed review of Sciatica market; historical and forecasted is included in the report, covering the 7MM drug outreach.
  • The report provides an edge while developing business strategies by understanding trends shaping and driving the 7MM Sciatica market.

Report Highlights:

  • Sciatica market is anticipated to increase at a CAGR of 4.57% for the study period 2017-2030.
  • The United States accounted for more than half (59.75%) of the market share in the 7MM.
  • SP-102 is projected to lead the market with the largest market share in 2030.
  • Japan accounts for the second-highest market share (15.79%) in the 7MM.
  • In the coming years, sciatica market is set to change due to the rising awareness of the disease, and incremental healthcare spending across the world; which would expand the size of the market to enable the drug manufacturers to penetrate more into the market.
  • The companies and academics are working to assess challenges and seek opportunities that could influence sciatica R&D. The therapies under development are focused on novel approaches to treat/improve the disease condition.
  • Major players are involved in developing therapies for Sciatica. Launch of emerging therapies will significantly impact the sciatica market.
  • Our in-depth analysis of the pipeline assets across different stages of development (phase III and phase II), different emerging trends and comparative analysis of pipeline products with detailed clinical profiles, key competitors, launch date along with product development activities will support the clients in the decision-making process regarding their therapeutic portfolio by identifying the overall scenario of the research and development activities.

Sciatica Report Insights

  • Patient Population
  • Therapeutic Approaches
  • Sciatica Pipeline Analysis
  • Sciatica Market Size and Trends
  • Market Opportunities
  • Impact of upcoming Therapies

Sciatica Report Key Strengths

  • Eleven Years Forecast
  • 7MMCoverage
  • Sciatica Epidemiology Segmentation
  • Key Cross Competition
  • Highly Analyzed Market
  • Drugs Uptake

Sciatica Report Assessment

  • Current Treatment Practices
  • Unmet Needs
  • Pipeline Product Profiles
  • Market Attractiveness
  • Market Drivers and Barriers

Companies:

  • SP-102 (Semdexa): Scilex Holding Company
  • Hernicore (Condoliase): Seikagaku Corporation
  • Clonidine Micropellets: Sollis Therapeutics
  • SX600: SpineThera
  • KLS-2031: Kolon Life Science
  • KTP-001: Teijin America

Key Questions:

Market Insights:

  • What was the Sciatica market share (%) distribution in 2017 and how it would look like in 2030?
  • What would be the Sciatica total market size as well as market size by therapies across the 7MM during the forecast period (2020-2030)?
  • What are the key findings pertaining to the market across the 7MM and which country will have the largest Sciatica market size during the forecast period (2020-2030)?
  • At what CAGR, the Sciatica market is expected to grow at the 7MM level during the forecast period (2020-2030)?
  • What would be the Sciatica market outlook across the 7MM during the forecast period (2020-2030)?
  • What would be the Sciatica market growth till 2030, and what will be the resultant market size in the year 2030?
  • How would the market drivers, barriers and future opportunities affect the market dynamics and subsequent analysis of the associated trends?

Epidemiology Insights:

  • What is the disease risk, burden and unmet needs of Sciatica?
  • What is the historical Sciatica patient pool in the United States, EU5 (Germany, France, Italy, Spain, and the UK) and Japan?
  • What would be the forecasted patient pool of Sciatica at the 7MM level?
  • What will be the growth opportunities across the 7MM with respect to the patient population pertaining to aspergillosis?
  • Out of the countries mentioned above, which country would have the highest prevalent population of Sciatica during the forecast period (2020-2030)?
  • At what CAGR the population is expected to grow across the 7MM during the forecast period (2020-2030)?

