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Abstract
This report analyzes the worldwide markets for Biocompatible Materials in US$
Million by the following product segments: Polymeric Materials, Metallic
Materials, Natural Materials, and Other Materials. The report provides
separate comprehensive analytics for the North America, Japan, Europe, and
Rest of World. Annual estimates and forecasts are provided for the period 2007
through 2015. Also, a seven-year historic analysis is provided for these
markets.The report profiles 69 companies including many key and niche players
such as A.P. Pharma, Inc., Angiotech Pharmaceuticals Inc., Artimplant AB, AST
Products, Inc., Biocoat, Inc., DENTSPLY International Inc., Invibio, Integra
LifeSciences Holdings Corporation, Orthovita Inc., SaluMedica, LLC, SurModics,
Synthes Inc, and United States Surgical. Market data and analytics are derived
from primary and secondary research. Company profiles are mostly extracted
from URL research and reported select online sources.
Table of Contents
1. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS 1
- Study Reliability and Reporting Limitations 1
- Disclaimers 2
- Data Interpretation & Reporting Level 3
- Quantitative Techniques & Analytics 3
- Product Definition and Scope of Study 3
- Polymeric Materials 4
- Metallic Materials 4
- Natural Materials 4
- Other Materials 4
2. INDUSTRY OVERVIEW 5
- Biocompatible Materials Market Continues to Surge, Despite Recession 5
- Current and Future Analysis 5
- Regional Perspective 5
- Developing Regions to Propel Future Growth 6
- Material-Wise Perspective 6
- R&D Creates Brighter Avenues 6
- Competitive Scenario 6
- Factors Determining Market Growth 6
- Awareness of Basic Mechanisms of Cell-Material Interaction 6
- Birth of Cross-Disciplinary Field of Tissue Engineering 7
- Rise in Biomaterial Prices 7
- Stem-Cell Technology - A Threat 7
3. PRODUCT TRENDS 8
- Biomaterials Play Crucial Role in Implants Market 8
- Natural Substances find Increasing Application in Biomaterial Syntheses 8
- Plastic Companies Join the Fray as Manufacturers of Biodegradable
Materials 8
- Ceramic Fillings as Substitute for Silver-Tin-Mercury Amalgam Fillings 9
- Ceramics Offer Significant Potential in Crown Syntheses 9
- Hafnium - A Promising Material for Biocompatible Coatings 9
- Chitin as a New Biomaterial 9
- Bioglass - A Potential Material for Bone Regeneration 9
- Collagen - An Efficient Biomaterial for Synthetic Vascular Grafts 10
- Biopolymers as Biomaterials 10
- Bioabsorbable Intelligent Materials 10
- Biocompatible Coatings - A Boon for Medical Implant Applications 10
- Nanotechnology - Revolutionizes Development of Biomaterial Implants 11
4. END-USE MARKET ANALYSIS 12
- Biosensors 12
- Implants 12
- Common Orthopedic Implants: Merits and Demerits 12
- Biocompatibility of Implants with Blood 13
- Integrating Heparin to Polymeric Surface 13
- Dental Implants 14
- Recession Decelerates Dental Implant Market, Outlook Remains Positive 14
- Significant Market Opportunities Exist for Dental Implants 14
- Nanotechnology Permeates Dental Implant Market 15
- Competitive Scenario 15
- Table 1: Global Dental Implant Market by LeadingPlayers (2009): Market
Share Breakdown ofRevenue for Nobel Biocare, Straumann, Biomet/3i,Zimmer
Dental, Dentsply and Others (includes corresponding Graph/Chart) 15
- Joint Implant 16
- Artificial Organs 16
- Artificial Heart 16
- Totally Implantable Artificial Heart (TAH) System 16
- Pneumatic Total Artificial Heart (PTAH) 16
- Cardiopulmonary Bypass System for Long-term Use 16
- Ventricular Assist Device 16
- Artificial Blood Vessels 16
- Artificial Blood 17
- Artificial Skin 17
- Surface Coatings 17
- Materials for Drug Delivery Systems 18
- Polyethylene Glycol as a Drug Delivery System 18
- Hydrogels as Drug Delivery System 18
- Vinylic based Drug Delivery Systems 18
- Collagen Based Drug Delivery System 18
