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市場調查報告書

Apokyn(帕金森氏症治療藥):市場預測與分析

Apokyn (Parkinson's Disease) - Forecast and Market Analysis to 2022

出版商 GlobalData 商品編碼 217348
出版日期 內容資訊 英文 60 Pages
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Apokyn(帕金森氏症治療藥):市場預測與分析 Apokyn (Parkinson's Disease) - Forecast and Market Analysis to 2022
出版日期: 2014年03月31日 內容資訊: 英文 60 Pages
簡介

apomorphine的抗帕金森氏症效果在1951年最初發現,由於嚴重的副作用(嫌惡感、嘔吐、體位性低血壓、鎮壓效果等),使用相當受限(但這些副作用可藉由多巴胺拮抗劑的donperidon來部分緩解(Ostergaard et al., 1995))。再加上其口服給藥又與腎毒性有關(Ostergaard et al., 1995)。之後Britannia Pharmaceuticals與Laboratoire Aguettant開發了自我注射用(連續注射)筆,並以Apo-go(後改名為Apokyn)在美國及日本上市。

アポモルヒネ(アポモルフィン)の抗パーキンソン病効果は1951年に最初に発見されましたが、深刻な副作用(嫌悪感、嘔吐、体位性低血圧、鎮静効果など)により、その利用は限定されてきました(ただし、これらの副作用はドーパミン拮抗薬のドンペリドンにより部分的な緩和が可能です(Ostergaard et al., 1995))。さらに、その経口投与は腎毒性と関連性があります(Ostergaard et al., 1995)。その後、Britannia PharmaceuticalsとLaboratoire Aguettantが自己注射用(連続注入)ペンを開発し、Apo-goという商品名(後にApokynと改名)で米国・日本で上市しました。

本報告提供帕金森氏症的治療藥之一──Apokyn的全球市場相關分析,提供疾病概要和治療方法,競爭的企業·藥品概要,市場競爭概況,Apokyn的商品資訊(特色·功效·安全性等),全球主要國家的市場販售額預測(今後10年份)等調查,並將結果概述為以下內容。

第1章 目錄

第2章 簡介

  • 本報告概要
  • 相關調查

第3章 疾病概要

  • 病因與病情
    • 病因
    • 病理生理學
    • 預測
    • QoL(生活品質)
  • 症狀

第4章 疾病管理

  • 概要
    • 診斷:The UK Brain Bank的評估標準
    • 治療指南與主要的處方藥
  • 治療方法概要
    • 多巴胺有作用之等級
    • 帕金森氏症的各階段治療方法
    • 其他治療選擇
  • 帕金森氏症的評估規模
    • 帕金森氏症統一規模(UPDRS)
    • Hoehn and Yahr的病期分類
    • 其他臨床評估方法

第5章 競爭企業的評估

  • 概要
  • 競爭企業的策略性評估
  • 多巴胺受體激動劑

第6章 關於Apokyn(apomorphine)

  • 概要
  • 功效
  • 安全性
  • SWOT分析
  • 未來預測

第7章 附錄

圖表一覽

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目錄
Product Code: GDHC395DFR

Parkinson's disease is a progressive condition that is characterized by bradykinesia, muscular rigidity, tremor, and postural instability. As the second most common neurodegenerative disorder, Parkinson's disease may affect individuals of any age but prevalence is increased with age and it is most common in the elderly. Dopaminergic therapies have been fairly effective in treating bradykinesia, but several unmet needs remain. Some needs will be met during the forecast period from 2012-2022, while others, such as the need for disease-modifying drugs, will remain. GlobalData expects that advancements will be made in levodopa administration and that four new molecular entities will be introduced to the market by 2022, these factors along with increased patient numbers from an aging population will drive the market during the forecast period.

The anti-Parkinsonian effect of apomorphine was first discovered in 1951. Its use was limited due to severe side effects such as nausea, vomiting, postural hypotension, and sedation, which was partially alleviated with use of the dopamine antagonist domperidone (Pietz et al., 1998). In addition, oral use is associated with nephrotoxicity (Ostergaard et al., 1995). It was developed as a self-injectable pen or continuous infusion by Britannia Pharmaceuticals and Laboratoire Aguettant under the name Apo-go, later renamed Apokyn in the US and Japan.

