Self Administration of High Viscosity Drugs
|出版商||Greystone Research Associates||商品編碼||345525|
Devices, Therapies, Players, Strategies and Forecasts
Formulations that Push the Device Envelope
Growth in biological drugs has been driven by advances in biotechnology and host-vector engineering - advances that have led to a steady stream of biologics for a number of ailments and conditions. These powerful drugs come with a high cost-per-dose and the risk of significant side effects - factors that place an elevated emphasis on administration efficiency, safety and reliability. Many drugs in this class are characterized by physical properties and sensitivities that challenge the drug commercialization ecosystem. For example, monoclonal antibodies, perhaps the most significant category in terms of therapeutic and commercial importance, typically possess viscosities that are well above the normal limits of subcutaneous injection techniques. Drug developers and device designers are increasingly working in collaboration to address the goal of patient self-administration for biological injectables.
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A longer life span is expected to translate to a growing number of patients diagnosed with chronic conditions. To counteract the financial and medical infrastructure implications of this trend, pressure from the public sector and managed care organizations will place a premium on therapeutic self-administration, an expectation that is creating an increased interest in routes of administration that are patient-friendly and cost-effective. Pharma company decision makers have come to the realization that for many products, success no longer only depends on the medication itself but also on achieving a consumer-compatible form of packaging and application.
'Most biological products are stored at 2 to 8°C. To avoid injection pain, an injectable/infusible drug is typically equilibrated to room temperature prior injection. The effect of temperature on viscosity is non-negligible and has to be factored into any product development program relying on a delivery method other than a traditional infusion set.' Table of Contents
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