- Electrodes 18
- Tissue Replacement Materials 19
- Dialysis/Separation/Filtration Systems 19
- Dialysis 19
- Filtration and Separation 20
- Cosmetic and Dental Materials 20
- Biomaterials for Cosmetic Formulations 20
5. RESEARCH AND DEVELOPMENT 21
- Biocompatible Materials - Key Research Objectives 21
- R&D Activity In the Recent Past 22
- French Inventors Develop Three-Dimensional Filet Stitch Fabric Wall
Reinforcement 22
- California Inventor Develops Biocompatible Material 22
- Scientists Develop Process for Producing Biocompatible Fibers 22
- Penn State Researchers Develop New Niobium Molding Process 22
- Doxa Commences Clinical Trials for Novel Biomaterial 22
- FzioMed Concludes Preliminary Study for Oxiplex Gel 23
- MIV' s Biomaterial Stent Coating Clears Pyrogen Clinical Testing 23
6. REGULATORY ENVIRONMENT 24
- FDA Regulations 24
- American Society for Testing and Materials (ASTM) 24
- Joint Research Center (JRC) 24
- Biocompatibility Testing of Materials 24
- Testing Levels 24
- General Biocompatibility Testing 24
- Individual Biocompatibility Testing 25
- Testing Methods 25
7. PRODUCT OVERVIEW 26
- Biocompatible Materials - An Introduction 26
- Definition of Biocompatible Materials 26
- Applications 26
- Orthopedic Applications 26
- Cardiovascular Applications 26
- Dental Applications 27
- Biomaterials as Skin Replacements 27
- Biomaterials as Scaffolds for Tissue Engineering 27
- Product Segments 27
- Polymeric Materials 27
- Hydrogels 28
- Biodegradable Polymers 28
- Metallic Materials 29
- Natural Materials 30
- Collagen 30
- Hyaluronic Acid 30
- Other Materials 30
- Ceramics 30
- Bioactive Ceramics 31
- Applications 31
- Bone Substitutes 31
- Articulating Surfaces in Joint Implants 31
- Composites 31
- Pyrolitic Carbon 32
- Biomaterial Segments and Applications: An Outline 32
8. PRODUCT INTRODUCTIONS/INNOVATIONS 33
- Bayer MaterialScience Launches Baymedix Brand 33
- Exotech Bio Solutions Develops Super-Absorbent Polymers 33
- Wacker Launches Silpuran 6600 33
- Thermo Fisher Scientific Launches HyperSep Retain Polymers 33
- Aesculap to Launch MonoMax Monofilament Absorbable Suture 34
- Lifecore Biomedical Launches Corgel BioHydrogel Research Hydrogel 34
- Incisive Surgical to Unveil Advanced INSORB(r) Absorbable Staple 34
- AGY Launches HPB Glass Fiber 34
- DSM Biomedical Unveils Modern Application for ComfortCoat 35
- Medtronic Launches X-STOP PEEK IPD System 35
- K2M Enters into Biomaterials Sector 35
- Orthovita to Launch Vitoss Bioactive Foam Pack 35
- Cook Medical Unveils Umbilical Hernia Graft 36
- Stratasys Launches ABS-M30i Biocompatible Material 36
- K2M Launches Aleutian AN and Aleutian Anterior 36
9. PRODUCT INTRODUCTIONS/INNOVATIONS IN RECENT PAST - A PERSPECTIVE BUILDER 38
- Invibio(r) Launches ENDOLIGN(tm) Polymer Composite 38
- Zimmer Dental Launches the Puros(r) Dermis Allograft Tissue Matrix 38
- Integra Launches Nerve Injury Products 38
- DePuy Mitek Expands Orthopedics Product Portfolio 39
- DSM Dyneema Introduces Polyethylene Fiber 39
10. RECENT INDUSTRY ACTIVITY 40
- Piramal Healthcare to Acquire Assets of BioSyntech 40
- DSM Biomedical and CID Enter into Partnership 40
- Angiotech Acquires Haemacure' s Technology Assets and Product Candidates 40
- Sigma-Aldrich and Boehringer Ingelheim Pharma Ink Distribution Agreement 41
- ETEX Corporation' s CarriGen Receives FDA Approval 41
- FDA Approves Custom Spine' s PATHWAY ACIF 41
- Bayer Material Science Acquires PolyBioMed 42
- Allergan Snaps Up Serica Technologies 42
- ETEX and Orthopediatrics Enter Distribution Agreement 42
- Anika Therapeutics Takes Over Fidia Advanced Biopolymers 42
- TiGenix Acquires Orthomimetics 43
- ETEX Corporation and Alphatec Spine Sign Distribution Agreement 43
- NeuroVasx' s cPAX Receives Canadian Approval 43
- PolyMedix Receives Grant for Developing Anti-Bacterial Materials 43
