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市場調查報告書

Gamma Secretase :開發中產品分析

Gamma Secretase (EC 3.4.23.) - Pipeline Review, H2 2017

出版商 Global Markets Direct 商品編碼 363575
出版日期 內容資訊 英文 56 Pages
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Gamma Secretase :開發中產品分析 Gamma Secretase (EC 3.4.23.) - Pipeline Review, H2 2017
出版日期: 2017年09月30日 內容資訊: 英文 56 Pages
簡介

本報告提供Gamma Secretase 的開發情形相關的資訊,各開發階段、藥物標的、作用機制、給藥途徑及各分子類型的分析,開發治療藥的企業概要,最新消息和新聞稿等資訊,為您概述為以下內容。

簡介

  • 調查範圍

Gamma Secretase 的概要

治療藥的開發

Gamma Secretase :開發中的產品 - 各開發階段

Gamma Secretase :開發中的產品 - 各治療範圍

Gamma Secretase :開發中的產品 - 各適應症

Gamma Secretase :開發中產品概況

  • 後期階段的產品
  • 初期階段的產品

Gamma Secretase :企業開發中的產品

Gamma Secretase :大學/機關開發中的產品

Gamma Secretase :治療藥的評估

  • 各單劑療法/聯合治療產品
  • 各作用機制
  • 各給藥途徑
  • 各分子類型

Gamma Secretase 的治療藥的開發企業

  • Amgen Inc.
  • Astellas Pharma Inc.
  • Bristol-Myers Squibb Company
  • Critical Outcome Technologies Inc.
  • FORUM Pharmaceuticals Inc.
  • Humanetics Corporation
  • Lipopharma Therapeutics SL
  • Merck & Co., Inc.
  • NeuroGenetic Pharmaceuticals, Inc.
  • Pfizer Inc.
  • Stemline Therapeutics, Inc.
  • 大日本住友製藥
  • 武田藥品工業

藥物簡介

Gamma Secretase :暫停中的計劃

Gamma Secretase :開發中止的產品

Gamma Secretase :主要消息和新聞稿

附錄

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目錄
Product Code: GMDHC1031TDB

Summary

Gamma Secretase (EC 3.4.23.) pipeline Target constitutes close to 19 molecules. Out of which approximately 16 molecules are developed by companies and remaining by the universities/institutes. The latest report Gamma Secretase (EC 3.4.23.) - Pipeline Review, H2 2017, outlays comprehensive information on the Gamma Secretase (EC 3.4.23.) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.

Gamma Secretase (EC 3.4.23.) - Gamma secretase is a multi-subunit protease complex, itself an integral membrane protein, that cleaves single-pass transmembrane proteins at residues within the transmembrane domain. The most well-known substrate of gamma secretase is amyloid precursor protein, when cleaved by both gamma and beta secretase, produces a short 39-42 amino acid peptide called amyloid beta whose abnormally folded fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients. Gamma secretase is also critical in the related processing of the Notch protein. The molecules developed by companies in Phase II, Phase I, Preclinical and Discovery stages are 1, 3, 11 and 1 respectively. Similarly, the universities portfolio in Preclinical and Discovery stages comprises 1 and 2 molecules, respectively. Report covers products from therapy areas Central Nervous System, Oncology and Ear Nose Throat Disorders which include indications Alzheimer's Disease, Hearing Disorders, Acute Lymphoblastic Lymphoma, Acute Lymphocytic Leukemia (ALL, Acute Lymphoblastic Leukemia), Brain Cancer, Burkitt Lymphoma, Glioblastoma Multiforme (GBM), Leukemias, Medulloblastoma, Metastatic Breast Cancer, Soft Tissue Sarcoma, Solid Tumor and T-Cell Leukemia.

Furthermore, this report also reviews key players involved in Gamma Secretase (EC 3.4.23.) targeted therapeutics development with respective active and dormant or discontinued projects. Driven by data and information sourced from proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources.

Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope

  • The report provides a snapshot of the global therapeutic landscape for Gamma Secretase (EC 3.4.23.)
  • The report reviews Gamma Secretase (EC 3.4.23.) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
  • The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
  • The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
  • The report reviews key players involved in Gamma Secretase (EC 3.4.23.) targeted therapeutics and enlists all their major and minor projects
  • The report assesses Gamma Secretase (EC 3.4.23.) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
  • The report summarizes all the dormant and discontinued pipeline projects
  • The report reviews latest news and deals related to Gamma Secretase (EC 3.4.23.) targeted therapeutics

Reasons to buy

  • Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
  • Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
  • Identify and understand the targeted therapy areas and indications for Gamma Secretase (EC 3.4.23.)
  • Identify the use of drugs for target identification and drug repurposing
  • Identify potential new clients or partners in the target demographic
  • Develop strategic initiatives by understanding the focus areas of leading companies
  • Plan mergers and acquisitions effectively by identifying key players and it's most promising pipeline therapeutics
  • Devise corrective measures for pipeline projects by understanding Gamma Secretase (EC 3.4.23.) development landscape
  • Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Table of Contents

