表紙
市場調查報告書

3D細胞培養的全球市場

3D Cell Cultures: Technologies and Global Markets

出版商 BCC Research 商品編碼 950326
出版日期 內容資訊 英文 398 Pages
訂單完成後即時交付
價格
3D細胞培養的全球市場 3D Cell Cultures: Technologies and Global Markets
出版日期: 2020年07月15日內容資訊: 英文 398 Pages
簡介

預計全球細胞培養市場從2020年到2025年的複合年增長率(CAGR)為7.5%,將從2020年的103億美元增長到2025年的148億美元。

研究市場預計將從2020年的51億美元增長到2025年的76億美元,複合年增長率為8.2%。

預計生物加工市場將從2020年的52億美元增長到2025年的6.8%的複合年增長率,到2025年將增長到72億美元。

該報告調查和分析了全球3D細胞培養市場,並提供了有關技術背景,市場分析,細分分析和主要公司的系統信息。

內容

第1章簡介

  • 調查目標和目的
  • 調查原因
  • 報告範圍
  • 目標受眾
  • 調查方法和信息來源
  • 分析師職業
  • 調查
  • 相關報告

第2章摘要

  • 自2015年以來確定的新申請報告
  • 與2015年報告相比的變化
  • 與2017年報告相比的變化
  • 自2017年以來的新應用
  • 自2017年以來的變化

第3章亮點和問題

  • 驚人的行業
  • 行業問題
  • 體外和體內
  • 維度
  • 2D和3D細胞培養研究鏈
  • 成功故事
  • 標準化
  • 規定
  • FDA批准的基因組學
  • 浸出液和浸出液
  • 普遍存在的問題
  • 缺乏研究人員
  • 不斷變化的國際形勢
  • 創新的步伐與多元化
  • 關於細胞培養"其他"領域的評論
  • 無處不在
  • 2020年將成為細胞培養行業的轉折點嗎?
  • 初步市場分析
  • 估計細胞培養市場的增長率
  • 評估大型媒體消費需求
  • 為生物製藥的未來增長建模
  • 細胞培養市場規範示例
  • 預測銷售和增長方面的挑戰
  • 估計細胞培養基市場
  • 細胞和基因療法生物加工領域
  • 生物仿製藥的中等消費量評估
  • 關於合同製造組織(CDMO)
  • 微流體
  • 生物反應器
  • 內部細胞培養資源
  • 藥物開發費用
  • 生物技術所有權集中
  • 3D細胞文化創新的特徵
  • 生物打印戰略路線圖
  • COVID-19對細胞培養行業的影響
  • COVID-19臨床試驗

第4章組織和細胞培養:技術和產品背景

  • 組織和細胞培養的起點
  • 歷史和早期應用
  • 組織培養的發明
  • 連續細胞系的開發
  • 首款細胞培養瓶和嚴格的技術
  • Lindbergh:細胞培養設備的先驅
  • 建立連續細胞系
  • 主要設備開發
  • 術語和概念
  • 組織和細胞培養行業
  • 組織
  • 單元格
  • 電池類型
  • 組織培養和細胞培養的定義
  • 細胞系
  • 細胞培養系統的保養與生長
  • 耗材
  • 培養基,血清,試劑
  • 凝膠和腳手架
  • 微孔板/微量滴定板
  • 設備
  • 生物分析儀器
  • 生物分析成像
  • 生物打印
  • 生物反應器
  • 其他用於細胞培養的設備
  • 嚴格的方法
  • 常規滾瓶
  • 其他系統
  • 信息技術:用於細胞培養研究市場的軟件和服務
  • 用於細胞培養研究市場的軟件
  • 與軟件相關的支持服務
  • 用於細胞培養的生物加工耗材
  • 用於大規模3D文化的微載體
  • 用於大規模3D文化的血清
  • 大規模3D文化的媒介
  • 用於大規模3D培養的生物反應器袋
  • 其他
  • 生物工藝設備
  • 生物處理分析儀器
  • 生物過程自動化系統
  • 生物過程支持裝置
  • 生物製藥和疫苗的大規模生產方面
  • 懸浮蛋白和單克隆抗體
  • 基於細胞的貼壁療法和疫苗
  • 小規模粘附,可製造體細胞,幹細胞和組織
  • 疫苗
  • 疫苗開發的催化劑 使用人類細胞系開發的疫苗
  • 外來體產生
  • 病毒載體的生產
  • 慢病毒生產
  • 質粒生產
  • 細胞培養最終用戶
  • 製藥/生物製藥
  • 大學
  • 政府
  • CRO/CDMOS
  • 其他
  • 細胞培養應用
  • 藥物發現
  • 臨床發展
  • 毒理學
  • 基本調查
  • 生物加工開發
  • 其他
  • 區域市場
  • 美洲
  • 歐洲
  • 亞太地區
  • 其他地區

