市場調查報告書

尋常型天皰瘡 (PV):市場分析,流行病學,市場預測 (2030年)

Pemphigus Vulgaris (PV) - Market Insights, Epidemiology, and Market Forecast-2030

出版商 DelveInsight Business Research LLP 商品編碼 955858
出版日期 內容資訊 英文 200 Pages
商品交期: 最快1-2個工作天內
價格
尋常型天皰瘡 (PV):市場分析,流行病學,市場預測 (2030年) Pemphigus Vulgaris (PV) - Market Insights, Epidemiology, and Market Forecast-2030
出版日期: 2020年07月01日內容資訊: 英文 200 Pages
簡介

全球主要7個國家的尋常型天皰瘡 (PV)的市場規模,2017年達到了1億8178萬美元。各國市場規模中,美國是世界最大的市場,及歐洲是德國最大 (2624萬美元),法國最小 (875萬美元) 。日本的市場規模2017年達到1023萬美元。2013∼2014年,美國預定Ianalumab (VAY736) 和Efgartigimod (ARGX-113),Rilzabrutinib (PRN1008) 等開發中產品將上市。

本報告提供全球主要7個國家 - 美國,歐洲主要5個國家 (EU5:法國、德國、義大利、西班牙、英國),日本 - 的尋常型天皰瘡 (PV)的疫情趨勢和今後的市場預測相關分析,疾病概要和市場基本結構,目前治療方法和未滿足需求,各國的患病人數趨勢預測,已上市/臨床實驗中的治療藥的簡介,全球整體/各國的市場規模 (2017∼2030年),主要的推動及阻礙市場要素等資訊彙整,為您概述為以下內容。

目錄

第1章 主要考察

第2章 尋常型天皰瘡 (PV):摘要整理

第3章 尋常型天皰瘡 (PV):市場概要

  • 整體市場佔有率結構 (2017年)
  • 整體市場佔有率結構 (2030年)

第4章 尋常型天皰瘡 (PV):疾病概要

  • 簡介
  • 臨床症狀
  • 病因
  • 尋常型天皰瘡的症狀
  • 病理生理學
  • 尋常型天皰瘡的診斷方法

第5章 病例報告

  • 由於尋常型天皰瘡造成的指甲疾病
  • 尋常型天皰瘡的管理:病例報告和臨床更新
  • 46歲的男性的尋常型天皰瘡和全身性紅斑性狼瘡
  • 併發了葉狀天皰瘡和尋常型天皰瘡的1例
  • 臨床性特徵,從組織學的觀察,及尋常型天皰瘡向葉狀天皰瘡抗原簡介的變化 - 2個案例研究

第6章 流行病學和患者人口

  • 主要的分析結果
  • 專家 (KOL)的見解
  • 分析方法
  • 尋常型天皰瘡 (PV)的已受診患者數 (主要7個國家的情況)

第7章 美國:流行病學的趨勢

  • 前提條件與根據
  • 尋常型天皰瘡 (PV)的已受診患者總數
  • 尋常型天皰瘡 (PV)的已受診患者數:男女
  • 尋常型天皰瘡 (PV)的已受診患者數:各年齡
  • 尋常型天皰瘡 (PV)的已受診患者數:各重症度

第8章 (EU5):流行病學的趨勢歐洲主要5個國家

  • 德國
  • 法國
  • 義大利
  • 西班牙
  • 英國

第9章 日本:流行病學的趨勢

第10章 目前治療、診療方法

  • 治療流程
  • 指南 (國際/各國標準)

第11章 未滿足需求

第12章 成藥

  • Mabthera/Rituxan:Genentech/Roche Group
    • 產品說明
    • 法規的里程碑
    • 臨床開發
    • 安全性和有效性
    • 產品的簡介

第13章 新藥

第14章 主要十字競爭

  • Rilzabrutinib (PRN1008):Principia Biopharma
  • Ianalumab (VAY736):Novartis Pharmaceuticals/MorphoSys
  • Efgartigimod (ARGX-113):Argenx BVBA
  • TPM203:Topas Therapeutics

第15章 (7MM)的市場分析尋常型天皰瘡 (PV):主要7個國家

  • 分析的要點
  • 分析方法
  • 整體市場規模
  • 市場規模:各治療藥物

第16章 美國市場

  • 市場未來展望
  • 市場規模
    • 整體市場規模
    • 市場規模:各治療藥物

第17章 (EU5) 市場:未來展望歐洲主要5個國家

  • 德國市場
  • 法國市場
  • 義大利市場
  • 西班牙市場
  • 英國市場

第18章 日本市場:未來展望

第19章 推動市場要素

第20章 阻礙市場要素

第21章 SWOT分析

第22章 醫療費償付和市場進入

第23章 附錄

第24章 參考文件

第25章 DelveInsight的服務內容

第26章 免責聲明

第27章 關於DelveInsight

目錄
Product Code: DIMI0927

DelveInsight's 'Pemphigus Vulgaris (PV)-Market Insights, Epidemiology, and Market Forecast-2030' report deliver an in-depth understanding of the PV, historical and forecasted epidemiology as well as the PV market trends in the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom) and Japan.

The PV market report provides current treatment practices, emerging drugs, and market share of the individual therapies, current and forecasted 7MM PV market size from 2017 to 2030. The Report also covers current PV treatment practice/algorithm, market drivers, market barriers, unmet medical needs, SWOT analysis to curate the best of the opportunities and assesses the underlying potential of the market.

