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市場調查報告書

蛋白質體學研究市場:設備(質譜分析、液體層析法、電泳)、疾病領域(腫瘤、心臟/血液、神經、其他):市場佔有率與趨勢

Proteomics Research Markets: Instruments & Consumables (Mass Spectrometry, Liquid Chromatography, Electrophoresis), Disease Areas (Oncology, Cardio/Blood, Neurology, Other), Market Share and Trends

出版商 Kalorama Information 商品編碼 331925
出版日期 內容資訊 英文 165 Pages
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蛋白質體學研究市場:設備(質譜分析、液體層析法、電泳)、疾病領域(腫瘤、心臟/血液、神經、其他):市場佔有率與趨勢 Proteomics Research Markets: Instruments & Consumables (Mass Spectrometry, Liquid Chromatography, Electrophoresis), Disease Areas (Oncology, Cardio/Blood, Neurology, Other), Market Share and Trends
出版日期: 2015年05月13日 內容資訊: 英文 165 Pages
簡介

蛋白質體學研究、廣用於藥物標的識別的臨床醫學發展、生物標記的驗證、藥引及化驗的最佳化等。製藥公司,診斷藥廠商投資數百億美元,並關注蛋白質的化驗和鑑定能力高的設備

本報告提供蛋白質體學研究市場相關調查、市場趨勢、未來的展望、各地區趨勢,及加入此市場的主要企業概要、產品、收益等簡介彙整。

第1章 摘要整理

第2章 蛋白質體學研究的簡介

  • 背景
  • 翻譯研究
  • 蛋白質體學和體學環境
  • 生物學的功能性與疾病的蛋白質所扮演的角色
  • 生物標記的蛋白質
  • 蛋白質體學研究案例
  • 結論

第3章 蛋白質體學研究技術

  • 背景
  • 質譜分析
  • 電泳
  • 液體層析法
  • 結論

第4章 蛋白質體學研究流程:生物標記及藥物標的開發

  • 背景
  • 生物標記研究的蛋白質體學
  • 生物標記藥物研發
  • 生物標記檢驗
  • 生物標記驗證
  • 藥物標的研究的蛋白質體學
  • 標的解迴旋
  • 結論

第5章 蛋白質體學研究設備市場

  • 背景
  • 質譜分析市場
  • 液體層析法市場
  • 電泳市場
  • 市場概要:各技術、地區、疾病
  • 結論

第6章 企業簡介

  • AB Sciex (Danaher)
  • Agilent Technologies
  • Bruker Corporation
  • Thermo Fisher Scientific
  • Bio-Rad Laboratories
  • GE Healthcare Life Sciences
  • JEOL Ltd.
  • 株式會社島津製作所

圖表

目錄
Product Code: KLI5556567

Proteomics research is increasingly involved in the development of modern clinical medicine from the identification of drug targets, the validation of biomarkers, and optimization of resulting drug leads and assays. Pharmaceutical and diagnostic companies spend tens of billions of dollars on translational research, which has increased the focus on instruments capable of powerfully assaying and identifying proteins implicated in disease pathways.

The Proteomic Research Market Opportunity, Defined

Report analyst Emil Salazar examines proteomics research processes in detail and in terms of their instrument and technological requirements relating to mass spectrometry, liquid chromatography and electrophoresis. The instruments and technologies of this report are profiled in terms of their application in proteomics research workflows; analytical strengths and weaknesses; diverse features; major suppliers and their market shares; and market trends. As part of its coverage, the report includes market size estimates (2014) and market projections (2019) for the following instrument groups:

  • Mass Spectrometry
  • Liquid Chromatography
  • Electrophoresis

Proteomics research factors into life sciences research as a demanding, advanced area of research antecedent to clinical research and clinical trials that are performed more widely across the world. Proteomics is only one strand of systems biology or one of several “omics” fields comprehensively tasked with elucidating various biological molecules in terms of their structure and interaction within cells and organisms. Among the “omics,” proteomics trails only the fields of genomics and transcriptomics in terms of maturity and heft in research investment. Systems biology is a significant resource for translational research and achieving a greater depth of understanding regarding disease pathways. This report also explores proteomics research market by the current and forecast size of disease group market segments that include:

