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葉狀魚鱗癬(LI)- 流行病學預測 2030年

Lamellar Ichthyosis (LI) - Epidemiology Forecast to 2030

出版商 DelveInsight Business Research LLP 商品編碼 928279
出版日期 按訂單生產 內容資訊 英文 100 Pages
商品交期: 10個工作天內
價格
葉狀魚鱗癬(LI)- 流行病學預測 2030年 Lamellar Ichthyosis (LI) - Epidemiology Forecast to 2030
出版日期: 按訂單生產內容資訊: 英文 100 Pages
簡介

主要7個國家(美國、英國、德國、法國、義大利、西班牙、日本)的葉狀魚鱗癬(LI)的2017年的患病數估計為4038人。

本報告提供主要7個國家(美國、英國、德國、法國、義大利、西班牙、日本)的葉狀魚鱗癬(LI)市場調查,疾病概要,整體以及各國流行病學的預測等資訊詳細彙整。

目錄

第1章 主要洞察

第2章 葉狀魚鱗癬(LI)概要

第3章 葉狀魚鱗癬(LI):疾病的背景和概要

  • 簡介
    • 魚鱗癬
    • 葉狀魚鱗癬(LI)
  • 症狀
  • 病因
  • 原因
  • 診斷
    • 診斷的評分系統
  • 先天性魚鱗癬的診斷演算法

第4章 主要7個國家的流行病學和患者人口

  • 主要調查結果
  • 假設和根據
  • 總患病數
  • 總診斷數
  • 遺傳基因變異型的病例數
  • 各重症度的病例數
  • 總治療數

第5章 美國的流行病學

  • 總患病數
  • 總診斷數
  • 遺傳基因變異型的病例數
  • 各重症度的病例數
  • 總治療數

第6章 歐洲5個國家的流行病學

  • 德國
    • 總患病數
    • 總診斷數
    • 遺傳基因變異型的病例數
    • 各重症度的病例數
    • 總治療數
  • 法國
  • 義大利
  • 西班牙
  • 英國

第7章 日本

  • 總患病數
  • 總診斷數
  • 遺傳基因變異型的病例數
  • 各重症度的病例數
  • 總治療數

第8章 附錄

  • 參考文獻
  • 調查手法

第9章 免責聲明

第10章 DelveInsight的服務內容

第11章 關於DelveInsight

目錄
Product Code: DIEI0880

Overview

DelveInsight's 'Lamellar Ichthyosis (LI)- Epidemiology Forecast to 2030' report delivers an in-depth understanding of the disease, historical and forecasted Lamellar Ichthyosis epidemiology in the 7MM, i.e., the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan.

Lamellar Ichthyosis (LI) Understanding

Ichthyosis is the term used to define repetitive and widespread scaling of the skin. It may be inherited (genetic) or acquired during the lifespan. The inherited forms are rare, usually present from infancy, and generally lifelong situations. Acquired Ichthyosis can progress at any age due to several medical problems, such as kidney disease. The most common forms of inherited Ichthyosis are mild, and it might improve during warm climate. There are many very rare conditions where Ichthyosis occurs with problems in other systems of the body. Inherited Ichthyosis is due to a single genetic trait that is passed on either from one or both parents or develops as a new error in the gene very early in fetal life. It can be mild as with Ichthyosis Vulgaris, or severe.

Lamellar Ichthyosis is a rare genetic disorder, where skin cells are produced at a normal rate, but they do not separate normally at the surface of the outermost layer of skin and are not shed as quickly as they should be which lead to the formation of scale.

The signs and symptoms of Lamellar Ichthyosis differ from individual to individual. Some have mild signs and symptoms, while for others it might be severe. It is mainly caused by the mutations affecting several different genes, the genes which mainly involved in Lamellar Ichthyosis include TGM1, ABCA12, CYP4F22, NIPAL4 and others like LIPN, ALOX12B. However, most of the cases (~90%) are caused due to mutation in the TGM1 gene.

