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市場調查報告書

全球蛋白質體學市場

Proteomics

出版商 Global Industry Analysts, Inc. 商品編碼 138619
出版日期 內容資訊 英文 234 Pages
商品交期: 最快1-2個工作天內
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全球蛋白質體學市場 Proteomics
出版日期: 2014年05月01日 內容資訊: 英文 234 Pages
簡介

本報告提供全球蛋白質體學市場相關調查,提供各產品,各地區的趨勢,今後的年度預測,及加入此市場的主要企業簡介等。

第1章 簡介,調查方法,產品定義

第2章 摘要整理

  • 全球市場概要
    • 蛋白質體學:現狀
    • 蛋白質體學:重要的藥物研發工具
    • 獨佔近未來的市場調查
    • 蛋白質體學技術
    • 蛋白質體學技術的新發展
    • 推動市場的要素/趨勢/課題
    • 個人化醫療正在緩慢成長
    • 由於蛋白質體學的進步生物標記備受關注 其他
  • 產業競爭
  • 產品及技術概要
    • 何謂蛋白質,蛋白質組,蛋白質體學
    • 蛋白質體學:簡介
    • 蛋白質體學的起源
    • 蛋白質體學的結構
    • 蛋白質體學的表現
    • 功能性蛋白質體學
    • Cell-map Proteomics
    • 結構性蛋白質體學
    • 技術和蛋白質體學
    • 蛋白質體學和基因學
    • 蛋白質產生途徑
    • 從基因學到蛋白質體學 其他
  • 蛋白質體學技術概要
  • 最終用途領域
    • 藥物研發及診斷上的蛋白質體學
    • 蛋白質體學與藥物研發
    • 蛋白質微陣列
    • 癌症的開發藥劑下蛋白質體學的方法
    • 癌症的藥物研發及開發新藥所採用的蛋白質體學技術
  • 新產品上市/開發
  • 近幾年的產業活動
  • 全球參與企業
    • ActivX Biosciences, Inc.
    • Agilent Technologies, Inc.
    • Bio-Rad Laboratories, Inc.
    • Bruker Daltonics, Inc.
    • Caprion Proteomics, Inc.
    • Digilab Genomic Solutions, Inc.
    • GE Healthcare
    • Geneva Bioinformatics S.A.
    • Hybrigenics SA
    • EMD Millipore/Merck Millipore Corp.
    • PerkinElmer, Inc.
    • 公司島津製作所
    • Sigma-Aldrich Corporation
    • Thermo Fisher Scientific
    • Waters Corp.
    • Xencor Inc.
  • 全球市場預測

第3章 市場

  • 美國
  • 加拿大
  • 日本
  • 歐洲
    • 法國
    • 德國
    • 義大利
    • 英國
    • 其他
  • 亞太地區
  • 南美
  • 其他各國

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目錄
Product Code: MCP-1029

This report analyzes the worldwide markets for Proteomics in US$ Million. The report provides separate comprehensive analytics for the US, Canada, Japan, Europe, Asia-Pacific, Latin America, and Rest of World. Annual estimates and forecasts are provided for the period 2013 through 2020. Also, a seven-year historic analysis is provided for these markets. Market data and analytics are derived from primary and secondary research. Company profiles are primarily based on public domain information including company URLs. The report profiles 82 companies including many key and niche players such as -

ActivX Biosciences, Inc.
Agilent Technologies, Inc.
Bio-Rad Laboratories, Inc.
Bruker Daltonics, Inc.
Caprion Proteomics, Inc.

Table of Contents

I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

  • Study Reliability and Reporting Limitations
  • Disclaimers
  • Data Interpretation & Reporting Level
    • Quantitative Techniques & Analytics
  • Product Definitions and Scope of Study