  • Oncology
  • Neurology
  • Cardiovascular
  • Other

How Proteomics Research is Conducted Today

No market assessment of proteomics research is complete without a thorough discussion of its instrument-based core processes, current practices and future trends, and where pitfalls occur and opportunities for companies might lie. The backbone of proteomics research is formed by electrophoresis and liquid chromatography for sample fractionation and analytical separation and mass spectrometry for protein identification, characterization and quantitative analysis. The report discusses each instrument, how it is used, and what might be future positions of different instrument technologies. Proteomics ideally functions within a translational research pipeline for the development of therapeutics and assays for research and clinical use. The proteomics research workflow for translational product development is in large part facilitated by mass spectrometry, liquid chromatography and electrophoresis technologies - the market focus of this report.

Mass spectrometry-based proteomics is a particular focus of this report, as MS-based research methods represent a leading option for pharmaceutical and life science companies to mitigate research expenditures by multiplexing detection in a relatively ‘antibody-less' workflow. This report compares the following types of MS in terms of resolution, mass accuracy, sensitivity, dynamic range, speed, cost, and proteomics research workflow applications:

  • Triple Quadrupole (QqQ)
  • Time-of-flight (TOF)
  • Quadrupole-TOF (Q-TOF)
  • Ion Traps (IT,QIT,LIT)
  • Orbitraps
  • FT-ICR

The process of validating useful proteins for new drugs and clinical tests begins with translational research that transforms laboratory or preclinical study discoveries into useful pre-clinical studies and clinical trials. Following protein biomarker and drug target validation, translational research proceeds alternatively with the optimization of drug leads active for the identified target or the development of assays used in preclinical studies, as a less-regulated lab developed test (LDT), research use only (RUO) assay, or clinically.

The following is among the topics addressed in this report:

  • Current Practices in Drug Discovery
  • The Translational Research Workflow
  • Proteomics in Biomarker Research
  • Biomarker Discovery
  • Biomarker Verification
  • Biomarker Validation
  • Company Market Shares by Research Instrument
  • Company Revenues and Detailed Product Offerings
  • Analyst Conclusions Regarding the Present and Future Market

Global Segmentation

Kalorama Information's market analysis is worldwide and this report breaks out the market for proteomic research into geographic regions. North America is the dominant regional market for proteomics research with instrumentation distributed widely among universities, research centers, medical centers, core pharmaceutical laboratories, and specialty contract research organizations (CROs) focusing on biomarker development. Asia-Pacific is expected to see build-up of proteomics instrumentation capacity following the same trajectory of genomics research development in the region. The report defines the geographic trend in the market and provides specific proteomic research market sizes for the following regions.

  • United States
  • Europe
  • Asia-Pacific
  • Rest of World (ROW)

Who Competes in This Market and Where Do They Stand?

As part of its superior analysis of proteomics research instrument markets, the report identifies company market share for specific instrument areas including liquid chromatography and mass spectrometry as well as the market leaders in electrophoresis.

The report notes the background, products and revenue of the major market players. Companies profiled include:

  • AB Sciex (Danaher)
  • Agilent Technologies
  • Bruker Corporation
  • Thermo Fisher Scientific
  • Waters Corporation
  • Bio-Rad Laboratories
  • GE Healthcare Life Sciences
  • JEOL Ltd.
  • Shimadzu Corporation

Table of Contents

ONE: EXECUTIVE SUMMARY

  • Background
  • Proteomics in Translational Research
  • Proteomics in Biomarker Research
  • Proteomics in Drug Target Research
  • Proteomics Research Instruments
  • Mass Spectrometry
  • Liquid Chromatography
  • Electrophoresis
  • Industry Landscape - Major Competitors
  • AB Sciex
  • Agilent Technologies
  • Bruker Corporation
  • Thermo Fisher Scientific
  • Waters Corporation
  • Major Conclusions

TWO: INTRODUCTION TO PROTEOMICS RESEARCH

  • Background
  • Translational Research
  • Proteomics and the ‘Omics Landscape
  • The Role of Proteins in Biological Functioning and Disease
  • Proteins as Biomarkers
  • Proteomics Research Samples
  • Conclusion

