未來的美國分子診斷市場:成長機會及產業擴張策略

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	市場調查報告書 - 224815 未來的美國分子診斷市場:成長機會及產業擴張策略 US Molecular Diagnostics Market Outlook: Innovations, Trends and Opportunities for Suppliers
出版商	Venture Planning Group
出版日期	2013年05月16日	內容資訊	英文
價格	USD 2,100 PDF by E-mail (Global license) USD 6,200 DataPack USD 9,500 PDF by E-mail (Local license)

簡介
目錄

簡介

本報告提供美國的分子診斷市場最新趨勢與未來展望相關分析，提供診斷技術的研究開發最新趨勢，全球市場概況，美國市場的基本結構與趨勢，今後10年趨勢預測，市場擴大的策略與課題，再加上主要企業簡介等資訊彙整，為您概述為以下內容。

簡介

全球市場及技術概要

DNA定序
DNA及RNA核酸探針技術
檢測技術
醫療設備的檢討(全9種)
生物晶片:基因感測器·微陣列·Labs-on-the-Chip
藥理基因學
主要用途
- 微生物學/感染疾病
- 癌症篩檢
- 遺傳基因疾病
- 法醫檢查
- 親子鑑定/HLA鑑定
- 其他用途
成本分析
競爭·補充技術
醫療費退還的問題
全球市場概況
- 商業環境
- 市場結構
- 市場規模·成長

美國市場

執行摘要
商業環境
- 醫療費用支出
- 成本意願
- 醫療費退還
- 產業內的企業整合
- 管理護理(管理型醫療)
- 醫院
- 住院
- 逗留期間
- 產業的多樣化
- 醫生的事項組成
- 人口的高齡化
- 研究機關比法規
- FDA的改革
市場結構
- 醫院
- 民間/私有研究機關
- 血液銀行
市場規模，成長，及主要業者的銷售額·市場佔有率

主要的產品開發機會

測量設備
試劑組以及檢查系統/操作板
電腦·軟體·自動化
輔助產品

分散檢驗產品的設計標準

替代性的市場滲透策略

內部開發
合資企業協定
與大學的契約
分散檢驗產品的流通策略
- 行銷的方法
- 產品的複雜性
- 客戶的偏好
- 現有的供應商
- 新加入廠商供應商
- 主要的種類的經銷商
- 市場分類

潛在性打入市場的障礙與風險

市場的成熟度
成本控制
競爭
技術的優勢與限制
專利保護
來自法規的抑制
分散檢驗市場課題

競爭企業簡介

Abbott
Aclara
Affymetrix
Agilent
Ambion
Applied Biosystems
ARCA Biopharma
Beckman Coulter
BD
Biokit
bioMerieux
Biotest
Caliper
Cepheid
Chiron
Decode
Diadexus
Digene
榮研化學
Enzo
Exact Sciences
富士Rebio
Gen-Probe
Gene Tec
Illumina
Innogenetics
Kreatech
Li-Cor
Myriad Genetics
Nanogen
Orchid Biosciences
Qiagen
Roche
Sangtec
Sequenom
Seracare Life Science
Scienion
Sierra Diagnostics
島津製作所
TaKaRa BIO
Tepnel Life Sciences
Tecan Group
Third Wave

附錄

附錄1:開發販售分子診斷用試劑、套件的主要企業
附錄2:開發分子診斷技術的大學及研究中心
附錄3:詞彙
附錄4:匯率

圖表一覽

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Description

This report presents a comprehensive analysis of the US molecular diagnostics market, including:

Major issues pertaining to the US molecular diagnostics laboratory practice, as well as key economic, regulatory, demographic, social and technological trends with significant market impact during the next ten years.
An extensive review of DNA probe and biochip technologies, test formats, detection methodologies, trends in testing automation and amplification methods.
Ten-year test volume and reagent sales forecasts for the following categories:

   - Infectious Diseases
   - Genetic Diseases
   - Cancer
   - Paternity Testing/HLA Typing
   - Forensic Testing

Review of testing methodologies an instrumentation technologies.
Feature comparison of automated and semiautomated analyzers.
Sales and market shares of leading suppliers.
Over 60 specific opportunities for molecular diagnostic instruments, test systems, IT and auxiliary products.
Profiles of major suppliers, and emerging market entrants, including their sales, product portfolios, marketing tactics, technological know-how, new products in R&D, collaborative arrangements and business strategies.
Alternative market penetration strategies.
Potential market entry barriers and risks.
Business planning issues and concerns.

