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市場調查報告書

溴結構域蛋白4:開發中產品分析

Bromodomain Containing Protein 4 (Protein HUNK1 or BRD4) - Pipeline Review, H2 2017

出版商 Global Markets Direct 商品編碼 371018
出版日期 內容資訊 英文 115 Pages
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溴結構域蛋白4:開發中產品分析 Bromodomain Containing Protein 4 (Protein HUNK1 or BRD4) - Pipeline Review, H2 2017
出版日期: 2017年12月29日 內容資訊: 英文 115 Pages
簡介

本報告提供以溴結構域蛋白4為標的之治療藥開發平台現狀及最新更新的各開發階段比較分析,提供您加上最新的新聞和發表之企業和研究機關開發中的治療藥,治療藥評估,後期階段及中止的計劃等相關資訊。

簡介

  • 調查範圍

溴結構域蛋白4 概要

治療藥的開發

  • 開發中的產品:各開發階段
  • 開發中的產品:各治療領域
  • 開發中的產品:不同症狀

開發中產品概況

  • 後期階段的產品
  • 初期階段的產品
  • 開發階段不明的產品

企業開發中的產品

大學/機關開發中的產品

治療藥的評估

  • 單劑/並用治療藥的情況
  • 各作用機制
  • 各給藥途徑
  • 各分子類型

治療藥的開發企業

  • Aptose Biosciences Inc.
  • Arvinas, Inc.
  • C4 Therapeutics, Inc.
  • Constellation Pharmaceuticals, Inc.
  • ConverGene, LLC
  • 第一三共
  • Dybly AG
  • F. Hoffmann-La Roche Ltd.
  • Incyte Corporation
  • Kainos Medicine, Inc.
  • Merck & Co., Inc.
  • Resverlogix Corp.
  • Trillium Therapeutics Inc.
  • Zenith Epigenetics Corp

藥物簡介

暫停中的計劃

主要消息及新聞稿

附錄

圖表

本網頁內容可能與最新版本有所差異。詳細情況請與我們聯繫。

目錄
Product Code: GMDHC1204TDB

Summary:

Bromodomain Containing Protein 4 (Protein HUNK1 or BRD4) pipeline Target constitutes close to 38 molecules. Out of which approximately 28 molecules are developed by companies and remaining by the universities/institutes. The latest report Bromodomain Containing Protein 4 - Pipeline Review, H2 2017, outlays comprehensive information on the Bromodomain Containing Protein 4 (Protein HUNK1 or BRD4) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.

