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市場調查報告書

PharmaPoint:大腸癌 - 日本的醫藥品的預測與市場分析

PharmaPoint: Colorectal Cancer - Japan Drug Forecast and Market Analysis to 2023

出版商 GlobalData 商品編碼 321680
出版日期 內容資訊 英文 153 Pages
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PharmaPoint:大腸癌 - 日本的醫藥品的預測與市場分析 PharmaPoint: Colorectal Cancer - Japan Drug Forecast and Market Analysis to 2023
出版日期: 2014年11月28日 內容資訊: 英文 153 Pages
簡介

大腸癌(結腸直腸癌:CRC)是全球癌症死亡原因第二位。也是確診癌症患者最多的第三名,對醫療制度而言已經是一大負擔。

本報告提供日本的大腸癌(結腸直腸癌:CRC)治療藥市場相關調查分析,提供您疾病的概要與指南,競爭情形,主要藥物的詳細資訊(產品說明,安全性,有效性),SWOT分析,銷售額預測,影響分析(趨勢,推動因素·阻礙因素)等相關的系統性資訊。

第1章 目錄

第2章 簡介

第3章 疾病概要

  • 病因·病理生理學
    • 病因
    • 病理生理學
  • 臨床階段
  • 症狀

第4章 疾病的管理

  • 診斷和治療概要
  • 日本

第5章 競爭評估

  • 概要
  • 產品簡介:領導品牌

第6章 未滿足需求和機會

  • 概要
  • 可實質提升轉移性患者整體生存率的治療
  • KRAS·BRAF變異陽性患者的標靶治療
  • 可切除的高風險患者之有效新佐劑/佐劑療法
  • 化療阻力性患者可接受的後期治療

第7章 開發平台評估

  • 概要
  • 臨床開發中的潛力藥物
  • 開發初期階段的潛力療法

第8章 市場預測

  • 日本

第9章 附錄

圖表

目錄
Product Code: GDHC259CFR

GlobalData has released its new PharmaPoint Country Evaluation report, "PharmaPoint: Colorectal Cancer - Japan Drug Forecast and Market Analysis to 2023". Colorectal cancer (CRC) is the second leading cause of mortality among cancer patients in the world and is the third most diagnosed cancer globally, and thus represents a huge burden on healthcare systems. This report focuses on the current treatment landscape, unmet needs, current pipeline, and commercial opportunities in the colorectal cancer market, with coverage of multiple settings of the disease including neoadjuvant/adjuvant, first-, second-, third-line KRAS wild-type and mutation-positive, and fourth-line metastatic. In terms of targeted treatments, the metastatic CRC treatment landscape is mature, including the branded treatments Avastin (bevacizumab), Avastin (cetuximab), and Vectibix (panitumumab), treatments that have extended the survival of metastatic patients compared to chemotherapy-only regimens. However, high unmet needs remain for the extension of survival of metastatic patients, and particularly those with KRAS mutation-positive disease, for whom the epidermal growth factor receptor (EGFR) inhibitors Avastin and Vectibix are not recommended.

Japan represents the second-largest market for CRC across the countries covered in this report. Japan is a major CRC market, due to the high incidence of the disease and high drug treatment rates. Increased sales of CRC therapies over the forecast period will be driven by increasing disease incident cases as the population ages, label extension of Stivarga as an adjuvant treatment for resected liver metastases patients, and the launch of expensive new therapies that provide further treatment options for patients in later-line settings, replacing cheaper generic chemotherapy only regimens.

Scope

  • Overview of CRC including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.
  • Detailed information on the key drugs in Japan including product description, safety and efficacy profiles as well as a SWOT analysis.
  • Sales forecast for the top drugs in Japan from 2013-2023.
  • Analysis of the impact of key events as well the drivers and restraints affecting the Japan CRC market.

Reasons to buy

  • Understand and capitalize by identifying products that are most likely to ensure a robust return
  • Stay ahead of the competition by understanding the changing competitive landscape for CRC
  • Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential
  • Make more informed business decisions from insightful and in-depth analysis of drug performance
  • Obtain sales forecast for drugs from 2013-2023 in Japan.

Table of Contents

1. Table of Contents

  • 1.1. List of Tables
  • 1.2. List of Figures

2. Introduction

  • 2.1. Catalyst
  • 2.2. Related Reports
  • 2.3. Upcoming Related Reports

3. Disease Overview

  • 3.1. Etiology and Pathophysiology
    • 3.1.1. Etiology
    • 3.1.2. Pathophysiology
  • 3.2. Clinical Staging
  • 3.3. Symptoms

4. Disease Management

  • 4.1. Diagnosis and Treatment Overview
    • 4.1.1. Screening and Diagnosis
    • 4.1.2. Treatment Guidelines and Leading Prescribed Drugs
    • 4.1.3. Clinical Practice
  • 4.2. Japan
    • 4.2.1. Screening and Diagnosis
    • 4.2.2. Clinical Practice

5. Competitive Assessment

  • 5.1. Overview
  • 5.2. Product Profiles - Major Brands
    • 5.2.1. Avastin (Bevacizumab)
    • 5.2.2. Erbitux (Cetuximab)
    • 5.2.3. Vectibix (Panitumumab)
    • 5.2.4. Stivarga (Regorafenib)
    • 5.2.5. Zaltrap (Ziv-Aflibrcept)
    • 5.2.6. Lonsurf (TAS-102)
    • 5.2.7. TS-1 (Tegafur, Gimeracil, Oteracil)
    • 5.2.8. Xeloda (Capecitabine)