Geography Covered:

  • The United States
  • EU5 (Germany, France, Italy, Spain, and the United Kingdom)
  • Japan

Study Period: 2017-2030

Pemphigus Vulgaris (PV) Disease Understanding and Treatment Algorithm

Pemphigus Vulgaris (PV) Overview

Pemphigus Vulgaris (PV) is defined as a potentially fatal, autoimmune and intraepithelial disease characterized by flaccid blisters, and erosions of the skin and mucous membrane. It is histologically marked by acantholysis and is mediated by circulating desmoglein-reactive autoantibodies, directed against keratinocyte cell surfaces.

PV is subdivided into two subtypes: mucosal-dominant type and mucocutaneous type. The mucosal-dominant type of PV shows blisters mainly and erosive lesions on the oral mucosa while mucocutaneous type also shows flaccid bullae and intractable erosions of the skin. PV is further segmented based on the severity of the disease as mild, moderate and severe.

Pemphigus Vulgaris (PV) Diagnosis

Generally, patients with unexplained chronic mucosal ulceration, particularly with bullous skin lesions, have been suspected of having PV. It is essential to differentiate PV from other bullous dermatoses. Two clinical findings that are specific for PV include the Nikolsky sign and Asboe-Hansen sign. The diagnosis of PV is confirmed by biopsy of lesion and surrounding (perilesional) normal skin. Immunofluorescence testing shows IgG autoantibodies against the keratinocyte's cell surface. Serum autoantibodies to desmoglein 1 and desmoglein 3 transmembrane glycoproteins can be identified via direct immunofluorescence, indirect immunofluorescence, and enzyme-linked immunosorbent assay (ELISA).

Continued in the report…..

Pemphigus Vulgaris (PV) Treatment

There is currently no cure for the treatment of PV, but treatment can help keep the symptoms under control. The majority of the therapies aim to improve the symptoms associated with pemphigus by the reduction of serum autoantibodies, either directly or through generalized immune suppression. The goal of the initial phase of therapy is disease control that means preventing the formation of new blisters and starting the healing process of the existing blisters. This initial phase ends when there is no blister appearing for 2 weeks, and the existing lesions have been healed.

The first line of treatment during the initial phase of therapy is corticosteroids (prednisolone)., owing to their rapid effect (within days). Completed remission with minimal treatment needs months while complete treatment remission off treatment requires several months or years of therapy. Systemic corticosteroids can also be used in combination with immunosuppressive agents (Azathioprine, Mycophenolate mofetil, Rituximab), in the cases where there are expected complications of hypertension, diabetes mellitus, or osteoporosis due to prolonged use (>4 months) of the steroids.

The second line of treatment in the cases of contraindications to glucocorticosteroids or complications due to prolonged use consists of the combined or single use of immunosuppressants such as azathioprine, mycophenolate mofetil (MMF), dapsone, methotrexate, cyclophosphamide, and cyclosporine.

Other treatment options include intravenous immunoglobulins (IVIG), immunoadsorption, plasmapheresis, and extracorporeal photochemotherapy.

Pemphigus Vulgaris (PV) Epidemiology

The disease epidemiology covered in the report provides historical as well as forecasted epidemiology segmented by Total Diagnosed Prevalent Population of PV, Gender-specific Diagnosed Prevalent Population of PV, Severity-specific Diagnosed Prevalent Population of PV, and Age-specific Diagnosed Prevalent Population of PV scenario of PV in the 7MM covering the United States, EU5 countries (Germany, France, Italy, Spain, and the United Kingdom) and Japan from 2017 to 2030.

Key Findings

  • The increasing geriatric population and rising prevalence of PV generates a large patient population in the 7MM. In 2017, the diagnosed prevalent population of PV in the 7MM was 41,217.
  • The United States contributes the largest share with 13,526 cases in 2017 acquiring near about 32.81% of the totals 7MM share. On the other hand, EU5 and Japan account for 60.10% and 7.09% diagnosed prevalent population share respectively in 2017.
  • A female predominance in PV is well established. However, the genetic and physiological basis for this gender bias is not well understood. In 2017, males and female contribute to 5,275 and 8,251 diagnosed prevalent cases in the US.
  • DelveInsight's epidemiology model for PV estimates that out of the total diagnosed prevalent population of 13,526 cases in the US for PV in 2017, 5,814 cases are of mild, 3,678 cases are of moderate, and 4,034 accounted for severe cases, respectively.
  • The majority of the PV cases were found in adults between 60-70 years of age. In 2017, 3,014 cases, 2,449 cases, were contributed by patients age 60-69 years, 70-79 years, and lowest cases observed in the age-group of 0-17 years (406 cases) in 2017, respectively in the US.

Pemphigus Vulgaris (PV) Epidemiology

The epidemiology segment also provides the PV epidemiology data and findings across the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom) and Japan.

Pemphigus Vulgaris (PV) Drug Chapters

The drug chapter segment of the PV report encloses the detailed analysis of PV marketed drugs, mid-phase, and late-stage pipeline drugs. It also helps to understand the PV clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details of each included drug and the latest news and press releases.

Pemphigus Vulgaris (PV) Marketed Drugs

Mabthera/Rituxan: Genentech/Roche Group

MabThera (Rituxan in the US) in combination with methotrexate is indicated for the treatment of adults with severe active rheumatoid arthritis (RA) who has had an inadequate response or intolerance to other disease-modifying antirheumatic drugs (DMARD) including one or more tumor necrosis factor (TNF) inhibitor therapies.

Rituxan is the first biologic therapy approved by the FDA for PV and the first major advancement in the treatment of the disease in more than 60 years. Also, the FDA has granted Priority Review, Breakthrough Therapy Designation, and Orphan Drug Designation to Rituxan for the treatment of PV.

Products detail in the report…

Pemphigus Vulgaris (PV) Emerging Drugs

Rilzabrutinib (PRN1008): Principia Biopharma

Rilzabrutinib/PRN1008 is being evaluated in patients with pemphigus. It is an oral, reversible covalent BTK inhibitor. This investigational, small molecule therapy acts by blocking BTK (Bruton's Tyrosine Kinase-a component of B-cell signaling). Principia believes Rilzabrutinib can potentially lead to positive outcomes in IgG4-RD by impacting many of the driving features of the disease, including inflammation, allergic components (IgE and eosinophils), monocytes, macrophages (involved in fibrosis), and B-cells implicated in initiation and maintenance of disease.

Principia has an ongoing phase III clinical trial in patients with moderate to severe pemphigus. It has completed a phase II part A trial in patients with pemphigus and, in conjunction with this trial, the company has an ongoing phase II part B trial to increase the active treatment period from 3 to 6 months. Between the phase II parts A and B of the pemphigus trial, the company has been able to observe consistent safety and efficacy data in approximately 40 pemphigus patients

Products detail in the report…

Ianalumab (VAY736): Novartis Pharmaceuticals/MorphoSys

Ianalumab (VAY736) is a human IgG1/K mAb designed to target human BAFF-R and to competitively inhibit binding of BAFF to BAFF-R, thereby blocking BAFF-R-mediated signaling in B cells. Also, Ianalumab was engineered to effectively eliminate B cells from circulation in vivo by antibody-dependent cellular cytotoxicity (ADCC). ADCC activity of Ianalumab is greatly enhanced by the elimination of fucose residues from the carbohydrate moiety attached to the Fc part of the antibody. Accordingly, Ianalumab shows potent ADCC activity in vitro with an EC50 of 2.0 pM.

Thus, Ianalumab eliminates BAFF-R + mature and immature B cells via dual mechanisms: antibody-dependent cytotoxicity (ADCC) and induction of B cell apoptosis by blocking BAFF: BAFF-R interaction and downstream survival pathway in B cells. BAFF-R expression is limited to immature and mature B cells up to the lymphoblast stage. Thus, earlier stage pro-B and pre-B cells are not directly affected by Ianalumab. MorphoSys and Novartis are investigating the molecule for the treatment of PV. The molecule has completed a phase II clinical study for PV.

Products detail in the report…

Efgartigimod (ARGX-113): Argenx BVBA

Efgartigimod (ARGX-113) is an investigational therapy for IgG-mediated autoimmune diseases and was designed to exploit the natural interaction between IgG antibodies and the recycling receptor FcRn. The company has designed Efgartigimod to degrade circulating disease-causing autoimmune antibodies and has potential in many large and orphan indications namely multiple sclerosis, PV, systemic lupus erythematosus, myasthenia gravis, and skin blistering diseases. Efgartigimod is currently being tested in Phase II clinical trials for PV.

Products detail in the report…

List to be continued in the report…

Pemphigus Vulgaris (PV) Market Outlook

Treatment of the disease is difficult and sometimes unsafe. For decades, the mainstay of treatment has been glucocorticoids, followed by other drugs.

Management of acute attacks and original management of the disease are enabled with systemic glucocorticoids such as prednisolone, 1-1.5 mg/kg/day PO. The idea is to bring the patient into remission with steroids, using the smallest dosage possible; the reason for the smallest possible dosages is to avoid the possible comorbidities, such as Cushing's disease, osteoporosis, hypertension, and diabetes. As the patient begins to take systemic glucocorticoids, they can also be prescribed an adjunct treatment protocol with nonsteroidal but immunosuppressant drugs such as azathioprine and mycophenolate.

Many patients go on to have recalcitrant PV after long periods of successful treatment with the medications mentioned above. A vast majority do achieve remission for at least 6 months if they have been treated with glucocorticoids and adjunct medications for close to 10 years; however, around 20-40% of patients do not ever go into remission and are considered refractory. Rituximab can curb the disease, especially in refractory cases. Rituxan (rituximab) was approved by the US FDA for the treatment of adults with moderate to severe PV in July 2018. In 2019, it was also approved in the EU as MabThera for the treatment of moderate to severe PV.

Cyclophosphamide is also used in refractory cases, but it has an unsafe side effect profile. It can cause hemorrhagic cystitis. Because of its safety profile, it requires regular monitoring by the patient, which is an inconvenience. Plasmapheresis is also used occasionally by nonspecifically removing proteins from the blood, but it is costly and has its unfavorable side effects, depending on the patient's condition. Also, intravenous immunoglobulins can be used to dilute the autoantibodies with regular immunoglobulin.

According to DelveInsight, PV seven major market is expected to change in the study period 2017-2030.

Key Findings

  • The market size of PV in the 7MM was found to be USD 181.78 million in 2017.
  • The United States accounts for the highest market size of PV, in comparison to the other major markets i.e., EU5 countries, and Japan
  • Among the EU5 countries, Germany had the highest market size with USD 26.24 million in 2017, while France had the lowest market size of PV with USD 8.75 million in 2017.
  • The market size of PV in Japan was USD 10.23 million in 2017.
  • The upcoming therapies Ianalumab (VAY736) and Efgartigimod (ARGX-113) are anticipated to reach the US market by 2024, and Rilzabrutinib (PRN1008), is expected to enter the US market in year 2023.

The United States Market Outlook

This section provides the total PV market size and; market size by therapies in the United States.

EU-5 Market Outlook

The total PV market size and market size by therapies in Germany, France, Italy, Spain, and the United Kingdom are provided in this section.

Japan Market Outlook

The total PV market size and market size by therapies in Japan are provided.

Pemphigus Vulgaris (PV) Drugs Uptake

This section focusses on the rate of uptake of the potential drugs recently launched in the PV market or expected to get launched in the market during the study period 2017-2030. The analysis covers PV market uptake by drugs; patient uptake by therapies; and sales of each drug.

This helps in understanding the drugs with the most rapid uptake, reasons behind the maximal use of new drugs and allows the comparison of the drugs based on market share and size which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.

Pemphigus Vulgaris (PV) Development Activities

The report provides insights into different therapeutic candidates in phase II, and phase III stage. It also analyzes key players involved in developing targeted therapeutics.

Pipeline Development Activities

The report covers the detailed information of collaborations, acquisition, and merger, licensing and patent details for PV emerging therapies.

Reimbursement Scenario in Pemphigus Vulgaris (PV)

The US Centers for Medicare & Medicaid Services has assigned J code 'J9312' for Rituxan which is effective from effective January 1, 2019. This coding information assists the patients to complete the payer forms for Rituxan. The J codes are used by physicians, hospitals and other healthcare professionals for billing for Medicare. Rituxan is covered under Medicare Part B and Medicare Advantage plan. Patients with Medicare Advantage plan will be covered by Medicare Part B. Also some Medicare Advantage plans include coverage for other prescription drugs that may not be covered by Original Medicare (MedicareAdvantage.com, n.d.). Medicare coverage of Rituxan can vary. If the treatment is covered by Medicare Part B, patients have to pay the Part B coinsurance or copayment (20% of the Medicare-approved amount) after they meet the Part B deductible, which was USD 185 per year in 2019.

As per the International Pemphigus Pemphigoid Foundation (IPPF) registry, 22% of pemphigoid and pemphigus patients have Medicare coverage, 61% commercial insurance, and 17% other insurance (National Organization for Rare Disorders, 2019).

In January 2020, the National Authority for Health (Haute Autorite de Sante - HAS) in France has given a favorable opinion to reimburse MabThera for the treatment of patients with moderate to severe PV (Haute Autorite de Sante, 2020).

Competitive Intelligence Analysis

We perform competitive and market Intelligence analysis of the PV market by using various competitive intelligence tools that include-SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies, etc. The inclusion of the analysis entirely depends upon the data availability.

Scope of the Report:

  • The report covers the descriptive overview of PV, explaining its causes, signs and symptoms, pathophysiology and currently available therapies.
  • Comprehensive insight has been provided into the PV epidemiology and treatment.
  • Additionally, an all-inclusive account of both the current and emerging therapies for PV is provided, along with the assessment of new therapies, which will have an impact on the current treatment landscape.
  • A detailed review of the PV market; historical and forecasted is included in the report, covering the 7MM drug outreach.
  • The report provides an edge while developing business strategies, by understanding trends shaping and driving the 7MM PV market.

Report Highlights:

  • The increasing prevalence of the disease along with promising emerging pipeline therapies will positively drive the PV market.
  • The companies and academics are working to assess challenges and seek opportunities that could influence PV R&D.
  • Major players are involved in developing therapies for PV. Launch of emerging therapies will significantly impact the PV market.
  • Our in-depth analysis of the pipeline assets across different stages of development (phase III and phase II), different emerging trends and comparative analysis of pipeline products with detailed clinical profiles, key cross-competition, launch date along with product development activities will support the clients in the decision-making process regarding their therapeutic portfolio by identifying the overall scenario of the research and development activities.

Pemphigus Vulgaris (PV) Report Insights

  • Patient Population
  • Therapeutic Approaches
  • PV Pipeline Analysis
  • PV Market Size and Trends
  • Market Opportunities
  • Impact of Upcoming Therapies

Pemphigus Vulgaris (PV) Report Key Strengths

  • Eleven Years Forecast
  • 7MM Coverage
  • PV Epidemiology Segmentation
  • Key Cross Competition
  • Highly Analyzed Market
  • Drugs Uptake

Pemphigus Vulgaris (PV) Report Assessment

  • Current Treatment Practices
  • Unmet Needs
  • Pipeline Product Profiles
  • Market Attractiveness
  • Market Drivers and Barriers
  • SWOT Analysis
  • Market Access and Reimbursement

Key Questions:

Market Insights:

  • What was the PV market share (%) distribution in 2017 and how it would look like in 2030?
  • What would be the PV total market size as well as market size by therapies across the 7MM during the forecast period (2020-2030)?
  • What are the key findings pertaining to the market across the 7MM and which country will have the largest PV market size during the forecast period (2020-2030)?
  • At what CAGR, the PV market is expected to grow at the 7MM level during the forecast period (2020-2030)?
  • What would be the PV market outlook across the 7MM during the forecast period (2020-2030)?
  • What would be the PV market growth till 2030 and what will be the resultant market size in the year 2030?
  • How would the market drivers, barriers and future opportunities affect the market dynamics and subsequent analysis of the associated trends?

Epidemiology Insights:

  • What is the disease risk, burden and unmet needs of PV?
  • What is the historical PV patient pool in the United States, EU5 (Germany, France, Italy, Spain, and the UK) and Japan?
  • What would be the forecasted patient pool of PV at the 7MM level?
  • What will be the growth opportunities across the 7MM with respect to the patient population pertaining to PV?
  • Out of the above-mentioned countries, which country would have the highest prevalent population of PV during the forecast period (2020-2030)?
  • At what CAGR the population is expected to grow across the 7MM during the forecast period (2020-2030)?

Current Treatment Scenario, Marketed Drugs, and Emerging Therapies:

  • What are the current options for the treatment of PV along with the approved therapy?
  • What are the current treatment guidelines for the treatment of PV in the US, Europe and Japan?
  • What are the PV marketed drugs and their MOA, regulatory milestones, product development activities, advantages, disadvantages, safety, and efficacy, etc.?
  • How many companies are developing therapies for the treatment of PV?
  • How many emerging therapies are in the mid-stage and late stages of development for the treatment of PV?
  • What are the key collaborations (Industry-Industry, Industry-Academia), Mergers and acquisitions, licensing activities related to the PV therapies?
  • What are the recent novel therapies, targets, mechanisms of action and technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for PV and their status?
  • What are the key designations that have been granted for the emerging therapies for PV?
  • What are the 7MM historical and forecasted market of PV?

Reasons to buy:

  • The report will help in developing business strategies by understanding trends shaping and driving the PV.
  • To understand the future market competition in the PV market and Insightful review of the key market drivers and barriers.
  • Organize sales and marketing efforts by identifying the best opportunities for PV in the US, Europe (Germany, Spain, Italy, France, and the United Kingdom) and Japan.
  • Identification of strong upcoming players in the market will help in devising strategies that will help in getting ahead of competitors.
  • Organize sales and marketing efforts by identifying the best opportunities for the PV market.
  • To understand the future market competition in the PV market.

Table of Contents

1. Key Insights

2. Executive Summary of Pemphigus Vulgaris (PV)

3. Pemphigus Vulgaris (PV) Market Overview at a Glance

  • 3.1. Market Share (%) Distribution of PV in 2017
  • 3.2. Market Share (%) Distribution of PV in 2030

4. Disease Background and Overview: Pemphigus Vulgaris (PV)

  • 4.1. Introduction
  • 4.2. Clinical Manifestations
  • 4.3. Disease Causes
  • 4.4. Symptom of PV
  • 4.5. Pathophysiology
  • 4.6. PV Diagnosis
    • 4.6.1. Diagnosis of Pemphigus Vulgaris: Recommendations by an International Panel of Experts
    • 4.6.2. Pemphigus S2 Guideline for diagnosis and treatment - guided by the European Dermatology Forum (EDF) in cooperation with the European Academy of Dermatology and Venereology (EADV)

5. Case Reports

  • 5.1. Nail disease in Pemphigus Vulgaris
  • 5.2. Management of oral pemphigus vulgaris: A case report and a clinical update
  • 5.3. Pemphigus Vulgaris and systemic lupus erythematosus in a 46 years old man
  • 5.4. A case of concomitant pemphigus foliaceus and oral pemphigus vulgaris
  • 5.5. A shift in clinical features, histologic findings and antigen profiles from Pemphigus Vulgaris to pemphigus foliaceus - two case studies

6. Epidemiology and Patient Population

  • 6.1. Key Findings
  • 6.2. KOL Views
  • 6.3. Epidemiology Methodology
  • 6.4. Total Diagnosed Prevalent Population of Pemphigus Vulgaris (PV) in the 7MM

7. United States Epidemiology

  • 7.1. Assumptions and Rationale
  • 7.2. Total Diagnosed Prevalent Population of Pemphigus Vulgaris (PV) in the United States
  • 7.3. Gender-specific Diagnosed Prevalent Population of Pemphigus Vulgaris (PV) in the United States
  • 7.4. Age-specific Diagnosed Prevalence of Pemphigus Vulgaris (PV) in the United States
  • 7.5. Severity-specific Diagnosed Prevalent Population of Pemphigus Vulgaris in the United States

8. EU5 Epidemiology

  • 8.1. Germany Epidemiology
    • 8.1.1. Assumptions and Rationale
    • 8.1.2. Total Diagnosed Prevalent Population of Pemphigus Vulgaris (PV) in Germany
    • 8.1.3. Gender-specific Diagnosed Prevalence of Pemphigus Vulgaris (PV) in Germany
    • 8.1.4. Age-specific Diagnosed Prevalence of Pemphigus Vulgaris (PV) in Germany
    • 8.1.5. Severity-specific Diagnosed Prevalence of Pemphigus Vulgaris (PV) in Germany
  • 8.2. France Epidemiology
    • 8.2.1. Assumptions and Rationale
    • 8.2.2. Diagnosed Prevalent Population of Pemphigus Vulgaris (PV) in France
    • 8.2.3. Gender-specific Diagnosed Prevalence of Pemphigus Vulgaris (PV) in France
    • 8.2.4. Age-specific Diagnosed Prevalence of Pemphigus Vulgaris (PV) in France
    • 8.2.5. Severity-specific Diagnosed Prevalence of Pemphigus Vulgaris (PV) in France
  • 8.3. Italy Epidemiology
    • 8.3.1. Assumptions and Rationale
    • 8.3.2. Diagnosed Prevalent Population of Pemphigus Vulgaris (PV) in Italy
    • 8.3.3. Gender-specific Diagnosed Prevalence of Pemphigus Vulgaris (PV) in Italy
    • 8.3.4. Age-specific Diagnosed Prevalence of Pemphigus Vulgaris (PV) in Italy
    • 8.3.5. Severity-specific Diagnosed Prevalence of Pemphigus Vulgaris (PV) in Italy
  • 8.4. Spain Epidemiology
    • 8.4.1. Assumptions and Rationale
    • 8.4.2. Diagnosed Prevalent Population of Pemphigus Vulgaris (PV) in Spain
    • 8.4.3. Gender-specific Diagnosed Prevalence of Pemphigus Vulgaris (PV) in Spain
    • 8.4.4. Age-specific Diagnosed Prevalence of Pemphigus Vulgaris (PV) in Spain
    • 8.4.5. Severity-specific Diagnosed Prevalence of Pemphigus Vulgaris (PV) in Spain
  • 8.5. United Kingdom Epidemiology
    • 8.5.1. Assumptions and Rationale
    • 8.5.2. Diagnosed Prevalence of Pemphigus Vulgaris (PV) in the UK
    • 8.5.3. Gender-specific Diagnosed Prevalence of Pemphigus Vulgaris (PV) in the UK
    • 8.5.4. Age-specific Diagnosed Prevalence of Pemphigus Vulgaris (PV) in the United Kingdom
    • 8.5.5. Severity-Specific Diagnosed Prevalence of Pemphigus Vulgaris (PV) in the United Kingdom