- Synovis Life Technologies Acquires Assets of Pegasus Biologics 44
- Immuno-Biological laboratories to Purchase NEOSILK 44
- NMT Medical Obtains Pre-Market Approval 44
- Xiros Launches Research Laboratory 44
- SyntheMed Receives Pre-Market approval for REPEL-CV Adhesion Barrier 44
- Neovasc Enters into Agreement with LeMaitre Vascular 45
- Healionics Inks Agreement with TR BioSurgical 45
- Xceed Capital Raises Stake in PolyNovo Biomaterials 45
- CorMatrix Cardiovascular Receives Clearance for ECM(tm) Technology 46
- OPKO Health Takes Over Vidus Ocular 46
- Royal DSM NV to Acquire DSM PTG 46
- ETEX Signs Supply Agreement with AllloSource 46
- Orthovita and Medafor Enter into Distribution Agreement 47
- Bio-Bridge Signs Memorandum of Understanding with JR Scientific 47
- Etex Inks Supply Agreement with LifeNet Health 47
- Heparinex and Choncept Sign Option/License Agreement with Biological E. 48
- LeMaitre Acquires Biomateriali 48
- Angiotech Pharmaceuticals inks Licensing Agreement with Symphony Medical 48
- Vertellus Biomaterials Signs License and Supply Agreement 49
11. INDUSTRY ACTIVITY IN THE RECENT PAST - A PERSPECTIVE BUILDER 50
- Tyco International Acquires Confluent Surgical 50
- SurModics Acquires Intralytix' s Biodegradable Polymer Technology 50
- Orthovita Signs a Collaboration Agreement with Aastrom Biosciences for
Orthopedic Products 50
- Kuhnil Pharma Acquires Rights from BioSyntech 50
- SurModics Licenses Hydrophilic Coating to Devax 50
- BioSyntech Receives Notice of Allowance from the US Patent and Trademark
Office for BST-CarGel(r) 51
- Artimplant Signs License and Development Agreements with Small Bone
Innovations 51
- SaluMedica Licenses Proprietary Biomaterial to Spine Medica 51
- SurModics Licenses Hydrophilic Technology to Medtronic 51
- SurModics Obtains Exclusive Rights from Rutgers University to
Biodegradable Polymers for Ophthalmology 51
- MIV Therapeutics Inks Research Agreement with University of British
Columbia 52
- Zimmer Acquires Implex 52
- Biomet Acquires Interpore 52
- Angiotech Acquires NeuColl 52
- Synthes-Stratec Inc and Mathys Medizinaltechnik AG Merge 53
- Kyocera and Kobe Steel Form a Joint Venture 53
- Angiotech Expands Biomaterial Licensing Agreement with Poly-Med 53
- Genzyme Corp Enters into Agreement with Wyeth Pharmaceuticals 53
- OctoPlus Grants License to SurModics to Acquire Two Novel Biodegradable
Polymers 54
- GP Surgical Receives FDA Approval for TiMESH 54
12. FOCUS ON SELECT PLAYERS 55
- A.P. Pharma, Inc. (USA) 55
- Angiotech Pharmaceuticals Inc. (Canada) 55
- Artimplant AB (Sweden) 55
- AST Products, Inc. (USA) 56
- Biocoat, Inc. (USA) 56
- DENTSPLY International Inc. (USA) 56
- Invibio (UK) 57
- Integra LifeSciences Holdings Corporation (USA) 57
- Orthovita Inc. (USA) 58
- SaluMedica, LLC (USA) 58
- SurModics Inc. (USA) 58
- Synthes Inc. (USA) 59
- United States Surgical (USA) 59
13. GLOBAL MARKET PERSPECTIVE 60
- Table 2: World Recent Past, Current and Future Analysis for Biocompatible
Materials by Geographic Region - North America, Japan, Europe, and Rest of
World Markets Independently Analyzed with Annual Sales Figures in US$ Million
for Years 2007 through 2015 (includes corresponding Graph/Chart) 60
- Table 3: World Historic Review for Biocompatible Materialsby Geographic
Region -North America, Japan, Europe andRest of World Markets Independently
Analyzed withAnnual Sales Figures in US$ Million for Years 2000through 2006
(includes corresponding Graph/Chart) 61
- Table 4: World 11-Year Perspective for BiocompatibleMaterials by
Geographic Region - Percentage Breakdownof Dollar Sales for North America,
Japan, Europe, andRest of World Markets for Years 2005, 2010 and 2015(includes
corresponding Graph/Chart) 62
- Table 5: World Recent Past, Current and Future Analysis for Polymeric
Materials by Geographic Region - North America, Japan, Europe, and Rest of
World Markets Independently Analyzed with Annual Sales Figures in US$
