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MicroRNA: An Insight to miRNA-based Microarrays, Diagnostics and Therapeutics

出版商 Insight Pharma Reports 商品編碼 298557
出版日期 內容資訊 英文 104 Pages
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微型核糖核酸:miRNA為基礎的微陣列、診斷、治療概要 MicroRNA: An Insight to miRNA-based Microarrays, Diagnostics and Therapeutics
出版日期: 2014年04月28日 內容資訊: 英文 104 Pages




第1章 背景和簡介

  • 所謂miRNA

第2章 miRNA:寡核苷酸合成和微陣列技術

  • miRNA的創造與應用
    • 寡核苷酸的工程
    • 光刻合成
    • miRNA拮抗劑的工程
    • 其他的工程方法
  • Affymetrix:miRNA微陣列和光刻技術
    • 企業資料
    • GeneChip miRNA 4.0陣列
    • 光刻流程和化驗的特徵
    • 改善領域與未來的期待
    • Dr. Johanne McGregor的採訪
  • Exiqon:使用了LNA技術的miRNA檢測的改良
    • 研究的背景
    • 生物標記的miRNA的生物學
    • LNA技術
    • miRCURY LNA qPCR平台:優點與市場展望
    • Dr. Henrik M. Pfundheller 的採訪

第3章 miRNA:診斷及治療的應用

  • miRNA使用於診斷生物標記
    • 診斷的應用
  • Rosetta Genomics
    • 研究及企業資料
    • 微型核糖核酸診斷平台
    • 醫療的進步
    • 改善領域與限制
    • Ken Berlin的採訪
  • DiamiR:miRNA神經診斷
    • 企業資料
    • 通用的篩檢檢驗和規格
    • 優點與未來的展望
    • Kira Sheinerman的採訪
  • Gensignia:miRNA的肺癌診斷
    • 企業資料
    • miRNA信號分類的肺癌檢驗
    • 醫療的進步
    • Dr. Elisa Romeo 的採訪
  • Eisai:miRNA的研究及老年癡呆症診斷
    • 企業資料
    • miRNA作為循環生物標記
    • 老年癡呆症的研究
    • 競爭策略
    • 改善與限制
    • 未來的期待
    • Dr. Pavan Kumar 的採訪

第4章 學術領域的miRNA的研究:目標、診斷、終端用戶的展望

  • 學術領域的miRNA:分子相互作用、診斷及治療方法、理解技術進步的重要性
  • Stony Brook University School of Medicine:大腸癌的miRNA
  • Grand Valley State University:帕金森氏症的miRNA
  • 獨立的miRNA研究:腎臟學的miRNA所扮演的角色
  • Van Andel Research Institute:miRNA藥物研發及技術的進步

第5章 miRNA焦點、課題、研究開發的進步

  • 調查分析



New to Insight Pharma Reports is: MicroRNA: An Insight to miRNA-Based Microarrays, Diagnostics and Therapeutics. This report covers the specifics of microRNA (miRNA) as it is a relatively new space in heavy pursuit of research due to its versatility and stability, properties that are unique to miRNAs compared to other RNA components. miRNA's non-coding nature and ability to affect genetic expression make it a novel candidate for use as a biomarker for a variety of diseases. This prompted the pursuit of miRNA-based microarrays and diagnostics for the advancement in therapeutic development. Furthermore there are a number of academic laboratories not only validating miRNAs, but also identifying them in a number of diseases and examining their molecular actions in the presence of other molecules. This report is broken up into several parts, highlighting miRNA in several areas of research.

After covering background information, the second and third parts of this report expand upon several microarrays and diagnostics for specific analysis and therapeutic development. Several companies featured in this section include:

  • Affymetrix
  • Exiqon
  • Diamir
  • Rosetta Genomics
  • Eisai

Chapters within these sections feature company backgrounds and highlight proprietary technologies and platforms. Additionally, several advantages and limitations are also discussed. More significantly, these chapters are accompanied by interviews with company representatives, exclusively conducted for this report.

The fourth part of this report explores the academic, research and community perspectives. Although not developing diagnostics per se, academia is diligently investigating several aspects of miRNAs including their molecular properties for use as biomarkers for neurodegenerative diseases, diabetes, and even cancer. Universities and research institutes included in this area are:

  • Stony Brook University School of Medicine
  • Grand Valley State University
  • Van Andel Research Institute

Also included in these sections are interviews with experts in leading research from these universities. From a community perspective, Dr. Argyropoulos, a Medical Affairs Consultant, provides insight to the rapidly growing space and rising opportunities.

Finally, the report concludes with an in depth analysis of survey results. With 152 researchers, these results provide an overall perspective of the research community, capturing a number of miRNA applications, challenges afloat in the industry, and miRNA mechanisms of study.

Table of Contents

Executive Summary

Part I: Background and Introduction

CHAPTER 1: What is miRNA?

