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市場調查報告書

急性失償心臟衰竭:流行病學、病患人數的市場預測、治療流程、已上市及開發中的藥物分析

Acute Decompensated Heart Failure Forecast and Market Analysis to 2034

出版商 Datamonitor Healthcare 商品編碼 365171
出版日期 內容資訊 英文 90 Pages
商品交期: 最快1-2個工作天內
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急性失償心臟衰竭:流行病學、病患人數的市場預測、治療流程、已上市及開發中的藥物分析 Acute Decompensated Heart Failure Forecast and Market Analysis to 2034
出版日期: 2018年01月18日 內容資訊: 英文 90 Pages
簡介

新的血管擴張劑的Reasanz及ularitide,通用化發展,隱藏著再活化已成熟的急性失償心臟衰竭 (ADHF)的市場的可能性。

本報告提供急性失償心臟衰竭治療藥趨勢調查,市場定義和概要,疾病定義與診斷,處方趨勢,主要的已上市產品簡介,開發後期的開發平台趨勢等彙整資料。

預測:急性失償心臟衰竭

  • 摘要整理
  • 市場概要、趨勢
  • 市場定義、調查手法
  • Reasanz (serelaxin)
  • Simdax (levosimendan)
  • Ularitide
  • 主要調查技術

治療:急性失償心臟衰竭

  • 摘要整理
  • 主要調查技術
  • 疾病定義與診斷
  • 各國治療樹
  • 處方趨勢

流行病學:急性失償心臟衰竭

  • 摘要整理
  • 資訊來源、調查手法
  • 預測
  • 流行病學者分析

已上市藥物:急性失償心臟衰竭

  • 摘要整理
  • 產品概要
  • 產品簡介:Natrecor
  • 產品簡介:Simdax

開發平台:急性失償心臟衰竭

  • 摘要整理
  • 臨床實驗平台概要
  • 產品簡介 (開發後期):Reasanz
  • 產品簡介 (開發後期):ularitide

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目錄
Product Code: DMKC13163

Disease Overview

Acute decompensated heart failure (ADHF) is defined as the sudden worsening of heart failure symptoms (mainly edema, dyspnea, and fatigue), which results in severe respiratory distress. ADHF is categorized into hemodynamic stages based on the degree of perfusion and pulmonary capillary wedge pressure. Despite improvements in treatment, ADHF is a burdensome disease associated with high hospitalization and mortality rates in the elderly population.

Recent events and opinion

Recent pipeline discontinuations and negative trial results have limited the future growth of the ADHF market.

ADHF treatment is focused on hemodynamic stabilization and alleviation of symptoms.

Datamonitor Healthcare estimates that in 2016, there were 1.2 million diagnosed incident cases of ADHF in the US, Japan, and five major EU markets.

Negative results of the LEVO-CTS trial will prevent expansion of Simdax into the low cardiac output syndrome market.

The discontinuations of ularitide and Reasanz dramatically reduce the number of agents in development for ADHF.