Mutations in Lamellar Ichthyosis commonly transmitted through autosomal recessive inheritance. Individuals must inherit two recessive genes for Lamellar Ichthyosis to show the disease, one from each parent. Also, the diagnosis of a genetic or rare disease can often be puzzling. Healthcare specialists usually look at an individuals' medical history, symptoms, physical exam, and laboratory test results to make a diagnosis. The patient's history includes thorough family history.

The diagnosis of Lamellar Ichthyosis is mainly done skin biopsy for histological analysis, electron microscopy, DNA sequencing analysis and immunohistochemical analysis and Ultrasonography.

Epidemiology Perspective by DelveInsight

The Lamellar Ichthyosis epidemiology division provides the insights about historical and current patient pool and forecasted trend for each seven major countries. The Lamellar Ichthyosis epidemiology data are studied through Lamellar Ichthyosis possible division to give a better understanding of the Disease scenario in the 7MM.

The disease epidemiology covered in the report provides historical as well as forecasted Lamellar Ichthyosis epidemiology [segmented as Total Prevalent Cases of Lamellar Ichthyosis, Total Diagnosed Cases of Lamellar Ichthyosis, Genetic Mutation-Specific Cases of Lamellar Ichthyosis, Severity-Specific Cases of Lamellar Ichthyosis, and Total Treated Cases of Lamellar Ichthyosis] scenario of Lamellar Ichthyosis in the 7MM covering United States, EU5 countries (Germany, France, Italy , Spain, and United Kingdom), and Japan from 2017 to 2030.

Lamellar Ichthyosis Detailed Epidemiology Segmentation

  • The total prevalent cases of Lamellar Ichthyosis in the 7MM were found to be 4,038 in 2017 which is expected grow during the study period, i.e., 2017-2030.
  • Estimates show the highest prevalent population of Lamellar Ichthyosis is in the United States followed by Japan, Germany, France, and the United Kingdom in the year 2017.
  • The total diagnosed prevalent population of Lamellar Ichthyosis in the 7MM was assessed to be 2,019 in 2017 which is expected to increase during the study period.
  • As per the DelveInsight analysis, the genetic mutation-specific cases of Lamellar Ichthyosis in the 7MM for TGM1 estimated to be 1,817 for the year 2017. These cases are estimated to increase in upcoming years.
  • The severity-specific cases of Lamellar Ichthyosis in the 7MM for mild and moderate-to-severe cases estimated to be 686 and 1,332, respectively, in 2017.

Scope of the Report

  • The Lamellar Ichthyosis report covers a detailed overview explaining its causes, symptoms, classification, pathophysiology, diagnosis and treatment patterns
  • The Lamellar Ichthyosis Report and Model provide an overview of the risk factors and global trends of Lamellar Ichthyosis in the seven major markets (7MM: US, Germany, France, Italy, Spain, and the United Kingdom, and Japan)
  • The report provides insight about the historical and forecasted patient pool of Lamellar Ichthyosis in seven major markets covering the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom) and Japan
  • The report helps to recognize the growth opportunities in the 7MM with respect to the patient population
  • The report assesses the disease risk and burden and highlights the unmet needs of Lamellar Ichthyosis
  • The report provides the segmentation of the Lamellar Ichthyosis epidemiology by Diagnosed Prevalent Cases of Lamellar Ichthyosis in the 7MM
  • The report provides the segmentation of the Lamellar Ichthyosis epidemiology by Genetic Mutation-specific Diagnosed Prevalent Cases of Lamellar Ichthyosis in the 7MM
  • The report provides the segmentation of the Lamellar Ichthyosis epidemiology by Severity- specific Diagnosed Prevalent of Lamellar Ichthyosis in the 7MM
  • The report provides the segmentation of the Lamellar Ichthyosis epidemiology by Treated Patient Pool of Lamellar Ichthyosis in the 7MM

Report Highlights

  • 11-Year Forecast of Lamellar Ichthyosis epidemiology
  • 7MM Coverage
  • Total Prevalent Cases of Lamellar Ichthyosis
  • Prevalent Cases according to segmentation: Genetic Mutation-specific, Severity-specific Prevalence
  • Treated cases of Lamellar Ichthyosis

KOL-Views

We interview, KOLs and SME's opinion through primary research to fill the data gaps and validate our secondary research. The opinion helps to understand the total patient population and current treatment pattern. This will support the clients in potential upcoming novel treatment by identifying the over Lamellar Ichthyosis scenario of the indications.