II. EXECUTIVE SUMMARY

1. GLOBAL MARKET OVERVIEW

  • Proteomics - The Current Spotlight
  • Proteomics: A Critical Drug Discovery Tool
  • Research to Dominate the Market in the Immediate Future
  • Proteomics Technologies: Growing in Significance
  • New Developments in Proteomics Technologies
  • Market Drivers/Trends/Challenges
  • Personalized Medicine Slowly Gaining Ground
    • Table 1: Drug Ineffectiveness for Select Therapeutic Categories as a Percentage of Patient Population (includes corresponding Graph/Chart)
    • Table 2: Global Population Statistics for the 65+ Age Group (2012) (includes corresponding Graph/Chart)
    • Table 3: Percentage of Population Aged 65 and Above in Europe, US, and Japan (1960-2030) (includes corresponding Graph/Chart)
    • Table 4: Elderly Population (65+ Years) as a Percentage of the Total Population: 2025 (includes corresponding Graph/Chart)
  • Advancements in Proteomics Bring Biomarkers into Limelight
    • List of US-FDA Approved Biomarkers for Cancer
  • Oncology - A Key Focus Area for Proteomics
    • Table 5: World Cancer Incidence by Geographic Region and Gender (2012): Number of New Cancer Cases Reported (in Thousands) for Asia-Oceania, Europe, North America, Latin America & The Caribbean, and Africa (includes corresponding Graph/Chart)
    • Table 6: New Cancer Cases in the World by Affected Site (2012) (in Thousands) (includes corresponding Graph/Chart)
    • Table 7: Cancer Incidence in Developed Nations by Site: 2012 (includes corresponding Graph/Chart)
    • Table 8: Global Incidence of Common Cancers in Men (2012): Number of New Cases Reported in Thousands for Lung & Bronchus, Prostate, Colorectal, and Liver Cancers (includes corresponding Graph/Chart)
    • Table 9: Global Incidence of Common Cancers in Women (2012): Number of New Cases Reported in Thousands for Breast, Colorectal, Lung & Bronchus, and Liver Cancers (includes corresponding Graph/Chart)
    • Table 10: World Cancer Mortality by Geographic Region and Gender (2012): Number of Cancer- Related Deaths (in Thousands) for Asia-Oceania, Europe, North America, Latin America & The Caribbean, and Africa (includes corresponding Graph/Chart)
  • International Initiatives in the Proteomics Market
  • China All Set To Play a Major Role in the Proteomics Industry
  • Global Proteomics Sample Preparation Market - On a Growth Curve
    • Challenges Facing Proteomics Sample Preparation Market
    • Industrialization of Proteomics Research Propels Sample Preparation Technologies
    • Factors Limiting Market Growth
  • Impact of the Economic Recession on the Life Sciences Industry in Retrospect
  • Challenges Facing Proteomics Industry
  • Protein Chemistry and its Complexities
  • Quantitation
  • Integration of Data & Equipment
  • Data Validation - A Burning Issue
  • Standardization & Consistency - A Prime Concern
  • Incomplete and Disorganized Data

2. INDUSTRY COMPETITION

  • A Highly Fragmented Market
  • Tool Providers: Leading the Proteomics Market
  • Role of Contract Research Organizations - All Set to Increase in Proteomics

3. PRODUCT AND TECHNOLOGY OVERVIEW

  • Proteins, Proteome and Proteomics!!! - What are they?
  • Proteomics - An Introduction
  • Genesis of Proteomics
  • Components of Proteomics
  • Expression Proteomics
  • Functional Proteomics
  • Cell-map Proteomics
  • Structural Proteomics
  • Technologies and Proteomics
  • Proteomics and Genomics
  • Proteomics and Genomics: A Comparison
  • Protein Production Pathway: From Gene Expression to Functional Protein with Controls
  • From Genomics to Proteomics
  • Functional Genomics and Proteomics
  • Push from Genomic Information
    • An Insight into Proteomics Data Type and their Characteristics / Features
  • Standard Proteomics Approach
  • Sample Preparation - Step I
  • Protein Separation - Step II
    • Protein Visualization
  • Protein Expression Analysis-Step III
    • Image Analysis - Identify differentially expressed spots
  • Protein Identification - Step IV
    • Data Storage and Processing - Step V

4. OVERVIEW OF PROTEOMICS TECHNOLOGIES

  • A Snapshot of Various Proteomics Tools
  • An Insight into Various Proteomics Technologies and their Application Areas
  • Protein Separation
  • 2-Dimensional Gel Electrophoresis (2DGE)
  • Elements of 2-DE Proteomics
  • Two -Dimensional Differential Gel Electrophoresis
  • Combining 2D Gel Electrophoresis with Mass Spectrometry (MS)
  • 2D Capillary LC
  • Analytical Strength of LC-MS and MS/MS in Shotgun Protein Sequencing
  • Protein Characterization
  • Analysis of Protein through Mass Spectrometry
  • MS and Proteins
    • Comparison of MS Techniques
  • Applications of MS
  • Problems Associated with MS
  • Types of Analyzers or Filters
    • MALDI-TOF MS
    • MS/MS
    • SELDI-TOF
    • Laser Capture Microdissection
    • Tandem MS
  • Y2H, Yeast 2-Hybrid System
  • Sensitivity of Two-Hybrid Assays
  • Limitations of Y2H
  • Protein Microarrays
  • Market Influencers in Protein Microarrays Market
  • Chip Technology
  • Microfluidic Applications
  • Role of Bioinformatics in Proteomics
  • Bioinformatics Applications and Tools in Proteomics
  • MS Programs
  • 2- DE gel Comparison
  • 2-DE Databases
    • Databases of 2D-electrophoretic maps
  • Emerging Proteomics Technologies
  • MudPIT
  • ICAT
  • ICAT strategy: A solution to quantitative proteome analysis
  • Phage Display Technique
  • Advanced Proteomics Technologies: Structural Analysis Tools
  • X-ray Crystallography
  • Nuclear Magnetic Resonance (NMR)
  • In silico Modelling
    • Physicochemical Factors Constraining Metabolic Functions