Current Treatment Scenario, Marketed Drugs and Emerging Therapies:

  • What are the current options for the treatment of Sciatica along with the approved therapy?
  • What are the current treatment guidelines for the treatment of Sciatica in the US and Europe?
  • What are the Sciatica marketed drugs and their MOA, regulatory milestones, product development activities, advantages, disadvantages, safety and efficacy, etc.?
  • How many companies are developing therapies for the treatment of Sciatica?
  • How many therapies are developed by each company for the treatment of Sciatica?
  • How many emerging therapies are in the mid-stage and late stage of development for the treatment of Sciatica?
  • What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the Sciatica therapies?
  • What are the recent novel therapies, targets, mechanisms of action and technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Sciatica and their status?
  • What are the key designations that have been granted for the emerging therapies for Sciatica?
  • What are the 7MM historical and forecasted market of Sciatica?

Reasons to buy:

  • The report will help in developing business strategies by understanding trends shaping and driving the Sciatica.
  • To understand the future market competition in the aspergillosis market and Insightful review of the key market drivers and barriers.
  • Organize sales and marketing efforts by identifying the best opportunities for Sciatica in the US, Europe (Germany, Spain, Italy, France, and the United Kingdom) and Japan.
  • Identification of strong upcoming players in the market will help in devising strategies that will help in getting ahead of competitors.
  • Organize sales and marketing efforts by identifying the best opportunities for Sciatica market.
  • To understand the future market competition in the Sciatica market.

Table of Contents

1 Key Insights

2 Executive Summary

3 SWOT Analysis

4 Sciatica Market Overview at a Glance

  • 4.1 Market Share (%) Distribution of Sciatica in 2017
  • 4.2 Market Share (%) Distribution of Sciatica in 2030

5 Disease Background and Overview: Sciatica

  • 5.1 Introduction
  • 5.2 Difference between Sciatica and Lower Back Pain
  • 5.3 Symptoms of Sciatica
  • 5.4 Causes of Sciatica
    • 5.4.1 Spinal Disc Herniation
    • 5.4.2 Spinal Stenosis
    • 5.4.3 Pregnancy
    • 5.4.4 Piriformis syndrome
    • 5.4.5 Osteoarthritis
    • 5.4.6 Spondylosis and spondylolisthesis
    • 5.4.7 Nondiscogenic causes
  • 5.5 Pathophysiology of disk-related sciatica
    • 5.5.1 Clinical observation
    • 5.5.2 Physiologic Variants of Sciatica
  • 5.6 Pathophysiological Mechanisms in Radicular Pain
    • 5.6.1 Inflammatory mechanism
    • 5.6.2 Immunological mechanism
    • 5.6.3 Compressive mechanism
    • 5.6.4 Lumbar spinal stenosis
    • 5.6.5 Skeletal Causes of Radiculopathy
    • 5.6.6 Lumbar bulging or herniated disc
  • 5.7 Prognosis
  • 5.8 Biomarkers for Sciatica
  • 5.9 Diagnosis of sciatica
    • 5.9.1 Indicators for sciatica
    • 5.9.2 Imaging
    • 5.9.3 Selective Nerve Root Block (SRNB)
  • 5.1 Differential Diagnosis
  • 5.11 Clinical Guidelines for the Diagnosis for Sciatica
    • 5.11.1 Clinical guideline for diagnosis for General Practice
  • 5.12 Diagnostic algorithm
  • 5.13 Prevention of sciatica

6 Recognized Establishments

7 Treatment

  • 7.1 Nonsurgical Treatment for Sciatica
    • 7.1.1 Physical therapy
    • 7.1.2 Psychological therapies
    • 7.1.3 Medications
  • 7.2 Surgical Treatment of Sciatica

8 The American College of Physicians (ACP) Guidelines for the Treatment of Low Back Pain

  • 8.1 Grading the Evidence and Developing Recommendations
  • 8.2 Comparative Benefits of Pharmacologic Therapies
  • 8.3 Comparative Benefits of Nonpharmacologic Therapies
  • 8.4 Recommendations

9 The National Institute for Health and Care Excellence (NICE) Treatment Guidelines

10 Epidemiology and Patient Population

  • 10.1 Key Findings
  • 10.2 Epidemiology Methodology
  • 10.3 7MM Total Prevalent Population of Sciatica

