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市場調查報告書

高血壓治療藥的亞太地區市場

Anti-hypertensive Therapeutics in Asia-Pacific Markets to 2022 - Increasing Prevalence of Hypertension Drives Market Growth despite Weak Pipeline

出版商 GBI Research 商品編碼 336890
出版日期 內容資訊 英文 110 Pages
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高血壓治療藥的亞太地區市場 Anti-hypertensive Therapeutics in Asia-Pacific Markets to 2022 - Increasing Prevalence of Hypertension Drives Market Growth despite Weak Pipeline
出版日期: 2016年12月01日 內容資訊: 英文 110 Pages
簡介

高血壓的盛行率增加,使得醫療費的增加和今後的發病率進一步上升,不過,醫生和患者,一般民眾對疾病的認識也很低,未診斷和未治療的案例變得非常多。高血壓治療藥的亞太地區市場,2015年達到191億美元,估計到2022年以5.1%的年複合成長率(CAGR) 持續增加,同年達到270億美元。高血壓的盛行率成為決定調查對象國家的市場規模的一大要素。市場幾乎由學名藥品獨佔,專利取得產品只有一點點。

本報告提供亞太地區高血壓的治療藥市場相關分析,疾病概要和到目前為止的臨床實驗的進展,主要的已上市產品的特徵,現在臨床實驗中的開發中產品的概要,亞太地區市場趨勢預測 (今後8年份) 等調查評估。

第1章 目錄

第2章 簡介

  • 關於疾病
  • 流行病學
  • 前兆、症狀
  • 病因/病理學
  • 並存症、併發症
  • 診斷
    • 在開業醫生、診所的血壓監測
    • 在門診病人窗口的血壓監測
    • 血壓監測可攜式24小時
    • 家庭的血壓監測
    • 其他技術
    • 特定組織的損傷的診斷
    • 妊娠中的高血壓的診斷
  • 預後
  • 分期
  • 治療方法的選項
    • 治療流程
    • 藥物治療
    • 非藥物治療
  • 第3章 已上市產品
  • 主要的已上市產品
    • 血管收縮素II受體拮抗劑
    • 鈣拮抗劑
    • 腎素抑製劑
    • 血管收縮素轉化酵素抑制劑
    • β- 阻斷劑
    • 複數的藥物級的組合
  • 已上市產品的有效性及安全性比較

第4章 開發中產品分析

  • 概要
  • 各開發階段/各分子類型/各給藥途徑/各計劃類型
  • 分子各標的
  • 有前途的開發平台候補
    • CS-3150

第5章 臨床實驗分析

  • 臨床實驗的失敗率
  • 臨床實驗期間
  • 臨床實驗的規模
  • 競爭性的臨床實驗的評價標準

第6章 各地區市場預測

地理市場 亞太地區市場 ▼印度 治療模式 年度治療費用 市場規模 ▼中國 ▼澳洲 ▼韓國 ▼日本

第7章 市場促進、阻礙因素

  • 推動市場要素
  • 阻礙因素

第8章 資本交易與策略性的市場重組

  • 授權合約
  • 共同開發契約

第9章 附錄

  • 所有開發中產品:各相位
    • 藥物研發階段
    • 前臨床階段
    • 第一階段
    • 第二階段
    • 第三階段
    • 預註冊階段
  • 市場預測 (今後8年份)
    • 亞太地區
    • 印度
    • 中國
    • 澳洲
    • 韓國
    • 日本
  • 參考資料
  • 簡稱集
  • 分析方法
  • 諮詢方式
  • 法律上的免責聲明

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目錄
Product Code: GBIHC426MR

Executive Summary

Hypertension is a serious and common medical condition characterized by elevated blood pressure. It is commonly seen in the aging population, and in people with sedentary lifestyles and obesity. As one of the most significant preventable causes of death worldwide, early diagnosis of the condition is crucial to improve health outcomes. Hypertension is the key risk factor for stroke; according to the National Stroke Association (NSA), two-thirds of patients who suffer a stroke have hypertension.

Hypertension itself does not manifest any symptoms, but direct damage can occur to various organs due to high blood pressure. In cases of hypertensive emergency (where blood pressure is higher than 180/110mmHg) patients have reported headaches, breathlessness or malaise due to heart failure and kidney failure. Whether symptomatic or asymptomatic, hypertension requires attention and appropriate changes in lifestyle or medical treatment

The marketed products landscape for hypertension comprises a wide range of treatment options, which includes angiotensin converting enzyme inhibitors, angiotensin receptor blockers, calcium channel blockers, beta blockers, renin inhibitors, and diuretics. These are used both as monotherapy and combination therapy (including fixed-dose combinations), and the proportion of patients treated using the various therapy approaches varies from country to country.