第5章分析,成像,分析

  • 測定
  • 間充質乾細胞的測定方法開發
  • 國外代理商的體外測試
  • 檢測試劑盒
  • 基於細胞的測定法:概述和新進展
  • 用於基於細胞的測定的細胞
  • 基於3D細胞的分析筆記
  • 動力學代謝測定
  • 細胞增殖
  • 生存力和細胞毒性
  • 細胞活力和通透性測定
  • 細胞浸潤
  • 細胞信號傳導和通信
  • 抑制細胞分裂
  • 細胞死亡分析
  • 圖像技術
  • 圖像分析 螢光作為篩選的生長因子
  • 用於組織和細胞培養的分析系統
  • 瞭解 "細胞組學"
  • HCS支持3D細胞培養
  • NGS檢測池
  • 多重分析
  • 預測毒理學
  • 神經安全
  • 組學攻擊
  • 成績單組合

第6章法規與標準化

  • 美國生物打印產品的監管狀況
  • 生物製劑監管基本指南
  • 再生醫學指導
  • 異種移植指南
  • 再生醫學指導:緊急批准
  • 生物打印產品法規

第7章癌症的3D模型

  • 疾病建模
  • 癌症
  • 研究癌症和其他疾病的主要模型
  • 細胞系
  • 球體和類器官
  • 轉基因小鼠模型(GEMM)
  • 患者源性腫瘤異種移植物(PDX)
  • 概述:細胞水平的癌症
  • 體內(動物)測試標準
  • 鼠標帝國
  • 人性化鼠標
  • 2D文化
  • 3D要求
  • 細胞計數和活力
  • 遷移和入侵
  • 未滿足的需求:血管生成和免疫系統避免
  • 用於癌症研究的3D模型的優勢
  • 區分細胞形態和增殖
  • 更好的基因表達和細胞行為
  • 更好的細胞遷移和侵襲模型
  • 細胞異質性
  • 乳腺癌是3D文化中的生長因子
  • 結構,極性,凋亡
  • 黑色素瘤是3D文化中的生長因子
  • 過渡到球體配置
  • 3D系統用於癌症研究
  • 多細胞腫瘤球
  • 多層細胞培養
  • 3D設計腳手架
  • 天然材料
  • 合成材料
  • 人類癌症模型倡議(HCMI)
  • 下一代人類癌症模型
  • 藥物敏感性和耐藥性
  • 信號和靈敏度變化
  • 耐藥性
  • 細胞信號
  • 整合素介導的細胞信號轉導
  • 藥物篩查
  • 方法和終點
  • 球體應用
  • 基於3D細胞遷移模型的轉移
  • 肺上轉移
  • 癌症新陳代謝
  • 未來領域
  • 換位
  • 共培養
  • 血管生成
  • 癌症相關的成纖維細胞
  • 癌症幹細胞
  • 聯合療法
  • 生物製劑的發展
  • 腫瘤復發
  • 患者來源的細胞
  • 患者源性腫瘤異種移植物(PDX)
  • PDX平台演進

第8章毒性和藥物安全性檢測的情況

  • 簡介
  • 肝臟
  • 心血管毒性
  • 毒理學背景
  • 測試不良皮膚效應
  • 新評估方法對3D細胞培養的影響
  • 化妝品毒性試驗
  • 法規要求的更新
  • 化妝品和含藥化妝品的功效
  • 化妝品毒性試驗方面
  • 皮膚刺激
  • 皮膚腐蝕
  • 光毒性
  • 皮膚過敏
  • 眼睛刺激
  • 急性全身毒性
  • 急性毒性試驗
  • 細胞毒性試驗,用於急性毒性試驗
  • 慢性和反覆劑量毒性
  • 致癌性和遺傳毒性
  • 概述
  • 體外方法:背景和最新發展
  • 法規和藥物開發應用
  • 減少誤報的努力
  • 篩選中的最新創新
  • 未來問題:非遺傳毒性致癌物
  • 生殖和發育毒性
  • 背景
  • 跟隨生殖週期
  • 發育和生殖毒性測試類型 斑馬魚發育毒性篩選模型
  • 斑馬魚與幹細胞的結合
  • 生物醫學前沿:男性睪丸
  • 篩查內分泌干擾物
  • 背景
  • 體外方法對生態毒理學的影響
  • 批量生產化學品
  • ToxCast和Tox 21計劃
  • 未來挑戰:甲狀腺混亂
  • BG1測定
  • 毒物動力學和ADME
  • 體外開發
  • 代謝
  • 低營業額化合物的藥代動力學
  • 器官型模型
  • 皮膚3D模型
  • 3D角膜系統
  • 吸收壁壘模型
  • 胃腸道
  • 血腦屏障
  • 3D組織屏障和細胞外基質的實際架構
  • 肝毒性
  • 肝臟的獨特性和複雜性
  • 肝臟是3D創新的重要推動力
  • 體外肝應用
  • 體內肝臟的功能和結構
  • 肝臟代謝
  • 體外肝模型
  • 肝細胞和巨噬細胞的共培養
  • 3D肝臟模型
  • 生物打印的肝組織
  • 肝細胞的結構和功能
  • 理想標準
  • 耐藥性
  • 運輸者研究
  • 非典型細胞間接觸的實現
  • 未滿足的需求和創新的未來驅動力
  • 形態發生子信號
  • 多供體肝細胞
  • 腎毒性應用
  • 未來的問題:幹細胞衍生的腎細胞
  • 生物打印的腎臟組織
  • 胰腺毒性應用
  • 心血管毒性
  • 商業大道
  • 與監管機構的合作
  • 心血管藥物發現
  • 基於阻抗的微電極陣列(MEA)
  • 生物打印的磁性材料代表主動脈環測定
  • 血管舒張藥活動
  • 3D人造心臟組織