11 Country Wise-Epidemiology of Sciatica

  • 11.1 United States
    • 11.1.1 Assumption and Rationale
    • 11.1.2 Prevalence of Sciatica in the United States
    • 11.1.3 Diagnosed Prevalence of Sciatica in the United States
    • 11.1.4 Cause-specific Diagnosed Prevalence of Sciatica in the United States
    • 11.1.5 Gender-specific Diagnosed Prevalence of Sciatica in the United States
    • 11.1.6 Age-specific Diagnosed Prevalence in the United States
    • 11.1.7 Surgery Eligible Patient Pool in the United States
  • 11.2 EU5 Countries
    • 11.2.1 Assumption and Rationale
  • 11.3 Germany
    • 11.3.1 Prevalence of Sciatica in Germany
    • 11.3.2 Diagnosed Prevalence of Sciatica in Germany
    • 11.3.3 Cause-specific Diagnosed Prevalence of Sciatica in Germany
    • 11.3.4 Gender-specific Diagnosed Prevalence of Sciatica in Germany
    • 11.3.5 Age-specific Diagnosed Prevalence in Germany
    • 11.3.6 Surgery Eligible Patient Pool in Germany
  • 11.4 France
    • 11.4.1 Prevalence of Sciatica in France
    • 11.4.2 Diagnosed Prevalence of Sciatica in France
    • 11.4.3 Cause-specific Diagnosed Prevalence of Sciatica in France
    • 11.4.4 Gender-specific Diagnosed Prevalence of Sciatica in France
    • 11.4.5 Age-specific Diagnosed Prevalence in France
    • 11.4.6 Surgery Eligible Patient Pool in France
  • 11.5 Italy
    • 11.5.1 Prevalence of Sciatica in Italy
    • 11.5.2 Diagnosed Prevalence of Sciatica in Italy
    • 11.5.3 Cause-specific Diagnosed Prevalence of Sciatica in Italy
    • 11.5.4 Gender-specific Diagnosed Prevalence of Sciatica in Italy
    • 11.5.5 Age-specific Diagnosed Prevalence in Italy
    • 11.5.6 Surgery Eligible Patient Pool in Italy
  • 11.6 Spain
    • 11.6.1 Prevalence of Sciatica in Spain
    • 11.6.2 Diagnosed Prevalence of Sciatica in Spain
    • 11.6.3 Cause-specific Diagnosed Prevalence of Sciatica of Sciatica in Spain
    • 11.6.4 Gender-specific Diagnosed Prevalence of Sciatica in Spain
    • 11.6.5 Age-specific Diagnosed Prevalence in Spain
    • 11.6.6 Surgery Eligible Patient Pool in Spain
  • 11.7 United Kingdom
    • 11.7.1 Prevalence of Sciatica in the United Kingdom
    • 11.7.2 Diagnosed Prevalence of Sciatica in the United Kingdom
    • 11.7.3 Cause-specific Diagnosed Prevalence of Sciatica in the United Kingdom
    • 11.7.4 Gender-specific Diagnosed Prevalence of Sciatica in the United Kingdom
    • 11.7.5 Age-specific Diagnosed Prevalence in the United Kingdom
    • 11.7.6 Surgery Eligible Patient Pool in the United Kingdom
  • 11.8 Japan
    • 11.8.1 Assumptions and Rationale
    • 11.8.2 Prevalence of Sciatica in Japan
    • 11.8.3 Diagnosed Prevalence of Sciatica in Japan
    • 11.8.4 Cause-specific Diagnosed Prevalence of Sciatica in Japan
    • 11.8.5 Gender-specific Diagnosed Prevalence of Sciatica in Japan
    • 11.8.6 Age-specific Diagnosed Prevalence in Japan
    • 11.8.7 Surgery Eligible Patient Pool in Japan