Table of Contents

6 FORECAST: ACUTE DECOMPENSATED HEART FAILURE (Published on 05 April 2017)

6 EXECUTIVE SUMMARY

7 TREATMENT: ACUTE DECOMPENSATED HEART FAILURE (Published on 19 January 2018)

7 EXECUTIVE SUMMARY

8 PRIMARY RESEARCH METHODOLOGY

10 DISEASE DEFINITION AND DIAGNOSIS

19 CURRENT TREATMENT OPTIONS

22 PRESCRIBING TRENDS

36 EPIDEMIOLOGY: ACUTE DECOMPENSATED HEART FAILURE (Published on 18 January 2018)

36 EXECUTIVE SUMMARY

37 DISEASE BACKGROUND

39 SOURCES AND METHODOLOGY

43 FORECAST

51 EPIDEMIOLOGIST INSIGHT

52 STRENGTHS AND LIMITATIONS

53 BIBLIOGRAPHY

55 APPENDIX: ADDITIONAL SOURCES

57 MARKETED DRUGS: ACUTE DECOMPENSATED HEART FAILURE (Published on 05 April 2017)

57 EXECUTIVE SUMMARY

58 PRODUCT OVERVIEW

59 PRODUCT PROFILE: NATRECOR

71 PRODUCT PROFILE: SIMDAX

85 PIPELINE: ACUTE DECOMPENSATED HEART FAILURE (Published on 05 April 2017)

85 EXECUTIVE SUMMARY

86 RECENTLY DISCONTINUED DRUGS

LIST OF FIGURES

  • 11 Figure 1: Typical treatment flow for initial management of a patient hospitalized with suspected ADHF
  • 12 Figure 2: Clinical profiles of patients with acute heart failure based on the presence/absence of congestion and/or hypoperfusion
  • 22 Figure 3: Percentage of ADHF patients receiving each treatment type, by country
  • 23 Figure 4: Percentage of ADHF patients receiving each type of non-pharmacological therapy, by country
  • 24 Figure 5: Percentage of first-line ADHF regimens containing each drug class, by country
  • 26 Figure 6: Use of each diuretic class as a percentage of total diuretic use for the first-line treatment of ADHF, by country
  • 28 Figure 7: Use of each vasodilator as a percentage of total vasodilator use for the first-line treatment of ADHF, by country
  • 29 Figure 8: Use of each inotropic agent as a percentage of total inotropic use for the first-line treatment of ADHF, by country
  • 30 Figure 9: Percentage of regimens for the treatment of ADHF containing Entresto, by line of therapy and country
  • 31 Figure 10: Top three first-line regimens for ADHF, by country
  • 32 Figure 11: Percentage of ADHF patients moving on to second-line therapy who were responsive or non-responsive to firstline therapy, by country
  • 33 Figure 12: Percentage of second-line ADHF regimens containing each drug class for patients who show a response to firstline treatment, by country
  • 34 Figure 13: Percentage of second-line ADHF regimens containing each drug class for patients who do not show a response to first-line treatment, by country
  • 47 Figure 14: Trend in diagnosed incident cases of ADHF in the US, Japan, and five major EU markets, by country, 2016-36
  • 48 Figure 15: Absolute change in diagnosed incident cases of ADHF in the US, Japan, and five major EU markets, by country, 2016-36
  • 66 Figure 16: Natrecor for acute decompensated heart failure - SWOT analysis
  • 67 Figure 17: Datamonitor Healthcare's drug assessment summary of Natrecor in acute decompensated heart failure
  • 68 Figure 18: Datamonitor Healthcare's drug assessment summary of Natrecor in acute decompensated heart failure
  • 80 Figure 19: Simdax for acute decompensated heart failure - SWOT analysis
  • 81 Figure 20: Datamonitor Healthcare's drug assessment summary of Simdax in acute decompensated heart failure
  • 82 Figure 21: Datamonitor Healthcare's drug assessment summary of Simdax in acute decompensated heart failure

LIST OF TABLES

  • 8 Table 1: Cardiologists surveyed for the ADHF primary research study, 2017
  • 13 Table 2: Common triggers of ADHF
  • 15 Table 3: Mean percentage of ADHF patients who have risk factors/co-morbidities in the US, Japan, and five major EU markets, by country
  • 20 Table 4: Treatments available for ADHF across the US, Japan, and five major EU markets
  • 25 Table 5: Percentage of first-line ADHF regimens containing each drug class, by country
  • 40 Table 6: Sources used for the epidemiological analysis of ADHF in the US, Japan, and five major EU markets, by country
  • 45 Table 7: Diagnosed incident cases of ADHF in the US, Japan, and five major EU markets, by country, 2016-36
  • 49 Table 8: Age-specific diagnosed incident cases of ADHF in the US, Japan, and five major EU markets, by country, 2016
  • 50 Table 9: Gender-specific diagnosed incident cases of ADHF in the US, Japan, and five major EU markets, by country, 2016
  • 58 Table 10: Key marketed drugs for acute decompensated heart failure
  • 60 Table 11: Natrecor drug profile
  • 62 Table 12: Natrecor pivotal trial data in acute decompensated heart failure
  • 64 Table 13: Natrecor late-phase trial data in acute decompensated heart failure
  • 72 Table 14: Simdax drug profile
  • 74 Table 15: Simdax pivotal trial data in acute decompensated heart failure
  • 77 Table 16: Simdax late-phase trial data in acute decompensated heart failure
  • 86 Table 17: Late-stage compounds that were recently discontinued for acute decompensated heart failure
  • 87 Table 18: Reasanz drug profile
  • 88 Table 19: Ularitide drug profile
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