Key Questions Answered

  • What will be the growth opportunities in the 7MM with respect to the patient population pertaining to Lamellar Ichthyosis?
  • What are the key findings pertaining to the Lamellar Ichthyosis epidemiology across the 7MM and which country will have the highest number of patients during the study period (2017-2030)?
  • What would be the total number of patients of Lamellar Ichthyosis across the 7MM during the study period (2017-2030)?
  • Among the EU5 countries, which country will have the highest number of patients during the study period (2017-2030)?
  • At what CAGR the patient population is expected to grow in the 7MM during the study period (2017-2030)?
  • What are the various recent and upcoming events which are expected to improve the diagnosis of Lamellar Ichthyosis?
  • What are the different types of genetic mutations in Lamellar Ichthyosis? And among them, which are more prominent in Lamellar Ichthyosis patients?
  • What proportion of Lamellar Ichthyosis patients are suffering from moderate to severe symptoms?

Reasons to buy

The Lamellar Ichthyosis Epidemiology report will allow the user to -

  • Develop business strategies by understanding the trends shaping and driving the global Lamellar Ichthyosis market
  • Quantify patient populations in the global Lamellar Ichthyosis market to improve product design, pricing, and launch plans
  • Organize sales and marketing efforts by identifying the age groups and sex that present the best opportunities for Lamellar Ichthyosis therapeutics in each of the markets covered
  • Understand the magnitude of Lamellar Ichthyosis population by its severity
  • The Lamellar Ichthyosis epidemiology report and model were written and developed by Masters and PhD level epidemiologists
  • The Lamellar Ichthyosis Epidemiology Model developed by DelveInsight is easy to navigate, interactive with dashboards, and epidemiology based with transparent and consistent methodologies. Moreover, the model supports data presented in the report and showcases disease trends over 11-year forecast period using reputable sources

Key Assessments

  • Patient Segmentation
  • Disease Risk and Burden
  • Risk of disease by the segmentation
  • Factors driving growth in a specific patient population

Geographies Covered

  • The United States
  • EU5 (Germany, France, Italy, Spain, and the United Kingdom)
  • Japan

Study Period: 2017-2030

Total Prevalent cases of Lamellar Ichthyosis in the 7MM was assessed to be 4,038 in 2017, and are expected to increase during the study period. Furthermore, among the European-5 countries, the Germany had highest diagnosed prevalent population of Lamellar Ichthyosis, followed by France and the United Kingdom. On the other hand, Spain had the lowest diagnosed prevalent population of Lamellar Ichthyosis. In addition to this, Japan accounts for the 16% of the 7MM patient population of Lamellar Ichthyosis.

Table of Contents

1. Key Insights

2. Executive Summary of Lamellar Ichthyosis

3. Lamellar Ichthyosis (LI): Disease Background and Overview

  • 3.1. Introduction
    • 3.1.1. Ichthyosis
    • 3.1.2. Lamellar Ichthyosis
  • 3.2. Signs and Symptoms of Lamellar Ichthyosis
  • 3.3. Pathogenesis of Lamellar Ichthyosis
  • 3.4. Etiology
  • 3.5. Diagnosis of Lamellar Ichthyosis
    • 3.5.1. Scoring System for Diagnosis
  • 3.6. Algorithm for the Diagnosis of Congenital Ichthyosis Types

