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市場調查報告書

3D生物印刷:用途、市場、主要企業

3D Bioprinting 2014-2024: Applications, Markets and Players - A technology and market roadmap for the future of bioprinting in the coming decade

出版商 IDTechEx Ltd. 商品編碼 300641
出版日期 內容資訊 英文 104 Pages
商品交期: 最快1-2個工作天內
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3D生物印刷:用途、市場、主要企業 3D Bioprinting 2014-2024: Applications, Markets and Players - A technology and market roadmap for the future of bioprinting in the coming decade
出版日期: 2015年11月01日 內容資訊: 英文 104 Pages
簡介

有各式各樣3D生物印刷相關的技術,雖然投入市場的產品很少,但是未來潛藏許多影響重要的市場的可能性。特別被看好的是有效率的藥物研發的體外實驗,人保健產品的毒性實驗,人體細胞移植相關的臨床領域的研究用途。目前引進3D生物印表機的只有研究開發領域的組織,雖只是有效市場的一小部分,不過若今後技術開發推進,在各種領域引進的動向也有可能急速展開。在藥物研發的領域,由於使用3D生物印表機的研究室內再現3D的人體細胞環境,可提高藥物研發流程的可靠性。還有2013年歐洲聯盟全面禁止個人保健產品的動物實驗,對3D生物印表機來說也成為順風。此外,以3D生物印表機做出人的血管,皮膚,軟骨,腎臟和肝臟等的細胞技術的研究也推進著,是對再生醫療的發展有很大貢獻的技術而受矚目。

本報告以全球3D生物印刷技術為焦點,提供開發和商業化的現實計劃、今後的課題及有效市場評估、到2025年的預測等,再加上主要企業幹部的採訪,為您概述為以下內容。

第1章 摘要整理

第2章 簡介

第3章 技術

  • 噴墨為基礎的生物印刷
  • 注射/擠壓成型為基礎的生物印刷
  • 磁浮技術所利用的生物印刷
  • 雷射成型式生物印刷
  • 閥門為基礎的生物印刷
  • 相關技術的摘要

第4章 用途

  • 醫療
    • 藥物篩檢
    • 再生醫療
    • 組織置換(無血管)
    • 組織置換(血管)
  • 牙科
  • 消費品/個人保健產品的實驗
  • 生物感應器
  • 食品和動物性食品生物印刷
  • 生物墨水
    • 細胞
    • 成長因素/蛋白質
    • 支撐材料

第5章 市場

  • 市場結構與主要企業
  • 價值鏈
  • 市場障礙
  • 利益

第6章 藍圖與預測

第7章 主要企業幹部的採訪

  • Digilab Inc.
  • MicroFab Technologies Inc.
  • n3D Biosciences Inc.
  • nScrypt Inc.
  • Organovo
  • regenHU Ltd
  • TiVido Biodevices

圖表

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目錄

3D bioprinting will begin to realize its true potential within the coming decade

3D bioprinting constitutes a raft of technologies, commercial and not-yet commercial, which have the potential to significantly impact a number of major markets, including in vitro testing for more efficient drug discovery and toxicity testing of personal consumer products, as well as the clinical fields relating to implant/grafting of human tissue.

Though not yet employed within its addressable markets (current bioprinter sales and products are to research and development organisations only), the potential for rapid deployment in some areas already exists, subject to adequate funding being made available.

Drug discovery

Drug discovery is a highly expensive process which in most cases will end in failure to gain regulatory clearance (see figure 1). The reason for this high failure rate is related to the lack of sufficiently accurate pre-clinical (prior to human volunteer) testing methodologies which have to date been limited to 2-dimensional human cell assays together with animal testing.

Fig. 1. Drug discovery process

                     Source: IDTechEx

Different species can react to different drugs in very different ways, and further, 2-dimendional cell cultures behave very differently in terms of coalescence and proliferation compared to cells which inhabit a 3-dimensional environment. In short, humans are not 2-dimensional 70kg mice.