Contains 880 pages and 37 tables

Introduction

Worldwide Market And Technology Overview

A. DNA Sequencing
- 1. Introduction
- 2. Sequencing Methods
- 3. Autoradiography
- 4. The Human Genome Project
- 5. Sequencing Automation
- 6. Image Scanners
- 7. Fluorescent Detection
- 8. Gene Profiling
- 9. Gene Expression
- 10. Polymorphism Screening
- 11. Protein Interaction Networks
B. DNA And RNA Probe Technology
- 1. Basic Principles
- 2. Probe Preparation
- 3. The DNA Probe Test
  - a. Sample Preparation
  - b. Hybridization
  - c. Separation
  - d. Detection/Measurement
- 4. Test Formats
  - a. Filter Hybridization
  - b. Southern Blot
  - c. Northern Blot
  - d. In Situ Hybridization
  - e. Others
- 5. Labeling Techniques
- 6. Amplification Methods
  - Polymerase Chain Reaction
    - Temperature Cyclers
    - PCR Variations
      - Immuno-PCR
      - QC-PCR
      - DAP-PCR
  - Strand Displacement Activation
  - TMA
  - Ligase Chain Reaction
  - Branched DNA
    - Hybridization Protection Assay
  - Nucleic-Acid Sequence-Based Amplification
  - Self-Sustained Sequence Replicase
  - Others
    - Ampliprobe
    - CAR
    - CAS
    - CPT
    - Dendritic Polymer Technology
    - ISO-CR
    - LAT
    - Probe Networks
    - RAMP
    - Repair Chain Reaction
    - Rolling Circles
    - Sequence Independent Gene Amplification
    - Sequence Initiation Reaction
    - SISPA
    - Solid Phase Amplification
C. Detection Technologies
- 1. Radioactive Methods
  - a. Overview
  - b. Major Isotopes
    - P-32
    - S-35
    - H-3
    - I-125
- 2. Non-Isotopic Methods
  - a. Enzymatic Labels
  - b. Chemical Labeling
    - Indirect Chemical Labeling
    - Direct Chemical Labeling
  - c. Fluorescence
  - d. Chemiluminescence
  - e. Electrical Conductivity
D. Instrumentation Review
- 1. Abbott LCx
- 2. Beckman Coulter/Biomek FK
- 3. Becton Dickinson SDA
- 4. Bio-Rad GeneScope
- 5. Gen-Probe Tigris
- 6. Roche Cobas Amplicor
- 7. Tecan LS Series
E. Biochips: Genosensors, Microarrays, and Labs-on-the-Chip
- Liquid Transportation and Mixing
- Separation
- Reaction
- Detection
F. Pharmacogenomics
G. Major Applications
- 1. Microbiology/Infectious Diseases
  - a. Overview
  - b. Major Infectious Diseases
    - AIDS
      - Structure and Composition
      - Classification
      - AIDS Origins
      - Animal Lentivirus Systems
      - Virus Receptors
      - HIV Infections in Humans
        
        Pathogenesis and Pathology
      - CD4T Lymphocytes and Memory Cells
      - Monocytes and Macrophages
      - Lymphoid Organs
      - Neural Cells
      - Viral Coinfections
        
        Clinical Findings
      - Plasma Viral Load
      - Pediatric AIDS
        
        Neurologic Disease
        Opportunistic Infections
        Cancer
      - Immunity
        
        Virus Isolation
        Serology
        Viral Nucleic Acid/Antigen Detection
      - Epidemiology
        
        Worldwide Spread of AIDS
        United States
        Routes of Transmission
      - DNA Probes
        