第9章幹細胞的狀況

  • 幹細胞的歷史
  • 幹細胞主要和次要研究領域
  • 3D幹細胞培養系統
  • 盤子或培養皿
  • 旋轉瓶和旋轉壁容器
  • 灌註生物反應器和微載體系統
  • 缺點
  • 微流控和乾細胞
  • 幹細胞生物學簡述
  • 胚胎髮育
  • 幹細胞的生長,結構和形態
  • 幹細胞分化
  • 幹細胞分化和增殖
  • 細胞外基質和乾細胞
  • 可溶性因子
  • 幹細胞生產
  • 胚狀體形成的調控
  • 強制聚合文化
  • 吊降方法
  • 使用
  • 用於高通量篩選的干細胞標記
  • 畸胎瘤和畸胎瘤測定
  • 富士膠片(Cellular Dynamics Inc.)
  • 幹細胞研究的進展
  • 用於神經科學發現和發展的干細胞
  • 示例:阿爾茨海默氏病調查
  • 背景:B-澱粉樣蛋白級聯假說
  • 人類iPSC衍生模型
  • 新的3D模型
  • 3D的其他優點
  • 假定的申請
  • 其他3D神經應用
  • 用於心血管發現的干細胞
  • 幹細胞用於再生醫學的發展
  • 背景:同類還是家庭
  • 微小RNA
  • 誘導多能幹細胞(IPS)

第10章再生醫學:器官移植和皮膚置換

  • 再生醫學
  • 器官移植的必要性
  • 再生醫學的應用
  • 再生醫學投資
  • 皮膚替代行業
  • 同種異體移植和自體移植產品
  • 再生醫學的組織工程

第11章公司簡介

  • 3D BIOPINTING SOLUTIONS
  • 3D BIOTEK LLC
  • 4D TECHNOLOGY
  • ABCAM
  • AKRON BIOTECHNOLOGY LLC
  • AMSBIO LLC
  • AGILENT TECHNOLOGIES
  • ALPCO
  • APPLIKON BIOTECHNOLOGY
  • BECKMAN COULTER LIFE SCIENCES
  • BIOGELX LTD.
  • BIOINSPIRED SOLUTIONS
  • BIOTIME INC.
  • BIOVISION INC.
  • CELL APPLICATIONS INC.
  • CELLINK
  • CELLSPRING
  • CORNING LIFE SCIENCES
  • CYPROTEX PLC
  • CYTIVA
  • CYTOO SA
  • EMD MILLIPORE
  • EMULATE INC.
  • ENVISIONTEC INC.
  • EPITHELIX SARL
  • EUROFINS SAS
  • GREINER BIO-ONE
  • HAMILTON ROBOTICS
  • HUBRECHT ORGANOID TECHNOLOGY
  • HUREL CORP.
  • INSPHERO AG
  • INVITROCUE LTD.
  • KIYATEC INC.
  • LIFENET HEALTH
  • LOREM CYTORI
  • MATTEK CORP.
  • MIMETAS INC.
  • MITRA BIOTECH INC.
  • N3D BIOSCIENCES INC.
  • NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES (NCATS)
  • ORGANOVO
  • PANDORUM TECHNOLOGIES
  • PERKINELMER
  • PLASTICELL LTD.
  • PLURISTEM THERAPEUTICS, INC.
  • POIETIS SAS
  • PROMEGA CORP.
  • QUALYST TRANSPORTER SOLUTIONS LLC (SUBSIDIARY OF BIOIVT)
  • REGENHU LTD.
  • REGENOVO BIOTECHNOLOGY
  • SCREEN HOLDINGS CO. LTD.
  • SEAHORSE BIOSCIENCE
  • STEMCELL TECHNOLOGIES INC.
  • STRATATECH CORP.
  • SYNVIVO INC.
  • TAP BIOSYSTEMS
  • TECAN GROUP LTD.
  • TEVIDO BIODEVICES
  • THERMO FISHER SCIENTIFIC
  • ZEN-BIO INC.
目錄
Product Code: BIO140C

Highlights:

The global market for cell culture should grow from $10.3 billion in 2020 to $14.8 billion by 2025, at a compound annual growth rate (CAGR) of 7.5% for the period of 2020-2025.

