分子診斷產業中技術的進步

本報告已在2011年07月19日停止出版。

簡介

目錄

Abstract

Research Overview

Development of Highly Multiplexed Technology Platforms for Detection of Infectious Diseases Poses a Stiff Challenge

One of the challenges in the future for the molecular diagnostics industry is to analyze symptoms that may be caused by several diseases at the same time, and have technologies that can detect all of them at the same time. This implies that systems in the future need to be highly multiplexed certainly for detection of infectious diseases and even more as one moves toward oncology applications. So the challenge will be to have the entire field of nucleic acid chemistry to be involved with highly multiplexed type of tests. Also, companies must continuously work to get faster and quicker results compared to several hours or days time frames usually involved in testing.

Need for Real-time, Fast and Cost-Effective Assays Driving the Growth

There is a continuing need for real-time, faster, more sensitive, less labour-intensive and hence more cost-effective molecular diagnostic solutions that can replace or complement traditional methods.

Lack of skilled technicians poses a barrier for Molecular Diagnostic Systems

One of the biggest restraints, despite an increase in the number of automated platforms, is the lack of skilled technicians, and the time required for sample preparation on non- or semiautomated systems. Even the advent of automated systems demands an understanding of relatively complex assays with different forms of detection systems requiring trained technicians to perform the molecular assays on these systems.

Table of Contents

1 EXECUTIVE SUMMARY

• Scope and Methodology
  • Scope
  • Methodology
• Key Findings
  • Noteworthy Emerging Technologies
  • Noteworthy Emerging Applications

2 TECHNOLOGY AND APPLICATIONS VIEWPOINT

• Technology Primer
  • DNA Microarrays
  • Polymerase Chain Reaction
  • Other Key Primers
• Technology and Application Analysis
  • Analysis of Key Application Segments
  • Technology Roadmap
• Assessment of Stakeholder Innovation in Companies and Universities
  • Noteworthy Innovation at Key Companies
  • Noteworthy Innovation at Key Academic and Government-related Institutions
• Influential Market Factors
  • Regulations and Reimbursement
  • Industry Trends

3 TECHNOLOGY ADOPTION FACTOR ANALYSIS

• Key Challenges
  • Development and Commercialization
  • Market Applications
  • Future
• Drivers and Restraints
  • Drivers
  • Restraints

4 ASSESSMENT OF INNOVATION AND OPPORTUNITIES

• Innovative Developments in Companies--North America
  • Bayer's Molecular Product Lines-- Focused Expertise and Category--Leading Laboratory Solutions
  • Cepheid's GeneXpert and SmartCycler System for Genetic Analysis
  • Invitrogen's ChargeSwitch Technology for Nucleic Acid Purification
  • bioMerieux's New Generation Platform for Isolation of Nucleic Acids
  • Xenomics' Breakthrough Transrenal DNA Technology
  • Source MDx Molecular Diagnostics System
  • Gen-Probe and Chiron Partner for West Nile Virus Assay
  • Caliper's Microfluidics Technology for Molecular Diagnostics
  • Nanogen's Nucleic Acid Detection Technology
  • Tm Biosciences Tag-It Universal Array Technology for Multiple Applications
  • Monogram's eTag Assays for Utility in Various Types of Cancers
  • Abbott's Gene-based Test for Detection of Bladder Cancer
  • Third Wave Technologies First Pharmacogenetic Test
  • Digene's HPV Test for Screening of Cervical Cancer
• Innovative Developments in Companies--Europe and APAC
  • Roche's Amplichip Microarray Technology for Leukemia--Switzerland
  • A Unique Nano-JETA Technology Platform by Acrongenomics--Greece
  • Philips Unveils New Technologies for Molecular Diagnostics--Netherlands
  • DxS' Scorpions and ARMS Technology for Multiple Applications--UK
  • QIAGEN's Novel Test Kits for Detection of Influenza and Avian Flu--Netherlands
  • Exiqon's Unique LNA Technology--Denmark
  • Genoid's Revolutionary Real-Time Detection Kit for HPV--Hungary
  • AttoChip's Lab-on-Chip Technology for Real-Time Infectious Disease Detection--Singapore
• Innovative Developments in Universities--World
  • IBN Biochip for Early Cancer Detection--Singapore
  • Mass Tag PCR Technology Platform for Detection of Multiple Pathogens--US
  • A Portable Device for Rapid Detection of Infectious Diseases--US
  • DNA Wires for Application in Detecting Disease Biomarkers--US
  • A New Technique to Detect Cancer Biomarkers--US
  • An Autonomous Molecular Computer to Analyze Gene Expression--Israel

5 PATENTS; CONTACTS AND GLOSSARY

• Patents
  • Patents 1
  • Patents 2
  • Patents 3
• Contacts and Glossary
  • Contacts
  • Glossary

6 FROST & SULLIVAN 2005 SCIENCE AND TECHNOLOGY AWARDS

• Technology Innovation Award
  • Award Description
  • Award Recipient
• Excellence in Technology Award
  • Award Description
  • Award Recipient

7 CRITICAL REFERENCE TABLES

• Decision Support Database Tables
  • HIV Prevalence--World (1999-2006)
  • AIDS Mortality--World (1999-2006)
  • HIB Immunization--World (1999-2005)
  • Hep B Immunization--World (1999-2005)
  • Breast Cancer Incidence--World (1999-2006)
  • Lung Cancer Incidence--World (1999-2006)
  • Liver Cancer Incidence--World (1999-2006)

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