12 Unmet Needs

13 Emerging Drugs

  • 13.1 Key Cross Competition
  • 13.2 SP-102 (Semdexa): Scilex Holding Company
    • 13.2.1 Product Description
    • 13.2.2 Other Developmental Activities
    • 13.2.3 Clinical Development
    • 13.2.4 Product Profile
  • 13.3 Hernicore (SI-6603/Condoliase): Seikagaku Corporation
    • 13.3.1 Product Description
    • 13.3.2 Other Developmental Activities
    • 13.3.3 Clinical Development
    • 13.3.4 Product Profile
  • 13.4 Clonidine Micropellets: Sollis Therapeutics
    • 13.4.1 Product Description
    • 13.4.2 Other Developmental Activities
    • 13.4.3 Clinical Development
    • 13.4.4 Product Profile
  • 13.5 SX600: SpineThera
    • 13.5.1 Product Description
    • 13.5.2 Other Developmental Activities
    • 13.5.3 Clinical Development
    • 13.5.4 Product Profile
  • 13.6 KLS-2031: Kolon Life Science
    • 13.6.1 Product Description
    • 13.6.2 Other Developmental Activities
    • 13.6.3 Clinical Development
    • 13.6.4 Product Profile
  • 13.7 KTP-001: Teijin America
    • 13.7.1 Product Description
    • 13.7.2 Other Developmental Activities
    • 13.7.3 Clinical Development
    • 13.7.4 Product Profile

14 Sciatica: Seven Major Market Analysis

  • 14.1 Key Findings
  • 14.2 Market Methodology

15 Attribute Analysis

16 Key Market Assumptions

  • 16.1 Total Market Size of Sciatica in the 7MM
  • 16.2 Market Size by Therapies in the 7MM
  • 16.3 7MM Market Outlook
  • 16.4 United States Market Size
    • 16.4.1 Total Market size of Sciatica
    • 16.4.2 Market Size by Therapies
  • 16.5 Germany
    • 16.5.1 Total Market size of Sciatica in Germany
    • 16.5.2 Market Size by Therapies
  • 16.6 France
    • 16.6.1 Total Market Size of Sciatica
    • 16.6.2 Market Size by Therapies
  • 16.7 Italy
    • 16.7.1 Total Market Size of Sciatica
    • 16.7.2 Market Size by Therapies
  • 16.8 Spain
    • 16.8.1 Total Market Size of Sciatica
    • 16.8.2 Market Size by Therapies
  • 16.9 United Kingdom
    • 16.9.1 Total Market Size of Sciatica
    • 16.9.2 Market Size by Therapies
  • 16.1 Japan Market Size
    • 16.10.1 Total Market Size of Sciatica
    • 16.10.2 Market Size by Therapies

17 Case Reports

  • 17.1 Lumbar radicular symptoms in a 24-year-old male
  • 17.1 Physical therapy rehabilitation for lumbar radiculopathy: A case report
  • 17.3 Spinal endoscopy for delayed-onset lumbar radiculopathy resulting from foraminal stenosis after osteoporotic vertebral fracture: A case report of a new surgical strategy