        Overview
        Quantitative PCR
        In Situ PCR
        Needed Improvements
      - Viral Load/Drug Resistance Testing
      - Genotype and Phenotype Testing
      - Blood Banking Considerations
    - Adenovirus
      - Background
      - Diagnostic Tests
      - Vaccines and Drugs
      - Adeno-Associated Viruses (AAV)
    - Anthrax/Bacillus Anthracis
      - Background
      - Diagnostic Tests
      - Vaccines and Drugs
    - Babesiosis
      - Background
    - BEA and Other Bartonella Diseases
      - Background
      - Diagnostic Tests
      - Vaccines and Drugs
    - Chagas Disease
      - Background
    - Campylobacter
      - Background
      - Diagnostic Tests
        
        Culture Identification
      - Vaccines and Drugs
    - Chlamydia
      - Background
        
        Chlamydia psittaci
        Chlmaydia pneumoniae
        Chlamydia trachomatis
      - Diagnostic Tests
      - Vaccines and Drugs
    - Creutzfeldt-Jakob's Disease
      - Background
      - Blood Transmission
      - Diagnostic Tests
      - Major Commercial and Academic Players
        
        Bayer
        Disease Sciences/Bio Tec Global
        Imperial College School of Medicine
        Ortho-Clinical Diagnostics
        Pall
        ProMetic Life Sciences
        Proteome Sciences/Idexx
        Q-One Biotech
        Serono
        U.S. Agricultural Research Service
      - Drugs
      - Vaccines
    - Cytomegalovirus
      - Background
        
        Chorioretinitis
        Gastrointestinal
        Central Nervous System Disease
      - Diagnostic Tests
      - Vaccines and Drugs
    - Ebola Virus
      - Background
        
        Epidemiology
        Clinical Syndromes
      - Diagnostic Tests
      - Vaccines and Drugs
    - EchoVirus
      - Background
        
        Acute Aseptic Meningitisis
        Encephalitis
        Exanthems
        Respiratory Disease
        Myopericarditis
    - Neonatal Infections
      - Diagnostic Tests
      - Vaccines and Drugs
    - Encephalitis
      - Background
      - Diagnostic Tests
      - Vaccines and Drugs
    - Enteroviruses
      - Background
      - Diagnostic Tests
        
        Viral Isolation and Identification
        Antibody Tests
      - Vaccines and Drugs
    - Epstein-Barr Virus
      - Background
      - Diagnostic Tests
      - Vaccines and Drugs
    - Gonorrhea
      - Background
      - Diagnostic Tests
      - Vaccines and Drugs
    - Hepatitis
      - Hepatitis A
      - Hepatitis B
        
        Structure and Composition
        Replication
      - Hepatitis C
      - Hepatitis D (Delta)
      - Hepatitis E
      - Hepatitis G
      - Hepatitis Infections Pathology
      - Clinical Findings
      - Laboratory Tests
        
        Hepatitis A
        Hepatitis B
        Hepatitis C
        Hepatitis D
        Hepatitis E
      - Virus-Host Immune Reactions
      - Epidemiology
        
        Hepatitis A
        Hepatitis B
        Hepatitis C
        Hepatitis D (Delta)
      - Vaccines and Drugs
    - Herpes Simplex Virus
      - Background
      - Diagnostic Tests
      - Vaccines and Drugs
    - Legionella
      - Background
      - Diagnostic Tests
      - Vaccines and Drugs
    - Lyme Disease
      - Background
        
        Clinical Description
        Clinical Case Definition
        Laboratory Criteria for Diagnosis
        Case Classification
      - Diagnostic Tests
      - Vaccines and Drugs
    - Malaria
    - Mycoplasma
      - Background
        
        Ureaplasma Urealyticum & Mycoplasma Hominis
      - Diagnostic Tests
      - Vaccines and Drugs
    - Papillomaviruses/HPV
      - Background
        
        HPV in Cancer
        Cervical Neoplasm
      - Diagnostic Tests
      - Vaccines and Drugs
        