Millionfor Years 2007 through 2015 (includescorresponding Graph/Chart) 63
- Table 6: World Historic Review for Polymeric Materials by Geographic
Region -North America, Japan, Europe andRest of World Markets Independently
Analyzed withAnnual Sales Figures in US$ Million for Years 2000through 2006
(includes correspondingGraph/Chart) 64
- Table 7: World 11-Year Perspective for Polymeric Materialsby Geographic
Region - Percentage Breakdown of DollarSales for North America, Japan, Europe,
and Rest of World Markets for Years 2005, 2010 and 2015 (includescorresponding
Graph/Chart) 65
- Table 8: World Recent Past, Current and Future Analysis for Metallic
Materials by Geographic Region - North America, Japan, Europe, and Rest of
World Markets Independently Analyzed with Annual Sales Figures in US$
Millionfor Years 2007 through 2015 (includescorresponding Graph/Chart) 66
- Table 9: World Historic Review for Metallic Materials by Geographic Region
-North America, Japan, Europe andRest of World Markets Independently Analyzed
withAnnual Sales Figures in US$ Million for Years 2000through 2006 (includes
correspondingGraph/Chart) 67
- Table 10: World 11-Year Perspective for Metallic Materialsby Geographic
Region - Percentage Breakdown of DollarSales for North America, Japan, Europe,
and Rest of World Markets for Years 2005, 2010 and 2015 (includescorresponding
Graph/Chart) 68
- Table 11: World Recent Past, Current and Future Analysisfor Natural
Materials by Geographic Region - North America, Japan, Europe, and Rest of
World Markets Independently Analyzed with Annual Sales Figures in US$
Millionfor Years 2007 through 2015 (includescorresponding Graph/Chart) 69
- Table 12: World Historic Review for Natural Materials by Geographic Region
-North America, Japan, Europe andRest of World Markets Independently Analyzed
withAnnual Sales Figures in US$ Million for Years 2000through 2006 (includes
corresponding Graph/Chart) 70
- Table 13: World 11-Year Perspective for Natural Materialsby Geographic
Region - Percentage Breakdown ofDollar Sales for North America, Japan, Europe,
andRest of World Markets for Years 2005, 2010 and 2015(includes corresponding
Graph/Chart) 71
- Table 14: World Recent Past, Current and Future Analysisfor Other
Materials by Geographic Region - North America, Japan, Europe, and Rest of
World Markets Independently Analyzed with Annual Sales Figures in US$
Millionfor Years 2007 through 2015 (includescorresponding Graph/Chart) 72
- Table 15: World Historic Review for Other Materials by Geographic Region
-North America, Japan, Europe andRest of World Markets Independently Analyzed
withAnnual Sales Figures in US$ Million for Years 2000through 2006 (includes
corresponding Graph/Chart) 73
- Table 16: World 11-Year Perspective for Other Materialsby Geographic
Region - Percentage Breakdown ofDollar Sales for North America, Japan, Europe,
andRest of World Markets for Years 2005, 2010 and 2015(includes corresponding
Graph/Chart) 74
14. NORTH AMERICA 75
- A. Market Analysis 75
- Outlook 75
- Demand for Orthopedic Biomaterials Surges 75
- Orthopedic Biomaterials Emerge Recession Proof 76
- Developments in the United States Dental Biomaterial Market 76
- Regulatory Environment 76
- FDA Regulations 76
- Potential Biomaterial Shortage 77
- Effects of Potential Shortages 77
- B. Market Analytics 78
- Table 17: North America Recent Past, Current &Future Analysis for
Biocompatible Materials by Type - Polymeric Materials, Metallic Materials,
NaturalMaterials and Other Materials Markets Independently Analyzed with
Annual Sales Figures in US$ Millionfor Years 2007 through 2015
(includescorresponding Graph/Chart) 78
- Table 18: North America Historic Review forBiocompatible Materials by
Type - Polymeric Materials, Metallic Materials, Natural Materials &
Other Materials Markets Independently Analyzed with Annual SalesFigures in