Research market should grow from $5.1 billion in 2020 to $7.6 billion by 2025 at a CAGR of 8.2% through 2025.

Bioprocessing market should grow from $5.2 billion in 2020 to $7.2 billion by 2025 at a CAGR of 6.8% through 2025.

Report Scope:

The scope of the report encompasses the major types of 3D cell culture that are being used by industry, academic researchers, government labs, and independent research groups. This includes the main inputs such as cell lines, media, sera, reagents, software, and instrumentation. It analyzes the current market status, examines future market drivers, and presents forecasts of growth over the next five years. The previous edition had a separate section on patent analysis. Here patents have been included by type of technology instead.

The market structure has been re-organized for this edition. Also, more research was done on base case data for different product areas. The greater emphasis is on the different products used for 3D cell culture, but the report also investigates the market in terms of types of applications, end users and geographic regions.

Report Includes:

  • 79 tables
  • An overview of the global markets and technologies for 3D cell cultures
  • Estimation of the market size and analyses of global market trends with estimated data from 2020 to 2024, and projections of compound annual growth rates (CAGRs) through 2025
  • Information on analytical systems used in tissue and cell culture, cellomics and human cancer model initiative (HCMI)
  • Details about assay development for mesenchymal stem cells, In Vitro testing of adventitious agents and description of assays and assay kits
  • A look at the main classes of models for researching cancer and other diseases, benefits of 3D models to cancer research and description of 3D engineered scaffolds
  • Analysis of the market's dynamics, specifically growth drivers, restraints, and opportunities and discussion on the impact of COVID-19 on the world of cell culture
  • Insights into U.S. regulatory status of bioprinted products; basic guidance for the regulation of biologics, regenerative medicine and xenotransplants
  • Relevant patent analysis, including recent activity and a list of key patents
  • Market share analysis of the major players in the industry and their comprehensive company profiles including Agilent Technologies, BioVision Inc., Cell Applications Inc., Envisiontec Inc., Mitra Biotech Inc., Promega Corp. and Thermo Fisher Scientific

Table of Contents

Chapter 1 Introduction

  • Study Goals and Objectives
  • Reasons for Doing the Study
  • Scope of Report
  • Intended Audience
  • Methodology and Information Sources
  • Analyst's Credentials
  • BCC Custom Research
  • Related BCC Research Reports

Chapter 2 Summary

  • New Applications Identified Since 2015 Report
  • Changes from 2015 Report
  • Changes from 2017 Report
  • New Applications Since 2017
  • Changes Since 2017

Chapter 3 Highlights and Issues

  • An Opening Comment on an Amazing Industry
  • Industry Issues
  • In Vitro versus In Vivo
  • Dimensionality
  • The Research Chain for 2D and 3D Cell Culture
  • Best Practices
  • Standardization
  • Regulation
  • Genomics Forcing the Hand of the FDA
  • Leachables and Extractables
  • Broad Issues
  • Research Talent Shortages
  • The Shifting International Picture
  • Pace and Diversification of Innovation
  • A Comment on the "Other" Areas of Cell Culture
  • Omics Everywhere
  • Is 2020 a Watershed Year for the Cell Culture Industry?
  • Preliminary Market Analysis
  • Cell Culture Market Growth Rate Estimates
  • Assessing Large-Scale Media Consumption Needs
  • Modeling Future Growth in Biopharmaceuticals
  • Base Case for the Cell Culture Market
  • Challenges in Projecting Sales and Growth
  • Cell Culture Media Market Estimates
  • Cell and Gene Therapy Bioprocessing Segment
  • Evaluating Media Consumption for Biosimilars
  • What About CDMOs?
  • Microfluidics
  • Bioreactors
  • Internal Cell Culture Resources
  • Drug Development Costs: What to Believe?
  • Is There Too Much Concentration of Ownership in Biotechnology?
  • Characterizing Innovation in 3D Cell Culture
  • Bioprinting Strategic Roadmap
  • Impact of COVID-19 on the World of Cell Culture
  • Clinical Trials on COVID-19