9. Japan Epidemiology

  • 9.1. Assumptions and Rationale
  • 9.2. Diagnosed Prevalent Population of Pemphigus Vulgaris (PV) in Japan
  • 9.3. Gender-specific Diagnosed Prevalence of Pemphigus Vulgaris (PV) in Japan
  • 9.4. Age-specific Diagnosed Prevalence of Pemphigus Vulgaris (PV) in Japan
  • 9.5. Severity-specific Diagnosed Prevalence of Pemphigus Vulgaris (PV) in Japan

10. Current Treatment and Medical Practices

  • 10.1. Treatment Algorithm
  • 10.2. Guidelines
    • 10.2.1. Treatment of Pemphigus Vulgaris: Recommendations by an International Panel of Experts
    • 10.2.2. British Association of Dermatologists' Guidelines for management of Pemphigus Vulgaris, 2017
    • 10.2.3. Treatment Strategies for Pemphigus Vulgaris in Japan

11. Unmet needs

12. Marketed Drugs

  • 12.1. Mabthera/Rituxan: Genentech/Roche Group
    • 12.1.1. Product Description
    • 12.1.2. Regulatory Milestones
    • 12.1.3. Clinical Development
    • 12.1.4. Safety and Efficacy
    • 12.1.5. Product Profile

13. Emerging Drugs

14. Key Cross Competition

  • 14.1. Rilzabrutinib (PRN1008): Principia Biopharma
    • 14.1.1. Product Description
    • 14.1.2. Regulatory Milestones
    • 14.1.3. Clinical Development
    • 14.1.4. Safety and Efficacy
    • 14.1.5. Product Profile
  • 14.2. Ianalumab (VAY736): Novartis Pharmaceuticals/MorphoSys
    • 14.2.1. Product Description
    • 14.2.2. Regulatory Milestones
    • 14.2.3. Clinical Development
    • 14.2.4. Product Profile
  • 14.3. Efgartigimod (ARGX-113): Argenx BVBA
    • 14.3.1. Product Description
    • 14.3.2. Regulatory Milestones
    • 14.3.3. Clinical Development
    • 14.3.4. Safety and Efficacy
    • 14.3.5. Product Profile
  • 14.4. TPM203: Topas Therapeutics
    • 14.4.1. Product Description
    • 14.4.2. Regulatory Milestones
    • 14.4.3. Clinical Development
    • 14.4.4. Product Profile

15. Pemphigus Vulgaris (PV): 7MM Market Analysis

  • 15.1. Key Findings
  • 15.2. Market Methodology
  • 15.3. Market Size of Pemphigus Vulgaris (PV) in the 7MM
  • 15.4. Market Size of Pemphigus Vulgaris (PV) by Therapies in the 7MM

16. United States

  • 16.1. United States Market Outlook
  • 16.2. United States Market Size
    • 16.2.1. Total Market size of Pemphigus Vulgaris (PV) in the United States
    • 16.2.2. Market Size of Pemphigus Vulgaris (PV) by Therapies in the US

17. EU-5 countries: Market Outlook

  • 17.1. Germany Market Size
    • 17.1.1. Total Market size of Pemphigus Vulgaris (PV) in Germany
    • 17.1.2. Market Size of Pemphigus Vulgaris (PV) by therapies in Germany
  • 17.2. France Market Size
    • 17.2.1. Total Market size of Pemphigus Vulgaris (PV) in France
    • 17.2.2. Market Size of Pemphigus Vulgaris (PV) by therapies in France
  • 17.3. Italy Market Size
    • 17.3.1. Total Market size of Pemphigus Vulgaris (PV) in Italy
    • 17.3.2. Market Size of Pemphigus Vulgaris (PV) by therapies in Italy
  • 17.4. Spain Market Size
    • 17.4.1. Total Market size of Pemphigus Vulgaris (PV) in Spain
    • 17.4.2. Market Size of Pemphigus Vulgaris (PV) by therapies in Spain
  • 17.5. United Kingdom Market Size
    • 17.5.1. Total Market size of Pemphigus Vulgaris (PV) in the United Kingdom
    • 17.5.2. Market Size of Pemphigus Vulgaris (PV) by therapies in the UK

18. Japan Market Outlook

  • 18.1. Japan Market Size
    • 18.1.1. Total Market size of Pemphigus Vulgaris (PV) in Japan
    • 18.1.2. Market Size of Pemphigus Vulgaris (PV) by therapies in Japan