  • Table of Contents
    • List of Tables
    • List of Figures
  • Introduction
    • Global Markets Direct Report Coverage
  • Gamma Secretase (EC 3.4.23.) - Overview
    • Gamma Secretase (EC 3.4.23.) - Therapeutics Development
    • Products under Development by Stage of Development
    • Products under Development by Therapy Area
    • Products under Development by Indication
    • Products under Development by Companies
    • Products under Development by Universities/Institutes
  • Gamma Secretase (EC 3.4.23.) - Therapeutics Assessment
    • Assessment by Mechanism of Action
    • Assessment by Route of Administration
    • Assessment by Molecule Type
  • Gamma Secretase (EC 3.4.23.) - Companies Involved in Therapeutics Development
    • Astellas Pharma Inc
    • Bristol-Myers Squibb Co
    • Critical Outcome Technologies Inc
    • Lipopharma Therapeutics SL
    • Merck & Co Inc
    • NeuroGenetic Pharmaceuticals Inc
    • Pfizer Inc
    • Stemline Therapeutics Inc
    • Takeda Pharmaceutical Co Ltd
  • Gamma Secretase (EC 3.4.23.) - Drug Profiles
    • AS-2715348 - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • BMS-932481 - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • BMS-986133 - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • GSI-34 - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • LP-226A1 - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • LY-3056480 - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • NGP-328 - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • NGP-555 - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • nirogacestat - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • Peptides to Inhibit PSEN1 for Alzheimer's Disease - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • PF-06648671 - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • SL-301 - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • SL-302 - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • Small Molecule 2 to Inhibit Gamma Secretase for Alzheimer's Disease - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • Small Molecule to Inhibit Gamma Secretase for Alzheimer's Disease - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • Small Molecules to Inhibit Beta and Gamma Secretase for Alzheimer's Disease - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • Small Molecules to Inhibit Beta Secretase and Gamma Secretase for Alzheimer's Disease - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • Small Molecules to Inhibit Gamma Secretase for Hearing Loss - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
    • Small Molecules to Inhibit PSEN1 for Alzheimer's Disease - Drug Profile
      • Product Description
      • Mechanism Of Action
      • R&D Progress
  • Gamma Secretase (EC 3.4.23.) - Dormant Products
  • Gamma Secretase (EC 3.4.23.) - Discontinued Products
  • Gamma Secretase (EC 3.4.23.) - Product Development Milestones
    • Featured News & Press Releases
      • Jan 09, 2017: NeuroGenetic Pharmaceuticals Completes Phase 1 Clinical Trials for NGP 555 to Treat and Prevent Alzheimer's Disease; Shown as Safe and Well-Tolerated in Healthy Volunteers
      • Nov 10, 2015: NeuroGenetic Pharmaceuticals Awarded $2.5 Million Grant From NIA to Conduct Clinical Trials with NGP 555 to Treat and Prevent Alzheimer's Disease; Reports Initial Results of Phase 1a Clinical Trial
      • Sep 29, 2014: FDA Approves NeuroGenetic Pharmaceuticals Application to Begin Clinical Trials for Its NGP 555 Compound to Treat and Prevent Alzheimer's Disease
      • Jun 16, 2014: Prof. G.L. Nicolson and Prof. R.M. Epand join Lipopharma's SAB
      • Jul 15, 2011: NeuroGenetic Pharma Receives SBIR Grant For Preclinical Development And IND Application Of NGP 555 To Treat Alzheimer's Disease
      • Jul 21, 2009: Critical Outcome Technologies Inc. Announces the Launch of a Drug Discovery Program for Alzheimer's disease
  • Appendix
    • Methodology
    • Coverage
    • Secondary Research
    • Primary Research
    • Expert Panel Validation
    • Contact Us
  • Disclaimer

List of Tables

  • Number of Products under Development by Stage of Development, H2 2017
  • Number of Products under Development by Therapy Areas, H2 2017
  • Number of Products under Development by Indication, H2 2017
  • Number of Products under Development by Companies, H2 2017
  • Products under Development by Companies, H2 2017
  • Products under Development by Companies, H2 2017 (Contd..1), H2 2017
  • Number of Products under Investigation by Universities/Institutes, H2 2017
  • Products under Investigation by Universities/Institutes, H2 2017
  • Number of Products by Stage and Mechanism of Actions, H2 2017
  • Number of Products by Stage and Route of Administration, H2 2017
  • Number of Products by Stage and Molecule Type, H2 2017
  • Pipeline by Astellas Pharma Inc, H2 2017
  • Pipeline by Bristol-Myers Squibb Co, H2 2017
  • Pipeline by Critical Outcome Technologies Inc, H2 2017
  • Pipeline by Lipopharma Therapeutics SL, H2 2017
  • Pipeline by Merck & Co Inc, H2 2017
  • Pipeline by NeuroGenetic Pharmaceuticals Inc, H2 2017
  • Pipeline by Pfizer Inc, H2 2017
  • Pipeline by Stemline Therapeutics Inc, H2 2017
  • Pipeline by Takeda Pharmaceutical Co Ltd, H2 2017
  • Dormant Products, H2 2017
  • Dormant Products, H2 2017 (Contd..1), H2 2017
  • Discontinued Products, H2 2017

List of Figures

  • Number of Products under Development by Stage of Development, H2 2017
  • Number of Products under Development by Therapy Areas, H2 2017
  • Number of Products under Development by Top 10 Indications, H2 2017
  • Number of Products by Mechanism of Actions, H2 2017
  • Number of Products by Stage and Mechanism of Actions, H2 2017
  • Number of Products by Routes of Administration, H2 2017
  • Number of Products by Stage and Routes of Administration, H2 2017
  • Number of Products by Molecule Types, H2 2017
  • Number of Products by Stage and Molecule Types, H2 2017
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