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市場調查報告書

非酒精性脂肪性肝炎 (NASH) :KOL的洞察

Nonalcoholic Steatohepatitis: KOL Insight

出版商 FirstWord 商品編碼 326367
出版日期 內容資訊 英文
商品交期: 最快1-2個工作天內
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非酒精性脂肪性肝炎 (NASH) :KOL的洞察 Nonalcoholic Steatohepatitis: KOL Insight
出版日期: 2015年03月01日 內容資訊: 英文
簡介

本報告提供非酒精性脂肪性肝炎 (NASH) 相關研究,揭示美國、歐洲的KOL的見解,開發中產品和帶來的治療流程大動作等相關分析。

調查對象

  • 目前治療
    • 維他命E
    • Actos (pioglitazone;武田藥品工業)
  • 開發平台藥物
    • Obeticholic酸 (INT-747; Intercept/Dainippon Sumitomo Pharma)
    • GFT505 (Genfit)
    • Simtuzumab (GS-6624; Gilead)
    • Cenicriviroc (TBR-652, Tobira Therapeutics)
    • 遲釋型半胱胺酒石酸鹽 (RP103; Raptor Pharmaceutical)
    • Aramchol (Galmed Pharmaceuticals)
    • Emricasan (IDN-6556; Conatus Pharmaceuticals)
    • Victoza/Saxenda (liraglutide; Novo Nordisk)
  • 主要的優點
    • 理解對目前治療策略的臨床考察,制定新產品的定位及臨床醫生通訊的有效策略
    • 準備市場規劃活動,含患者次級族群,對NASH領域的新治療選項的計劃
    • 關於處方決策,確定KOL認為最重要的產品特質、患者的特徵
    • 包含設計、試驗指標,KOL認為預計大幅影響未來治療決策的臨床實驗,並發現其引起的結果
    • 為了在有未來可能性的授權機會上處於優勢,評估發展的NASH競爭情形
  • 對重要問題的回答
  • 要點

關鍵意見領袖 (KOL)

  • 北美
  • 歐洲
目錄
Product Code: 596200318

Why This Report is Essential

Expect a revolution in the treatment of nonalcoholic steatohepatitis (NASH) as a number of new therapies compete to become the first approved treatment for a disease that has high unmet clinical need. Nonalcoholic Steatohepatitis: KOL Insight reveals the critical views of US and European KOLs whose insights hold key lessons for pharma. Gain insights on products in the pipeline and how they could revolutionise the treatment algorithm.

Among the pipeline products analysed in this report is Intercept's/Dainippon Sumitomo Pharm's FXR agonist, obeticholic acid, Genfit's PPAR alpha/delta agonist, GFT505 and Gilead's Simutuzumab. Others vying for market voice include Tobira Therapeutics's dual CCR2/CCR5 antagonist, cenicriviroc (TBR-652) and in the paediatric sector, Raptor Pharmaceuticals' delayed-release cysteamine bitartrate.

The upcoming products vary in their effectiveness in resolving the steatohepatitis and controlling fibrosis associated with NASH. Combination therapy is likely to shape the treatment paradigm in the future, as none offer a single solution.

Nonalcoholic Steatohepatitis: KOL Insight gives exclusive insights on what leading NASH specialists think about the emerging clinical benefits and disadvantages of key pipeline programmes and what will influence prescribing decisions. In addition, specialists voice their opinions on optimal clinical trial designs, including endpoint selection, which could help clarify future treatment decisions.

