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市場調查報告書
細胞培養：全球培養基、血清、測試藥物市場
Cell Culture: The World Market for Media, Sera and Reagents, 2nd Edition
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本報告已在2011年10月08日停止出版。
更改為出版
Cell Culture: The World Market for Media, Sera and Reagents, 3rd. Edition
出版日期 : 2011年10月
商品編碼: 217055
本報告書內容包括：研發生物藥劑所用的細胞培養市場、培養基、血清、測試藥物調查、市場規模與預測（至2013年）、主要供應商市佔率、市場成長與阻礙因素、細胞培養技術、各種發現與所製造的生物藥劑、主要供應商資訊等，內容綱要摘記如下：
第1章 摘要
- 調查範圍與方法
- 生產生物藥劑所使用的細胞
- 發酵槽與生物反應器
- 發酵過程
- 細胞培養環境
- 細胞培養基
- 血清
- 測試藥物
- 全球細胞培養市場
- 影響細胞培養市場的動向
第2章 研發生物藥劑的基因抽換細胞
- 對生物藥劑的高度需求
- 關於生物科技
- 由有蓋培養皿到生物藥劑
- 細胞培養與規範準則
第3章 細胞培養技術
- 前言、概要
- 生物製造所需細胞株
- 發酵槽與生物反應器
- 發酵槽與生物反應器種類
- 攪拌槽反應器
- Airlift發酵器
- 充填層反應器
- 中空反應
- 拋棄式系統
- 發酵過程
- Batch與Fed-Batch發酵
- 懸浮細胞 vs 固定細胞
- 微膠囊化
- 細胞培養環境
- 細胞培養基
- 血清
- 測試藥物
第4章 現在與未來動向
- 概要
- 往血清細胞培養的轉變
- 對細胞培養供應商的影響
- 對研究的影響
- 生物科技：BSE問題的避免
- 細胞培養市場
- 市場成長牽引因素
- 市場預測
- 類別分析
- 市場特徵
- 細胞培養供應商市佔率
- 影響細胞培養市場的動向
- 幹細胞研究
- 以細胞培養為基礎的疫苗生產
- 生物學名藥
- 生物抽換藥物
第5章 企業資訊
圖表
Abstract
Cell culture is a major foundation of biopharmaceutical development,
bioprocessing and manufacturing. As the biopharmaceutical market grows, so
should interest in the cell culture products market. Biopharmaceutical
products are developed from large, complex protein molecules, which require
equally complex manufacturing methods and an array of analytical techniques.
As growing cells for biopharmaceutical production is slow, expensive and
complicated, optimizing cell culture development is of paramount concern to
companies developing biopharmaceuticals.
This report, Cell Culture represents the second time that Kalorama has focused
on culture used in the research and production of biopharmaceuticals,
analyzing the world cell culture market and the major trends driving this
market in three specific segments:
- Media,
- Sera, and
- Reagents
In addition to a thorough discussion of the technologies and techniques
currently employed and emerging in the cell culture area, the Kalorama' s
exhaustive report provides specific information on:
- Market Size, growth, and forecasts of the segments through 2013
- Competitive Market Share by leading supplier as of 2008.
- Estimated Market Share by Region (North America, Europe, U.S.)
- Key Market Drivers and Restraints for suppliers, including discussions of
biopharmaceutical pipelines, biomedical R&D directions, and the future of
transgenic plant and animal production.
- Review of the various expression systems (Bacteria, Yeast, Insect, and
Mammal) and the biopharmaceutical product manufactured by these systems
- Discussion of the preferences in media types vying for dominance in the
market, including the following:
- ADCF - animal derived component free media
- CD - chemically defined media
- CSFM - complete serum free medium
- PF - protein free media
- SF - serum free media
- SFM - serum free medium
- Major Trends Impacting the Market stem cell research (including plans of
major companies)cell culture-based vaccine Production and generic
bipharmaceuticals
- Profiles of 27 Leading Suppliers and information about M&A activities in
recent years
The information for this report was gathered using both primary and secondary
research including comprehensive research of secondary sources such as company
literature, databases, investment reports, and medical and business journals.
Telephone interviews and email correspondence were the primary method of
gathering information. For the purpose of this study Kalorama Information
conducted interviews with key industry officials, consultants, and government
personnel. These sources were the primary basis in gathering information
specifically relating to revenue and market share data presented in this
report. Specific interviews with pharmaceutical company and cell culture
supply company representatives included marketing directors, division
managers, and product representatives.