Scope

  • Overview of Parkinson's disease, including epidemiology, etiology, symptoms, diagnosis, pathology and treatment guidelines as well as an overview on the competitive landscape.
  • Detailed information on Apokyn including product description, safety and efficacy profiles as well as a SWOT analysis.
  • Sales forecast for Apokyn for the top seven countries from 2012 to 2022.
  • Sales information covered for the US, France, Germany, Italy, Spain, the UK and Japan.

Reasons to buy

  • Understand and capitalize by identifying products that are most likely to ensure a robust return
  • Stay ahead of the competition by understanding the changing competitive landscape for Parkinson's disease
  • Effectively plan your M&A and partnership strategies by identifying drugs with the most promising sales potential
  • Make more informed business decisions from insightful and in-depth analysis of Apokyn performance
  • Obtain sales forecast for Apokyn from 2012-2022 in the top seven countries (the US, France, Germany, Italy, Spain, the UK and Japan).

Table of Contents

1. Table of Contents

  • 1.1. List of Tables
  • 1.2. List of Figures

2. Introduction

  • 2.1. Catalyst
  • 2.2. Related Reports

3. Disease Overview

  • 3.1. Etiology and Pathophysiology
    • 3.1.1. Etiology
    • 3.1.2. Pathophysiology
    • 3.1.3. Prognosis
    • 3.1.4. Quality of Life
  • 3.2. Symptoms

4. Disease Management

  • 4.1. Overview
    • 4.1.1. Diagnosis - The UK Brain Bank Criteria
    • 4.1.2. Treatment Guidelines and Leading Prescribed Drugs
  • 4.2. Treatment Synopsis
    • 4.2.1. Dopaminergic Therapy Classes
    • 4.2.2. Treatment of Parkinson's Disease by Stage
    • 4.2.3. Other Treatment Options
  • 4.3. Parkinson's Disease Assessment Scales
    • 4.3.1. Unified Parkinson's Disease Rating Scale (UPDRS)
    • 4.3.2. Hoehn and Yahr Clinical Staging
    • 4.3.3. Other Clinical Assessments

5. Competitive Assessment

  • 5.1. Overview
  • 5.2. Strategic Competitor Assessment
  • 5.3. Dopamine Agonists

6. Apokyn (apomorphine)

  • 6.1. Overview
  • 6.2. Efficacy
  • 6.3. Safety
  • 6.4 SWOT Analysis
  • 6.5. Forecast

7. Appendix

  • 7.1. Bibliography
  • 7.2. Abbreviations
  • 7.3. Methodology
  • 7.4. Forecasting Methodology
    • 7.4.1. Diagnosed Parkinson's Disease Patients
    • 7.4.2. Percent Drug-Treated Patients
    • 7.4.3. General Pricing Assumptions
    • 7.4.4. Compliance Assumptions
    • 7.4.5. Individual Drug Assumptions
    • 7.4.6. Generic Erosion
  • 7.5. Physicians and Specialists Included in this Study
  • 7.6. About the Authors
    • 7.6.1. Author
    • 7.6.2. Global Head of Healthcare
  • 7.7. About GlobalData
  • 7.8. Disclaimer

List of Tables

  • Table 1: Symptoms of Parkinson's Disease
  • Table 2: UK Brain Bank Diagnostic Criteria
  • Table 3: Diagnosis and Treatment Guidelines for Parkinson's Disease
  • Table 4: Most Prescribed Drugs for Parkinson's Disease by Class in the Global Markets, 2014
  • Table 5: Dopaminergic Therapy in Parkinson's Disease
  • Table 6: UPDRS Clinical Assessment of Disease Severity
  • Table 7: Parkinson's Disease Assessment Scales Used in Clinical Trials
  • Table 8: Treatment of Motor Symptoms in Parkinson's Disease
  • Table 9: Leading Treatments for Parkinson's Disease, 2014
  • Table 10: Product Profile - Apokyn
  • Table 11: Apokyn SWOT Analysis, 2014
  • Table 12: Global Sales Forecasts ($m) for Apokyn Continuous Infusion, 2012-2022
  • Table 13: Global Sales Forecasts ($m) for Apokyn Pen, 2012-2022

List of Figures

  • Figure 1: Overview - L-dopa Metabolism and Inhibitor Classes
  • Figure 2: Overview - Treatment of Motor Symptoms of Parkinson's Disease
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