4. Epidemiology and Patient Population

  • 4.1. Key Findings: 7MM
  • 4.2. Assumptions and Rationale: 7MM
  • 4.3. Total Prevalent Cases of Lamellar Ichthyosis in the 7MM
  • 4.4. Total Diagnosed Cases of Lamellar Ichthyosis in the 7MM
  • 4.5. Genetic Mutation-specific Cases of Lamellar Ichthyosis in the 7MM
  • 4.6. Severity-Specific Cases of Lamellar Ichthyosis in the 7MM
  • 4.7. Total Treated Cases of Lamellar Ichthyosis in the 7MM

5. United States

  • 5.1. Total Prevalent Cases of Lamellar Ichthyosis in the United States
  • 5.2. Total Diagnosed Cases of Lamellar Ichthyosis in the United States
  • 5.3. Genetic Mutation-specific Cases of LI in the United States
  • 5.4. Severity-Specific Cases of Lamellar Ichthyosis in the United States
  • 5.5. Total Treated Cases of Lamellar Ichthyosis in the United States

6. EU-5 Country-wise Epidemiology

  • 6.1. Germany
    • 6.1.1. Total Prevalent cases of Lamellar Ichthyosis in Germany
    • 6.1.2. Total Diagnosed cases of Lamellar Ichthyosis in Germany
    • 6.1.3. Genetic mutation-specific cases of Lamellar Ichthyosis in Germany
    • 6.1.4. Severity-Specific cases of Lamellar Ichthyosis in Germany
    • 6.1.5. Total Treated cases of Lamellar Ichthyosis in Germany
  • 6.2. France
    • 6.2.1. Total Prevalent cases of Lamellar Ichthyosis in France
    • 6.2.2. Total Diagnosed cases of Lamellar Ichthyosis in France
    • 6.2.3. Genetic mutation-specific cases of Lamellar Ichthyosis in France
    • 6.2.4. Severity-Specific Cases of Lamellar Ichthyosis in France
    • 6.2.5. Total Treated Case of Lamellar Ichthyosis in France
  • 6.3. Italy
    • 6.3.1. Total Prevalent cases of Lamellar Ichthyosis in Italy
    • 6.3.2. Total Diagnosed cases of Lamellar Ichthyosis in Italy
    • 6.3.3. Genetic mutation-specific cases of Lamellar Ichthyosis in Italy
    • 6.3.4. Severity-Specific Cases of Lamellar Ichthyosis in Italy
    • 6.3.5. Total Treated Case of Lamellar Ichthyosis in Italy
  • 6.4. Spain
    • 6.4.1. Total Prevalent cases of Lamellar Ichthyosis in Spain
    • 6.4.2. Total Diagnosed cases of Lamellar Ichthyosis in Spain
    • 6.4.3. Genetic mutation-specific cases of Lamellar Ichthyosis in Spain
    • 6.4.4. Severity-Specific Cases of Lamellar Ichthyosis in Spain
    • 6.4.5. Total Treated Case of Lamellar Ichthyosis in Spain
  • 6.5. United Kingdom
    • 6.5.1. Total Prevalent cases of Lamellar Ichthyosis in the United Kingdom
    • 6.5.2. Total Diagnosed cases of Lamellar Ichthyosis in the United Kingdom
    • 6.5.3. Genetic mutation-specific cases of Lamellar Ichthyosis in the United Kingdom
    • 6.5.4. Severity-Specific Cases of Lamellar Ichthyosis in the United Kingdom
    • 6.5.5. Total Treated Case of Lamellar Ichthyosis in the United Kingdom

7. Japan

  • 7.1. Total Prevalent Cases of Lamellar Ichthyosis in Japan
  • 7.2. Total Diagnosed Cases of Lamellar Ichthyosis in Japan
  • 7.3. Genetic Mutation-specific Cases of Lamellar Ichthyosis in Japan
  • 7.4. Severity-specific Cases of Lamellar Ichthyosis in Japan
  • 7.5. Total Treated Cases of Lamellar Ichthyosis in Japan