19. Market Drivers

20. Market Barriers

21. SWOT Analysis

22. Reimbursement and market access

23. Appendix

24. Bibliography

  • 24.1. Report Methodology

25. DelveInsight Capabilities

26. Disclaimer

27. About DelveInsight

List of Tables

  • Table 1 Summary of Pemphigus Vulgaris (PV), Market, Epidemiology and Key Events (2017-2030)
  • Table 2 Drugs associated with PV
  • Table 3 Association of non-HLA genes with PV
  • Table 4 Differential diagnosis of oral lesions in PV
  • Table 5 PV diagnostic algorithm
  • Table 6 Total Diagnosed Prevalent Population of Pemphigus Vulgaris (PV) in the 7MM (2017-2030)
  • Table 7 Total Diagnosed Prevalent Population of Pemphigus Vulgaris (PV) in the US (2017-2030)
  • Table 8 Gender-specific Diagnosed Prevalence of PV in the US (2017-2030)
  • Table 9 Age-specific Diagnosed Prevalence of PV in the US (2017-2030)
  • Table 10 Severity-specific Diagnosed Prevalence of PV in the US (2017-2030)
  • Table 11 Total Diagnosed Prevalent Population of PV in Germany (2017-2030)
  • Table 12 Gender-Specific Diagnosed Prevalence of PV in Germany (2017-2030)
  • Table 13 Age-specific Diagnosed Prevalence of PV in Germany (2017-2030)
  • Table 14 Severity-specific Diagnosed Prevalence of PV in Germany (2017-2030)
  • Table 15 Diagnosed Prevalent Population of PV in France (2017-2030)
  • Table 16 Gender-specific Diagnosed Prevalence of PV in France (2017-2030)
  • Table 17 Age-specific Diagnosed Prevalence of PV in France (2017-2030)
  • Table 18 Severity-specific Diagnosed Prevalence of PV in France (2017-2030)
  • Table 19 Diagnosed Prevalent Population of PV in Italy (2017-2030)
  • Table 20 Gender-specific Diagnosed Prevalence of PV1 in Italy (2017-2030)
  • Table 21 Age-specific Diagnosed Prevalence of PV in Italy (2017-2030)
  • Table 22 Severity-specific Diagnosed Prevalence of PV in Italy (2017-2030)
  • Table 23 Diagnosed Prevalent Population of PV in Spain (2017-2030)
  • Table 24 Gender-specific Diagnosed Prevalence of PV in Spain (2017-2030)
  • Table 25 Age-specific Diagnosed Prevalence of PV in Spain (2017-2030)
  • Table 26 Severity-specific Diagnosed Prevalence of PV in Spain (2017-2030)
  • Table 27 Diagnosed Prevalence of PV in the UK (2017-2030)
  • Table 28 Gender-Specific Diagnosed Prevalence of PV in the UK (2017-2030)
  • Table 29 Age-specific Diagnosed Prevalence of PV in the UK (2017-2030)
  • Table 30 Severity-Specific Diagnosed Prevalence of PV in the United Kingdom (2017-2030)
  • Table 31 Diagnosed Prevalent Population of PV in Japan (2017-2030)
  • Table 32 Gender-specific Diagnosed Prevalence of PV in Japan (2017-2030)
  • Table 33 Age-specific Diagnosed Prevalence of PV in Japan (2017-2030)
  • Table 34 Severity-specific Diagnosed Prevalence of PV in Japan (2017-2030)
  • Table 35 Medication Dosing
  • Table 36 Overview of Management of PV
  • Table 37 Management of PV
  • Table 38 The summary of treatments for PV
  • Table 39 MabThera, Clinical Trial Description, 2020
  • Table 40 Emerging Drugs Analysis
  • Table 41 Emerging Drugs Analysis Contd…
  • Table 42 Rilzabrutinib, Clinical Trial Description, 2020
  • Table 43 Ianalumab (VAY736), Clinical Trial Description, 2020
  • Table 44 Efgartigimod (ARGX-113), Clinical Trial Description, 2020
  • Table 45 TPM203, Clinical Trial Description, 2020
  • Table 46 Market Size of Pemphigus Vulgaris (PV) in the 7MM in USD Million (2017-2030)
  • Table 47 Market Size of Pemphigus Vulgaris (PV) by therapies in the 7MM, in USD Million (2017-2030)
  • Table 48 The US Market Size of PV in USD Million (2017-2030)
  • Table 49 Market Size of Pemphigus Vulgaris (PV) by therapies in the US, in USD Million (2017-2030)
  • Table 50 Germany Market Size of Pemphigus Vulgaris (PV) in USD Million (2017-2030)
  • Table 51 Market Size of Pemphigus Vulgaris (PV) by therapies in Germany, in USD Million (2017-2030)
  • Table 52 France Market Size of Pemphigus Vulgaris (PV) in USD Million (2017-2030)
  • Table 53 Market Size of Pemphigus Vulgaris (PV) by therapies in France, in USD Million (2017-2030)
  • Table 54 Italy Market Size of Pemphigus Vulgaris (PV) in USD Million (2017-2030)
  • Table 55 Market Size of Pemphigus Vulgaris (PV) by therapies in Italy, in USD Million (2017-2030)
  • Table 56 Spain Market Size of Pemphigus Vulgaris (PV) in USD Million (2017-2030)
  • Table 57 Market Size of Pemphigus Vulgaris (PV) by therapies in Spain, in USD Million (2017-2030)
  • Table 58 The UK Market Size of Pemphigus Vulgaris (PV) in USD Million (2017-2030)
  • Table 59 Market Size of Pemphigus Vulgaris (PV) by therapies in the UK, in USD Million (2017-2030)
  • Table 60 Japan Market Size of Pemphigus Vulgaris (PV) in USD Million (2017-2030)
  • Table 61 Market Size of Pemphigus Vulgaris (PV) by therapies in Japan, in USD Million (2017-2030)
  • Table 62 Sample Coding for Pemphigus Vulgaris (PV)

