Abstract
Introduction:
From 2002 to 2005, global sales of monoclonal antibodies (MAbs) increased 179%
to $14.1 billion. MAbs are revolutionizing cancer therapy, and promising new
MAbs crowd the pipeline. But the industry landscape is changing-big pharma is
moving in, competition is increasing, business strategies are proving
inadequate, and pricing/reimbursement issues are increasingly vexing.
Get the Answers You Need to Shape Your Strategy:
- Small companies drive MAb technology development, but most survive
precariously on license and royalty income from the big pharma/big biotech
companies that dominate MAb commercialization. How can these technology
leaders fend off acquisition by their big-and increasingly
interested-licensees? What can they do to maximize income from their own
technologies and ensure their continued independence?
- Three major acquisitions were announced in the first half of 2006. Three
big pharma companies will acquire, among other assets, unique technologies
that enable creation of fully human MAbs. Will competitors' access to these
technologies be diminished? Will current license holders find they must
renegotiate agreements on less favorable terms?
- Cancer-treating MAbs dominate the market, followed by MAbs for autoimmune
and respiratory disease. Some 162 new MAbs are in pipelines worldwide, and
more than 400 clinical trials are under way. Which companies lead the MAb
market today? Why do some MAbs become blockbusters while others do not? Which
MAbs now in the pipeline look like potential blockbusters?
- The MAb industry' s strong and evolving technology will continue to improve
cancer treatment, but a more competitive market and escalating criticism of
the extremely high cost of MAb therapy will present challenges. How can
companies maintain their competitive advantage, deliver more efficacious
therapies while controlling costs, and simultaneously respond to patients' and
insurers' demands for reasonably priced MAb therapies?
Scope:
Monoclonal antibody technology: A review of technology methodologies.
Industry leaders: Companies, technology platforms, products, and
pipelines.
Markets: Leading cancer-targeting MAbs, sales growth, and market share.
Industry dynamics: Important acquisitions, evolving business and deal
strategies, and competition.
Pricing and reimbursement: Controversies and criticism from payers as
well as the public.
Outlook: MAb industry strengths, weaknesses, opportunities, and threats.
Spectrum Expert Commentary: The view from an executive at an
industry-leading company.
Table of Contents
- Executive Summary
- Strategic Considerations
- Stakeholder Implications
- Huge Success of Monoclonal Antibodies
- Technology in a Nutshell
- Major Monoclonal Technology Leaders
- Spectrum Expert Commentary: Monoclonal Antibodies as Drug Delivery Agents
- Red Hot Monoclonal Products and Markets
- Rituximab-Targeted B-Cell Therapy
- Trastuzumab-Targeted HER2 Therapy
- Bevacizumab-First Approved Antiangiogenesis Therapy
- Cetuximab-First MAb to Treat Colorectal Cancer
- Sales Growth and Market Share of Cancer-Targeting MAbs
- A Run on MAb Companies
- Amgen Acquires Abgenix
- Panitumumab
- Denosumab
- Combination Treatments
- Manufacturing Facility
- Antibody Patent Rights
- AstraZeneca to Acquire Cambridge Antibody Technology
- Merck & Co. Acquires Abmaxis
- Deal Strategies
- Making the Switch from Platform-Based to Product-Based Company
- Overflowing Clinical Pipelines for MAbs
- When Things Go Very Wrong
- Pricing and Reimbursement Controversies
- Bevacizumab
- Cetuximab and Trastuzumab
- Cost-Containment Measures
- Companion Diagnostics
- Outlook
Tables
- 1. Key Technology Leaders-Evolution of MAb Technologies
- 2. Financial Position of Key MAb Technology Leaders, 2005
- 3. Ranking of MAbs by Indication and Worldwide Sales
- 4. Select Codevelopment Alliances for MAbs in Cancer, 2004-2006
- 5. Late-Stage MAbs in Clinical Development for Cancer
- 6. Sales of Currently Marketed Cancer MAbs
Figures
- 1. Worldwide Sales of Select MAbs, 2005
- 2. MAbs: From Mouse to Human
- 3. Sales of MAbs by Therapeutic Indication, 2002 and 2005
- 4. Market Cap of Key MAb Companies .