KOL Views Covered

Current Treatments

  • Vitamin E
  • Actos (pioglitazone; Takeda)

Pipeline Drugs

  • Obeticholic acid (INT-747; Intercept/Dainippon Sumitomo Pharma)
  • GFT505 (Genfit)
  • Simtuzumab (GS-6624; Gilead)
  • Cenicriviroc (TBR-652, Tobira Therapeutics)
  • Delayed-release cysteamine bitartrate (RP103; Raptor Pharmaceutical)
  • Aramchol (Galmed Pharmaceuticals)
  • Emricasan (IDN-6556; Conatus Pharmaceuticals)
  • Victoza/Saxenda (liraglutide; Novo Nordisk)

Key Benefits

  • Understand the clinical insights of current treatment strategies and formulate effective strategies for new product positioning and clinician communication.
  • Map new treatment options to the NASH spectrum, including patient sub groups, in preparation for market planning activities.
  • Identify what emerging product attributes and patient characteristics KOLs think will be most important in terms of influencing prescribing decisions.
  • Discover which clinical trials, including designs and endpoints, the KOLs believe will have a significant impact on future treatment decisions and their likely outcomes.
  • Evaluate the evolving NASH competitive landscape to get an edge on potential licensing opportunities in the future

Get Answers to Critical Questions

  • Intercept's/Dainippon Sumitomo Pharma's obeticholic acid addresses NASH on many levels but how will adverse reactions impact its approval and the future use of the drug?
  • What key clinical differentiators could Genfit exploit for GFT505, its PPAR alpha/delta agonist?
  • What pricing strategy should Gilead consider for anti- lysyl oxidase-like-2 (LOXL2) mAb, simtuzumab?
  • Preliminary results for Tobira's dual CCR2/CCR5 antagonist, cenicriviroc, are seen as encouraging by KOLs, but what do KOLs think are the best combination approaches with this product?
  • Raptor Pharmaceuticals' RP103 is expected to be first-to-market for paediatric NASH, but cost and competition from other therapies which gain the same indication remain challenges for the future; how might the company best meet these?
  • What role will biomarkers play in shaping the NASH treatment landscape?
  • The use of combination therapy looks set to deliver the best outcomes for patients with NASH, but which products and MOAs are looking compatible at this stage?

Top Takeaways

  • Hear the detailed opinions of leading front line clinicians on current and future treatments for NASH, and what they see as the critical advantages/disadvantages affecting their decision to use.
  • Understand important clinical and market factors that will shape the NASH sector and identify key areas for strategic and tactical action.
  • Benchmark current thinking on how the new therapies will fit into the treatment paradigm.
  • Review KOL attitudes to important clinical trials such as FLINT, GOLDEN, CENTAUR, ORION, CyNCH, and LEAN.

Key Opinion Leaders

North America

  • Scott L. Friedman, Professor, Icahn School of Medicine at Mount Sinai
  • Brent A. Neuschwander-Tetri, Professor, Saint Louis University School of Medicine
  • Stephen A. Harrison, University of Texas Health Science Center in San Antonio and Brooke Army Medical Center, Fort Sam Houston, Texas
  • Philip Rosenthal, Professor, University of California, San Francisco
  • Mary Rinella, Northwestern University Feinberg School of Medicine
  • Joel Lavine, Morgan Stanley Children's Hospital and Columbia University Medical Center

Europe

  • Vlad Ratziu, Professor, Université Pierre et Marie Curie and the Hôpital Pitié-Salpêtrière Medical School in Paris
  • Elisabetta Bugianesi, S. Giovanni Battista Hospital, University of Torino
  • Giulo Marchesini Reggiani, Professor, University of Bologna
  • Fabio Marra, University of Florence
  • Guruprasad P. Aithal, Nottingham Digestive Diseases Centre, University of Nottingham
  • Anonymous German KOL

Update Bulletins Offer Ongoing Benefits

The world of pharma is ever changing and executives must always be up-to-date with new developments that could affect their own products, position and research. That is why FirstWord's guarantee to keep Therapy Trends clients up to date with Update Bulletins offers a real commercial advantage.

Update Bulletins include expert insight and analysis based on FirstWord analyst re-engagement with the KOLs after major events such as product approvals, key data releases and major conferences to deliver the most valuable insights with each update.

  • Your Therapy Trends Report purchase entitles you to receive three Update Bulletins, which are published approximately every three months for 12 months following the report's publication date, March 2015.
  • You will receive a copy of each Update Bulletin once available, which are issued each quarter after the publication date.
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