幹細胞研究產品：機會、工具以及技術

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簡介

目錄

Abstract

Executive Summary:

BIO-Informant' s latest market report, "Stem Cell Research Products: Opportunities, Tools & Technologies" was produced using a detailed end-user survey of research scientists, in which over 400 stem cell researchers from the U.S., Canada, Europe, Asia, Australia and other international regions participated. The findings represent perspectives across a global audience of researchers.

As a technology company, BIO-Informant also used proprietary data-derivation techniques to quantify and assess critical trends in the stem cells marketplace.

Since 2001, funding for research on embryonic stem cells has been extremely limited. However, on March 9, 2009, President Obama overturned the order signed by President Bush in 2001 that barred the NIH from funding research on embryonic stem cells beyond using 60 cell lines that existed at that time. This dramatic policy change represents a major opportunity for life science suppliers.

Featured elements of this report include:

• What are novel stem cells research products that can be developed?
• What stem cells types are most frequently used by research scientists?
• Which species of stem cells do scientists prefer and what are the factors driving this preference (access, pricing, funding, handling advantages)?
• What are the most frequently used stem cell markers?
• What are the most common research applications, and how do they differ by segment (academic, industrial, and government)?
• Who are the leading suppliers of stem cell products?
• What stem cell product categories are already available in the marketplace?
• What are current grant, patent, and scientific publication rate trends?
• What are the major funding sources, trends, and dollar values, for domestic and international researchers?
• What is the size of the stem cell research products marketplace and how fast is it growing?
• What are communication strategies for accessing the marketplace?
• And much more...

In summary, the report provides detailed insight into the stem cells research products marketplace and the needs of stem cell scientists.

Table of Contents

I. ABSTRACT

II. BACKGROUND: TYPES OF STEM CELLS

A. Human Embryonic Stem Cells (hESCs)

• 1. Early, 5-7 days (totipotent)
• 2. Gonadal Ridge, 6 months (multipotent)

B. Fetal Stem Cells (pluripotent)

C. Umbilical Cord Stem Cells (multipotent)

• 1. Cord Blood
• 2. Cord Matrix / “Wharton' s Jelly”

D. Dental Stem Cells (multipotent)

E. Adult Stem Cells (multipotent)

• 1. Hematopoietic Stem Cells
• 2. Mesenchymal Stem Cells
• 3. Neuronal Stem Cells

F. Cancer Stem Cells (multipotent)

G. Animal Stem Cells (multipotent)

H. Novel (recently discovered and uncharacterized) Stem Cell Types

• 1. Induced Pluripotent Stem (iPS) Cells
• 2. Neural Rosette Cells (R-NSCs)
• 3. Very Small Embryonic Like (VSEL) Stem Cells

III. STEM CELL RESEARCH APPLICATIONS

A. Regenerative medicine (“Cell-Based Therapies”)

• 1. Diabetes & Kidney Disease Research
• 2. Cardiovascular Disease Research
• 3. Neurological Diseases
• 4. Autoimmune diseases
• 5. Hematopoietic Disease and Transplantation Research
• 6. Orthopedic Diseases
• 7. Cancer Research

B. Drug Screening, Discovery, and Development

• 1. