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市場調查報告書
G蛋白質偶合受體（GPCR）的全球市場
G-Protein Coupled Receptors (GPCRs)
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本報告已在2012年05月14日停止出版。
更改為出版
G-Protein Coupled Receptors (GPCRs)
出版日期 : 2012年04月
商品編碼: 240203
本報告書內容包括:全球的G蛋白質偶合受體（GPCR）市場為焦點、其規模的銷售價格層面中的總合性觀點的分析、2007年到2015年為止的獨自銷售實績檢證及預測的提供、以及活躍於此領域的精銳企業43家的特選資訊之彙整、內容綱要摘記如下:
目錄
第1章 介紹、調查方法、產品的定義
第2章 產業概要
- 概略基礎知識
- G蛋白質偶合受體被重視的理由
- 作為醫藥開發目標目前所可以使用的GPCR具體範例
- 喚起關心的GPCR未開發藥理學的有望性
- 從療法上觀點所聚集更多關注的目前研究中之GPCR形式例
- 只是冰山一角的目前GPCR結晶結構知識
- 核磁気共鳴（NMR）分光法：貴重的GPCR研究工具
- 孤兒GPCR：創藥的有希望領域
- GPCR篩選技術的發展
- GPCR定量分析的細胞膜檢查
- 醫藥品產業中目前所進行的事項
- 充滿困難的GPRC空間
- 孤兒GPCR的計劃
- 結構資訊的欠缺
- 易位部位的識別和分類
第3章 G蛋白質偶合受體（GPCR） - 概念
- GPCR：細胞的入口
- GPCR的分類
- 孤兒GPCR和組織
- 相反藥理學方法所發現的oGPCR‐配位子對合一覧
- 結構資訊
- 視紫質：常研究的GPCR
- 人類Beta-2Antagonists作動性GPCR的結晶結構
- 人類A2A腺甘酸受體的結構
- GPCR結晶結構的重要性
- GPCR的訊號傳達路徑
- GPCR所扮演的生理學角色
- 視覺
- 細胞密度感應
- 姿勢及行動的控制
- 嗅覺
- 免疫系統的炎症和活動
- 神經系統的自動傳達功能
- 受體 - 配位子相互作用
- 配位子的種類
- GPCR的治療能力
- 代表性病狀和所了解的相關GPCR一覧
- 易位調節因子和創藥的易位效果意義
- 易位調節因子的優點
- 二量化和創藥的二量體角色
- 寡合體形成和創藥的寡合體角色
- 功能選擇性
- GPCR空間所存在的藥劑後補
- 目前市場銷售的GPCR系列藥劑和其目標受體、適應症的一覧
- 生產線GPCR藥劑後補
- 離子通路
- GPCR空間的創藥對策
- GPCR篩選及目標技術
第4章 最近的業界趨勢
第5章 全球的主要加入企業
第6章 全球市場展望
競爭環境
Abstract
This report analyzes the Global market for G-Protein Coupled Receptors (GPCRs)
in US$ Billion. Annual estimates and forecasts are provided for the period
2007 through 2015. Also, a six-year historic analysis is provided for these
markets. The report profiles 43 companies including 7TM Pharma A/S, Actelion
Pharmaceuticals Ltd., Acure Pharma AB, Anchor Therapeutics, Arena
Pharmaceuticals, Inc., Addex Pharmaceuticals, Acadia Pharmaceuticals Inc.,
Cara Therapeutics, Inc., DiscoveRx Corporation, Dimerix Bioscience Pty Ltd.,
Domain Therapeutics, Euroscreen SA, Millipore Corporation, and Trevena, Inc.
Market data and analytics are derived from primary and secondary research.
Company profiles are mostly extracted from URL research and reported select
online sources.
Table of Contents
1. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS
- Study Reliability and Reporting Limitations
- Disclaimers
- Data Interpretation & Reporting Level
- Quantitative Techniques & Analytics
- Product Definitions and Scope of Study
2. INDUSTRY OVERVIEW
- A Quick Primer
- Why GPCRs Are Important?