Table of Contents
CHAPTER ONE: EXECUTIVE SUMMARY
- Scope and Methodology
- Cells for Biopharmaceutical Production
- Bacteria and Yeasts Systems
- Animal Cell Systems
- Insect Cell Systems
- Cell Lines and Cell Banks
- Fermentors and Bioreactors
- Stirred-tank Reactors
- Airlift Fermentors
- Packed Bed Reactors
- Hollow-fiber Reactor
- Disposable Systems
- Fermentation Processes
- Batch and Fed-Batch Fermentation
- Suspended vs. Anchored Cells
- Microencapsulation
- Cell Culture Environment
- Functions and Components of Basal Media
- pH and Osmotic Pressure
- Energy Sources
- Nutrients
- Cell Culture Media
- Lysogeny broth (LB)
- Classical Media
- Serum-free Media
- Protein-free Media
- Chemically Defined Media
- Specialty Media
- Sera
- Reagents
- Shifting Towards Non-animal Derived Reagents
- Addressing Reagent Safety Issues
- World Cell Culture Market
- Impact of Shift to Serum-free Products on Cell Culture Suppliers
- Impact of Shift to Serum-free Products on Research
- Impact of Shift Serum-free Products on Biopharmaceutical Manufacturers
- Cell Culture Market and Forecast
- Trends Impacting The Cell Culture Market
CHAPTER TWO: GENETICALLY MODIFIED CELLS FOR BIOPHARMACEUTICAL DEVELOPMENT
- Growing Demand for Biopharmaceuticals
- Demand Increasing for Cell Culture Products
- A Brief History of Biotechnology
- Science of Genetic Manipulation
- From Petri Dish to Biopharmaceutical
- Upstream Bioprocessing: Cell Culture Expression Systems
- Cells for Biopharmaceutical Production
- Bacteria and Yeasts Systems
- Animal Cell Systems
- Insect Cell Systems
- Advantages/Disadvantages of Cell Culture Systems
- Cell Lines and Cell Banks
- Biopharmaceuticals Produced from Cell Culture
- Cell Culture Practices and Regulatory Guidelines
- Validation of Facilities
- Maintaining Sterilization Standards
CHAPTER THREE: CELL CULTURE TECHNOLOGY
- Introduction and Overview
- Milestones in Cell Culture Development
- Cell Lines for Bioproduction
- Predominant Cell Lines
- Chinese Hamster Ovary (CHO)
- SP2/0, and NS0
- HEK 293 and PER. C6
- Sources: Largest Collections of Cell Lines
- Fermentors and Bioreactors
- Types of Bioreactors/Fermentors
- Stirred-tank Reactors
- Airlift Fermentors
- Packed Bed Reactors
- Hollow-fiber Reactor
- Disposable Systems
- Fermentation Processes
- Batch and Fed-Batch Fermentation
- Suspended vs. Anchored Cells
- Microencapsulation
- Cell Culture Environment
- Functions and Components of Basal Media
- pH and Osmotic Pressure
- Energy Sources
- Nutrients
- Cell Culture Media
- Types of Media
- Lysogeny broth (LB)
- Classical Media
- Serum-free Media
- Protein-free Media
- Chemically Defined Media
- Specialty Media
- Sera
- Sources of Sera
- Bovine Serum Safety Issues and Regulations
- Shift to Serum-free Media
- Reagents
- Major Types of Biologic Reagents
- Amino Acids
- Growth Factors and Cytokines
- Albumin
- Transferrin
- Thrombin
- Growth Supplements
- Protease Inhibitor
- Attachment Factors
- Shifting Towards Non-animal Derived Reagents
- Addressing Reagent Safety Issues
CHAPTER FOUR: CELL CULTURE MARKET: CURRENT AND FUTURE TRENDS
- Overview
- Shift Away From Serum-Based Cell Culture
- Impact of Shift to Serum-free Products on Cell Culture Suppliers
- Impact of Shift to Serum-free Products on Research
- Life Technologies' End Run Around the BSE Issue
- Cell Culture Market
- Market Drivers
- Cell Culture Market and Forecast
- Segment Analysis
- Market Characteristics
- Market Share: Cell Culture Suppliers
- Trends Impacting The Cell Culture Market
- Stem Cell Research
- Life Technologies
- Sigma-Aldrich
- Millipore Corporation
- ThermoFisher Scientific
- Lonza Bioscience
- Cell Culture-based Vaccine Production
- Generic Biopharmaceuticals
- Transgenically Produced Biopharmaceuticals