8. Appendix

  • 8.1. Bibliography
  • 8.2. Report Methodology

9. Disclaimer

10. DelveInsight Capabilities

11. About DelveInsight

List of Tables

  • Table 1 Summary of Lamellar Ichthyosis Epidemiology (2017-2030)
  • Table 2 Symptoms of Lamellar Ichthyosis
  • Table 3 Molecular Genetics of Autosomal Recessive Congenital Ichthyosis: Most Common Genetic Causes
  • Table 4 Molecular Genetics of Autosomal Recessive Congenital Ichthyosis: Less Common Genetic Causes
  • Table 5 Lamellar Scale Severity Standards-arm
  • Table 6 Investigator's Global Assessment (IGA) Scale
  • Table 7 Major Sources Used
  • Table 8 Total Prevalent Cases of LI in the 7MM (2017-2030)
  • Table 9 Total Diagnosed Cases of LI in the 7MM (2017-2030)
  • Table 10 Genetic Mutation-specific Cases of LI in the 7MM (2017-2030)
  • Table 11 Severity-specific Cases of LI in the 7MM (2017-2030)
  • Table 12 Total Treated Cases of LI in the 7MM (2017-2030)
  • Table 13 Total Prevalent Cases of LI in the United States (2017-2030)
  • Table 14 Total Diagnosed Cases of LI in the United States (2017-2030)
  • Table 15 Genetic Mutation-specific Cases of LI in the United States (2017-2030)
  • Table 16 Severity-specific Cases of LI in the United States (2017-2030)
  • Table 17 Total Treated Cases of LI in the United States (2017-2030)
  • Table 18 Total Prevalent Cases of LI in Germany (2017-2030)
  • Table 19 Total Diagnosed Cases of LI in Germany (2017-2030)
  • Table 20 Genetic Mutation-specific Cases of LI in Germany (2017-2030)
  • Table 21 Severity-specific Cases of LI in Germany (2017-2030)
  • Table 22 Total Treated Cases of LI in Germany (2017-2030)
  • Table 23 Total Prevalent Cases of LI in France (2017-2030)
  • Table 24 Total Diagnosed Cases of LI in France (2017-2030)
  • Table 25 Genetic Mutation-specific Cases of LI in France (2017-2030)
  • Table 26 Severity-specific Cases of LI in France (2017-2030)
  • Table 27 Total Treated Case of LI in France (2017-2030)
  • Table 28 Total Prevalent Cases of LI in Italy (2017-2030)
  • Table 29 Total Diagnosed Cases of LI in Italy (2017-2030)
  • Table 30 Genetic Mutation-specific Cases of LI in Italy (2017-2030)
  • Table 31 Severity-specific Cases of LI in Italy (2017-2030)
  • Table 32 Total Treated Case of LI in Italy (2017-2030)
  • Table 33 Total Prevalent Cases of LI in Spain (2017-2030)
  • Table 34 Total Diagnosed Cases of LI in Spain (2017-2030)
  • Table 35 Genetic Mutation-specific Cases of LI in Spain (2017-2030)
  • Table 36 Severity-specific Cases of LI in Spain (2017-2030)
  • Table 37 Total Treated Case of LI in Spain (2017-2030)
  • Table 38 Total Prevalent Cases of LI In the United Kingdom (2017-2030)
  • Table 39 Total Diagnosed Cases of LI In the United Kingdom (2017-2030)
  • Table 40 Genetic Mutation-specific Cases of LI in the United Kingdom (2017-2030)
  • Table 41 Severity-specific Cases of LI in the United Kingdom (2017-2030)
  • Table 42 Total Treated Case of LI in the United Kingdom (2017-2030)
  • Table 43 Total Prevalent Cases of LI in Japan (2017-2030)
  • Table 44 Total Diagnosed Cases of LI Japan (2017-2030)
  • Table 45 Genetic Mutation-specific Cases of LI in Japan (2017-2030)
  • Table 46 Severity-specific Cases of LI in Japan (2017-2030)
  • Table 47 Total Treated Cases of LI in Japan (2017-2030)