  • Transcription
  • Gene Expression

Part II: miRNA: Oligonucleotide Synthesis and Microarray Technologies

CHAPTER 2: miRNA Creation and Application

  • Engineering Oligonucleotides
  • Photolithographic Synthesis
  • Engineering miRNA Antagonists: OMe, MOE, and LNA
  • Other Engineering Methods: miRNA Mimicry

CHAPTER 3: Affymetrix: miRNA Microarrays and Photolithographic Technology

  • Company Bckground
  • GeneChip miRNA 4.0 Array
  • Photolithographic Process and Assay Features
    • Specificity and Sensitivity
    • Applications
  • Areas of Improvements and Future Expectations
  • Interview with Dr. Johanne McGregor
    • Company Background
    • GeneChip miRNA 4.0 Array
    • Targets and Applications
    • Technology
    • Challenges, Benefits, Improvements, and Future Expectations

CHAPTER 4: Exiqon: Improving miRNA Detection with LNA Technology

  • Research Background
  • The Biology of miRNAs as Biomarkers
  • Locked Nucleic Acid (LNA) Technology
  • miRCURY LNA qPCR Platform: Advantages and Market Outlook
  • Interview with Dr. Henrik M. Pfundheller
    • Research Background
    • Locked Nucleic Acid (LNA) Technology
    • microRNA qPCR Platform

Part III: miRNA: Diagnostic and Therapeutic Applications

CHAPTER 5: miRNA Use as Diagnostic Biomarkers

  • miRNA Diagnostic Applications

CHAPTER 6: Rosetta Genomics

  • Research and Company Background
  • microRNA Diagnostic Platforms
  • Advancements in Healthcare
  • Areas of Improvement and Limitations
  • Interview with Ken Berlin
    • Company Background
    • microRNA Diagnostic Platforms
    • Platform Specifications
    • Advancements in Healthcare
    • Improvements and Limitations

CHAPTER 7: DiamiR: miRNA Neuro-Diagnostics

  • Company Background
  • Universal Screening Test and Specifications
  • Advantages and Future Outlook
  • Interview with Kira Sheinerman
    • Company Background
    • Platforms and Specifications
    • Advantages, Limitations, and Future Expectations

CHAPTER 8: Gensignia: miRNA Lung Cancer Diagnostics

  • Company Background
  • miRNA Signature Classifier (MSC) Lung Cancer Test
  • Advancements in Healthcare
  • Interview with Dr. Elisa Romeo
    • Company Background
    • MSC Lung Cancer Test
    • Advancements in Healthcare

CHAPTER 9: Eisai: miRNA Research and Diagnostics for Alzheimer's Disease

  • Company Background
  • miRNAs As Circulating Biomarkers
  • Eisai's miRNA Research in Alzheimer's Disease
  • Competitive Strategies
  • Improvements and Limitations
  • Future Expectations
  • Interview with Dr. Pavan Kumar
    • Company Background
    • miRNA Research
    • Competitive Strategies
    • Advancements
    • Improvements
    • Future Expectations

Part IV: miRNA Research in Academia: Targets, Diagnostics, and End User Perspectives

CHAPTER 10: miRNAs in Academia: Understanding Molecular Interactions, Diagnostic and Therapeutic Approaches, and Significance of Technology Advancements

CHAPTER 11: Stony Brook University School of Medicine: miRNA in Colorectal Cancer

  • miRNA in Colorectal Cancer
    • p53 and miRNA in Colon Cancer
    • Epithelial-to-Mesenchymal Transition (EMT)
  • Diagnostic and Therapeutic Applications
  • Challenges Encountered and Areas of Improvement
  • Interview with Dr. Jingfang Ju
    • miRNA Research
    • miRNA Properties and Technologies
    • p53 and miRNA
    • Epithelial-to-Mesenchymal Transition (EMT)
    • Diagnostics and Therapeutic Applications
    • Challenges and Areas of Improvement
    • Future Applications

CHAPTER 12: Grand Valley State University: miRNA in Parkinson's Disease

  • Circulating miRNA as a Biomarker for Parkinson's Disease
  • Cerebral Spinal Fluid vs. Plasma
  • Advantages, Limitations, and Areas of Improvement
  • Interview with Dr. Sok Kean Khoo
    • Research Background
    • Competition
    • Methods and Properties
    • Areas of Improvement and Challenges

CHAPTER 13: Independent miRNA Research: The Role of miRNAs in Nephrology

  • Research Background
  • miRNA in Type 1 Diabetes and Diabetic Kidney Disease
  • Research Limitations, Challenges, and Areas of Improvement
  • Future Outlook, Applications and Growth
  • Interview with Dr. Christos Argyropoulos
    • Research Background
    • Challenges, Benefits and Areas of Improvement
    • Future Outlook and Industry Impact

CHAPTER 14: Van Andel Research Institute: miRNA Discoveries and Technology Advancement

  • Institution Background
  • Research Background
  • miRNA Properties and Discoveries
  • miRNA Tissue Slide-Based Assays
    • Advantages of miRNA Tissue Slide-Based Assays
    • Challenges and Limitations of miRNA Tissue Slide-Based Assays
    • Areas of Improvement
  • miRNA Market Outlook
  • Interview with Dr. Lorenzo Sempere
    • Research Background
    • miRNA Properties
    • Diagnostics and Therapeutics
    • Limitations and Advantages
    • Future Expectations

Part V: miRNA Highlights, Challenges, and Advances in R&D

CHAPTER 15: Survey Analysis


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