CHAPTER FIVE: COMPANY PROFILES
- Advanced Biotechnologies, Inc
- History and Lines of Business
- Cell Culture Products and Services
- Amresco, Inc
- History and Lines of Business
- Cell Culture Products
- Analytical Biological Services Inc
- History and Lines of Business
- Cell Culture Products
- Mammalian Cell Culture
- Cell in Microtiter Plates for HTS
- Primary Cultures
- Insect Cell Culture
- Atlanta Biologicals, Inc
- History and Lines of Business
- Cell Culture Products
- Athena Enzyme Services
- History and Lines of Business
- Cell Culture Products
- BD Biosciences
- History and Lines of Business
- Cell Culture Products
- Financial Information
- Biochrom AG
- History and Lines of Business
- Cell Culture Products
- Cell Essentials, Inc
- History and Lines of Business
- Cell Culture Products
- CellGenix Technologie Transfer GmbH
- History and Lines of Business
- Cell Culture Products and Services
- Irvine Scientific
- History and Lines of Business
- Cell Culture Products
- J R Scientific, Inc
- History and Development
- Cell Culture Products
- Life Technologies Corporation
- History and Lines of Business
- Cell Culture Products
- Financial Information
- Lonza Bioscience
- History and Lines of Business
- Cell Culture Products and Services
- Culture Media Development
- Cell Line Creation
- Cell Banking
- Financial Information
- Mediatech, Inc
- History and Lines of Business
- Cell Culture Products
- Millipore Corporation
- History and Lines of Business
- Cell Culture Products
- Financial Information
- MP Biomedicals
- History and Lines of Business
- Cell Culture Products
- PAA laboratories, Inc
- History and Lines of Business
- Cell Culture Products
- PromoCell GmbH
- History and Lines of Business
- Cell Culture Products
- Quality Biological, Inc
- History and Lines of Business
- Cell Culture Products
- R&D Systems, Inc
- History and Lines of Business
- Cell Culture Products
- SBH Sciences
- History and Lines of Business
- Cell Culture Products
- Selexis SA
- History and Lines of Business
- Cell Culture Products
- SeraCare Life Sciences, Inc
- History and Lines of Business
- Cell Culture Products
- Financial Information
- Sigma-Aldrich Corporation
- History and Lines of Business
- Cell Culture Products
- Financial Information
- Thermo Fisher Scientific, Inc
- History and Lines of Business
- Cell Culture Products
- Financial Information
- USB Corporation
- History and Lines of Business
- Cell Culture Products
- Wisent, Inc
- History and Lines of Business
- Cell Culture Products
APPENDIX: A: COMPANY DIRECTORY
APPENDIX: B: PROFESSIONAL ORGANIZATIONS
TABLE OF EXHIBITS
CHAPTER ONE: EXECUTIVE SUMMARY
- Table 1-1: Worldwide Cell Culture Market
- Figure 1-1: Cell Culture World Market Share, by Region, 2008 (US,
Asia/Pacific, EU)
CHAPTER TWO: GENETICALLY MODIFIED CELLS FOR BIOPHARMACEUTICAL DEVELOPMENT
- Table 2-1: Biopharmaceuticals Approved in the USA and/or the EU in 2007
- Table 2-2: Approximate times from Introduced Gene to Protein Production at
Useable Levels
- Table 2-3: Disadvantages/Advantages of Cell Culture Systems
- Table 2-4: Selected Biopharmaceuticals Produced from Bacteria, Yeast and
Mammalian Cells
CHAPTER THREE: CELL CULTURE TECHNOLOGY
- Table 3-1: Selected Products/Companies Offering Alternatives to Animal
Sera Products for Hybridoma, Myeloma and CHO cell lines
CHAPTER FOUR: CELL CULTURE MARKET: CURRENT AND FUTURE TRENDS
- Table 4-1: Selected Brandname Serum-Free Formulations of Cell Culture
Products Currently on the Market
- Table 4-2: Worldwide Cell Culture Market
- Figure 4-1: Cell Culture World Market Share, by Region, 2008 (US, Asia, EU)
- Table 4-3: World Cell Culture Market by Segment: Media, Sera and Reagents
- Table 4-4: Cell Culture Market Share, 2008
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