Bromodomain Containing Protein 4 (Protein HUNK1 or BRD4) - Bromodomain-containing protein 4 is a protein encoded by the BRD4 gene. It plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. It promotes phosphorylation of Ser-2 of the C-terminal domain (CTD) of RNA polymerase II. It acts as a regulator of p53/TP53-mediated transcription. The molecules developed by companies in Phase III, Phase II, Phase I, Preclinical and Discovery stages are 1, 3, 6, 15 and 3 respectively. Similarly, the universities portfolio in Preclinical and Discovery stages comprises 5 and 5 molecules, respectively. Report covers products from therapy areas Oncology, Immunology, Cardiovascular, Central Nervous System, Metabolic Disorders, Dermatology, Genetic Disorders, Genito Urinary System And Sex Hormones, Ophthalmology and Respiratory which include indications Acute Myelocytic Leukemia (AML, Acute Myeloblastic Leukemia), Solid Tumor, Breast Cancer, Multiple Myeloma (Kahler Disease), Diffuse Large B-Cell Lymphoma, Myelodysplastic Syndrome, Ovarian Cancer, Refractory Acute Myeloid Leukemia, NUT Midline Carcinoma (NMC or Nuclear Protein in Testis Midline Carcinoma), Relapsed Acute Myeloid Leukemia, Acute Lymphocytic Leukemia (ALL, Acute Lymphoblastic Leukemia), Atherosclerosis, Colorectal Cancer, Follicular Lymphoma, Hematological Tumor, Inflammation, Lung Cancer, Neuroblastoma, Non-Hodgkin Lymphoma, Non-Small Cell Lung Cancer, Refractory Multiple Myeloma, Relapsed Multiple Myeloma, Rheumatoid Arthritis, Small-Cell Lung Cancer, Adenocarcinoma, Advanced Malignancy, Alzheimer's Disease, Atopic Dermatitis, B-Cell Leukemia, B-Cell Non-Hodgkin Lymphoma, Blood Cancer, Chronic Kidney Disease (Chronic Renal Failure), Chronic Lymphocytic Leukemia (CLL), Chronic Myelocytic Leukemia (CML, Chronic Myeloid Leukemia), Colon Cancer, Coronary Artery Disease (CAD) (Ischemic Heart Disease), Fabry Disease, Glioblastoma Multiforme (GBM), Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma), Hormone Refractory (Castration Resistant, Androgen-Independent) Prostate Cancer, Hypercholesterolemia, Idiopathic Pulmonary Fibrosis, Leukemias, Lymphoma, Malignant Pleural Mesothelioma, Melanoma, Metastatic Adenocarcinoma of The Pancreas, Metastatic Brain Tumor, Metastatic Hormone Refractory (Castration Resistant, Androgen-Independent) Prostate Cancer, Metastatic Liver Cancer, Myelofibrosis, Myeloproliferative Disorders, Pancreatic Cancer, Pancreatic Ductal Adenocarcinoma, Peripheral Arterial Disease (PAD)/ Peripheral Vascular Disease (PVD), Peripheral Nerve Sheath Tumor (Neurofibrosarcoma), Pre-Diabetes/Impaired Glucose Tolerance, Prostate Cancer, Psoriasis, Renal Cell Carcinoma, Retinal Degeneration, Substance (Drug) Abuse, Systemic Lupus Erythematosus, Systemic Sclerosis (Scleroderma) and Uveal Melanoma.

Furthermore, this report also reviews key players involved in Bromodomain Containing Protein 4 (Protein HUNK1 or BRD4) targeted therapeutics development with respective active and dormant or discontinued projects. Driven by data and information sourced from proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources.

Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope:

  • The report provides a snapshot of the global therapeutic landscape for Bromodomain Containing Protein 4 (Protein HUNK1 or BRD4)
  • The report reviews Bromodomain Containing Protein 4 (Protein HUNK1 or BRD4) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
  • The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
  • The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
  • The report reviews key players involved in Bromodomain Containing Protein 4 (Protein HUNK1 or BRD4) targeted therapeutics and enlists all their major and minor projects
  • The report assesses Bromodomain Containing Protein 4 (Protein HUNK1 or BRD4) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
  • The report summarizes all the dormant and discontinued pipeline projects
  • The report reviews latest news and deals related to Bromodomain Containing Protein 4 (Protein HUNK1 or BRD4) targeted therapeutics

Reasons to buy:

  • Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
  • Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
  • Identify and understand the targeted therapy areas and indications for Bromodomain Containing Protein 4 (Protein HUNK1 or BRD4)
  • Identify the use of drugs for target identification and drug repurposing
  • Identify potential new clients or partners in the target demographic
  • Develop strategic initiatives by understanding the focus areas of leading companies
  • Plan mergers and acquisitions effectively by identifying key players and it's most promising pipeline therapeutics
  • Devise corrective measures for pipeline projects by understanding Bromodomain Containing Protein 4 (Protein HUNK1 or BRD4) development landscape
  • Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Table of Contents