Chapter 4 Tissue and Cell Culture: Technology and Product Background

  • Where did Tissue and Cell Culture Start?
  • History and Early Applications
  • Invention of Tissue Culture
  • Development of Sustained Cell Lines
  • First Cell Culture Flask and Rigorous Techniques
  • Lindbergh: The Cell Culture Equipment Pioneer
  • Establishing Continuous Cell Lines
  • Key Developments in Equipment
  • Terminology and Concepts
  • Tissue and Cell Culture Industry
  • Tissue
  • Cells
  • Cell Types
  • Tissue Culture and Cell Culture Definitions
  • Cell Lines
  • Care and Growth of Cell Culture Systems
  • Consumables
  • Media, Sera and Reagents
  • Gels and Scaffolds
  • Microplates/Microtiter Plates
  • Equipment
  • Bioanalytical Instruments
  • Bioanalytical Imaging
  • Bioprinting
  • Bioreactors
  • Other Equipment for Cell Culture
  • Adherent Approaches
  • Traditional Roller Bottles
  • Other Systems
  • Information Technology: Software and Services for the Cell Culture Research Market
  • Software for the Research Market in Cell Culture
  • Software-Related Support Services
  • Bioprocessing Consumables for Cell Culture
  • Microcarriers for Large-Scale 3D Culture
  • Sera for Large-Scale 3D Culture
  • Media for Large-Scale 3D Culture
  • Bioreactor Bags for Large-Scale 3D Culture
  • Other
  • Bioprocessing Equipment
  • Analytical Equipment for Bioprocessing
  • Automation Systems for Bioprocessing
  • Support Equipment for Bioprocessing
  • Aspects of Large-Scale Manufacturing of Biopharmaceuticals and Vaccines
  • Suspension Proteins and Monoclonal Antibodies
  • Adherent-Cell-Based Therapies and Vaccines
  • Small-Scale Adherent to Make Somatic Cells, Stem Cells and Tissues
  • Vaccines
  • Vaccine Development as a Catalyst
  • Vaccines Developed Using Human Cell Strains
  • Exosome Manufacturing
  • Viral Vector Manufacturing
  • Lentivirus Manufacturing
  • Plasmid Manufacturing
  • Cell Culture End Users
  • Pharma/Biopharma
  • Universities
  • Government
  • CROs/CDMOS
  • Other
  • Cell Culture Applications
  • Drug Discovery
  • Clinical Development
  • Toxicology
  • Basic Research
  • Bioprocessing Development
  • Other
  • Regional Markets
  • The Americas
  • Europe
  • Asia-Pacific
  • Rest of the World

Chapter 5 Assays, Imaging and Analysis

  • Assays
  • Assay Development for Mesenchymal Stem Cells
  • In Vitro Testing of Adventitious Agents
  • Assays and Assay Kits
  • Cell-Based Assays: Overview and Newer Developments
  • Cells Used in Cell-Based Assays
  • Notes on 3D Cell-Based Assays
  • Kinetic Metabolism Assays
  • Cell Proliferation
  • Viability and Cytotoxicity
  • Permeability Assays for Cell Viability and Survival
  • Cell Invasion
  • Cell Signaling and Communication
  • Cytostatic
  • Cell Death Assays
  • Imaging Technology
  • Imaging Assays
  • Fluorescence as a Driver of Screening
  • Analytical Systems Used in Tissue and Cell Culture
  • Understanding "Cellomics"
  • HCS Support of 3D Cell Culture
  • NGS Discovery Pools
  • Multiplex Assays
  • Predictive Toxicology
  • Neuro Safety
  • The Omics Invasion
  • Transcriptomics

Chapter 6 Regulation and Standardization

  • U.S. Regulatory Status of Bioprinted Products
  • Basic Guidance for the Regulation of Biologics
  • Guidance for Regenerative Medicine
  • Guidance for Xenotransplants
  • Guidance for Regenerative Medicine: Emergency Approval
  • Regulating Bioprinted Products

Chapter 7 3D Models for Cancer

  • Disease Modeling
  • Cancer
  • Main Classes of Models for Researching Cancer and Other Diseases
  • Cell Lines
  • Spheroids and Organoids
  • Genetically Engineered Mouse Model (GEMM)
  • Patient-Derived Tumor Xenografts (PDXs)
  • Overview: Cancer at the Cellular Level
  • In Vivo (Animal) Testing Standard
  • Empire of the Mouse
  • Humanized Mice
  • 2D Culture
  • 3D Requirements
  • Cell Number and Viability
  • Migration and Invasion
  • Unmet Needs: Angiogenesis and Immune System Evasion
  • Benefits of 3D Models to Cancer Research
  • Greater Distinction in Cell Morphology and Proliferation
  • Greater Gene Expression and Cell Behavior
  • Better Models of Cell Migration and Invasion
  • Cell Heterogeneity
  • Breast Cancer as a Driver of 3D Cultures
  • Structure, Polarity and Apoptosis
  • Melanoma as a Driver of 3D Cultures
  • Moving to Spheroid Configurations
  • 3D Systems in Cancer Research
  • Multicellular Tumor Spheroids
  • Multilayered Cell Cultures
  • 3D Engineered Scaffolds
  • Natural Materials
  • Synthetic Materials
  • Human Cancer Model Initiative (HCMI)
  • Next-Generation Human Cancer Models
  • Drug Sensitivity and Resistance
  • Altered Signaling and Sensitivity
  • Drug Resistance
  • Cellular Signaling
  • Cellular Signaling Mediated by Integrins
  • Drug Screening
  • Approaches and Endpoints
  • Spheroid Applications
  • Metastasis via 3D Cell Migration Model
  • Metastasis via Lung-on-Chip
  • Cancer Metabolism
  • Future Horizons
  • Metastases
  • Coculture
  • Vascularization
  • Cancer-Associated Fibroblasts
  • Cancer Stem Cells
  • Combination Therapies
  • Biologics Development
  • Tumor Recurrence
  • Patient-Derived Cells
  • Patient-Derived Tumor Xenografts (PDXs)
  • Evolution of PDX Platforms