18 Market Drivers

19 Market Barriers

20 Appendix

21 DelveInsight Capabilities

22 Disclaimer

23 About DelveInsight

List of Tables

  • Table 1: Summary of Sciatica, Epidemiology, and Key Events (2017-2030)
  • Table 2: Non-discogenic causes of Sciatica
  • Table 3: Physiologic Variants of Sciatica
  • Table 4: Total Prevalent Population of Sciatica in the 7MM (2017-2030)
  • Table 5: Prevalence of Sciatica in the United States (2017-2030)
  • Table 6: Diagnosed Prevalence of Sciatica in the United States (2017-2030)
  • Table 7: Cause-specific Diagnosed Prevalence of Sciatica in the United States (2017-2030)
  • Table 8: Gender-specific Diagnosed Prevalence of Sciatica in the United States (2017-2030)
  • Table 9: Age-specific Diagnosed Prevalence of Sciatica in the United States (2017-2030)
  • Table 10: Surgery Eligible Patient Pool in the United States (2017-2030)
  • Table 11: Prevalence of Sciatica in Germany (2017-2030)
  • Table 12: Diagnosed Prevalence of Sciatica in Germany (2017-2030)
  • Table 13: Cause-specific Diagnosed Prevalence of Sciatica in Germany (2017-2030)
  • Table 14: Gender-specific Diagnosed Prevalence of Sciatica in Germany (2017-2030)
  • Table 15: Age-specific Diagnosed Prevalence of Sciatica in Germany (2017-2030)
  • Table 16: Surgery Eligible Patient Pool in Germany (2017-2030)
  • Table 17: Prevalence of Sciatica in France (2017-2030)
  • Table 18: Diagnosed Prevalence of Sciatica in France (2017-2030)
  • Table 19: Cause-specific Diagnosed Prevalence of Sciatica in France (2017-2030)
  • Table 20: Gender-specific Diagnosed Prevalence of Sciatica in France (2017-2030)
  • Table 21: Age-specific Diagnosed Prevalence of Sciatica in France (2017-2030)
  • Table 22: Surgery Eligible Patient Pool in France (2017-2030)
  • Table 23: Prevalence of Sciatica in Italy (2017-2030)
  • Table 24: Diagnosed Prevalence of Sciatica in Italy (2017-2030)
  • Table 25: Cause-specific Diagnosed Prevalence of Sciatica in Italy (2017-2030)
  • Table 26: Gender-specific Diagnosed Prevalence of Sciatica in Italy (2017-2030)
  • Table 27: Age-specific Diagnosed Prevalence of Sciatica in Italy (2017-2030)
  • Table 28: Surgery Eligible Patient Pool in Italy (2017-2030)
  • Table 29: Prevalence of Sciatica in Spain (2017-2030)
  • Table 30: Diagnosed Prevalence of Sciatica in Spain (2017-2030)
  • Table 31: Cause-specific Diagnosed Prevalence of Sciatica in Spain (2017-2030)
  • Table 32: Gender-specific Diagnosed Prevalence of Sciatica in Spain (2017-2030)
  • Table 33: Age-specific Diagnosed Prevalence of Sciatica in Spain (2017-2030)
  • Table 34: Surgery Eligible Patient Pool in Spain (2017-2030)
  • Table 35: Prevalence of Sciatica in the United Kingdom (2017-2030)
  • Table 36: Diagnosed Prevalence of Sciatica in the United Kingdom (2017-2030)
  • Table 37: Cause-specific Diagnosed Prevalence of Sciatica in the United Kingdom (2017-2030)
  • Table 38: Gender-specific Diagnosed Prevalence of Sciatica in the United Kingdom (2017-2030)
  • Table 39: Age-specific Diagnosed Prevalence of Sciatica in the United Kingdom (2017-2030)
  • Table 40: Surgery Eligible Patient Pool in the United Kingdom (2017-2030)
  • Table 41: Prevalence of Sciatica in Japan (2017-2030)
  • Table 42: Diagnosed Prevalence of Sciatica in Japan (2017-2030)
  • Table 43: Cause-specific Diagnosed Prevalence of Sciatica in Japan (2017-2030)
  • Table 44: Gender-specific Diagnosed Prevalence of Sciatica in Japan (2017-2030)
  • Table 45: Age-specific Diagnosed Prevalence of Sciatica in Japan (2017-2030)
  • Table 46: Surgery Eligible Patient Pool in Japan (2017-2030)
  • Table 47: Comparison of Emerging Drugs
  • Table 48: SP-102, Clinical Trial Description,2020
  • Table 49: Hernicore, Clinical Trial Description, 2020
  • Table 50: Clonidine Micropellets, Clinical Trial Description, 2020
  • Table 51: SX600, Clinical Trial Description, 2020
  • Table 52: KLS-2031, Clinical Trial Description, 2020
  • Table 53: KTP-001, Clinical Trial Description, 2020
  • Table 54: Key Market Assumptions for Hernicore (Condoliase)
  • Table 55: Key Market Assumptions for SP-102
  • Table 56: Seven Major Market Size of Sciatica in USD Million (2017-2028)
  • Table 57: Market size of Sciatica by Therapies in the 7MM, in USD Million (2017-2030)
  • Table 58: United States Market Size of Sciatica, USD Million (2017-2030)
  • Table 59: Market size of Sciatica by Therapies in the United States, in USD Million (2017-2030)
  • Table 60: Market Size of Sciatica in Germany, in USD Million (2017-2030)
  • Table 61: Market size of Sciatica by Therapies in Germany, in USD Million (2017-2030)
  • Table 62: Market Size of Sciatica in France, in USD Million (2017-2030)
  • Table 63: Market size of Sciatica by Therapies in France, in USD Million (2017-2030)
  • Table 64: Market Size of Sciatica in Italy, in USD Million (2017-2030)
  • Table 65: Market size of Sciatica by Therapies in Italy, in USD Million (2017-2030)
  • Table 66: Market Size of Sciatica in Spain, in USD Million (2017-2030)
  • Table 67: Market size of Sciatica by Therapies in Spain, in USD Million (2017-2030)
  • Table 68: Market Size of Sciatica in the UK, in USD Million (2017-2030)
  • Table 69: Market size of Sciatica by Therapies in the UK, in USD Million (2017-2030)
  • Table 70: Market Size of Sciatica in Japan, in USD Million (2017-2030)
  • Table 71: Market size of Sciatica by Therapies in Japan, in USD Million (2017-2030)