List of Figures

  • Figure 1 Major Function of Skin
  • Figure 2 Cross-section of Skin
  • Figure 3 Structure of the Cell Membrane Zone of Cornified Cells and Key Molecules for The Pathogenesis Of Congenital Ichthyoses
  • Figure 4 Autosomal Recessive Pattern of The Disease
  • Figure 5 Overview of the Diagnostic Procedures for Patients With Suspected Ichthyosis
  • Figure 6 Total Prevalent Cases of LI in The 7MM (2017-2030)
  • Figure 7 Total Diagnosed Cases of LI In The 7MM (2017-2030)
  • Figure 8 Genetic Mutation-specific Cases of LI in The 7MM (2017-2030)
  • Figure 9 Severity-specific Cases of LI in the 7MM (2017-2030)
  • Figure 10 Total Treated Cases of Li in the 7MM (2017-2030)
  • Figure 11 Total Prevalent Cases of LI in the United States (2017-2030)
  • Figure 12 Total Diagnosed Cases of LI in the United States (2017-2030)
  • Figure 13 Genetic Mutation-specific Cases Of LI in the United States (2017-2030)
  • Figure 14 Severity-specific Cases of LI in the United States (2017-2030)
  • Figure 15 Total Treated Cases of LI in the United States (2017-2030)
  • Figure 16 Total Prevalent Cases of LI in Germany (2017-2030)
  • Figure 17 Total Diagnosed Cases of LI in Germany (2017-2030)
  • Figure 18 Genetic Mutation-specific Cases of LI in Germany (2017-2030)
  • Figure 19 Severity-specific Cases of LI in Germany (2017-2030)
  • Figure 20 Total Treated Cases of LI in Germany (2017-2030)
  • Figure 21 Total Prevalent Cases of LI in France (2017-2030)
  • Figure 22 Total Diagnosed Cases of LI in France (2017-2030)
  • Figure 23 Genetic Mutation-specific Cases of LI in France (2017-2030)
  • Figure 24 Severity-specific Cases of LI in France (2017-2030)
  • Figure 25 Total Treated Case of LI in France (2017-2030)
  • Figure 26 Total Prevalent Cases of LI in Italy (2017-2030)
  • Figure 27 Total Diagnosed Cases of LI in Italy (2017-2030)
  • Figure 28 Genetic Mutation-specific Cases of LI in Italy (2017-2030)
  • Figure 29 Severity-specific Cases of LI in Italy (2017-2030)
  • Figure 30 Total Treated Case of LI in Italy (2017-2030)
  • Figure 31 Total Prevalent Cases of LI in Spain (2017-2030)
  • Figure 32 Total Diagnosed Cases of LI in Spain (2017-2030)
  • Figure 33 Genetic Mutation-specific Cases of LI in Spain (2017-2030)
  • Figure 34 Severity-specific Cases of LI in Spain (2017-2030)
  • Figure 35 Total Treated Case of LI in Spain (2017-2030)
  • Figure 36 Total Prevalent Cases of LI in the United Kingdom (2017-2030)
  • Figure 37 Total Diagnosed Cases of LI in the United Kingdom (2017-2030)
  • Figure 38 Genetic Mutation-specific Cases of LI in the United Kingdom (2017-2030)
  • Figure 39 Severity-specific Cases of LI in the United Kingdom (2017-2030)
  • Figure 40 Total Treated Case of LI in the United Kingdom (2017-2030)
  • Figure 41 Total Prevalent Cases of LI in Japan (2017-2030)
  • Figure 42 Total Diagnosed Cases of LI in Japan (2017-2030)
  • Figure 43 Genetic Mutation-specific Cases of LI in Japan (2017-2030)
  • Figure 44 Severity-specific Cases of LI in Japan (2017-2030)
  • Figure 45 Total Treated Cases of LI in Japan (2017-2030)