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市場調查報告書
表觀遺傳學：技術、用途、及商業展望
Epigenetics: Technologies, Applications, and the Commercial Landscape
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表觀遺傳學：技術、用途、及商業展望 是由出版商Insight Pharma Reports在2008年02月所出版的。
這份英文市場調查報告書包含130 pages 價格從美金1498起跳。
本報告書內容包括：表觀遺傳學的定義及發展歷史、現況介紹、未來在商業上的應用領域、癌症治療方針、進入市場中企業的動向等。內容綱要摘記如下：
第1章 表觀遺傳學的現況
- 關於表觀遺傳學
- DNA甲基化及組織蛋白修飾
- 癌症病因學：從突變中瞭解表觀遺傳學
- 癌症以外的疾病之表觀遺傳學
第2章 DNA甲基化生物標記及技術
- 表觀遺傳學的架構
- DNA甲基化的力量
- 自家製甲基化測試
- 表觀遺傳學診斷企業
- DNA甲基化技術
- 未來重點在基因領域
- DNA甲基化研究準備設備及服務合約
第3章 表觀遺傳學藥
- 表觀基因的性質
- 脱甲基劑
- 組織蛋白修飾：為維持乙酰基化的藥物
- 合併療法
第4章 表觀遺傳學商業
- 產業致力於提高各界對表觀遺傳學的關注程度
- 表觀遺傳學產業
- 產業動向No.1：近年來的主要商業交易
- 產業動向No.2：近年來與表觀遺傳學有關的專利申請
附錄
參考資料
含網址的企業索引
Abstract
Epigenetics is one of the fastest-growing areas of the biological sciences.
It' s also a budding industry. This new report offers in-depth analysis of:
- The definition, history, and current status of epigenetics
- Current and potential commercial applications
- An epigenetic approach to cancer etiology
- The epigenetics of noncancerous diseases
- DNA methylation and histone modifications as biomarkers
- The companies involved and their products
- Epigenetic therapeutics: demethylating agents, histone modifications, and
combinations
- The drivers of the epigenetics industry, plus recent major industry deals
and patent applications
- Results of a quantitative online survey of individuals involved in
epigenetics R&D
Epigenetics: Technologies, Applications, and the Commercial Landscape
provides an overview of the scientific and technological landscape from which
both the diagnostic and therapeutic sectors of the nascent "epigenetics
industry" are emerging, plus a qualitative analysis of the scientific,
technological, and commercial achievements and challenges facing both sectors.
Biologists are recognizing that to understand human health and disease, they
need to know more than the DNA sequence of any genes. Equally, if not more
important, they need to know how cells use the information encoded in the
genome. That information is essentially stagnant if a gene lies dormant. What
turns genes on and off, and under what circumstances? That is what epigenetics
is all about: how genomic information encoded in the DNA sequence is regulated
by various nonDNA factors. The science and technology of epigenetics are aimed
at understanding and, ultimately, manipulating the various chemical and
physical chromatin modifications that control gene expression.
This report focuses on the 2 major types of epigenetic control factors:
- DNA methylation patterns formed by the presence of methyl molecules (-CH3)
attached to CpG dinucleotides along the entire length of the DNA double helix
- Various covalent modifications to the histone proteins around which the
DNA helix is wound
Epigenetics: Technologies, Applications, and the Commercial Landscape
is a valuable tool for anyone involved in epigenetics R&D, portfolio
management, and commercialization of diagnostics and therapeutics.
Table of Contents
Chapter 1 EPIGENETICS TODAY
- 1.1 What Epigenetics is All About
- Epigenetics Defined
- Current and Potential Commercial Applications
- 1.2. DNA Methylation and Histone Modifications: Focus of This Report
- 1.3. The Etiology of Cancer: From a Mutational to Epigenetic Understanding
- Cancer as a Mutational Disease
- An Epigenetic Approach to Cancer Etiology
- 1.4. The Epigenetics of Noncancerous Diseases
- Rett Syndrome
- Schizophrenia
- Alzheimer' s Disease
Chapter 2 DNA METHYLATION BIOMARKERS AND TECHNOLOGY: THE RACE IS ON
- 2.1. The Mechanisms of Epigenetics
- A Focus on DNA Methylation
- Histone Modifications as Biomarkers: A Field in its Infancy
- 2.2. The Power of DNA Methylation: Biomarker or Bust
- Clinical Applications of Methylation Diagnostics
- Major Challenges to Realizing the Potential of Epigenetic Diagnostics:
Clinical Validation, Economic
- Validation and Provider Education
- Three Major Challenges to the Market Success of Epigenetic Diagnostics
- 2.3. Homebrew Methylation Testing
- 2.4. Epigenetic Diagnostic Companies
- Epigenomics
- OncoMethylome Sciences
- Orion Genomics
- Interview with Cathy-Lofton Day, PhD
- Vice President of Molecular Biology, Diagnostics
- Epigenomics
- 2.5. DNA Methylation Technology
- Gene-by-Gene Technologies: The Bisulfite Revolution and Beyond
- 2.6. The Future is Genomewide
- DNA Microarrays
- High-Throughput Sequencing
- ChIP-on-chip and ChIP-Seq: Frontrunner Epigenomic Technologies
- Interview with Jeff Falk, PhD
- Director of Technology and Business Applications
- Aviva Systems Biology
- 2.7. DNA Methylation Research Prep Kits and Service Contracts: Making It
Easy
- Companies Who Supply Kits
- QIAGEN
- Zymo Research
- BioChain
- Human Genetic Signatures
- Millipore
- Sigma-Aldrich
- Panomics
- Invitrogen
- Companies and Contract Services
- Interview with Christopher Adams, PhD
- Research Area Manager, Division of Epigenetic
- Invitrogen
Chapter 3 EPIGENETIC DRUGS: THE RACE TO REVERSE SILENCING
- 3.1. The Dynamic Nature of the Epigenome
- 3.2. Demethylating Agents
- Only 2 FDA-Approved Agents
- Major Advantages and Disadvantages of Demethylating Drugs
- 3.3 Histone Modifications: Using Drugs to Restore Acetylation
- 3.4. Combination Therapy: Epigenetic Drugs Make Good Partners
- Interview with Donald F. Corcoran
- President and CEO
- MethylGene
Chapter 4 The Business of Epigenetics
- 4.1. What is Driving Industry Interest in Epigenetics?
- New Knowledge
- New Technology
- Dry Pipelines
- Human Disease and Suffering
- 4.2. The "Epigenetics Industry"
- Diagnostics
- Therapeutics
- Research Tools
- 4.3. Industry Snapshot #1: Recent Major Business Deals
- 4.4. Industry Snapshot #2: Recent Patent Applications Related to
Epigenetics
Appendix
- Insight Pharma Reports - Epigenetics Survey - January 2008
References
- Company Index with Web Addresses
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