US$ Million for Years 2000 through 2006 (includes corresponding Graph/Chart)
79
- Table 19: North America 11-Year Perspective for Biocompatible Materials
by Type - PercentageBreakdown of Dollar Sales for Polymeric
Materials,Metallic Materials, Natural Materials and OtherMaterials Markets
for 2005, 2010 and 2015(includes corresponding Graph/Chart) 80
15. JAPAN 81
- A. Market Analysis 81
- Outlook 81
- An Overview 81
- Import Scenario: Implants 81
- Table 20: Japanese Percentage Imports byImplant Type (includes
correspondingGraph/Chart) 82
- History 82
- Major Biomaterial Research Groups 82
- Institute of Biomedical Engineering (Tokyo Women' s Medical University)
82
- Tissue Engineering Research Institute (Kyoto University) 82
- Institute of Biomaterials and Bioengineering (Tokyo Medical and Dental
University) 82
- Principal Research Institutions 83
- Regulatory Environment 83
- Medical Affairs Law 83
- B. Market Analytics 84
- Table 21: Japanese Recent Past, Current and FutureAnalysis for
Biocompatible Materials by Type - Polymeric Materials, Metallic Materials,
Natural Materials andOther Materials Markets Independently Analyzed
withAnnual Sales Figures in US$ Million for Years 2007through 2015 (includes
correspondingGraph/Chart) 84
- Table 22: Japanese Historic Review for Biocompatible Materials by Type
- Polymeric Materials, MetallicMaterials, Natural Materials & Other
MaterialsMarkets Independently Analyzed with Annual SalesFigures in US$
Million for Years 2000 through 2006 (includes corresponding Graph/Chart) 85
- Table 23: Japanese 11-Year Perspective for Biocompatible Materials by
Type - Percentage Breakdown of DollarSales for Polymeric Materials, Metallic
Materials,Natural Materials and Other Materials Marketsfor 2005, 2010 and
2015 (includescorresponding Graph/Chart) 86
16. EUROPE 87
- A. Market Analysis 87
- Outlook 87
- Key Growth Factors 87
- UK Bioceramic Market 87
- Regulatory Environment 87
- Government Regulations 87
- B. Market Analytics 88
- Table 24: European Recent Past, Current and Future Analysis for
Biocompatible Materials by Type - Polymeric Materials, Metallic Materials,
Natural Materials andOther Materials Markets Independently Analyzed
withAnnual Sales Figures in US$ Million for Years 2007through 2015 (includes
correspondingGraph/Chart) 88
- Table 25: European Historic Review for Biocompatible Materials by Type
- Polymeric Materials, MetallicMaterials, Natural Materials & Other
MaterialsMarkets Independently Analyzed with Annual SalesFigures in US$
Million for Years 2000 through 2006 (includes corresponding Graph/Chart) 89
- Table 26: European 11-Year Perspective for Biocompatible Materials by
Type - Percentage Breakdown of DollarSales for Polymeric Materials, Metallic
Materials,Natural Materials and Other Materials Marketsfor Years 2005, 2010
and 2015 (includescorresponding Graph/Chart) 90
17. REST OF WORLD 91
- A. Market Analysis 91
- B. Market Analytics 91
- Table 27: Rest of World Recent Past, Current andFuture Analysis for
Biocompatible Materials by Type - Polymeric Materials, Metallic Materials,
NaturalMaterials and Other Materials Markets Independently Analyzed with
Annual Sales Figures in US$ Millionfor Years 2007 through 2015
(includescorresponding Graph/Chart) 91
- Table 28: Rest of World Historic Review for Biocompatible Materials by
Type - Polymeric Materials, MetallicMaterials, Natural Materials & Other
MaterialsMarkets Independently Analyzed with Annual SalesFigures in US$
Million for Years 2000 through 2006 (includes corresponding Graph/Chart) 92
- Table 29: Rest of World 11-Year Perspective for Biocompatible Materials
by Type - Percentage Breakdownof Dollar Sales for Polymeric Materials,
MetallicMaterials, Natural Materials and Other MaterialsMarkets for 2005,
2010 and 2015 (includescorresponding Graph/Chart) 93
COMPETITIVE LANDSCAPE
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