        Prevention
    - Parvovirus B19
      - Background
        
        Microbiology
        Epidemiology
        Clinical Syndromes
        Erythema Infectiosum (Slapped Cheek)
        Adult Polyarthropathy
        Transient Aplastic Crisis
        Transient Pancytopenia
        Red Cell Aplasia in Immunocompromised
        Perinatal Infections
      - Diagnostic Test
      - Vaccines and Drugs
    - Pneumonia
      - Background
      - Diagnostic Tests
      - Vaccines and Drugs
    - Polyomaviruses
      - Background
      - Diagnostic Tests
      - Vaccines and Drugs
    - Salmonellosis
      - Background
      - Diagnostic Tests
      - Vaccines and Drugs
    - Shigellosis
      - Background
      - Diagnostic Tests
      - Vaccines and Drugs
    - Streptococci
      - Background
      - Diagnostic Tests
      - Vaccines and Drugs
        
        Group A Streptococci
        Group B Streptococci
    - Toxoplasmosis
      - Background
      - Diagnostic Tests
      - Vaccines and Drugs
    - Tuberculosis
      - Background
      - Diagnostic Tests
        
        Microscopic Characteristics
        Cultural Characteristics
        Skin Tests
        MDRTB
      - Vaccines and Drugs
    - West Nile Virus
      - Background
        
        Clinical Syndromes
      - Diagnostic Tests
      - Vaccines and Drugs
    - Yersinia
      - Background
      - Diagnostic Tests
      - Vaccines and Drugs
  - c. Antibiotic Susceptibility
- 2. Cancer Testing
  - a. Overview
  - b. Major Cancer Types
    - Prostate
    - Lung
    - Colon and Rectum
    - Breast
    - Skin
    - Uterine
    - Leukemia
    - Oral
  - c. Oncogenes
    - Abl/abl-bcr
    - AIB1
    - BCL-2
    - BRCA1
    - CD44
    - C-fos
    - C-myb
    - C-myc
    - CYP17
    - Erb-B
    - HPC1
    - N-myc
    - P40
    - P51
    - P53
    - PIK3CA
    - PTI-1
    - Ras
    - Reg
    - Sis
    - Src
- 3. Genetic Diseases
  - a. Overview
  - b. Nucleic Acid Amplification
  - c. Chromosome Imaging
  - d. Genomics Technologies
  - e. Proteomics Technologies
  - f. Current Pharmacogenomic Tests
  - g. Future Pharmacogenomic Testing
  - h. Major Diseases
    - Achondroplasia
    - Autosomal Dominant Polycystic Kidney Disease
    - Cancer
    - Cosmetogenomics
    - Cystic Fibrosis
    - Down's Syndrome
    - Duchenne and Becker Muscular Dystrophy
    - Factor V (Leiden)
    - Factor IX Deficiency
    - Fragile X Syndrome
    - Heart Disease
    - Hemochomatosis
    - Hemophilia
    - Huntington's Disease
    - Maternal-Fetal Incompatibility
    - Multiple Endocrine Neoplasia
    - Phenylketonuria (PKU)
    - Polycystic Kidney Disease (PKD)
    - Prenatal Screening
    - Retinitis Pigmentosa
    - Retinoblastoma
    - Sickle Cell Anemia
    - Spinal Muscular Atrophy
    - Vitamin B12 Metabolism
  - i. Social Issues and Concerns
- 4. Forensic Testing
  - a. Overview
  - b. Multilocus and Single Locus Probes
    - Multilocus Probes
    - Single Locus Probes
    - PCR and RFLP
  - c. The FBI
  - d. DNA Profile Data Banks
    - U.S.A.
    - U.K.
  - e. Judicial Implementation
  - f. Major Crime Categories
  - g. Factors Contributing to the DNA Probe Market Expansion
    - Technology Availability
    - Use of Hair as Evidence
  - h. Wildlife Forensics
- 5. Paternity Testing/HLA Typing
- 6. Other Applications
  - a. Disease Susceptibility Testing
  - b. Cardiovascular Diseases
  - c. Diabetes
  - d. Alzheimer's Disease
  - e. Periodontal Disease
  - f. Plasma Purification
  - g. Organ Transplantation
  - h. Water Contamination
  - i. Other
H. Competing/complementing Technologies
- 1. Monoclonal Antibodies/Immunoassays
- 2. RNA Probes
- 3. Two-Dimensional Electrophoresis
- 4. Flow Cytometry

U.S.A.