- Illustrative Examples of Currently Available Pharmaceutical Drugs
Targeting GPCRs
- Untapped Pharmacological Potential of GPCRs Ignites Interest
- Popular Types of GPCRs of Therapeutic Interest Currently Being Studied
Include:
- Current Knowledge of GPCR Crystal Structures Just the Tip of the Iceberg
- NMR Spectroscopy: An Invaluable Tool to Study GPCR Structures
- Orphan GPCRs: A Promising Area for Drug Discovery
- Developments in Screening Technology for GPCRs
- Cell Membrane Assays for GPCR Quantitative Analysis
- What' s in for the Pharmaceutical Industry?
- Challenges Aplenty in the GPCR Space
- Addressing Orphan GPCRs
- Lack of Structural Information
- Identification and Classification of Allosteric Sites
3. G-PROTEIN COUPLED RECEPTORS (GPCR) - A CONCEPTUAL OVERVIEW
- GPCR: Gateways to Cell
- Classification of GPCRs
- Table 1: List of Identified Known and Orphan (Non-Sensory) GPCRs in
Human Genome (includes corresponding Graph/Chart)
- Orphan GPCRs and Deorphanization
- List of oGPCR-Ligand Pairings Identified By Using Reverse Pharmacology
Approach
- Structural Information
- Rhodopsin: A Well Studied GPCR
- Crystal Structure of Human Beta-2 Adrenergic GPCR
- Structure of Human A2A Adenosine Receptor
- Significance of GPCR Crystal Structures
- GPCR Signaling Pathways
- Physiological Roles Performed by GPCRs
- Visual Sense
- Cell-density Sensing
- Regulation of mood and behavior
- Smelling Sense
- Regulating Immune-System Inflammation and Activity
- Automatic Transmission of Nervous System
- Receptor - Ligand Interaction
- Types of Ligands
- Therapeutic Potential of GPCRs
- List of Major Disease States and Associated Known GPCRs
- Allosteric Modulators and Implication of Allostery in Drug Discovery
- Advantages of Allosteric Modulators
- Dimerisation and Role of Dimers in Drug Discovery
- Oligomerisation and Role of Oligomers in Drug Discovery
- Functional Selectivity
- Existing Drug Candidates in GPCR Space
- List of Existing GPCR-Based Drugs Available In Market Along With Their
Target Receptor and Indication
- Pipeline GPCR Drug Candidates
- Ion Channels
- Approaches to Drug Discovery in GPCR Space
- Structure-Based Drug Discovery
- Ligand-Based Drug Discovery
- Target-Based Drug Discovery
- GPCR Screening and Targeting Technologies
- Cell-Based Screening Assays
- Virtual Screening
- Fragment screening
4. RECENT INDUSTRY ACTIVITY
- Domain Therapeutics Enters into an Agreement with Merck Serono
- Anchor Therapeutics Makes a Breakthrough in GPCR Collaboration
- Receptos Collaborates with Lilly GPCR target
- Sanofi-aventis Enters into Licensing Agreement with Metabolex
- Neurocrine and Boehringer Ingelheim Join Hands to Develop GPR119 Agonists
- Affitech Enters into Research Collaboration with NTS Plus
- Takeda Cambridge Inks an Agreement to Utilize Dimerix' GPCR-HIT Platform
- PerkinElmer Unveils New Detection Kit for Profiling and Screeing GPCRs
- Omeros Completes Acquisition of GPCR Assay Technology from Patobios
- DiscoveRx Corporation Takes Over KINOMEscan™
- Roche and ATCC Collaborate on Real-Time Endogenous GPCR Function Research
- Millipore Launches Luminescent GPCR Reporter Frozen Cells
- Ascent Therapeutics re-christened as Anchor Therapeutics
- Affitech Sells Cancer Vaccine Project to Focus on GPCR Research
