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乳癌:KOL (關鍵意見領袖) 的考察 (2017年)

Breast Cancer: KOL Insight [2017]

出版商 FirstWord 商品編碼 520358
出版日期 內容資訊 英文
商品交期: 最快1-2個工作天內
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乳癌:KOL (關鍵意見領袖) 的考察 (2017年) Breast Cancer: KOL Insight [2017]
出版日期: 2017年06月01日 內容資訊: 英文

本報告以乳癌的主要已上市藥物及開發階段的藥物為焦點,提供北美及歐洲的12名關鍵意見領袖 (KOL) 的各種見解彙整。


  • 幾個Trastuzumab生物相似藥版由法規當局審查中。KOL認為這些產品如何,以及怎麼估計未來的使用方法?
  • Perjeta作為HER2陽性疾病的輔助性治療調查中。對APHINITY調查結果有什麼影響?
  • Neratinib等候核准為輔助性治療
  • Ibrance在其他療法中的核準機會為何?
  • Alpha特有PI3激梅抑制劑,alpelisib 及taselisib如何形成針對CDK4/6抑制劑?
  • Kisqali對HER2陰性/ HR陽性的乳癌獲得美國的核准。為了有效競爭,這個產品需要展示怎樣的優點?
  • KOL對PARP抑制劑及查核點抑制劑在三重陰性乳癌 (TNBC) 中如何使用進行相關討論。關於這些藥物KOL的想法為何,以及今後TNBC估計要如何治療?


  • 已上市藥物
    • Herceptin (trastuzumab; Roche)
    • Kadcyla (ado-trastuzumab emtansine; Roche)
    • Perjeta (pertuzumab; Roche)
    • Tykerb/Tyverb (lapatinib; Novartis)
    • 其他
  • 第三階段
    • neratinib (PB 272; Puma Biotechnology)
    • margetuximab (MGAH 22; MacroGenics)
    • Gilotrif/Giotrif (afatinib; Boehringer Ingelheim)
    • Kisqali (ribociclib; Novartis)
    • 其他


  • 北美的KOL
  • 歐洲的KOL

How is Ibrance faring? Is Kisqali expected to be a threat?

Having dominated the HER2-positive breast cancer space for many years, Roche's blockbuster drug Herceptin is likely to face the threat of biosimilar trastuzumab in the coming years; KOLs weigh in on how biosimilar trastuzumab may be accepted by physicians and patients, its potential usage in different settings, as well as its chances to become the preferred agent in the HER2-positive space. Meanwhile, KOLs discuss how Roche's Perjeta is setting itself up for expanded use. Experts also give their views on how Pfizer's Ibrance is faring in the HER2-negative/HR-positive space and what challenges lie ahead for this drug, including the arrival of Novartis' Kisqali and Eli Lilly's abemaciclib. The potential usage of PARP inhibitors and PD-1/PD-L1 checkpoint inhibitors in triple-negative breast cancer is also explored. Twelve US and EU KOLs offer their candid insights on these issues and more.

In this 6 US and six EU KOLs offer their candid insights on 6 marketed therapies and 12 pipeline drugs.

Plus: Order the report and you'll receive three quarterly FirstWord Therapy Trends Update Bulletins free!

Take a tour of the report now:

  • The table of contents
  • The key business questions answered
  • The key KOL quotes
  • See the therapies covered
  • Find out who the 6 EU & 6 US KOLs are
  • Review an extract from the report - 1 drug profile

Top Takeaways

  • Several biosimilar trastuzumab versions are under regulatory review. How do KOLs view these products and how do they envisage their future use?
  • Perjeta is under investigation as an adjuvant therapy for HER2-positive disease. What impact will the APHINITY study results have?
  • Neratinib is awaiting approval in the extended adjuvant setting. How do KOLs view this agent and is uptake likely to be significant?
  • What are Ibrance's chances of approval in other settings? And can Pfizer fend off competition from Kisqali and abemaciclib?
  • How do the alpha specific PI3 kinase inhibitors, alpelisib and taselisib shape up against the CDK4/6 inhibitors? KOLs offer their views on these agents and how they could be positioned.
  • Kisqali has received US approval for HER2-negative/HR-positive breast cancer. What benefits does this product need to show in order to compete effectively?
  • KOLs discuss how PARP inhibitors and checkpoint inhibitors may be used in triple-negative breast cancer (TNBC). What are KOLs' thoughts on these agents and how do they envisage TNBC to be treated in the future?


“Alpelisib is clearly more selective or alpha specific. This should allow for better targeting but we'll see if that pans out clinically. I think we need to be careful with the toxicity of these drugs.” EU Key Opinion Leader.

“There are still studies that need to be completed to address the issue of sequencing of different therapies. The bulk of the evidence does support first-line use with a CDK4/6 inhibitor, but then after you get beyond first-line therapy, it starts to become a bit more confusing.” US Key Opinion Leader.

Sample of therapies covered

Marketed Therapies

  • Herceptin (trastuzumab; Roche)
  • Kadcyla (ado-trastuzumab emtansine; Roche)
  • Perjeta (pertuzumab; Roche)
  • Tykerb/Tyverb (lapatinib; Novartis)
  • Plus 2 more

Phase III

  • neratinib (PB 272; Puma Biotechnology)
  • margetuximab (MGAH 22; MacroGenics)
  • Gilotrif/Giotrif (afatinib; Boehringer Ingelheim)
  • Kisqali (ribociclib; Novartis)
  • Plus 8 more

Sample of KOLs interviewed

KOLs from North America

  • Dr. Charles L. Vogel, MD. Professor of Clinical Medicine, Division of Haematology/Oncology, Miller School of Medicine, University of Miami, Florida.
  • Dr. Adam M. Brufsky, MD, PhD. Professor of Medicine at the University of Pittsburgh School of Medicine, Pittsburgh, PA.
  • Dr. Joyce O'Shaughnessy, MD. Specialises in medical oncology with board certification in both internal medicine and medical oncology. She is a Diplomate of the American Board of Internal Medicine, with subspecialty certification in medical oncology.

KOLs from Europe

  • Dr. Thomas Bachelot, MD. Head of the Breast Cancer Unit and the Clinical Trial Unit at the Centre Leon Berard, Lyon, France.
  • Dr. Adrian L. Harris, MD, DPhil. Professor of Medical Oncology at the University of Oxford and Director of the Cancer Research UK Medical Oncology Unit, London, England.
  • Dr. Ahmad Awada, MD. Head of Medical Oncology Clinic at Jules Bordet Cancer Institute, Brussels, Belgium.
  • Plus 6 more

Ongoing Benefits

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Update Bulletins include expert insight and analysis based on FirstWord analyst re-engagement with the KOLs after major events such as product approvals, key data releases and major conferences to deliver the most valuable insights with each update.

  • Your Therapy Trends Report purchase entitles you to receive three Update Bulletins, which are published approximately every three months for 12 months following the report's publication date.
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