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市場調查報告書

全球單株抗體開發平台趨勢

Global Monoclonal Antibodies Pipeline Insight 2015

出版商 PNS Pharma 商品編碼 325326
出版日期 內容資訊 英文 1600 Pages
商品交期: 最快1-2個工作天內
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全球單株抗體開發平台趨勢 Global Monoclonal Antibodies Pipeline Insight 2015
出版日期: 2015年03月04日 內容資訊: 英文 1600 Pages
簡介

在現有的產品線正逐漸枯竭的情形下,醫藥品經營者應該充實自家公司的研發產品線,今後數年投資層級應將擴大。同時,為了改善單株抗體的有效性,現在進行許多研究。近幾年,癌症治療成為使用單株抗體的主要領域,也可能成為未來癌症治療最大的引進處。

本報告提供全球單株抗體的研發產品線趨勢的相關調查、單株抗體種類與概要、作用機制、需求、新的癌症治療的引進趨勢、單株抗體市場成長推進因素與開發及商業化的課題、各企業、適應症、階段的開發平台趨勢、已上市單株抗體概要,主要經營者簡介等彙整資料。

第1章 簡介:單株抗體

第2章 單株抗體的分類

  • 非結合單株抗體
  • 結合單株抗體
    • 放射性標識抗體
    • 化學標識抗體
    • 免疫毒素

第3章 單株抗體的作用機制

  • 融合瘤的生產
    • 單株抗體的體外生產
    • 批次式組織培養技術
    • 半透膜為基礎的系統
    • 體外、體內手法的優點及缺點
  • 單株抗體工作

第4章 單株抗體的需求

第5章 新的領域:癌症的單株抗體治療

第6章 全球單株抗體市場:概要

  • 目前市場方案
  • 單株抗體開發平台的考察
  • 癌症的單株抗體:臨床實驗平台的考察

第7章 單株抗體的市場動態

  • 好意性的市場參數
  • 開發及商業化的課題

第8章 全球單株抗體市場:未來展望

第9章 單株抗體臨床開發平台:各企業、適應症、階段

  • 不明
  • 研究
  • 前臨床
  • 臨床
  • 第0相
  • 第一階段
  • 第一/二階段
  • 第二階段
  • 第二/三階段
  • 第三階段
  • 申請完畢
  • 已通過核准

第10章 已上市單株抗體:企業、各適應症

第11章 競爭環境

  • Abbvie
  • Amgen
  • Bayer HealthCare
  • Biogen Idec
  • Eli Lilly
  • Genmab
  • Gilead Sciences
  • GlaxoSmithKline
  • Novartis
  • Pfizer
  • Roche
  • Seattle Genetics

圖表

目錄

Ever since the Nobel Prize was bestowed on the person who invented the technology which enabled the preparation of monoclonal antibodies in 1984, their use has considerably expanded far beyond the scientific realm. Paul Ehrlich framed a hypothesis that a "magic bullet" could be developed with an objective of targeting selective diseases. With the introduction and development of hybridoma technology by Kohler and Milstein, this hypothesis has become a reality. These monoclonal antibodies have come to be known as highly valuable therapeutic agents. This technology rendered mAbs to be highly potential of specific associations with their targeted antigens.Muromonab-CD3 (Orthoclone OKT3; Ortho Biotech) was the first of these antibodies which was approved in 1986, in the prevention of acute transplant rejection. This has been followed by an increasing number of other monoclonal antibodies, of which many were among the best-selling drugs across the globe.

Utility of mAbs in therapeutic treatment have been widely accepted among physicians and patients across the globe. This could be attributed to their high specificity due to which only diseased cells are eliminated while normal cells are spared. Their ability to bind target is high because they are made by using single antigen giving them high specificity. As a result, side effects are minimized as compared to other therapeutics available in global market. They are bit larger than other therapeutic molecules but they are highly customizable due to which they could be designed for particular disease. Clinical data has also shown that they have high safety and efficacy profiles due to which more patients are willing to include them in their regular therapeutic regime. They could be used to treat various ailments like cancer, auto-immune, anti-inflammatory and other disease indications. Out of these ailments, cancer mAb segment occupies major market shares and generates huge revenues across the globe. Pharmaceutical companies are trying to develop them for more ailments in other to generate diversify and strengthen their portfolio.

Different mAbs have different action mechanism due to which they can be used against multiple malignancies. Depending upon malignancy in question, mAb could be customized due to which their dominance in global cancer market could be observed. For instance, rituximab is used for lymphoma treatment; it binds to the cancerous cells and makes it more susceptible to attack by immune system. On the other hand, Ibritumomab for Non-Hodgkin Lymphoma (NHL) treatment consists of radioactive pay load to eliminate cancerous cells. Chemotherapeutics are one of the major contenders having largest market shares in cancer category but their severe side effects noticeable during treatment. To alleviate patients' medical condition pharmaceutical companies have also launched the mAb version of chemotherapeutics. For instance, ado-trastuzumab emtansine has been launched in market for Her 2 positive breast cancer treatment.