For some time therefore, medical researchers have sought means to mimic the 3-dimensional human tissue environment in the laboratory in an effort to make the drug discovery process more reliable, thereby (a) reducing complications associated to human clinical trials of novel drugs, (b) lowering the costs resulting from late-stage failures, (c) ensuring that dead-ends are abandoned quickly in order that attention can be focused on more promising avenues, and (d) shortening the drug discovery process timescale so that potentially life-saving drugs make it to the market as soon as possible.

Development of 3D assays has remained a challenge however, as the degree of precision required to emulate cell-to-cell communication in vivo (in the body) has proved elusive. Computer controlled 3D bioprinting, combined with curable bioinks, has now enabled the fabrication of 3D tissue, which moreover can survive for significantly longer periods of time compared to their 2D counterparts, enabling longer term impact of a novel drug on human tissue cultures to be analysed.

Cosmetic/consumer product testing

In 2013 the European Union (EU) enforced new legislation banning the use of animal testing on all personal consumer products. No such product, or any ingredient thereof, may be tested on animals, and no product/ingredient which has been tested on animals outside of the EU may be retailed within the EU. This has proved a major driver for companies in this sector to seek new means of testing the safety of their new products, not least as the EU represents the largest single market for cosmetics and other such products.

For example, in October 2013, the world's largest cosmetic company, L'Oreal, entered into an agreement with 3D bioprinting company Organovo to explore the use of 3D bioprinting for cosmetic safety testing, specifically skin care products.

Tissue grafts/implants

The longer term holy grail of 3D bioprinting is the ability to be able to print viable human tissue for grafting or implant into the human body. Research is already underway looking at the 3D bioprinting of non-vascular tissue (thin tissue which does not require a network of nutrient delivering capillaries) such as skin and cartilage. Work in this area is expected to commence clinical trials in the immediate future and will reduce the need for mechanical implants and human donors.

On a 30 year horizon, it is hoped that clinicians will be able to 3D bioprint vascular (thick) tissue such as a human kidney or liver. Transplant waiting lists continue to grow disproportionately in comparison to the availability of donor organs and 3D bioprinting of organs would have a number of advantages over donor organs including:

  • Earlier transplant when the patient is healthier yielding better outcomes
  • Reduced possibility of organ rejection where the organ is grown from the patient's own cells
  • Reduced requirement for eg. dialysis or other life supporting intervention, and
  • Reduced need for lifelong medication to supress the immune system.

This report provides a realistic timeline for the development and commercialisation of the 3D bioprinting technologies in what are largely heavily regulated application areas. A challenge matrix is presented, and evaluations of the addressable markets and their value provided. Forecasts are given for the period 2014-2025.

In addition to detailing each of the technologies currently employed, together with their state of commercialisation, future application areas are discussed including:

  • Medical - tissue engineering, drug discovery, regenerative medicine, dental implants etc.
  • Cosmetic/personal consumer product screening
  • Biosensors
  • Food and animal products

The report is informed by in depth interviews with the organisations working in the area of 3D bioprinting, analysing the challenges they face, both technological and otherwise, as well as the different business models employed.

The potential losers resulting from the large-scale uptake of 3D bioprinting are also outlined, emphasising their need for organisations working in the areas listed above to understand the technology and its likely evolutionary path.

This report draws on the wealth of experience of IDTechEx in the area of 3D printing in general, supported by expert opinion. The particular hurdles faced by each application area are addressed, and a timeline for the progressive commercialisation(s) presented (see figure 2).

Fig. 2. Commercialisation timeline

                     Source: IDTechEx

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Table of Contents

1. EXECUTIVE SUMMARY

2. INTRODUCTION

3. TECHNOLOGIES

  • 3.1. Inkjet based bioprinting
  • 3.2. Syringe/extrusion based bioprinting
  • 3.3. Magnetic levitation bioprinting
  • 3.4. Laser assisted bioprinting
  • 3.5. Valve-based bioprinting
  • 3.6. Technology summary