- Medarex Releases Pre-clinical Data for MDX-1338
- Compugen Declares Positive Therapeutic Effects of CGEN-25009
- Addex Releases Clinical Data for ADX10059
- Arana Receives Patent Approval for PMX53 and Related GPCR Compounds
- Epix Pharmaceuticals Receives Patent Approval for PRX-03140 and Related
Compounds
- Odyssey Thera Receives Patent Approval for Fluorescence-Based Assays
- Cisbio Bioassays Introduces Cellul' erk Assay
- DiscoveRx Introduces Products and Services to Assays and Reagents
Portfolio
- PerkinElmer Introduces Novel Ion Channel and GPCR Cell Lines
- Millipore Launches New AllostericProfiler™ Service
- Ligand Pharmaceuticals and Trevena Enter into Agreement
- ChanTest Takes Over ACS
- PerkinElmer Enters into Collaboration with Sangmyung University
- Debiopharm Group Inks Exclusive Agreement with MSM Protein Technologies
- GVK Biosciences and University of Tokyo Sign Agreement
- MSM Protein Technologies Enters into Alliance with Merck Serono
- Xenome Enters into Agreement with Axxam
- DiscoveRx and GlaxoSmithKline Inks Global Agreement
- Sygnature Enters into Contract Chemistry Agreement with Heptares
Therapeutics
- Enzo Life Sciences Enters into Partnership with BioTek Instruments
- Heptares Therapeutics Enters into Agreement with Novartis Option Fund
- CellAura Enters into Partnership with Cisbio Bioassays
- Euroscreen and Novartis Ink Research Collaboration Agreement
- Evotec Enters into Co-marketing Agreement with DiscoveRx
- Jubilant Biosys Inks Co-marketing Agreement with DiscoveRx
- Faust Pharmaceuticals Changes Name to Domain Therapeutics
- GSK, MRCT and DiscoveRx Collaborate for Deorphanization of GPCRs
- DiscoveRx Inks Agreement with BioFocus
- Actelion' s S1P1 Receptor Agonist to Enter into Phase II Clinical Trial
- AnaSpec Introduces Two Isoform Specific Antibodies
- Millipore Introduces MultiScreen®HTS+ Filter Plates
- Faust & Takeda Enter into Research Agreement
- Caliper Life Sciences Collaborates with DiscoveRx
- Compugen Inks Agreement with Merck Serono
- BioFocus and Amgen Extend Drug Discovery Agreement
- DiscoveRx Selects Cosmo Bio to Distribute GPCR Profiling Service across
Japan
- Euroscreen Extends Agreement with Cephalon
- BioFocus DPI Introduces Novel Version of GPCR SARfari
- PerkinElmer Takes Over Euroscreen Products
5. FOCUS ON SELECT GLOBAL PLAYERS
- 7TM Pharma A/S (Denmark)
- Actelion Pharmaceuticals Ltd. (Switzerland)
- Acure Pharma AB (Sweden)
- Anchor Therapeutics (USA)
- Arena Pharmaceuticals, Inc. (US)
- Addex Pharmaceuticals (Switzerland)
- Acadia Pharmaceuticals Inc., (USA)
- Cara Therapeutics, Inc. (USA)
- DiscoveRx Corporation (USA)
- Dimerix Bioscience Pty Ltd (Australia)
- Domain Therapeutics (France)
- Euroscreen SA (Belgium)
- Millipore Corporation (US)
- Trevena, Inc. (USA)
6. GLOBAL MARKET PERSPECTIVE
- Table 2: World Recent Past, Current & Future Market Analysis for
G-Protein Coupled Receptors (GPCRs) Addressing Drugs With Annual Sales Figures
in US$ Billion for Years 2007 through 2015 (includes corresponding
Graph/Chart)
- Table 3: World Historic Review for G-Protein Coupled Receptors (GPCRs)
Addressing Drugs With Annual Sales Figures in US$ Billion for Years 2001
through 2006 (includes corresponding Graph/Chart)
COMPETITIVE LANDSCAPE
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