早期細胞凋亡藥研發之發現與課題

本報告已在2011年07月19日停止出版。

簡介

目錄

Abstract

In This Issue...

Apoptosis, the major and best-studied pathway of programmed cell death, plays an important role in embryonic development, the immune system, and protection against mutations and cancer. As such, it has become an intriguing focus of investigation among pharmaceutical companies seeking to treat illnesses ranging from cancer to cirrhosis. In this report, we explain the apoptotic process, discuss several proteins within the apoptotic pathways that may represent potential targets for drug development, describe apoptosis modulators and inhibitors in development, and analyze the challenges associated with developing agents that target this pathway, especially those associated with caspase inhibitors.

Table of Contents

Introduction

An Overview of Apoptosis

• Characteristics of Apoptosis
• Detecting Apoptosis
• Role of Apoptosis in Human Development
• Role of Apoptosis in Disease
• The Apoptotic Pathways

Apoptosis Activators in Development for Cancer

• Bcl-2 Inhibitors
• IAP Inhibitors
• TRAIL Receptor Agonists
• Other Intrinsic Pathway Drug Discovery Methods

Caspase Inhibitors as Antiapoptotic Agents

• Challenges to Caspase Inhibitor Development
• IDN-6556

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