Market Spotlight: Acute Lymphoblastic Leukemia (ALL)
|出版日期||內容資訊||英文 58 Pages
|關注市場分析:急性淋巴性白血病 (ALL) Market Spotlight: Acute Lymphoblastic Leukemia (ALL)|
|出版日期: 2020年02月03日||內容資訊: 英文 58 Pages||
This Market Spotlight report covers the Acute Lymphoblastic Leukemia (ALL) market, comprising key marketed and pipeline drugs, clinical trials, recent events and analyst opinion, regulatory events, probability of success, patent information, a 10-year disease incidence forecast, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts.
Datamonitor Healthcare estimates that in 2018, there were 86,600 incident cases of acute lymphoblastic leukemia (ALL) worldwide, and expects that number to increase to 93,500 incident cases by 2027.
Approved drugs in the ALL space focus on a wide variety of targets. The majority of these therapies are administered via the intravenous route, with the remaining products being available in oral and intramuscular formulations.
The majority of industry-sponsored drugs in active clinical development for ALL are in Phase I, with two drugs in Phase III. Therapies in development for ALL focus on a wide variety of targets. The majority of pipeline drugs in development are administered via the intravenous route.
The only high-impact upcoming event for drugs in the ALL space is topline Phase II trial results for Sarclisa. The overall likelihood of approval of a Phase I hematologic asset is 10%, and the average probability a drug advances from Phase III is 59.6%. Drugs, on average, take 8.9 years from Phase I to approval, compared to 9.3 years in the overall oncology space.
There have been 32 licensing and asset acquisition deals involving ALL drugs during 2015-20. The $2,000m collaboration and license agreement signed in January 2020 between MorphoSys and Incyte to further develop and commercialize MorphoSys' proprietary anti-CD19 antibody, MOR208 (tafasitamab), globally was the largest deal.
The distribution of clinical trials across Phase I-IV indicates that the vast majority of trials for ALL have been in the early and midphases of development, with 91% of trials in Phase I-II, and only 9% in Phase III-IV.
The US has a substantial lead in the number of ALL clinical trials globally. France leads the major EU markets, while China has the top spot in Asia.
Novartis has the highest number of completed clinical trials for ALL, with 41 trials.
Novartis leads industry sponsors with the highest overall number of clinical trials for ALL.