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市場調查報告書
蛋白質結晶的商務市場：策略性市場機會分析
Protein Crystallography Strategic Opportunities
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本報告已在2011年07月19日停止出版。
CrystalScore 最早是作為結晶碟之造影・分析的完全自動化系統，現已獲得美國專利。
在生物工程・醫藥領域具有高業績的英國市調公司 Select Biosciences, Ltd.（總公司:薩特貝利），針對蛋白質結晶 的商務市場進行詳細的調查與分析，並出版系統化的報告書“Protein Crystallography Strategic Opportunities”。
該報告書針對蛋白質結晶訪問了專家學者，並對市場及競爭狀況進行詳盡的分析，整體概要摘記如下。
1. 摘要
2. 蛋白質結晶說明
- 蛋白質結晶之概念
- 晶化技術
- 晶化篩檢是檢體問題
- 詳說蛋白質結晶
- 何以結晶對創藥來說相當重要？
- 創藥的成本與時間
- 創藥上結晶的優勢
- 對蛋白質結晶的挑戰
- 為何高速處理蛋白質結晶？
- 警告與結論
- 蛋白的發現與晶化都要高速處理篩檢
- 高速處理蛋白晶化
- 高速處理蛋白結晶
- 晶化中液體控制的需要
- 晶化碟
- IMPAX、ORYX
- 碟轉換
- 不合格尺寸
- 軟體
- 蛋白結晶自動生成的瓶頸
- 蛋白結晶的用途與限制
3. 學者專家的訪談結果
4. 市場分析
- 市場潮流與現狀
- 結晶領域的潮流與現狀
- 結晶領域成長的潮流
- 市場的定量分析
- 蛋白結晶領域上的競爭狀況
- 市場機會摘要
5. 競爭狀況(主要 28 家)
附錄: 調查方法
Overview
Diversified Scientific provides CrystalScore, automated image acquisition and
analysis designed for protein crystallization plates.
Technology
- The database software provides automated hardware control, image and data
archiving, image processing, a searchable database, and surface plotting of
experimental data.
Stage of Development
CrystalScore was one of the first fully automated systems for imaging and
analyzing crystallization plates. A US Patent has been issued for a method for
acquiring, storing and analyzing crystal images.
Competitive Assessment
- STRENGTHS
- Solid installed base of users
- Issued US Patent on technology
- Relatively low cost system
- WEAKNESSES
- Lack of automation capabilities
- No incubated storage offered
- OPPORTUNITIES
- Partner with automated plate storage provider
- THREATS
- Complete crystallization system providers
- Microscope systems providers
Table of Contents
Chapter 1. Executive Summary
Chapter 2. Introduction to Protein Crystallography
- Protein Crystallography: The Concept
- Crystallization Techniques
- Crystallization Screening is a Sampling Problem
- Protein Crystallography: Motif to Crystal
- A Small Crystal
- Protein Crystallography: An Approach to Crystallization
- Protein Crystallography: Diffraction Set-Up
- Protein Crystallography: Crystal to Structure
- Protein Crystallography: Sample Data
- Why Crystallography in Drug Design
- Cost and Timeline of Drug Development
- Advantages of Crystallography in Drug Design
- Fundamental Protein Crystallography Challenges
- Why High-Throughput Protein Crystallography Now?
- Structural Genomics Progress Statistics
- Caveats and Conclusions from targetDB
- Both Protein Expression and Crystallization Are Comparable High-Throughput
Screening Tasks
- Basic Overview of High-Throughput Protein Crystallization
- Extended View of High-Throughput Protein Crystallography
- Customized High-Throughput Protein Crystallography Automation
- An Example of Customized High-Throughput Protein Crystallography
Automation
- Automation and Approaches for High-Throughput Protein Crystallography
- Demands on Liquid Handling in Crystallization
- Basic Two-Stage Set-up?Cocktail Preparation
- Second Stage: Crystallization Plate Set-up
- Combination: 96+8 Innovadyne Dispenser
- Multi-Purpose Batch Robot: IMPAX, ORYX
- Multiple Stages Needs Plate Transfer and Storage
- State of the Market, June 2004: Technology Trends?Drop Size
- State of the Market, June 2004: Technology Trends?Software
- Summary of Bottlenecks in the Automation of Protein Crystallography
- Applications and Limitations of Protein Crystallography
Chapter 3. Interviews With Experts
Chapter 4. Market Analysis
- State of the Market, June 2004: Market Trends
- State of the Crystallography Space, June 2004: Market Trends
- State of the Crystallography Space, June 2004: Growth Trends
- Market Evolution: Qualitative Depiction
- Protein Crystallography Competitive Landscape
- Summary of Market Opportunities
Chapter 5. Competitive Landscape
- Accelrys
- ActiveSight
- Astex Technology, Ltd.
- Bruker Biosciences
- Crystal Research
- DataCentric Automation/Kendro
- DeCode Genetics
- Diversified Scientific
- Douglas Instruments, Ltd.
- Fluidigm
- Formulatrix
- Genomic Solutions, Inc.
- Gilson
- Hamilton Company
- Hampton Research
- Innovadyne Technologies, Inc.
- Matrix Technologies
- Molecular Dimensions
- Oxford Diffraction
- Rigaku/MSC
- RoboDesign International, Inc.
- Shamrock Structures
- Structural GenomiX
- Syrrx
- Tecan AG
- TriTek Corporation
- TTP LabTech, Ltd.
- Veeco Instruments
Appendix I. Methodology
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