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市場調查報告書

離子通道檢驗受託服務趨勢

Outsourced Ion Channel Testing Trends 2016

出版商 HTStec Ltd 商品編碼 269952
出版日期 內容資訊 英文 63 Pages
商品交期: 最快1-2個工作天內
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離子通道檢驗受託服務趨勢 Outsourced Ion Channel Testing Trends 2016
出版日期: 2016年07月14日 內容資訊: 英文 63 Pages
簡介

本報告提供HTStec2013年4月實施的離子通道檢驗受託服務業整體為對象的全球規模WEB為基礎的基準調查結果,未來擔負成功期望的生命科學相關經營者的需求和關心的最新市場資訊彙整,為您概述為以下內容。

  • 調查方法
  • 組織調查與回答
  • 受訪者的所屬企業以及團體
  • 受訪者的居住地區
  • 受訪者的擔當業務
  • 採用一次篩檢法研究中的離子通道受訪者數
  • 作為治療標靶處理離子通道的計劃數
  • 離子通道一次篩檢受歡迎的平台技術(1)
  • 離子通道一次篩檢受歡迎的平台技術(2)
  • 委託外部機關進行一次篩檢的受訪者
  • 沒有經歷過離子通道一次篩檢的受訪者的理由
  • 離子通道一次篩檢受託服務的關注度(1)
  • 離子通道一次篩檢受託服務的關注度(2)
  • 委託離子通道一次篩檢受歡迎的平台技術(1)
  • 委託離子通道一次篩檢受歡迎的平台技術(2)
  • 不同的離子通道篩檢服務的關注度
  • 離子通道一次篩檢服務利用的價格分佈
  • 調查觀察摘要(1)
  • 想委託外部機關選擇性分析的時機
  • 離子通道選擇性分析受歡迎的分析方式選擇方法
  • 討論選擇性分析時關注度最高的離子通道面板
  • 委託離子通道選擇性分析受歡迎的平台技術(1)
  • 委託離子通道選擇性分析受歡迎的平台技術(2)
  • 受歡迎的供應商的膜片鉗資料平台
  • 選擇性分析利用的受訪者的關心度
  • 委託外部機關選擇性分析的受訪者數
  • 選擇離子通道選擇性分析提供機關的動機
  • 選擇性分析受託服務期待的工作(1)
  • 選擇性分析受託服務期待的工作(2)
  • 委託離子通道安全性實驗的各方面(1)
  • 委託離子通道安全性實驗的各方面(2)
  • 安全性實驗外部機關進行的化合物年度數量
  • 委託外部機關離子通道安全性實驗的受訪者數
  • 調查觀察摘要(2)
  • 選擇離子通道安全性實驗提供機關的動機
  • 委託離子通道實驗的年度預算
  • 委託離子通道實驗的詳細內容
  • 委託離子通道實驗市場估算(1)
  • 委託離子通道實驗市場估算(2)
  • 委託離子通道實驗市場估算的詳細內容
  • 受訪者面利用最關注的服務提供機關的形態
  • 最常要求利用的離子通道實驗提供機關的服務
  • 受歡迎的離子通道實驗受託服務提供機關(表)
  • 最信賴度·使用率高的自由離子通道實驗服務提供機關(表)
  • 受歡迎的委託離子通道一次篩檢提供機關
  • 受歡迎的委託離子通道選擇性分析提供機關
  • 受歡迎的委託離子通道安全性實驗提供機關
  • 信賴度最高的個別支付型離子通道服務提供機關
  • 使用率最高的個別支付型離子通道服務提供機關
  • 利用穩定轉染離子通道細胞線的受訪者數
  • 受訪者的研究設施所使用穩定轉染離子通道細胞線的供給來源
  • 穩定轉染離子通道細胞線的購買計劃
  • 今後數年的穩定轉染離子通道細胞線的購買預算
  • 受託離子通道實驗服務的未滿足需求
  • 調查觀察摘要(3)

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目錄

Executive Summary

This market report summarizes the results of HTStec's industry-wide global web-based benchmarking survey on outsourced ion channel testing carried out in July 2016.