With existing product pipelines on the verge of being exhausted, it is most likely that the future years would witness an increased level of investments from the pharma companies so as to fill up their R&D pipelines. Additionally, a significant amount of research is being currently conducted to improve the level of potency of monoclonal antibodies. Cancer is becoming a major area where the use of monoclonal antibodies is increasing substantially in the recent years. In the future also, this field is expected to have the maximum application of mAbs.

"Global Monoclonal Antibodies Pipeline Insight 2015" Report Highlight:

  • Monoclonal Antibodies Classification
  • Mechanism of Monoclonal Antibodies
  • Global Monoclonal Antibodies Market Overview
  • Global Monoclonal Antibodies Clinical Pipeline by Company, Indication & Phase
  • Global Monoclonal Antibodies Clinical Pipeline: 1096 mAb
  • Marketed Monoclonal Antibodies: 66 mAb
  • Global Cancer Monoclonal Antibodies Clinical Pipeline: 602 mAb
  • Marketed Cancer Monoclonal Antibodies: 34 mAb

Table of Contents

1. Introduction to Monoclonal Antibodies

2. Monoclonal Antibodies Classification

  • 2.1 Naked Monoclonal Antibodies
  • 2.2 Conjugated Monoclonal Antibodies
    • 2.2.1 Radiolabeled Antibodies
    • 2.2.2 Chemolabeled Antibodies
    • 2.2.3 Immunotoxins

3. Mechanism of Monoclonal Antibodies

  • 3.1 Generation of Hybridomas
    • 3.1.1 In Vitro Production of Monoclonal Antibodies
    • 3.1.2 Batch Tissue Culture Methods
    • 3.1.3 Semipermeable Membrane Based Systems
    • 3.1.4 Advantages & Disadvantages of In Vitro and In Vivo Methods
  • 3.2 Working of Monoclonal Antibodies

4. Need for Monoclonal Antibodies

5. Emerging Area: Cancer Monoclonal Antibodies Therapy

6. Global Monoclonal Antibodies Market Overview

  • 6.1 Current Market Scenario
  • 6.2 Monoclonal Antibodies Pipeline Insight
  • 6.3 Cancer Monoclonal Antibodies Clinical Pipeline Insight

7. Monoclonal Antibodies Market Dynamics

  • 7.1 Favorable Market Parameters
  • 7.2 Development & Commercialization Challenges

8. Global Monoclonal Antibodies Market Future Outlook

9. Monoclonal Antibodies Clinical Pipeline by Company, Indication & Phase

  • 9.1 Unknown
  • 9.2 Research
  • 9.3 Preclinical
  • 9.4 Clinical
  • 9.5 Phase-0
  • 9.6 Phase-I
  • 9.7 Phase-I/II
  • 9.8 Phase-II
  • 9.9 Phase-II/III
  • 9.10 Phase-III
  • 9.11 Preregistration
  • 9.12 Registered

10. Marketed Monoclonal Antibodies by Company & Indication

11. Competitive Landscape

  • 11.1 Abbvie
  • 11.2 Amgen
  • 11.3 Bayer HealthCare
  • 11.4 Biogen Idec
  • 11.5 Eli Lilly
  • 11.6 Genmab
  • 11.7 Gilead Sciences
  • 11.8 GlaxoSmithKline
  • 11.9 Novartis
  • 11.10 Pfizer
  • 11.11 Roche
  • 11.12 Seattle Genetics

List of Figures

  • Figure 1-1: Evolution of Monoclonal Antibody
  • Figure 1-2: History of Development of Monoclonal Antibodies
  • Figure 2-1: Types of Monoclonal Antibodies
  • Figure 5-1: Working of Monoclonal Antibodies
  • Figure 6-1: Global Biologics Market Segmentation
  • Figure 6-2: Share of Monoclonal Antibodies in Global Biologics Market
  • Figure 6-3: Global Market for Monoclonal Antibodies, (US$ Billion)
  • Figure 6-5: Monoclonal Antibodies Pipeline Overview by Phase, (%)
  • Figure 6-6: Monoclonal Antibodies Pipeline Overview by Phase, (Numbers)
  • Figure 6-7: Cancer Monoclonal Antibodies Therapy Pipeline by Phase (%), 2014
  • Figure 6-8: Cancer Monoclonal Antibodies Therapy Pipeline by Phase (Number), 2014
  • Figure 7-1: Monoclonal Antibodies Market Challenges
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