4. APPLICATIONS

  • 4.1. Medical
    • 4.1.1. Drug screening
    • 4.1.2. Regenerative medicine
    • 4.1.3. Tissue replacement (avascular)
    • 4.1.4. Tissue replacement (vascular)
  • 4.2. Dental
  • 4.3. Consumer/personal product testing
  • 4.4. Biosensors
  • 4.5. Food and animal product bioprinting
  • 4.6. Bioinks
    • 4.6.1. Cells
    • 4.6.2. Growth factors/proteins
    • 4.6.3. Support material

5. MARKETS

  • 5.1. Market structure and key players
  • 5.2. Value chain
  • 5.3. Market barriers
  • 5.4. Benefits

6. ROADMAP AND FORECASTS

7. COMPANY INTERVIEWS

  • 7.1. Biobots
  • 7.2. Digilab Inc
  • 7.3. Dyson
  • 7.4. EFESTO LLC
  • 7.5. EPSRC
  • 7.6. Fraunhofer Additive Manufacturing Alliance
  • 7.7. Fripp Design Ltd
  • 7.8. MicroFab Technologies Inc
  • 7.9. n3D Biosciences, Inc
  • 7.10. nScrypt Inc
  • 7.11. Organovo
  • 7.12. regenHU Ltd
  • 7.13. TeVido Biodevices
  • 7.14. Viridis 3D

IDTECHEX RESEARCH REPORTS AND CONSULTANCY

TABLES

  • 3.1. Comparison of 3D bioprinting technology specifications
  • 5.1. Incomes
  • 5.2. Cost of replacing a human kidney
  • 5.3. The benefits of 3D bioprinting
  • 6.1. Addressable markets with market value for 3D bioprinting
  • 6.2. Possible further opportunities for 3D bioprinting
  • 6.3. Compound annual growth rates under multiple scenarios for diffusion

FIGURES

  • 1.1. 3D bioprinting forecast scenarios to 2024
  • 1.2. The widening gap in transplant demand and supply
  • 1.3. A roadmap for 3D bioprinting
  • 2.1. 2D (left) vs. 3D (right) cultured cells
  • 2.2. Scaffold built human bladders
  • 2.3. Schematic of the 3D bioprinting process
  • 2.4. Timeline for medical applications of 3D bioprinting
  • 2.5. Organovo 3D bioprinter
  • 3.1. 3D inkjet bioprinting
  • 3.2. SWOT analysis for inkjet printing
  • 3.3. Extrusion based bioprinting
  • 3.4. SWOT analysis for extrusion/syringe based bioprinting
  • 3.5. Magnetic levitation bioprinting
  • 3.6. Magnetic levitation
  • 3.7. SWOT analysis for magnetic levitation based bioprinting
  • 3.8. Laser guided (left) and laser induced (right) bioprinting
  • 3.9. SWOT analysis for laser-assisted bioprinting
  • 3.10. SWOT analysis for valve-based bioprinting
  • 4.1. Pipeline for drug discovery
  • 4.2. Lung-on-a-chip (top) and gut-on-a-chip (bottom)
  • 4.3. Human organ vascular network
  • 4.4. Section of human skin
  • 4.5. 3D bioprinted skin
  • 4.6. The Dermal Repair Construct Printer
  • 4.7. In situ bioprinting device
  • 4.8. The BioPen
  • 4.9. 3D bioprinted IVD (right)
  • 4.10. 3D bioprinted heart valve
  • 4.11. Human organ bioprinting (illustration only)
  • 4.12. Illustration of a kidney vascular tree
  • 4.13. 3D bioprinted living tooth
  • 4.14. 3D bioprinted sensors
  • 4.15. The Algaerium bioprinter
  • 4.16. Growth factor mechanism
  • 5.1. Number of 3D bioprinting companies as a function of time
  • 5.2. 3D bioprinting company activities
  • 5.3. Technologies employed by commercial organisations
  • 5.4. Summary of product offerings of 3D bioprinting companies
  • 5.5. Patent activity of 3D bioprinting companies
  • 5.6. 3D bioprinting value chain
  • 6.1. Roadmap for 3D bioprinting
  • 6.2. Market forecasts for 3D bioprinting to 2024
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