The survey was initiated by HTStec as part of its tracking of life science marketplaces and to update HTStec's previous outsourced ion channel testing trends report (published May 2013).

The questionnaire was compiled to meet the needs and interests of the outsourced ion channel testing provider community. Many questions were the same as those in the 2013 report.

The main objectives were to comprehensively document current use of and potential interest in outsourcing ion channel primary screening, selectivity profiling and safety liability testing. The survey also investigated access to stably transfected cell lines and future purchasing plans. The aim was to compile a reference document on outsourced ion channel testing, which could be compared directly relative to HTStec's previous 2013 report. Equal emphasis was given to soliciting opinion from Pharma, Biotech and Academic Research market segments globally.

The survey looked at the following aspects of outsourced ion channel testing, as practiced to date (2016) and in some cases as predicted for the future (2018): targeting of ion channels as therapeutic targets using primary screening; number of on-going programs with ion channels as a therapeutic target; preferred and alternative primary screening platform technology; current outsourcing of ion channel primary screening; why some respondents have not outsourced ion channel primary screening to date; current level of interest in outsourcing ion channel primary screening; primary screening platforms respondents would most like to access at a fee-for-service service provider; primary screening services respondents most envisage accessing and price points for those services; stage where respondents are most interested in outsourcing ion channel selectivity profiling; preferred selection of assays when deciding on ion channel selectivity profiling; ion channel panels of most interest when considering selectivity profiling; technology platforms respondents most want to access at a fee-for-service service provider for selectivity profiling; with respect to patch clamping data the preferred vendor's platform; current level of interest in outsourcing ion channel selectivity profiling; current outsourcing of ion channel selectivity profiling; what motivates selection of an ion channel selectivity profiling service provider; selectivity profiling services respondents most envisage accessing and price points for those services; aspects of ion channel safety liability testing that are outsourced; current level of interest in outsourcing safety liability testing; current outsourcing of ion channel safety liability testing; what motivates selection of an ion channel safety liability testing service provider; outsourcing budget for all ion channel testing done at fee-for-service labs and its breakdown into fee-for-service categories; type of service providers most interested in accessing for ion channel outsourcing; importance of different ion channel testing services provided; preferred fee-for-service providers of ion channel primary screening, ion channel selectivity profiling and ion channel safety liability testing; most trusted and most used ion channel services providers; respondents with access to stably transfected ion channel cell lines in house; source of cell lines used in house; plans to purchase any stably transfected cell lines over the next few years; budget allocation to purchase stably transfected cell lines; and any unmet needs in outsourced ion channel testing.

The survey questionnaire consisted of 32 mainly multi-choice questions. In addition, there were 6 questions related solely to survey demographics.

The survey collected 71 validated responses, of these 75% provided comprehensive input.

Survey responses were geographically split: 38% North America; 35% Europe; 11% Asia (excluding Japan and China); 10% Japan; 3% China and 3% Rest of World.

Survey respondents were drawn from persons or groups actively using or interested in using outsourced ion channel primary screening, selectivity profiling and safety liability testing.

Respondents came from 23 Large Pharma; 15 Biotech Company; 14 Medium-Small Pharma; 9 University; 3 Research Institute: 2 Government Lab; 2 Academic Screening Center; 2 Other; and 1 Hospital/Clinic/ Medical School.

Most survey respondents had a senior job role or position which was in descending order: 11 research scientists; 11 section/group leaders; 11 senior scientists/researchers; 8 directors; 7 principal investigators; 6 lab managers; 6 professors/assistant professors; 4 department heads; 4 others; 2 outsourcing managers; and 1 vice president.