The high prevalence of the disease is a substantial contributor to healthcare costs and is a major cause of morbidity. However, awareness of hypertension is low among physicians, patients, and the public, leading to a high level of undiagnosed and untreated cases.

Scope

  • The Asia-Pacific antihypertensive market will be valued at $27 billion in 2022, growing from $19.1 billion in 2015 at a CAGR of 5.1%. Hypertension prevalence is a prominent contributor to market size in the assessed countries. The market is mostly dominated by generics, and there are only a few patented products.
    • Will generics continue to dominate treatment?
    • How do the elderly populations and their associated risk factors affect prevalence?
    • What effect will the patent expirations of currently branded therapies have on market value?
  • The current anti-hypertensive therapeutics pipeline is weak, comprising 112 molecules in various stages of development, dominated by small molecules.
    • Which molecular targets appear most frequently in the pipeline?
    • Is there potential for the pipeline to address unmet needs within the anti-hypertensive market?
  • Analysis of clinical trials since 2006 identified that anti-hypertensive products have a high rate of attrition.
    • How do failure rates vary by product stage of development, molecule type, and mechanism of action?
    • How do other factors such as average trial duration and trial size influence the costs and risks associated with product development?
  • The market forecasts indicate that Japan will contribute the most to the Asia-Pacific market value, due to the high annual cost of therapy. Growth in market size is projected to vary considerably across the five assessed markets.
    • How will the annual cost of therapy and market size vary between the five Asia-Pacific markets?
    • How could changes in risk factors such as aging population, metabolic disorders and high salt intake influence the market?
  • Various drivers and barriers will influence the market over the forecast period.
    • What are the barriers that limit the uptake of premium-priced therapeutics in the assessed countries?
    • Which factors are most likely to drive the market in these countries?

Reasons to buy

This report will allow you to -

  • Understand the current clinical and commercial landscape by considering disease pathogenesis, diagnosis, prognosis, and the treatment options available at each stage of diagnosis, including a clinical comparison of marketed therapies.
  • Visualize the composition of the anti-hypertensive market in terms of the dominant therapies, and their clinical and commercial standing. Unmet needs are highlighted to allow a competitive understanding of gaps in the market.
  • Analyze the anti-hypertensive pipeline and stratify pipeline therapies by stage of development, molecule type and molecular target.
  • Consider market opportunities and potential risks by examining trends in hypertension clinical trial size, duration, and failure rate by stage of development, molecule type, and mechanism of action.
  • Predict anti-hypertensive market growth in the five Asia-Pacific markets with epidemiological and annual cost of therapy forecasts across India, China, Australia, South Korea and Japan. The forecasts will provide an understanding of how epidemiology trends, new drug entries, and patent expirations will influence market value.
  • Identify commercial opportunities in the anti-hypertensive deals landscape by analyzing trends in licensing and co-development deals.

Table of Contents

1. Table of Contents

  • 1.1. List of Tables
  • 1.2. List of Figures

2. Introduction

  • 2.1. Disease Introduction
  • 2.2. Epidemiology
  • 2.3. Symptoms
  • 2.4. Etiology and Pathophysiology
  • 2.5. Diagnosis
    • 2.5.1. Office or Clinic Blood Pressure Monitoring
    • 2.5.2. Automated Office Blood Pressure Measurement
    • 2.5.3. Ambulatory Blood Pressure Monitoring
    • 2.5.4. Home Blood Pressure Monitoring
    • 2.5.5. Miscellaneous Methods
    • 2.5.6. Diagnosis of Target Organ Damage
    • 2.5.7. Diagnosis of Hypertension in Pregnancy
  • 2.6. Prognosis
  • 2.7. Disease Stage
  • 2.8. Treatment Options
    • 2.8.1. Treatment Algorithm
    • 2.8.2. Pharmacological Treatment
    • 2.8.3. Non-pharmacological Treatment