A. Executive Summary
B. Business Environment
- 1. Health Care Expenditures
- 2. Cost Consciousness
- 3. Reimbursement
- 4. Industry Consolidation
- 5. Managed Care
  - a. PPO
  - b. HMO
- 6. Hospitals
- 7. Admissions
- 8. Length of Stay
- 9. Industry Diversification
- 10. Physician Demographics
- 11. Population Aging
  - a. Chronic Illness
  - b. Disease Incidence
  - c. Susceptibility to Iatrogenesis
  - d. Multiple Illness Cases
- 12. Laboratory Regulations
- 13. FDA Reform
C. Market Structure
- 1. Hospitals
- 2. Commercial/Private Laboratories
- 3. Blood Banks
D. Market Size, Growth and Major Suppliers' Sales and Market Shares

Major Product Development Opportunities

A. Instrumentation
B. Reagent Kits and Test Systems/panels
C. Computers, Software and Automation
D. Auxiliary Products

Design Criteria For Decentralized Testing Products

Alternative Market Penetration Strategies

A. Internal Development
B. Collaborative Arrangements
C. University Contracts
D. Distribution Strategies For Decentralized Testing Markets
- 1. Marketing Approaches
- 2. Product Complexity
- 3. Customer Preference
- 4. Established Suppliers
- 5. Emerging Suppliers
- 6. Major Types Of Distributors
- 7. Market Segmentation

Potential Market Entry Barriers And Risks

A. Market Maturity
B. Cost Containment
C. Competition
D. Technological Edge And Limitations
E. Patent Protection
F. Regulatory Constraints
G. Decentralized Testing Market Challenges

Competitive Profiles

Abbott
Affymetrix
Agilent
Applied Gene Technologies
Arca
Beckman Coulter/Danaher
Becton Dickinson
Biokit
BioMerieux
Bio-Rad
Biotest
Caliper
Cepheid
Decode
Diadexus
Eiken
Enzo
Exact Sciences
Fujirebio
Gen-Probe
Hologic
Illumina
Innogenetics/Solvay
Kreatech
Li-Cor Biosciences
Life Technologies
Monogram Biosciences
Myriad Genetics
Nanogen/Elitech
Novartis
Orchid CellMark
Ortho-Clinical Diagnostics
Proteome Sciences
Qiagen
Roche
Scienion
Sequenom
Shimadzu
Siemens
Sierra Molecular
Takara Bio
Tecan Group

Appendixes

Appendix I: Major Universities and Research Centers Developing Molecular Diagnostic Technology
Appendix II: Glossary of Terms
Appendix III: Currency Exchange Rates

List of Tables

Major Companies Developing or Marketing AIDS Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Adenovirus Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Campylobacter Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Chlamydia Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing CMV Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing EBV Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Gonorrhea Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Hepatitis Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Herpes Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Legionella Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Lyme Disease Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Mycoplasma Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Papilloma Virus Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Pneumonia Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Salmonella Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Shigella Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Streptococci Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Toxoplasmosis Molecular Diagnostic And Other Direct Identification Tests
Major Companies Developing or Marketing Tuberculosis Molecular Diagnostic And Other Direct Identification Tests

Oncogenes Potential Application in Cancer Diagnosis
Major Companies Developing or Marketing Cancer Molecular Diagnostic Tests
Major Companies Developing or Marketing Molecular Diagnostic Test For Genetic Diseases

Summary Table U.S.A., Molecular Diagnostics Test Volume And Sales Forecast by Major Application
U.S.A., Laboratories Performing DNA Sequencing by Market Segment
U.S.A., Molecular Diagnostics Market, Potential Laboratory Universe by Market Segment
U.S.A., Molecular Diagnostics Test Volume Forecast By Major Application
U.S.A., Major Infectious Disease Molecular Diagnostics Test Volume Forecast
U.S.A., Infectious Disease Screening NAT Volume by Test Forecast
U.S.A., Molecular Diagnostics Market Forecast By Major Application
U.S.A., Infectious Disease Screening Nat Reagent Market Forecast by Test
U.S.A., Molecular Diagnostics Market by Major Supplier
U.S.A., HIV/Hepatitis C NAT Market Reagent Sales By Major Supplier
U.S.A., West Nile Virus NAT Market Reagent Sales By Major Supplier