6. Unmet Need and Opportunity

  • 6.1. Overview
  • 6.2. Therapies That Provide Substantial Overall Survival Benefit for Metastatic Patients
    • 6.2.1. Unmet Need
    • 6.2.2. Gap Analysis
    • 6.2.3. Opportunity
  • 6.3. Targeted Treatments for KRAS and BRAF Mutaton-Positive Patients
    • 6.3.1. Unmet Need
    • 6.3.2. Gap Analysis
    • 6.3.3. Opportunity
  • 6.4. Effective Neoadjuvant/Adjuvant Therapies for High Risk Resectable Disease
    • 6.4.1. Unmet Need
    • 6.4.2. Gap Analysis
    • 6.4.3. Opportunity
  • 6.5. Tolerable Later-Line Therapies For Chemotherapy-Resistant Patients
    • 6.5.1. Unmet Need
    • 6.5.2. Gap Analysis
    • 6.5.3. Opportunity

7. Pipeline Assessment

  • 7.1. Overview
  • 7.2. Promising Drugs in Clinical Development
    • 7.2.1. Cyramza (Ramucirumab)
    • 7.2.2. Nintedanib (BIBF-1120)
  • 7.3. Promising Approaches in Early-Stage Development
    • 7.3.1. Anti-Angiopoietin-2 Inhibitors
    • 7.3.2. Strategies for BRAF Mutation-Positive Disease
    • 7.3.3. Strategies for KRAS-Mutation Positive Disease
    • 7.3.4. Immune Checkpoint Inhibitors

8. Market Outlook

  • 8.1. Japan
    • 8.1.1. Forecast
    • 8.1.2. Key Events
    • 8.1.3. Drivers and Barriers - Global Issues
    • 8.1.4. Drivers and Barriers

9. Appendix

  • 9.1. Bibliography
  • 9.2. Abbreviations
  • 9.3. Methodology
  • 9.4. Forecasting Methodology
    • 9.4.1. Diagnosed Colorectal Cancer Patients
    • 9.4.2. Percent Drug-Treated Patients
    • 9.4.3. Drugs Included in Each Therapeutic Class
    • 9.4.4. Launch and Patent Expiration Dates
    • 9.4.5. General Pricing Assumptions
    • 9.4.6. Average Body Weight and Surface Area
    • 9.4.7. Individual Drug Assumptions
    • 9.4.8. Generic Erosion
    • 9.4.9. Pricing of Pipeline Agents
  • 9.5. Primary Research - KOLs Interviewed for this Report
  • 9.6. Primary Research - Prescriber Survey
  • 9.7. About the Authors
    • 9.7.1. Analyst
    • 9.7.2. Global Head of Healthcare
  • 9.8. About GlobalData
  • 9.9. Disclaimer

List of Tables

  • Table 1: TNM and Staging Classification System for CRC
  • Table 2: Symptoms of Colorectal Cancer
  • Table 3: Treatment Guidelines for CRC
  • Table 4: Most-Prescribed Neoadjuvant/Adjuvant Regimens for Early-Stage CRC in the US Markets, 2013
  • Table 5: Most Prescribed Targeted Therapies for Metastatic CRC by Segment in the US Markets, 2013
  • Table 6: Country Profile - Japan
  • Table 7: Leading Treatments for CRC, 2014
  • Table 8: Product Profile - Avastin
  • Table 9: Avastin SWOT Analysis, 2014
  • Table 10: Product Profile - Erbitux
  • Table 11: Erbitux SWOT Analysis, 2014
  • Table 12: Product Profile - Vectibix
  • Table 13: Vectibix SWOT Analysis, 2014
  • Table 14: Product Profile - Stivarga
  • Table 15: Stivarga SWOT Analysis, 2014
  • Table 16: Product Profile - Zaltrap
  • Table 17: Zaltrap SWOT Analysis, 2014
  • Table 18: Product Profile - Lonsurf
  • Table 19: Lonsurf SWOT Analysis, 2014
  • Table 20: Product Profile - TS-1
  • Table 21: TS-1 SWOT Analysis, 2014
  • Table 22: Product Profile - Xeloda
  • Table 23: Unmet Need and Opportunity in CRC
  • Table 24: Product Profile - Cyramza
  • Table 25: Cyramza SWOT Analysis, 2014
  • Table 26: Product Profile - Nintedanib
  • Table 27: Nintedanib SWOT Analysis, 2014
  • Table 28: Anti-Angiopoietin-2 Inhibitors in Development
  • Table 29: Early-stage Strategies for BRAF Mutation-Positive CRC
  • Table 30: Early-stage Strategies for KRAS Mutation-Positive CRC
  • Table 31: Anti-PD1 and Anti-PDL1 Drugs in Early-Stage Development for CRC
  • Table 32: Sales Forecasts ($m) for Colorectal Cancer in Japan, 2013-2023
  • Table 33: Key Events Impacting Sales for CRC in Japan, 2014
  • Table 34: CRC Market Drivers and Barriers, 2014
  • Table 35: Japan CRC Market - Drivers and Barriers, 2014
  • Table 36: Key Launch Dates
  • Table 37: Key Patent Expiries
  • Table 38: Average Body Weight and Surface Area
  • Table 39: High-Prescribing Physicians (non-KOLs) Surveyed, By Country

List of Figures

  • Figure 1: CRC - Phase III Pipeline
  • Figure 2: Competitive Assessment of Late-Stage Pipeline Agents in CRC, 2013-2023
  • Figure 3: Clinical and Commercial Positioning of Cyramza
  • Figure 4: Clinical and Commercial Positioning of Nintedanib
  • Figure 5: Sales for Colorectal Cancer in Japan by Drug Class, 2013-2023
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