5. END-USE APPLICATION AREAS

  • Proteomics in Drug Discovery and Diagnostics
  • Proteomics and Drug Discovery
  • Protein Microarrays: A New Tool for the Development of Pharmaceuticals
  • Proteomic Approaches Gain Prominence in Cancer Drug Discovery
  • Proteomics Technologies Used in Cancer Drug Discovery and Development

6. NEW PRODUCT LAUNCHES/DEVELOPMENTS

  • Proteome Sciences Validates Novel Protein Biomarkers
  • KineMed to Apply Its MS Proteomics Platform to Study Neurodegeneration
  • Agilent and MRM Proteomics Introduce PeptiQuant Kits for High-Quality Plasma Proteomic Analysis
  • Elsevier Launches 'Translational Proteomics' Open-Access Journal
  • Applied Biomics Introduces Global Protein Post- Translational Modification Profiling Service
  • AB SCIEX Launches New Column Chips
  • Applied Biomics Introduces New Mass Spectrometry Service
  • Norton Scientific Introduces Novel Specialist Applications Development Laboratory Service
  • Gentel Biosciences Introduces APiX(tm) Disease Profiling Kit
  • Integromics Introduces OmicsHub Proteomics 2.0
  • Bruker Introduces amaZon Speed Ion Trap Mass Spectrometers
  • Applied Biomics Introduces iTRAQ Service for Proteomics Research
  • Norton Scientifc Introduces New Lab Support Service for Rapid RNA/DNA and Protein Measurement
  • Bruker Launches MALDI Biotarget(tm)
  • Thermo Fisher Launches UHLPC System
  • Kinexus Introduces Human Gene Online TranscriptoNET KnowledgeBase
  • Bruker Launches PRIME Integrated Proteomics Solution
  • Applied Biosystems Launches LS*LIMS Laboratory Automation Technology for Proteomics and Genomics
  • Kinexus Bioinformatics Introduces Online KiNET-AM Proteomics DataBase
  • Bruker Rolls Out CaptiveSpray Electrospray Ion Source for Proteomics Applications
  • Thermo Fisher Launches New Capabilities for Performing Proteomics Workflows
  • National Cancer Institute Introduces Clinical Proteomic Tumor Analysis Consortium for Cancer Studies
  • KinaSorb(tm) - New Kit for Kinase Enrichment

7. RECENT INDUSTRY ACTIVITY

  • Retroscreen Virology Group Acquires Activiomics
  • Thermo Fisher Scientific Acquires Life Technologies Corporation
  • Fluidigm Corporation Buys DVS Sciences
  • Geneva Bioinformatics Collaborates with University of Washington
  • Applied Proteomics Partners with German Research Institute
  • Agilent Technologies Enters Agreement with SomaLogic
  • Biognosys Partners with CellnTEC
  • Proteome Sciences Enters Contract with Thermo Fisher Scientific
  • Agilent Technologies Partners with Sera Prognostics
  • Chicago Growth Partners Buys Caprion Proteomics from Thallion
  • GlaxoSmithKline Fully Acquires Cellzome
  • Proteome Sciences Signs Agreement with CHDI Foundation
  • Waters Corp. Inks Agreement with Nonlinear Dynamics
  • BioFocus Enters into Alliance with Activiomics
  • Great Point Partners Divests Caprion Proteomics
  • Glaxo Smith Kline Takes over Cellzome
  • Emerald BioSystems Changes Name to Emerald Bio
  • Bruker Unveils Novel Nano-Advance UHPLC System
  • Evotec Takes Over Kinaxo Biotechnologies
  • Kinaxo Biotechnologies and AstraZeneca Sign Agreement
  • Gentel Biosciences Takes over Eppendorf's SilverQuant Trademark
  • Thermo Fisher Takes Over Fermentas International
  • KINAXO to Collaborate with Takeda
  • Dualsystems and Bulldog Bio Signs Exclusive Marketing Agreement
  • Novartis Enters into Agreement with SomaLogic
  • Sage-N Inks Exclusive Pact with the U.S. Army
  • Proteome Sciences Inks Agreement with Moffitt Cancer Center
  • Gentel Biosciences Enters into Agreement with Oregon Health & Science University
  • Evotec OAI Forms Joint Venture with MeITec to Collaborate on Drug Discovery Services

