Market Spotlight: Basal Cell Carcinoma
|出版日期||內容資訊||英文 32 Pages
|焦點市場分析:基底細胞癌 Market Spotlight: Basal Cell Carcinoma|
|出版日期: 2019年11月27日||內容資訊: 英文 32 Pages||
This Market Spotlight report covers the basal cell carcinoma market, comprising key marketed and pipeline drugs, epidemiology, clinical trials, upcoming events, probability of success, patent information, and licensing and acquisition deals, as well as presenting drug-specific revenue forecasts.
The approved drugs in the basal cell carcinoma space target the immune system, thymidylate synthase, reactive oxygen species/free radicals, and Hedgehog signaling pathway. The majority of these therapies are administered via the topical route, with the remainder being oral formulations.
The greatest proportion of industry-sponsored drugs in active clinical development for basal cell carcinoma are in Phase II, with two drugs in Phase III.
Therapies in the pipeline for basal cell carcinoma focus on a wide variety of targets. These drugs are administered via the topical, oral, intravenous, and intratumoral routes.
High-impact upcoming events for drugs in the basal cell carcinoma space comprise topline Phase II trial results for Libtayo and topline Phase III trial results for Ameluz.
The overall likelihood of approval of a Phase I solid tumors asset is 5.6%, and the average probability a drug advances from Phase III is 41%. Drugs, on average, take 9.5 years from Phase I to approval, compared to 9.3 years in the overall oncology space.
There have been five licensing and asset acquisition deals involving basal cell carcinoma drugs during 2014-19. The $175m agreement between Sun Pharmaceutical and Novartis made in December 2016 for the acquisition of Novartis's branded oncology product Odomzo by Sun Pharmaceutical was the largest deal.
The distribution of clinical trials across Phase I-IV indicates that the majority of trials for basal cell carcinoma have been in the early and mid-phases of development, with 80% of trials in Phase I-II, and only 20% in Phase III-IV.
The US has a substantial lead in the number of basal cell carcinoma clinical trials globally, while the UK leads the major EU markets.
Clinical trial activity in the basal cell carcinoma space is dominated by completed trials. Roche has the highest number of completed clinical trials for basal cell carcinoma, with 17 trials.
Roche leads industry sponsors with the highest overall number of clinical trials for basal cell carcinoma, followed by Novartis.
8 Electrodesiccation and curettage (ED&C)
8 Mohs micrographic surgery
8 Excisional surgery
8 Radiation therapy
9 Photodynamic therapy (PDT)
9 Laser surgery
9 Pharmacological therapies
11 Recent incidence studies
19 SRT-100 for Basal Cell Carcinoma (April 23, 2019)
20 Erivedge for Basal Cell Carcinoma (March 25, 2019)
27 Sponsors by status
28 Sponsors by phase
29 Recent events
30 Prescription information