Survey results were expressed as an average of all survey respondents. In addition, where appropriate the data was reanalyzed after sub-division into the following 5 survey groups: 1) Large Pharma; 2) Other Screening Labs; 3) Academic Research; 4) Europe; and 5) North America.

The majority of respondents were investigating/targeting ion channels as therapeutic targets using primary screening, with a median of <5 programs undertaken today (2016).

Where primary screening of ion channels was undertaken in house the preferred screening platform was fluorescence-based assays (e.g. FLIPR/Hamamatsu FDSS),

Only a minority of respondents have outsourced the primary screening of ion channels to date and most of this was done at Charles River. Some feedback on why some respondents have not yet outsourced ion channel primary screening was documented.

The current (2016) level of interest in outsourcing ion channel primary screening was moderate for small-scale (10-100 compounds screened) or medium-scale (100-1,000 compounds screened) primary campaigns. The median maximum price point for accessing this screening was $1-$2 per data point.

Of those respondents interested in outsourcing primary screening a median of <5 programs per year were outsourced today (2016). The preferred platform to be accessed was automated patch-clamp (APC).

Most respondents want to outsource selectivity profiling after hits-to-leads (lead optimization).

Selection by target was the preferred way of selecting assays for ion channel selectivity profiling.

A cardiac channel panel was most wanted for selectivity profiling.

The preferred platform for selectivity profiling to be accessed at service providers was APC.

The preferred vendor's platform for patch clamping data was Sophion QPatch HT.

The median use of outsourced selectivity profiling today (2016) was 100-250 data points per year.

A majority of respondents have outsourced selectivity profiling of ion channels to date and most of that was done at Charles River and Eurofins.

Data quality (e.g. GΩ versus MΩ seal data) was rated of greatest motivation in selecting an ion channel selectivity profiling provider.

The following scenarios were envisaged for outsourced selectivity profiling services; 1) assay selection by target; 2) median 6-10 channels per profile; 3) median 6-10 compounds per profile; and 4) median $2-$5 maximum price point per data point.

hERG ion channel assays were the aspect of ion channel safety liability testing respondents most want to outsource today (2016).

A median 6-10 compounds per year were outsourced for safety liability testing today (2016).

Only a minority of respondents have outsourced safety liability testing of ion channels to date and most of that was done at Charles River and Eurofins.

Cutting-edge gold standard assays was ranked what most motivates respondent's selection of an ion channel safety liability provider.

The median annual outsourcing budget allocated for all ion channel testing was $50K-$100K today (2016), with the biggest proportion of this budget spent on selectivity profiling.

A bottom-up model was developed around the respondent's outsourcing budgets to estimate the global market for outsourced ion channel testing. The total market was estimated to be around $55Millon in 2016. Details of the segmentation and breakdown into component services are given in the full report.

The majority of respondents were interested in accessing a speciality CRO for ion channel testing services.

Selectivity profiling was rated the offering an ion channel service provider must provide.

The preferred providers of ion channel primary screening were Charles River, Eurofins, Axxam and Evotec.

The preferred providers of ion channel selectivity profiling were Charles River, Eurofins and Evotec.

The preferred providers of ion channel safety liability testing were Charles River, Eurofins and ThermoFisher Scientific.

The most trusted fee-for-service provider of ion channel testing was Charles River.

The most used fee-for-service providers of ion channel testing were Eurofins and Charles River.

The majority of respondents have access to stably transfected ion channel cell lines in house.

The majority of respondents make stably transfected ion channel cell lines themselves (i.e. in house).

The median budget allocated to purchase stably transfected ion channel cell lines was $10K-$25K.

The full report provides the data, details of the breakdown of the responses for each question, its segmentation, CAGR and the estimates for the future (2018). It also highlights some interesting differences between the survey groups.