8. FOCUS ON SELECT KEY PLAYERS

  • ActivX Biosciences, Inc.
  • Agilent Technologies, Inc.
  • Bio-Rad Laboratories, Inc.
  • Bruker Daltonics, Inc.
  • Caprion Proteomics, Inc.
  • Digilab Genomic Solutions, Inc.
  • GE Healthcare
  • Geneva Bioinformatics S.A.
  • Hybrigenics SA
  • EMD Millipore/Merck Millipore Corp.
  • PerkinElmer, Inc.
  • Shimadzu Corporation
  • Sigma-Aldrich Corporation
  • Thermo Fisher Scientific
  • Waters Corp.
  • Xencor Inc.

9. GLOBAL MARKET PERSPECTIVE

    • Table 11: World Recent Past, Current & Future Analysis for Proteomics by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific, Latin America, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 12: World Historic Review for Proteomics by Geographic Region - US, Canada, Japan, Europe, Asia-Pacific, Latin America, and Rest of World Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
    • Table 13: World 15-Year Perspective for Proteomics by Geographic Region - Percentage Breakdown of Dollar Sales for US, Canada, Japan, Europe, Asia-Pacific, Latin America, and Rest of World Markets for Years 2006, 2014 and 2020 (includes corresponding Graph/Chart)

III. MARKET

1. THE UNITED STATES

  • A. Market Analysis
    • Current & Future Analysis
    • Personalized Medicine - A Major Driver for the Proteomics Market
    • Table 14: US Market for Hospital Cancer Therapies by Treatment Type (2004 and 2010): Percentage Breakdown of Revenues for Surgery, Chemotherapy Drugs, Radiation Therapy, Biotechnology-Based Drugs, and Others (includes corresponding Graph/Chart)
    • Cancer Presumes Epidemic Proportion in the US
    • Table 15: New Cancer Cases by Gender and Affected Site in the US (2013)
    • Proteomics to Provide POCT for Patients in Hospice Care
    • Leading Market for Rapid and Automated Microbiological Tests
    • Demographic Changes Offer Growth Opportunities
    • Table 16: North American Aging Population by Age Group: 1975-2050 (includes corresponding Graph/Chart)
    • Proteomics Sample Preparation Market
    • FDA's Antidote
    • New Product Launches
    • Strategic Corporate Developments
    • Key Players
  • B. Market Analytics
    • Table 17: The US Recent Past, Current & Future Analysis for Proteomics Market Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 18: The US Historic Review for Proteomics Market Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)

2. CANADA

  • A. Market Analysis
    • Rising Incidence of Chronic Diseases Spurs Proteomics Demand
    • Table 19: New Cancer Cases in Canada by Gender and Affected Site (2012) (includes corresponding Graph/Chart)
    • Table 20: New Cancer Cases in Canada by Province (2012) (includes corresponding Graph/Chart)
    • Table 21: New Cancer Cases in Canada by Age Group and Gender (2012) (includes corresponding Graph/Chart)
    • New Product Developments
    • Strategic Corporate Development
    • Caprion proteomics, Inc. - A Key Player
  • B. Market Analytics
    • Table 22: Canadian Recent Past, Current & Future Analysis for Proteomics Market Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 23: Canadian Historic Review for Proteomics Market Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)

3. JAPAN

  • A. Market Analysis
    • Demographics Drive Market Growth
    • Table 24: Percentage Breakdown of Japanese Population by Age Group (2012) (includes corresponding Graph/Chart)
    • Table 25: Over 65 Years Population in Japan (1950-2010) (includes corresponding Graph/Chart)
    • Shimadzu Corp. - A Key Player
  • B. Market Analytics
    • Table 26: Japanese Recent Past, Current & Future Analysis for Proteomics Market Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 27: Japanese Historic Review for Proteomics Market Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)