3. Marketed Products

  • 3.1. Angiotensin II Receptor Antagonists
    • 3.1.1. Losartan - Merck & Co
    • 3.1.2. Olmesartan - Daiichi Sankyo
    • 3.1.3. Olmesartan + Amlodipine + Hydrochlorothiazide - Daiichi Sankyo
    • 3.1.4. Valsartan - Novartis
    • 3.1.5. Telmisartan - Boehringer Ingelheim
    • 3.1.6. Azilsartan Medoxomil - Takeda
  • 3.2. Calcium Channel Blockers
    • 3.2.1. Amlodipine - Pfizer
  • 3.3. Renin Inhibitors
    • 3.3.1. Aliskiren - Novartis
  • 3.4. Angiotensin Converting Enzyme Inhibitors
    • 3.4.1. Ramipril - Sanofi
  • 3.5. Beta Blockers
    • 3.5.1. Carvedilol - GlaxoSmithKline
  • 3.6. Multiple Drug Class Combinations
    • 3.6.1. Perindopril Arginine + Amlodipine Besylate - Les Laboratoires Servier
    • 3.6.2. Amlodipine + Valsartan - Novartis
  • 3.7. Comparative Efficacy and Safety of Marketed Products

4. Pipeline Analysis

  • 4.1. Overview
  • 4.2. Pipeline by Stage of Development, Molecule Type, Route of Administration and Program Type
  • 4.3. Pipeline by Molecular Target
  • 4.4. Promising Pipeline Candidates
    • 4.4.1. CS-3150

5. Clinical Trial Analysis

  • 5.1. Failure Rate
    • 5.1.1. Overall Failure Rate
    • 5.1.2. Failure Rate by Phase and Molecule Type
    • 5.1.3. Failure Rate by Phase and Molecular Target
  • 5.2. Clinical Trial Duration
    • 5.2.1. Clinical Trial Duration by Molecule Type
    • 5.2.2. Clinical Trial Duration by Molecular Target
  • 5.3. Clinical Trial Size
    • 5.3.1. Patient Enrollment per Trial by Molecule Type, Molecular Target and Stage of Development
    • 5.3.2. Patient Enrollment per Product by Molecule Type, Molecular Target and Stage of Development
  • 5.4. Competitive Clinical Trials Metrics Analysis

6. Multi-Scenario Forecast

  • 6.1.1. Geographical Markets
  • 6.1.2. Asia-Pacific Market
  • 6.2. India
    • 6.2.1. Treatment Use Patterns
    • 6.2.2. Annual Cost of Therapy
    • 6.2.3. Market Size
  • 6.3. China
    • 6.3.1. Treatment Use Patterns
    • 6.3.2. Annual Cost of Therapy
    • 6.3.3. Market Size
  • 6.4. Australia
    • 6.4.1. Treatment Use Patterns
    • 6.4.2. Annual Cost of Therapy
    • 6.4.3. Market Size
  • 6.5. South Korea
    • 6.5.1. Treatment Usage Patterns
    • 6.5.2. Annual Cost of Therapy
    • 6.5.3. Market Size
  • 6.6. Japan
    • 6.6.1. Treatment Use Patterns
    • 6.6.2. Annual Cost of Therapy
    • 6.6.3. Market Size

7. Drivers and Barriers

  • 7.1. Drivers
    • 7.1.1. Increasing Aging Populations to Increase Prevalence
    • 7.1.2. Increasing Overweight and Obese Population
    • 7.1.3. Increase in Daily Sodium Intake
    • 7.1.4. Sedentary Lifestyle or Less Physical Activity
    • 7.1.5. High Prevalence of Smoking and Alcoholism
    • 7.1.6. Diversified Healthcare Reform to Boost Market Growth
  • 7.2. Barriers
    • 7.2.1. Weak Pipeline and Widespread Usage of Generic Drugs
    • 7.2.2. Non-pharmacological First-Line Treatment
    • 7.2.3. Lack of Awareness of the Disease Condition

8. Deals and Strategic Consolidations

  • 8.1. Licensing Deals
    • 8.1.1. Deals by Region and Value
    • 8.1.2. Number of Disclosed and Undisclosed Deals by Year, Aggregate Deal Value
    • 8.1.3. Deal Value by Stage of Development, Molecule Type, and Molecular Target
    • 8.1.4. Key Licensing Deals
  • 8.2. Co-development Deals
    • 8.2.1. Deals by Region and Value
    • 8.2.2. Deal Value by Stage of Development, Molecule Type, and Molecular Target
    • 8.2.3. Deal Value by Stage of Development, Molecule Type, and Molecular Target
    • 8.2.4. Key Co-development Deals