THREE: PROTEOMICS RESEARCH TECHNOLOGIES

  • Background
  • Mass Spectrometry
  • Triple Quadrupole
  • Time-of-Flight
  • Ion Trap / Orbitrap
  • Ion Sources
  • Ion Activation
  • Reagents
  • Electrophoresis
  • Gel Electrophoresis
  • Off-Gel Electrophoresis
  • GelFree / Continuous Flow Electrophoresis / Free Flow Electrophoresis
  • Capillary Electrophoresis
  • Liquid Chromatography
  • Conclusion

FOUR: PROTEOMICS RESEARCH PROCESSES - BIOMARKER AND DRUG TARGET DEVELOPMENT

  • Background
  • Proteomics in Biomarker Research
  • Biomarker Discovery
  • Biomarker Verification
  • Biomarker Validation
  • Proteomics in Drug Target Research (Chemical Proteomics)
  • Target Deconvolution
  • Conclusion

FIVE: PROTEOMICS RESEARCH INSTRUMENT MARKETS

  • Background
  • Mass Spectrometry Market in Proteomics Research
  • Liquid Chromatography Market in Proteomics Research
  • Electrophoresis Market in Proteomics Research
  • Proteomics Research Market Overview - Technologies, Geographies and Disease
  • Conclusion

SIX: COMPANY PROFILES

  • AB Sciex (Danaher)
  • Background
  • Products
  • Revenues
  • Agilent Technologies
  • Background
  • Products
  • Revenues
  • Bruker Corporation
  • Background
  • Products
  • Revenues
  • Thermo Fisher Scientific
  • Background
  • Products
  • Revenues
  • Waters Corporation
  • Background
  • Products
  • Revenue
  • Second-Tier Market Players
  • Bio-Rad Laboratories
  • Background
  • Products
  • GE Healthcare Life Sciences
  • Background
  • Products
  • JEOL Ltd.
  • Background
  • Products
  • Shimadzu Corporation
  • Background
  • Products

LIST OF EXHIBITS

ONE: EXECUTIVE SUMMARY

  • Figure 1-1: Translational Research Workflow Schematic
  • Table 1-1: Mass Spectrometer Instrument Type Comparison (QqQ, TOF, QIT/LIT,
  • Orbitrap, FT-ICR) - Resolution, Mass Accuracy, Sensitivity, Dynamic Range,Cost
  • Table 1-2: Proteomics Research Mass Spectrometry Market (Orbitraps, Ion Traps,TOF, Q-TOF, Triple Quadrupole, FT-MS) (2015/2020)
  • Table 1-3: Proteomics Research Market (Mass Spectrometry, Liquid Chromatography, Electrophoresis) (2015/2020)
  • Figure 1-2: Proteomics Research Market by Company Share (AB Sciex, Agilent, Bio-Rad Laboratories, Bruker, GE Healthcare Life Sciences, Thermo Fisher Scientific, Waters, Other) (2015)

TWO: INTRODUCTION TO PROTEOMICS RESEARCH

  • Figure 2-1: Translational Research Workflow Schematic
  • Figure 2-2: Systems Biology Schematic (Genome, Transcriptome, Proteome,Metabolome)
  • Table 2-1: Proteomics Research Sample Comparison by Advantages/Disadvantages -Cell Culture, Dried Blood Spot, Plasma, Serum, Tissue, Whole Blood

THREE: PROTEOMICS RESEARCH TECHNOLOGIES

  • Table 3-1: Mass Spectrometer Instrument Type Comparison (QqQ, TOF, QIT/LIT,Orbitrap, FT-ICR) - Resolution, Mass Accuracy, Sensitivity, Dynamic Range,Cost
  • Table 3-2: Triple Quadrupole Parameters and Summary (Resolution, Mass Accuracy, Sensitivity, Mass Range, Dynamic Range, Cost, Speed, Advantages/Disadvantages)
  • Table 3-3: Time-of-Flight / TOF Hybrid Parameters and Summary (Resolution,Mass Accuracy, Sensitivity, Mass Range, Dynamic Range, Cost, Speed, Advantages/Disadvantages)
  • Table 3-4: Fourier Transform Ion Cyclotron Resonance Parameters and Summary(Resolution, Mass Accuracy, Sensitivity, Mass Range, Dynamic Range, Cost,Speed, Advantages/Disadvantages)
  • Table 3-5: Quadrupolar, Linear and Hybrid Ion Trap Parameters and Summary(Resolution, Mass Accuracy, Sensitivity, Mass Range, Dynamic Range, Cost,Speed, Advantages/Disadvantages)
  • Table 3-6: Orbitrap Parameters and Summary (Resolution, Mass Accuracy,Sensitivity, Mass Range, Dynamic Range, Cost, Speed,Advantages/Disadvantages)
  • Table 3-7: Major Vendor Electrospray Ionization Innovations Summary
  • Table 3-8: Surface Analysis Ionization Technique Advantages/Disadvantages(MALDI, SELDI, DESI, LAESI)
  • Table 3-9: Ion Activation Method Advantages/Disadvantages (Low-Energy CID,High-Energy CID, SID, PSD, ISD, UVPD, IRMPD, ECD, ETD)
  • Table 3-10: Electrophoresis Method Advantages/Disadvantages (SDS-PAGE, 2DGE,DIGE, OFFGEL, GELFREE, Continuous and Free Flow, Capillary)