Chapter 8 Landscape for Toxicology and Drug Safety Testing

  • Introduction
  • Liver
  • Cardiovascular Toxicity
  • Toxicology Background
  • Testing for Adverse Effects on the Skin
  • New Assessment Methodologies Impact on 3D Cell Culture
  • Toxicology Testing in Cosmetics
  • Updated Regulatory Requirements
  • Efficacy of Cosmetics and Cosmeceuticals
  • Aspects of Cosmetic Toxicity Testing
  • Skin Irritation
  • Skin Corrosion
  • Phototoxicity
  • Skin Sensitization
  • Eye Irritation
  • Acute Systemic Toxicity
  • Acute Toxicity Testing
  • Cytotoxicity Assays for Acute Toxicity Testing
  • Chronic and Repeated Dose Toxicity
  • Carcinogenicity and Genotoxicity
  • Overview
  • In Vitro Methods: Background and Recent Developments
  • Regulatory versus Drug Development Applications
  • Efforts to Reduce False Positives
  • Recent Innovations in Screening
  • Future Challenge: Non-genotoxic Carcinogens
  • Reproductive and Developmental Toxicity
  • Background
  • Following the Reproductive Cycle
  • Development and Reproductive Tox Testing Types
  • Zebrafish Model for Developmental Toxicity Screening
  • Combination of Zebrafish and Stem Cells
  • Biomedical Frontiers: Male Testis
  • Endocrine Disruptor Screening
  • Background
  • Environmental Toxicology Impacts In Vitro Methods
  • High-Production Volume Chemicals
  • ToxCast and Tox 21 Initiatives
  • Future Challenge: Thyroid Disruption
  • BG1 Assay
  • Toxicokinetics and ADME
  • In Vitro Developments
  • Metabolism
  • Pharmacokinetics of Low Turnover Compounds
  • Organotypic Models
  • 3D Models for Skin
  • 3D Corneal System
  • Absorption Barrier Models
  • Gastrointestinal
  • Lung
  • Blood-Brain Barrier
  • Real Architecture for 3D Tissue Barriers and Extracellular Matrix
  • Liver Toxicity
  • Uniqueness and Complexity of Liver
  • Liver as a Key Driver for 3D Innovation
  • In Vitro Liver Applications
  • In Vivo Liver Function and Structure
  • Liver Metabolism
  • In Vitro Liver Models
  • Cocultures of Hepatocytes and Macrophages
  • 3D Liver Models
  • Bioprinted Liver Tissue
  • Detected Hepatosphere Structures and Functionality
  • Ideal Criteria
  • Drug Resistance
  • Transporter Studies
  • Achieving Heterotypic Cell-Cell Contacts
  • Unmet Needs and Future Drivers of Innovation
  • Morphogen Signaling
  • Multi-donor Liver Cells
  • Kidney Toxicity Applications
  • Future Challenge: Stem-Cell Derived Kidney Cells
  • Bioprinted Kidney Tissue
  • Pancreatic Toxicology Applications
  • Cardiovascular Toxicity
  • Commercial Avenue
  • Collaboration with Regulators
  • Cardiovascular Drug Discovery
  • Microelectrode Arrays (MEAs) Based on Impedance
  • Surrogate for Aortic Ring Assay via Bioprinted Magnetics
  • Vasodilator Activity
  • 3D Engineered Heart Tissues

Chapter 9 Stem Cell Landscape

  • A History of Stem Cells
  • Major and Minor Research Areas for Stem Cells
  • 3D Stem Cell Culture Systems
  • Plate or Culture Dish
  • Spinner Flask and Rotating Wall Vessel
  • Perfusion Bioreactor and Microcarrier Systems
  • Shortcomings
  • Microfluidics and Stem Cells
  • Short Review of Stem Cell Biology
  • Embryogenesis
  • Growth, Structure and Morphology of Stem Cells
  • Stem Cell Differentiation
  • Stem Cell Differentiation versus Proliferation
  • Extracellular Matrix and Stem Cells
  • Soluble Factors
  • Manufacturing Stem Cells
  • Controlling Embryoid Body Formation
  • Forced Aggregation Cultures
  • Hanging-Drop Approach
  • Applications
  • Stem Cell Markers for High-Throughput Screening
  • Teratomas and the Teratoma Assay
  • Fujifilm (Cellular Dynamics Inc.)
  • Stem Cell Research Breakthroughs
  • Stem Cells for Neuroscience Discovery and Development
  • Example: Alzheimer's Research
  • Background: B-Amyloid Cascade Hypothesis
  • Human iPSC-Derived Models
  • New 3D Model
  • Other Advantages of 3D
  • Envisioned Applications
  • Other 3D Neuro Applications
  • Stem Cells for Cardiovascular Discovery
  • Stem Cells for the Development of Regenerative Medicine
  • Background: Allogenic versus Autologous
  • MicroRNAs
  • Induced Pluripotent Stem Cells (IPS)