9. Appendix

  • 9.1. All Pipeline Drugs by Stage of Development
    • 9.1.1. Discovery
    • 9.1.2. Preclinical
    • 9.1.3. Investigational New Drug/ Clinical Trial Authorization-Filed
    • 9.1.4. Phase I
    • 9.1.5. Phase II
    • 9.1.6. Phase III
    • 9.1.7. Pre-registration
  • 9.2. Market Forecasts to 2022
    • 9.2.1. Asia-Pacific
    • 9.2.2. India
    • 9.2.3. China
    • 9.2.4. Australia
    • 9.2.5. South Korea
    • 9.2.6. Japan
  • 9.3. Reference
  • 9.4. Abbreviations
  • 9.5. Research Methodology
    • 9.5.1. Secondary Research
    • 9.5.2. Marketed Product Profiles
    • 9.5.3. Late-Stage Pipeline Candidates
    • 9.5.4. Comparative Efficacy and Safety Heat Map for Marketed and Pipeline Products
    • 9.5.5. Product Competitiveness Framework
    • 9.5.6. Pipeline Analysis
    • 9.5.7. Forecasting Model
    • 9.5.8. Deals Data Analysis
  • 9.6. Contact Us
  • 9.7. Disclaimer

List of Tables

  • Table 1: Anti-hypertensive Therapeutics, Prevalence Rate
  • Table 2: Anti-hypertensive Therapeutics, Definitions of Hypertension by Office and Out-of-Office Blood Pressure Levels (mmHg)
  • Table 3: Anti-hypertensive Therapeutics, Proposal for Outcome-Driven Reference Values for Ambulatory Blood Pressure Measurement (mmHg)
  • Table 4: Anti-hypertensive Therapeutics, Blood Pressure Stages in Adults (mmHg)
  • Table 5: Anti-hypertensive Therapeutics, Compelling and Possible Contra-indications of Anti-hypertensive Drugs
  • Table 6: Anti-hypertensive Therapeutics, Lifestyle Measures and Recommendations
  • Table 7: Anti-hypertensive Therapeutics Market, Global, All Pipeline Products, Discovery, 2016
  • Table 8: Anti-hypertensive Therapeutics Market, Global, All Pipeline Products, Preclinical, 2016
  • Table 9: Anti-hypertensive Therapeutics Market, Global, All Pipeline Products, Investigational New Drug, 2016
  • Table 10: Anti-hypertensive Therapeutics Market, Global, All Pipeline Products, Phase I, 2016
  • Table 11: Anti-hypertensive Therapeutics Market, Global, All Pipeline Products, Phase-II, 2016
  • Table 12: Anti-hypertensive Therapeutics Market, Global, All Pipeline Products, Phase III, 2016
  • Table 13: Anti-hypertensive Therapeutics Market, Global, All Pipeline Products, Pre-registration, 2016
  • Table 14: Anti-hypertensive Therapeutics Market, Asia-Pacific, Market Forecast, 2015-2022
  • Table 15: Anti-hypertensive Therapeutics Market, India, Market Forecast, 2015-2022
  • Table 16: Anti-hypertensive Therapeutics Market, China, Market Forecast, 2015-2022
  • Table 17: Anti-hypertensive Therapeutics Market, Australia, Market Forecast, 2015-2022
  • Table 18: Anti-hypertensive Therapeutics Market, South Korea, Market Forecast, 2015-2022
  • Table 19: Anti-hypertensive Therapeutics Market, Japan, Market Forecast, 2015-2022
  • Table 20: Abbreviations