List of Tables

List of Figures

  • Introduction
  • Global Markets Direct Report Coverage
  • Bromodomain Containing Protein 4 (Protein HUNK1 or BRD4) - Overview
  • Bromodomain Containing Protein 4 (Protein HUNK1 or BRD4) - Therapeutics Development
  • Products under Development by Stage of Development
  • Products under Development by Therapy Area
  • Products under Development by Indication
  • Products under Development by Companies
  • Products under Development by Universities/Institutes
  • Bromodomain Containing Protein 4 (Protein HUNK1 or BRD4) - Therapeutics Assessment
  • Assessment by Mechanism of Action
  • Assessment by Route of Administration
  • Assessment by Molecule Type
  • Bromodomain Containing Protein 4 (Protein HUNK1 or BRD4) - Companies Involved in Therapeutics Development
  • Aptose Biosciences Inc
  • AstraZeneca Plc
  • Checkpoint Therapeutics Inc
  • ConverGene LLC
  • Dybly AG
  • F. Hoffmann-La Roche Ltd
  • Forma Therapeutics Inc
  • GlaxoSmithKline Plc
  • Kainos Medicine Inc
  • Mitsubishi Tanabe Pharma Corp
  • Nuevolution AB
  • Plexxikon Inc
  • Red Glead Discovery AB
  • Resverlogix Corp
  • Trillium Therapeutics Inc
  • Zenith Epigenetics Ltd
  • Bromodomain Containing Protein 4 (Protein HUNK1 or BRD4) - Drug Profiles
  • apabetalone - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • APL-581 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • AZD-5153 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • birabresib - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • CG-202 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • CG-223 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • CG-250 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • CK-103 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • CPI-0610 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • dBET-1 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • DCBD-005 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • DYB-186 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • EP-11313 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • FT-1101 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • GSK-525762 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • KM-601 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • MA-2014 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • MS-417 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • MZ-1 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • NEO-2734 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • NUE-7770 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • PLX-2853 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • PLX-51107 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • RG-6146 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • S-10 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • SBX-1301 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • SF-2523 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • SF-2535 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • Small Molecule to Inhibit BRD4 for Multiple Myeloma - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • Small Molecule to Inhibit Bromodomain Containing Protein-4 for Oncology - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • Small Molecules to Inhibit BRD4 and HDAC1 for Oncology - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • Small Molecules to Inhibit BRD4 for Breast Cancer - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • Small Molecules to Inhibit BRD4 for Malignant Peripheral Nerve Sheath Tumors - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • Small Molecules to Inhibit BRD4 for Ovarian Cancer - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • SRX-3177 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • TTI-281 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • ZBC-260 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • ZEN-3694 - Drug Profile
  • Product Description
  • Mechanism Of Action
  • R&D Progress
  • Bromodomain Containing Protein 4 (Protein HUNK1 or BRD4) - Dormant Products
  • Bromodomain Containing Protein 4 (Protein HUNK1 or BRD4) - Discontinued Products
  • Bromodomain Containing Protein 4 (Protein HUNK1 or BRD4) - Product Development Milestones
  • Featured News & Press Releases
  • Dec 12, 2017: Natures Recent Scientific Reports Publication Describes How Apabetalone May Be a Powerful Agent Against HIV-1
  • Nov 27, 2017: Nuevolution to Present New Data on its BET BD1 Program Supporting Effect in Psoriasis/Atopic Dermatitis
  • Nov 02, 2017: Resverlogix Announces Participation in Upcoming Conferences
  • Nov 01, 2017: Resverlogix Announces Fifth Positive Recommendation From Data Safety Monitoring Board For Phase 3 Study of Apabetalone
  • Oct 27, 2017: Nuevolution to present new data on its BET BD1 program supporting the understanding of the biological mode-of-action
  • Sep 25, 2017: SignalRx Presents in silico Design of Dual PI3K/BRD4 Inhibitors for Combinatorial Activation of Anti-tumor Immunity in Treating Cancer
  • Aug 29, 2017: Successful CANTOS Inflammation Trial Supports Rationale for Resverlogix Ongoing BETonMACE Trial
  • Aug 24, 2017: Cancer Drug Can Reactivate HIV
  • Jul 25, 2017: Resverlogix Receives Approval Pathway from the FDA as to the Inclusion of USA Patients in the Phase 3 BETonMACE Trial
  • Jul 10, 2017: Resverlogix Randomizes First Patient in Taiwan/China Portion of the Phase 3 BETonMACE Clinical Trial
  • Jul 05, 2017: Trillium Provides Update on Preclinical Development Program, TTI-281
  • Jun 28, 2017: Resverlogix Announces Fourth Positive Recommendation From Data Safety Monitoring Board For Phase 3 Study of Apabetalone
  • Jun 19, 2017: Nuevolution Presents Additional Positive Animal Results in Lupus From its BET Selective Program
  • Jun 05, 2017: Resverlogix Announces Lead Drug Apabetalone Publication and Presentation at BIO International 2017
  • Jun 05, 2017: Zenith Announces Issuance of Patent for ZEN-3694 and Presentation Details at BIO International Convention
  • Appendix
  • Methodology
  • Coverage
  • Secondary Research
  • Primary Research
  • Expert Panel Validation
  • Contact Us
  • Disclaimer