FOUR: PROTEOMICS RESEARCH PROCESSES - BIOMARKER AND DRUG TARGET DEVELOPMENT

  • Table 4-1: Shotgun Proteomics Summary (MS Types, Separation/Fractionation Methods, Advantages, Disadvantages)
  • Table 4-2: Gel-Based Discovery Proteomics Summary (MS Types,Separation/Fractionation Methods, Advantages, Disadvantages)
  • Table 4-3: Capillary Electrophoresis-Based Discovery Proteomics Summary(MS Types, Separation/Fractionation Methods, Advantages, Disadvantages)
  • Table 4-4: Data-Independent Acquisition Discovery Proteomics Summary(MS Types, Separation/Fractionation Methods, Advantages, Disadvantages)
  • Table 4-5: Major Vendor DIA Product Comparison (Waters MSE, Thermo Fisher AIF,AB Sciex SWATH, Thermo Fisher MSX, Thermo Fisher PRM)
  • Table 4-6: Selected and Multiple Reaction Monitoring (SRM/MRM) Summary(MS Types, Separation/Fractionation Methods, Advantages, Disadvantages)
  • Table 4-7: Chemical Proteomics/Drug Target Proteomics Summary (MS Types,Separation/Fractionation Methods, Advantages, Disadvantages)

FIVE: ROTEOMICS RESEARCH INSTRUMENT MARKETS

  • Table 5-1: Proteomics Research Mass Spectrometry Market (Orbitraps, Ion Traps,TOF, Q-TOF, Triple Quadrupole, FT-MS) (2015/2020)
  • Table 5-2: Proteomics Research Mass Spectrometry Market by Company Share(2015)
  • Table 5-3: Proteomics Research Liquid Chromatography Market (2015/2020)
  • Table 5-4: Proteomics Research Liquid Chromatography Market by Company Share(2015)
  • Table 5-5: Proteomics Research Electrophoresis Market (2015/2020)
  • Table 5-6: Proteomics Research Market (Mass Spectrometry, Liquid Chromatography, Electrophoresis) (2015/2020)
  • Table 5-7: Proteomics Research Market by Geography (North America, Europe, Asia-Pacific, ROW) (2015/2020)
  • Table 5-8: Proteomics Research Market by Disease Area (Cardiovascular, Neurology, Oncology, Other) (2015)

SIX: COMPANY PROFILES

  • Table 6-1: AB Sciex Proteomics Products
  • Table 6-2: AB Sciex Revenue (2009-2014)
  • Table 6-3: Agilent Technologies Proteomics Products
  • Table 6-4: Agilent Technologies Revenue (FY 2009-2014)
  • Table 6-5: Bruker Corporation Proteomics Products
  • Table 6-6: Bruker Corporation Revenue (2009-2014)
  • Table 6-7: Thermo Fisher Scientific Proteomics Products
  • Table 6-8: Thermo Fisher Scientific Revenue (2009-2014)
  • Table 6-9: Waters Corporation Proteomics Products
  • Table 6-10: Waters Corporation Revenue (2009-2014)
  • Table 6-11: Bio-Rad Laboratories Proteomics Products
  • Table 6-12: GE Healthcare Life Sciences Proteomics Products
  • Table 6-13: JEOL Ltd. Proteomics Products
  • Table 6-14: Shimadzu Corporation Proteomics Products 800.298.5603
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