List of Figures

  • Figure 1: SWOT Analysis of Sciatica
  • Figure 2: The sciatic nerve runs from the back, under the buttock, and downward through the hip area into each leg
  • Figure 3: Types of lumbar disc herniation classification based on the location of the disc herniation relative to the facet joint and spinal canal.
  • Figure 4: Lumbar spinal stenosis is a common cause of Sciatica
  • Figure 5: Piriformis Muscles Syndrome
  • Figure 6: Pathophysiological mechanisms in radicular pain.
  • Figure 7: Pathoanatomical Features of Degenerative Lumbar Spinal Stenosis
  • Figure 8: Algorithm for the diagnostic evaluation of patients with low-back pain.
  • Figure 9: Treatment algorithm of Sciatica
  • Table 10: Adverse events for treatment for Acute, Chronic, and Radicular Low Back Pain
  • Table 11: Adverse events for treatment for Acute, Chronic, and Radicular Low Back Pain
  • Figure 12: Total Prevalent Population of Sciatica in the 7MM (2017-2030)
  • Figure 13: Prevalence of Sciatica in the United States (2017-2030)
  • Figure 14: Diagnosed Prevalence of Sciatica in the United States (2017-2030)
  • Figure 15: Cause-specific Diagnosed Prevalence of Sciatica in the United States (2017-2030)
  • Figure 16: Gender-specific Diagnosed Prevalence of Sciatica in the United States (2017-2030)
  • Figure 17: Age-specific Diagnosed Prevalence of Sciatica in the United States (2017-2030)
  • Figure 18: Surgery Eligible Patient Pool in the United States (2017-2030)
  • Figure 19: Prevalence of Sciatica in Germany (2017-2030)
  • Figure 20: Diagnosed Prevalence of Sciatica in Germany (2017-2030)
  • Figure 21: Cause-specific Diagnosed Prevalence of Sciatica of Sciatica in Germany (2017-2030)
  • Figure 22: Gender-specific Diagnosed Prevalence of Sciatica in Germany (2017-2030)
  • Figure 23: Age-specific Diagnosed Prevalence of Sciatica in Germany (2017-2030)
  • Figure 24: Surgery Eligible Patient Pool in Germany (2017-2030)
  • Figure 25: Prevalence of Sciatica in France (2017-2030)
  • Figure 26: Diagnosed Prevalence of Sciatica in France (2017-2030)
  • Figure 27: Cause-specific Diagnosed Prevalence of Sciatica in France (2017-2030)
  • Figure 28: Gender-specific Diagnosed Prevalence of Sciatica in France (2017-2030)
  • Figure 29: Age-specific Diagnosed Prevalence of Sciatica in France (2017-2030)
  • Figure 30: Surgery Eligible Patient Pool in France (2017-2030)
  • Figure 31: Prevalence of Sciatica in Italy (2017-2030)
  • Figure 32: Diagnosed Prevalence of Sciatica in Italy (2017-2030)
  • Figure 33: Cause-specific Diagnosed Prevalence of Sciatica in Italy (2017-2030)
  • Figure 34: Gender-specific Diagnosed Prevalence of Sciatica in Italy (2017-2030)
  • Figure 35: Age-specific Diagnosed Prevalence of Sciatica in Italy (2017-2030)
  • Figure 36: Surgery Eligible Patient Pool in Italy (2017-2030)