List of Figures

  • Figure 1 Typical features of a patient with PV
  • Figure 2 Clinical manifestations of Pemphigus
  • Figure 3 World map showing association of type II HLA genes with PV in different populations, grouped according to geographical regions
  • Figure 4 Pathogenesis of Pemphigus
  • Figure 5 Mechanisms of Acantholysis
  • Figure 6 B-cell and T-cell responses in Pemphigus
  • Figure 7 A multi-step approach for diagnosing PV
  • Figure 8 Pemphigus area and activity score
  • Figure 9 Pemphigus activity score
  • Figure 10 Pemphigus Disease Area Index
  • Figure 11 Pemphigus Vulgaris Lesion Severity Score
  • Figure 12 Harman's Pemphigus Grading
  • Figure 13 Kumar's Scoring system
  • Figure 14 Mahajan's Scoring system
  • Figure 15 Diagnostic recommendations for PV by the International Panel of Experts
  • Figure 16 US KOL Views
  • Figure 17 Europe KOL Views
  • Figure 18 Total Diagnosed Prevalent Population of Pemphigus Vulgaris (PV) in the 7MM (2017-2030)
  • Figure 19 Total Diagnosed Prevalent Population of Pemphigus Vulgaris (PV) in the US (2017-2030)
  • Figure 20 Gender-Specific Diagnosed Prevalence of PV in the US (2017-2030)
  • Figure 21 Age-specific Diagnosed Prevalence of PV in the US (2017-2030)
  • Figure 22 Severity -specific Diagnosed Prevalence of PV in the US (2017-2030)
  • Figure 23 Total Diagnosed Prevalent Population of Pemphigus Vulgaris (PV) in Germany (2017-2030)
  • Figure 24 Gender-Specific Diagnosed Prevalence of Pemphigus Vulgaris (PV) in Germany (2017-2030)
  • Figure 25 Age-specific Diagnosed Prevalence of PV in Germany (2017-2030)
  • Figure 26 Severity-specific Diagnosed Prevalence of PV in Germany (2017-2030)
  • Figure 27 Diagnosed Prevalent Population of PV in France (2017-2030)
  • Figure 28 Gender-specific Diagnosed Prevalence of PV in France (2017-2030)
  • Figure 29 Age-specific Diagnosed Prevalence of PV in France (2017-2030)
  • Figure 30 Severity-specific Diagnosed Prevalence of PV in France (2017-2030)
  • Figure 31 Diagnosed Prevalent Population of PV in Italy (2017-2030)
  • Figure 32 Gender-specific Diagnosed Prevalence of PV in Italy (2017-2030)
  • Figure 33 Age-specific Diagnosed Prevalence of PV in Italy (2017-2030)
  • Figure 34 Severity-specific Diagnosed Prevalence of PV in Italy (2017-2030)
  • Figure 35 Diagnosed Prevalent Population of PV in Spain (2017-2030)
  • Figure 36 Gender-specific Diagnosed Prevalence of PV in Spain (2017-2030)
  • Figure 37 Age-specific Diagnosed Prevalence of PV in Spain (2017-2030)
  • Figure 38 Severity-specific Diagnosed Prevalence of PV in Spain (2017-2030)
  • Figure 39 Diagnosed Prevalence of PV in the UK (2017-2030)
  • Figure 40 Gender-Specific Diagnosed Prevalence of PV in the UK (2017-2030)
  • Figure 41 Age-Specific Diagnosed Prevalence of PV in the UK (2017-2030)
  • Figure 42 Severity-specific Diagnosed Prevalence of PV in the United Kingdom (2017-2030)
  • Figure 43 Diagnosed Prevalent Population of PV in Japan (2017-2030)
  • Figure 44 Gender-specific Diagnosed Prevalence of PV in Japan (2017-2030)
  • Figure 45 Age-specific Diagnosed Prevalence of PV in Japan (2017-2030)
  • Figure 46 Severity-specific Diagnosed Prevalence of PV in Japan (2017-2030)
  • Figure 47 Treatment Algorithm of PV
  • Figure 48 Mild Pemphigus
  • Figure 49 Severe Pemphigus
  • Figure 50 Therapy of relapse
  • Figure 51 Treatment recommendations for PV by the International Panel of Experts
  • Figure 52 Algorithm to treat patients with PV
  • Figure 53 Unmet needs of PV
  • Figure 54 Market Size of Pemphigus Vulgaris (PV) in the 7MM in USD Million (2017-2030)
  • Figure 55 Market Size of Pemphigus Vulgaris (PV) by therapies in the 7MM, in USD Million (2017-2030)
  • Figure 56 Market Size of Pemphigus Vulgaris (PV) in the US, USD Millions (2017-2030)
  • Figure 57 Market Size of Pemphigus Vulgaris (PV) by therapies in the US, in USD Million (2017-2030)
  • Figure 58 Market Size of Pemphigus Vulgaris (PV) in Germany, USD Millions (2017-2030)
  • Figure 59 Market Size of PV by therapies in Germany, in USD Million (2017-2030)
  • Figure 60 Market Size of Pemphigus Vulgaris (PV) in France, USD Millions (2017-2030)
  • Figure 61 Market Size of PV by therapies in France, in USD Million (2017-2030)
  • Figure 62 Market Size of Pemphigus Vulgaris (PV) in Italy, USD Millions (2017-2030)
  • Figure 63 Market Size of Pemphigus Vulgaris (PV) by therapies in Italy in USD Million (2017-2030)
  • Figure 64 Market Size of Pemphigus Vulgaris (PV) in Spain, USD Millions (2017-2030)
  • Figure 65 Market Size of Pemphigus Vulgaris (PV) by therapies in Spain in USD Million (2017-2030)
  • Figure 66 Market Size of Pemphigus Vulgaris (PV) in the UK, USD Millions (2017-2030)
  • Figure 67 Market Size of Pemphigus Vulgaris (PV) by therapies in the UK in USD Million (2017-2030)
  • Figure 68 Market Size of Pemphigus Vulgaris (PV) in Japan, USD Millions (2017-2030)
  • Figure 69 Market Size of PV by therapies in Japan in USD Million (2017-2030)
  • Figure 70 Market Drivers of PV
  • Figure 71 Market Barriers of PV
  • Figure 72 SWOT analysis of PV