Table of Contents

  • Survey Methodology
  • Organisation & Response To The Survey
  • Respondent's Company Or Organisational Origin
  • Respondent's Geographic Origin
  • Respondent's Job Role
  • Respondents Investigating Ion Channels Using Primary Screening
  • No. of Programs With Ion Channels As Therapeutic Targets
  • Preferred Platform Technologies For Ion Channel Primary Screening (1)
  • Preferred Platform Technologies For Ion Channel Primary Screening (2)
  • Respondents Who Have Outsourced Primary Screening
  • Why Some Respondents Have Not Yet Outsourced Ion Channel Primary Screening
  • Level Of Interest In Outsourcing Ion Channel Primary Screening (1)
  • Level Of Interest In Outsourcing Ion Channel Primary Screening (2)
  • Preferred Platform Technologies For Outsourced Ion Channel Primary Screening (1)
  • Preferred Platform Technologies For Outsourced Ion Channel Primary Screening (2)
  • Interest In Outsourcing Different Ion Channel Screening Services
  • Price Points For Accessing Ion Channel Primary Screening Services
  • Summary Of Survey Findings (1)
  • When Respondents Want To Outsource Selectivity Profiling
  • Preferred Way Of Selecting Assays For Ion Channel Selectivity Profiling
  • Ion Channel Panels Of Most Interest When Considering Selectivity Profiling
  • Preferred Platform Technologies For Outsourced Ion Channel Selectivity Profiling (1)
  • Preferred Platform Technologies For Outsourced Ion Channel Selectivity Profiling (2)
  • Preferred Vendor's Platform For Patch Clamping Data
  • Respondent's Level Of Use Of Selectivity Profiling
  • Respondents Who Have Outsourced Selectivity Profiling
  • What Motivates Selection Of An Ion Channel Selectivity Profiling Provider (1)
  • What Motivates Selection Of An Ion Channel Selectivity Profiling Provider (2)
  • Scenarios Envisaged For Outsourced Selectivity Profiling Services (1)
  • Scenarios Envisaged For Outsourced Selectivity Profiling Services (2)
  • Aspects Of Ion Channel Safety Liability Testing Outsourced (1)
  • Aspects Of Ion Channel Safety Liability Testing Outsourced (2)
  • No. Of Compounds Outsourced For Safety Liability Testing Per Year
  • Respondents Who Have Outsourced Ion Channel Safety Liability Testing
  • Summary Of Survey Findings (2)
  • What Motivates Selection Of An Ion Channel Safety Liability Provider (1)
  • What Motivates Selection Of An Ion Channel Safety Liability Provider (2)
  • Annual Budget For Outsourced Ion Channel Testing
  • Breakdown Of Outsourced Ion Channel Testing Budget
  • Outsourced Ion Channel Testing Market Estimate (1)
  • Outsourced Ion Channel Testing Market Estimate (2)
  • Breakdown Of Ion Channel Outsourcing Market Estimate
  • Type Of Service Provider Respondents Are Most Interested In Accessing
  • Importance Of An Ion Channel Provider Offering Various Services (1)
  • Importance Of An Ion Channel Provider Offering Various Services (2)
  • Preferred Providers Of Ion Channel Outsourced Services (Table)
  • Most Trusted & Most Used Fee-For-Service Providers Of Ion Channel Testing (Table)
  • Preferred Providers Of Outsourced Ion Channel Primary Screening
  • Preferred Providers Of Outsourced Ion Channel Selectivity Profiling
  • Preferred Providers Of Outsourced Ion Channel Safety Liability Testing
  • Most Trusted Fee-For-Service Providers Of Ion Channel Testing
  • Most Used Fee-For-Service Providers Of Ion Channel Testing
  • Respondents With Access To Stably Transfected Ion Channel Cell Lines
  • Source of Stably Transfected Cell Lines Used In Respondent's Lab
  • Plans To Purchase Stably Transfected Cell Lines
  • Budget To Purchase Stably Transfect Cells Over The Next Few Years
  • Unmet Needs In Outsourced Ion Channel Testing
  • Summary Of Survey Findings (3)
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