  • Figure 37: Prevalence of Sciatica in Spain (2017-2030)
  • Figure 38: Diagnosed Prevalence of Sciatica in Spain (2017-2030)
  • Figure 39: Cause-specific Diagnosed Prevalence of Sciatica in Spain (2017-2030)
  • Figure 40: Gender-specific Diagnosed Prevalence of Sciatica in Spain (2017-2030)
  • Figure 41: Age-specific Diagnosed Prevalence of Sciatica in Spain (2017-2030)
  • Figure 42: Surgery Eligible Patient Pool in Spain (2017-2030)
  • Figure 43: Prevalence of Sciatica in the United Kingdom (2017-2030)
  • Figure 44: Diagnosed Prevalence of Sciatica in the United Kingdom (2017-2030)
  • Figure 45: Cause-specific Diagnosed Prevalence of Sciatica in the United Kingdom (2017-2030)
  • Figure 46: Gender-specific Diagnosed Prevalence of Sciatica in the United Kingdom (2017-2030)
  • Figure 47: Age-specific Diagnosed Prevalence of Sciatica in the United Kingdom (2017-2030)
  • Figure 48: Surgery Eligible Patient Pool in the United Kingdom (2017-2030)
  • Figure 49: Prevalence of Sciatica in Japan (2017-2030)
  • Figure 50: Diagnosed Prevalence of Sciatica in Japan (2017-2030)
  • Figure 51: Cause-specific Diagnosed Prevalence of Sciatica in Japan (2017-2030)
  • Figure 52: Gender-specific Diagnosed Prevalence of Sciatica in Japan (2017-2030)
  • Figure 53: Age-specific Diagnosed Prevalence of Sciatica in Japan (2017-2030)
  • Figure 54: Surgery Eligible Patient Pool in Japan (2017-2030)
  • Figure 55: Unmet Needs of Sciatica
  • Figure 56: Seven Major Market Size of Sciatica in USD Million (2017-2030)
  • Figure 57: Market size of Sciatica by Therapies in the 7MM, in USD Million (2017-2030)
  • Figure 58: Market Size of Sciatica in the United States, USD Millions (2017-2030)
  • Figure 59: Market size of Sciatica by Therapies in the US, in USD Million (2017-2030)
  • Figure 60: Market Size of Sciatica in Germany, USD Million (2017-2030)
  • Figure 61: Market size of Sciatica by therapies in Germany, in USD Million (2017-2030)
  • Figure 62: Market Size of Sciatica in France, USD Million (2017-2030)
  • Figure 63: Market size of Sciatica by therapies in France, in USD Million (2017-2030)
  • Figure 64: Market Size of Sciatica in Italy, USD Million (2017-2030)
  • Figure 65: Market size of Sciatica by therapies in Italy, in USD Million (2017-2030)
  • Figure 66: Market Size of Sciatica in Spain, USD Million (2017-2030)
  • Figure 67: Market Size of Sciatica by therapies in Spain, in USD Million (2017-2030)
  • Figure 68: Market Size of Sciatica in the UK, USD Million (2017-2030)
  • Figure 69: Market Size of Sciatica by therapies in the UK, in USD Million (2017-2030)
  • Figure 70: Market Size of Sciatica in Japan, USD Million (2017-2030)
  • Figure 71: Market size of Sciatica by therapies in Japan, in USD Million (2017-2030)
  • Figure 72: Market Drivers
  • Figure 73: Market Barriers