Chapter 10 Regenerative Medicine: Organ Transplants and Skin Substitutes

  • Regenerative Medicine
  • Need for Organ Transplants
  • Applications in Regenerative Medicine
  • Investments in Regenerative Medicine
  • Skin Substitutes Industry
  • Tissue Culture Allograft and Autograft Products
  • Tissue Engineering in Regenerative Medicine

Chapter 11 Company Profiles

  • 3D BIOPINTING SOLUTIONS
  • 3D BIOTEK LLC
  • 4D TECHNOLOGY
  • ABCAM
  • AKRON BIOTECHNOLOGY LLC
  • AMSBIO LLC
  • AGILENT TECHNOLOGIES
  • ALPCO
  • APPLIKON BIOTECHNOLOGY
  • BECKMAN COULTER LIFE SCIENCES
  • BIOGELX LTD.
  • BIOINSPIRED SOLUTIONS
  • BIOTIME INC.
  • BIOVISION INC.
  • CELL APPLICATIONS INC.
  • CELLINK
  • CELLSPRING
  • CORNING LIFE SCIENCES
  • CYPROTEX PLC
  • CYTIVA
  • CYTOO SA
  • EMD MILLIPORE
  • EMULATE INC.
  • ENVISIONTEC INC.
  • EPITHELIX SARL
  • EUROFINS SAS
  • GREINER BIO-ONE
  • HAMILTON ROBOTICS
  • HUBRECHT ORGANOID TECHNOLOGY
  • HUREL CORP.
  • INSPHERO AG
  • INVITROCUE LTD.
  • KIYATEC INC.
  • LIFENET HEALTH
  • LOREM CYTORI
  • MATTEK CORP.
  • MIMETAS INC.
  • MITRA BIOTECH INC.
  • N3D BIOSCIENCES INC.
  • NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES (NCATS)
  • ORGANOVO
  • PANDORUM TECHNOLOGIES
  • PERKINELMER
  • PLASTICELL LTD.
  • PLURISTEM THERAPEUTICS, INC.
  • POIETIS SAS
  • PROMEGA CORP.
  • QUALYST TRANSPORTER SOLUTIONS LLC (SUBSIDIARY OF BIOIVT)
  • REGENHU LTD.
  • REGENOVO BIOTECHNOLOGY
  • SCREEN HOLDINGS CO. LTD.
  • SEAHORSE BIOSCIENCE
  • STEMCELL TECHNOLOGIES INC.
  • STRATATECH CORP.
  • SYNVIVO INC.
  • TAP BIOSYSTEMS
  • TECAN GROUP LTD.
  • TEVIDO BIODEVICES
  • THERMO FISHER SCIENTIFIC
  • ZEN-BIO INC.