List of Figures

  • Figure 1: Anti-hypertensive Therapeutics, Global, Hypertension Prevalence Rate (%), 2009-2012
  • Figure 2: Anti-hypertensive Therapeutics, Physiological Mechanism of Renin-Angiotensin-Aldosterone System
  • Figure 3: Anti-hypertensive Therapeutics: Blood Pressure Measurements and Examination of a Patient to Detect Hypertension
  • Figure 4: Anti-hypertensive Therapeutics, Treatment Algorithm of Hypertension
  • Figure 5: Anti-hypertensive Therapeutics, Combination Therapy Strategies for Blood Pressure Reduction
  • Figure 6: Anti-hypertensive Market, Comparative Efficacy and Safety Heatmap for Marketed Products for the Treatment of Hypertension
  • Figure 7: Anti-hypertensive Market, Comparative Efficacy and Safety Heatmap for Marketed Products for Pediatrics for the Treatment of Hypertension
  • Figure 8: Anti-hypertensive Therapeutics Market, Global, Pipeline, 2016
  • Figure 9: Anti-hypertensive Therapeutics Market, Global, Pipeline by Molecular Target, 2016
  • Figure 10: Anti-hypertensive Therapeutics, Global, Pipeline by Molecular Target and Stage of Development, 2016
  • Figure 11: Anti-hypertensive Therapeutics, Global, Average Clinical Trial Failure Rate (%), 2016
  • Figure 12: Anti-hypertensive Therapeutics, Global, Clinical Trial Failure Rate by Molecule Type (%), 2006-2015
  • Figure 13: Anti-hypertensive Therapeutics, Global, Clinical Trial Failure Rate by Molecular Target (%), 2006-2015
  • Figure 14: Anti-hypertensive Therapeutics, Global, Clinical Trial Size per Product by Stage of Development and Molecule Type, 2006-2015
  • Figure 15: Anti-hypertensive Therapeutics, Global, Clinical Trial Duration by Molecular Target, 2006-2015
  • Figure 16: Anti-hypertensive Therapeutics, Global, Clinical Trial Size per Trial by Molecular Type, 2006-2015
  • Figure 17: Anti-hypertensive Therapeutics, Global, Clinical Trial Size per Trial by Molecular Target, 2006-2015
  • Figure 18: Anti-hypertensive Therapeutics, Global, Clinical Trial Size per Product by Molecule Type, 2006-2015
  • Figure 19: Anti-hypertensive Therapeutics, Global, Clinical Trial Size per Product by Molecular Target, 2006-2015
  • Figure 20: Anti-hypertensive Therapeutics Market, Global, Comparison of Average Trial Metrics by Phase and Molecule Type
  • Figure 21: Anti-hypertensive Therapeutics Market, Global, Comparison of Average Trial Metrics by Phase and Molecular Target
  • Figure 22: Anti-hypertensive Therapeutics Market, Asia-Pacific, Treatment Patterns (million) and Market Size ($bn), 2015-2022
  • Figure 23: Anti-hypertensive Therapeutics Market, India, Treatment Patterns (million), 2015-2022
  • Figure 24: Anti-hypertensive Therapeutics Market, India, Annual Cost of Therapy ($), 2015-2022
  • Figure 25: Anti-hypertensive Therapeutics Market, India, Market Size ($bn), 2015-2022
  • Figure 26: Anti-hypertensive Therapeutics Market, China, Treatment Patterns (million), 2015-2022
  • Figure 27: Anti-hypertensive Therapeutics Market, China, Annual Cost of Therapy ($), 2015-2022
  • Figure 28: Anti-hypertensive Therapeutics Market, China, Market Size ($bn), 2015-2022
  • Figure 29: Anti-hypertensive Therapeutics Market, Australia, Treatment Patterns (million), 2015-2022
  • Figure 30: Anti-hypertensive Therapeutics Market, Australia, Annual Cost of Therapy ($), 2015-2022
  • Figure 31: Anti-hypertensive Therapeutics Market, Australia, Market Size ($bn), 2015-2022
  • Figure 32: Anti-hypertensive Therapeutics Market, South Korea, Treatment Patterns (million), 2015-2022
  • Figure 33: Anti-hypertensive Therapeutics Market, South Korea, Annual Cost of Therapy ($), 2015-2022
  • Figure 34: Anti-hypertensive Therapeutics Market, South Korea, Market Size ($bn), 2015-2022
  • Figure 35: Anti-hypertensive Therapeutics Market, Japan, Treatment Patterns (million), 2015-2022
  • Figure 36: Anti-hypertensive Therapeutics Market, Japan, Annual Cost of Therapy ($), 2015-2022
  • Figure 37: Anti-hypertensive Therapeutics Market, Japan, Market Size ($bn), 2015-2022
  • Figure 38: Anti-hypertensive Therapeutics Market, Global, Licensing Deals by Region and Value, 2006-2016
  • Figure 39: Anti-hypertensive Therapeutics Market, Global, Number of Disclosed and Undisclosed Licensing Deals by Year, Aggregate Deal Value and Aggregate Upfront Payment Value, 2006-2016
  • Figure 40: Anti-hypertensive Therapeutics Market, Global, Licensing Deals by Stage of Development, Deal Value and Upfront Payment Value, 2006-2016
  • Figure 41: Anti-hypertensive Therapeutics Market, Global, Licensing Deals by Molecule Type and Stage of Development, 2006-2016
  • Figure 42: Anti-hypertensive Therapeutics Market, Global, Licensing Deals by Molecular Targets and Aggregate Deal Value ($), 2006-2016
  • Figure 43: Anti-hypertensive Therapeutics Market, Global, Co-development Deals by Region and Deal Value, 2006-2016
  • Figure 44: Anti-hypertensive Therapeutics Market, Global, Number of Disclosed and Undisclosed Co-development Deals by Year, Aggregate Deal Value and Aggregate Upfront Payment Value, 2006-2016
  • Figure 45: Anti-hypertensive Therapeutics, Global, Co-development Deals by Phase and Mechanism of Action, 2006-2016
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