List of Tables

  • Number of Products under Development by Stage of Development, H2 2017
  • Number of Products under Development by Therapy Areas, H2 2017
  • Number of Products under Development by Indications, H2 2017
  • Number of Products under Development by Indications, H2 2017 (Contd..1), H2 2017
  • Number of Products under Development by Indications, H2 2017 (Contd..2), H2 2017
  • Number of Products under Development by Indications, H2 2017 (Contd..3), H2 2017
  • Number of Products under Development by Companies, H2 2017
  • Number of Products under Development by Companies, H2 2017 (Contd..1)
  • Products under Development by Companies, H2 2017
  • Products under Development by Companies, H2 2017 (Contd..1), H2 2017
  • Products under Development by Companies, H2 2017 (Contd..2), H2 2017
  • Products under Development by Companies, H2 2017 (Contd..3), H2 2017
  • Products under Development by Companies, H2 2017 (Contd..4), H2 2017
  • Products under Development by Companies, H2 2017 (Contd..5), H2 2017
  • Products under Development by Companies, H2 2017 (Contd..6), H2 2017
  • Number of Products under Investigation by Universities/Institutes, H2 2017
  • Products under Investigation by Universities/Institutes, H2 2017
  • Number of Products by Stage and Mechanism of Actions, H2 2017
  • Number of Products by Stage and Route of Administration, H2 2017
  • Number of Products by Stage and Molecule Type, H2 2017
  • Pipeline by Aptose Biosciences Inc, H2 2017
  • Pipeline by AstraZeneca Plc, H2 2017
  • Pipeline by Checkpoint Therapeutics Inc, H2 2017
  • Pipeline by ConverGene LLC, H2 2017
  • Pipeline by Dybly AG, H2 2017
  • Pipeline by F. Hoffmann-La Roche Ltd, H2 2017
  • Pipeline by Forma Therapeutics Inc, H2 2017
  • Pipeline by GlaxoSmithKline Plc, H2 2017
  • Pipeline by Kainos Medicine Inc, H2 2017
  • Pipeline by Mitsubishi Tanabe Pharma Corp, H2 2017
  • Pipeline by Nuevolution AB, H2 2017
  • Pipeline by Plexxikon Inc, H2 2017
  • Pipeline by Red Glead Discovery AB, H2 2017
  • Pipeline by Resverlogix Corp, H2 2017
  • Pipeline by Trillium Therapeutics Inc, H2 2017
  • Pipeline by Zenith Epigenetics Ltd, H2 2017
  • Dormant Products, H2 2017
  • Dormant Products, H2 2017 (Contd..1), H2 2017
  • Discontinued Products, H2 2017

List of Figures

  • Number of Products under Development by Stage of Development, H2 2017
  • Number of Products under Development by Therapy Areas, H2 2017
  • Number of Products under Development by Top 10 Indications, H2 2017
  • Number of Products by Stage and Mechanism of Actions, H2 2017
  • Number of Products by Routes of Administration, H2 2017
  • Number of Products by Stage and Routes of Administration, H2 2017
  • Number of Products by Stage and Molecule Type, H2 2017
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