List of Tables

  • Summary Table: Global Market for Cell Culture, by Segment, Through 2025
    • Table 1: Dimensionality of Cell Culture
    • Table 2: WHO R&D Roadmap of Priority Infectious Diseases
    • Table 3: 3D Bioprinting Roadmap
    • Table 4: Selected Online Prices for Bioreactors
    • Table 5: Current Clinical Trials on Remdesivir
    • Table 6: Tissue Types
    • Table 7: Cell Types Based on Developmental Origin
    • Table 8: Leading Cell Line Suppliers, April 2020
    • Table 9: Commonly Used Transformed Cells Lines
    • Table 10: Major Primary Cell Lines
    • Table 11: Leading Primary Cell Suppliers, April 2020
    • Table 12: Main Types of Stem Cells
    • Table 13: Stem Cell Services
    • Table 14: Areas of Interest in 3D Spheroid Research
    • Table 15: Global Market for Cell Culture Consumables in Research, Through 2025
    • Table 16: Selected Nanoparticle Products Used in Life Science Research
    • Table 17: Results of Liver-Chip Drugs Halted in Previous Clinical Trials Based on Animal Studies
    • Table 18: Companies and Universities Involved in the Organ-on-a-Chip Industry
    • Table 19: Global Market for Cell Culture Equipment, by Type, Through 2025
    • Table 20: Microfluidics Companies
    • Table 21: Selected Recent Patents Issued on Microfluidic Devices Related to Cell Culture Applications
    • Table 22: Selected Papers Published on Recent Microfluidic Advances in Cell Culture
    • Table 23: High-Content Screening Suppliers and Key Attributes, April 2020
    • Table 24: Selected Patents Issued Related to Flow Cytometers
    • Table 25: Thermo Fisher Imaging Products
    • Table 26: Publicly Disclosed Funding of Bioprinting Companies, 2017-2020*
    • Table 27: Bioprinting Company Deals and Strategic Partnerships, 2019 and 2020
    • Table 28: Bioprinting Modalities
    • Table 29: Maintaining Cell Viability During Printing
    • Table 30: Bioprinting Instrument Industry
    • Table 31: Biomaterial Components
    • Table 32: Bioink Types
    • Table 33: Classes of Matrix Bioink Hydrogels
    • Table 34: Matrix Bioink Selection Criteria
    • Table 35: Selected Bioink Companies, 2020
    • Table 36: Projected Unit Sales of Research Bioreactors, <10 Liters, 2020
    • Table 37: Leading Bioreactor Suppliers, 2020
    • Table 38: Label-Free Technologies and Suppliers, April 2020
    • Table 39: Global Market for Software and Services for Cell Culture Research, Through 2025
    • Table 40: Global Market for Bioprocessing Consumables for Cell Culture, Through 2025
    • Table 41: Global Market for Cell Culture Bioprocessing Equipment, by Type, Through 2025
    • Table 42: Global Market for Software for Cell Culture in Bioprocessing, Through 2025
    • Table 43: Developmental Issues Facing the Commercialization of Exosomes
    • Table 44: Companies Working on Exosome Products
    • Table 45: Global Market for Cell Culture, by End User, Through 2025
    • Table 46: Global Market for Cell Culture, by Application, Through 2025
    • Table 47: Global Market for Cell Culture, by Region, Through 2025
    • Table 48: Typical Assay Endpoints and Tests
    • Table 49: U.S. Patents on Assays Systems, 2019 and 2020
    • Table 50: Selected U.S. Patents on Assay Imaging, 2019 and 2020
    • Table 51: Recently Issued U.S. Patents on Cellomics, 2017-2019
    • Table 52: Toxicology Issues That Need to Be Addressed for FDA-Regulated Products
    • Table 53: Overview of Federal Regulation of the Cell Culture Markets
    • Table 54: FDA List of Cell, Biologic and Tissue Products Regulated Under CBER and CDRH
    • Table 55: FDA "Talking Point" Recommendations for Regenerative Medicine Advanced Therapies (RMATs)
    • Table 56: U.S. Regulatory Considerations
    • Table 57: Main Types of Models for Researching Cancer and Other Diseases
    • Table 58: Goals of Funding Opportunity Announcement RFA-CA-19-055
    • Table 59: Common 3D Assays
    • Table 60: 3D Tumor Models Developed for Drug Discovery, June 2017
    • Table 61: Summary of the Benefits and Advantages of EV3D
    • Table 62: ECVAM List of Current Activities, 2020
    • Table 63: In Vitro Testing in Cosmetics, by Test Class
    • Table 64: In Vitro and In Vivo Assays in the Tier 1 Screening Battery, January 2014
    • Table 65: Timeline of Key Developments in Stem Cell Research, 1978-2006
    • Table 66: Major and Minor Research Areas in Stem Cells
    • Table 67: Stem Cell Usage in Research
    • Table 68: Recent U.S. Patents Granted on Stem Cell Technologies
    • Table 69: Papers Published on Selected Stem Cell Research Trends
    • Table 70: Comparison of the Number of Citations in the Literature on Cell Culture versus Stem Cell Culture
    • Table 71: Number of Organ Transplants Performed in the United States, 2018 and 2019
    • Table 72: Total Global Financing of Regenerative Medicine
    • Table 73: Total Financing of Regenerative Medicine, by Therapeutic Area
    • Table 74: Leading Tissue Products and Suppliers, April 2020
    • Table 75: Printed Tissue and Organs: Commercialization Timeframe
    • Table 76: Tissue/Organ Complexity
    • Table 77: New Bioassay Kits Introduced by BioVision
    • Table 78: Partial List of Specialty Media Formulations Sold by Cell Applications Inc.

List of Figures

  • Summary Figure: Global Market for Cell Culture, by Segment, 2020-2025
    • Figure 1: Research Chain for Cell Culture
    • Figure 2: A Model for The Evolution of FDA Regulation
    • Figure 3: An Innovation Matrix
    • Figure 4: Bioprinting Strategic Roadmap
    • Figure 5: Gastrointestinal Organotype Cultures
    • Figure 6: iCELLis Nanoreactor: Example of Commercial 2D Cell Culture Systems
    • Figure 7: Prototype of 3D Model Lung-on-a-Chip from Wake Forest
    • Figure 8: Recent Photos of the HepaChip
    • Figure 9: Recent Photos of the HepaChip-MWP
    • Figure 10: University of Toronto Handheld Bioprinting Device
    • Figure 11: Collaborative Experiment Conducted by American, Russian and Israeli Scientists
    • Figure 12: Smart Marbles Concept for Quantifying Process Heterogeneity
    • Figure 13: Porcine Intestinal Organoids
    • Figure 14: Diagram of the Components of a Predictive Toxicology System
    • Figure 15: Gleason's Pattern
    • Figure 16: Diagram of PDXs, Cell Lines and Organoid/Spheroid Xenografts
    • Figure 17: Cell Heterogeneity and Its Function
    • Figure 18: Electron Micrograph of Porous Microcarrier for Stem Cell Production
    • Figure 19: Photograph of Apligraf