探求離子通道調控劑的新研究

本報告已在2011年12月21日停止出版。

簡介

目錄

Abstract

Ion-channel protein complexes represent a promising and exciting class of therapeutic targets with applications across many disease indications. Drugs that modulate ion-channel activity are first-line therapies in several therapeutic areas, such as cardiovascular disorders, central and peripheral nervous system disorders, and metabolic disorders, and the use of specific ion-channel modulators will likely expand into other major therapeutic areas, such as oncology. However, the pharmaceutical and biotechnology industries have not aggressively exploited ion channels as drug targets because they require difficult, labor-intensive, and low-throughput assays. Fortunately, recent scientific and technological advances are affecting ion-channel R&D significantly. In this report, we examine the function of ion channels and potential ion-channel targets, describe traditional and new methods of screening, profile companies specializing in ion-channel research, and discuss the outlook for the field.

Table of Contents

Introduction

Ion-Channel Overview

• Function and Classification
• Many Potential Targets
• Undesirable Targets and HERG
• Few Marketed Ion-Channel Modulators

Screening Assays for the Discovery of Ion-Channel Modulators

• Traditional Screening Methods
• The Road to Higher Throughput
• New Screening Technologies
• Improved Fluorescent Assays
• High-Throughput Patch Clamping
• In Silico Methods

The Role of Specialist Companies

Corporate Highlights

• Icagen
• Lectus Therapeutics
• Neurion Pharmaceuticals
• Neuromed
• NeuroSearch
• Xention Discovery

Outlook for the Discovery of Ion-Channel Modulators

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