4. EUROPE

  • A. Market Analysis
    • Debt Crisis in Europe Affects Healthcare Industry
    • European Healthcare System: In a State of Transition?
    • Cancer Trends
    • Table 28: Cancer Incidence in Europe by Site: 2012 (in Thousands) (includes corresponding Graph/Chart)
    • Aging Population to Drive Demand for Proteomics
    • Table 29: Population Breakup by Age Group for Select European Countries: 2012 (As a % of Total Population) (includes corresponding Graph/Chart)
    • European Personalized Medicine Market to Exhibit Robust Growth
    • Proteomics Market in Europe
    • Table 30: European Proteomics Market (2013): Percentage Breakdown of Deployment of Proteomics Technologies in End-Use Segment - Research and Academic Institutions, Pharmaceutical Companies, and Clinical Laboratories (includes corresponding Graph/Chart)
    • Proteomics Research in Europe - An Overview
    • Protein Identification Market
    • Protein Separation Market
    • Market Challenges
    • Gaining Edge in the Proteomics Industry - Player Strategies
    • European 2DE Market - Benefiting from Recession
    • New Product Developments
    • Strategic Corporate Developments
    • Select Key Players
  • B. Market Analytics
    • Table 31: European Recent Past, Current & Future Analysis for Proteomics by Geographic Region - France, Germany, Italy, UK and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 32: European Historic Review for Proteomics by Geographic Region - France, Germany, Italy, UK and Rest of Europe Markets Independently Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
    • Table 33: European 15-Year Perspective for Proteomics by Geographic Region - Percentage Breakdown of Dollar Sales for France, Germany, Italy, UK and Rest of Europe Markets for Years 2006, 2014 and 2020 (includes corresponding Graph/Chart)

4a. FRANCE

  • A. Market Analysis
    • French Proteomics Player - Hybrigenics Sa
  • B. Market Analytics
    • Table 34: French Recent Past, Current & Future Analysis for Proteomics Market Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 35: French Historic Review for Proteomics Market Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)

4b. GERMANY

  • Market Analysis
    • Table 36: German Recent Past, Current & Future Analysis for Proteomics Market Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 37: German Historic Review for Proteomics Market Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)

4c. ITALY

  • Market Analysis
    • Table 38: Italian Recent Past, Current & Future Analysis for Proteomics Market Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 39: Italian Historic Review for Proteomics Market Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)

4d. THE UNITED KINGDOM

  • A. Market Analysis
    • Highlights
    • Increased Support for Personalized Medicine to Drive Proteomics Demand
    • Strategic Corporate Development
    • Key Player - Ge Healthcare
  • B. Market Analytics
    • Table 40: The UK Recent Past, Current & Future Analysis for Proteomics Market Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 41: The UK Historic Review for Proteomics Market Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)

4e. REST OF EUROPE

  • A. Market Analysis
    • Key Swiss Player - Geneva Bioinformatics S.A.
  • B. Market Analytics
    • Table 42: Rest of European Recent Past, Current & Future Analysis for Proteomics Market Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 43: Rest of European Historic Review for Proteomics Market Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)

5. ASIA-PACIFIC

  • A. Market Analysis
    • Healthcare Spending in Asia-Pacific: On the Rise
    • China
    • Table 44: China - The Most Populous Country Worldwide (July 2013): Total Population (in Millions) by Age Group 0-14 Years, 15-44 Years, 45-64 Years, and 65+ Years for China Vis-a-Vis Other Countries (includes corresponding Graph/Chart)
    • Table 45: China - The Most Populous Country Worldwide (July 2013): Percentage Population by Age Group 0-14 Years, 15-44 Years, 45-64 Years, and 65+ Years for China Vis-a-Vis Other Countries (includes corresponding Graph/Chart)
    • Government Support Drives Personalized Medicine Market in China
    • Australia
    • India
      • Indian Scientific Research towards Functional Genomics and Proteomics
  • B. Market Analytics
    • Table 46: Asia-Pacific Recent Past, Current & Future Analysis for Proteomics Market Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 47: Asia-Pacific Historic Review for Proteomics Market Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)

6. LATIN AMERICA

  • Market Analysis
    • Table 48: Latin American Recent Past, Current & Future Analysis for Proteomics Market Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 49: Latin American Historic Review for Proteomics Market Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)

7. REST OF WORLD

  • Market Analysis
    • Table 50: Rest of World Recent Past, Current & Future Analysis for Proteomics Market Analyzed with Annual Sales Figures in US$ Million for Years 2013 through 2020 (includes corresponding Graph/Chart)
    • Table 51: Rest of World Historic Review for Proteomics Market Analyzed with Annual Sales Figures in US$ Million for Years 2006 through 2012 (includes corresponding Graph/Chart)
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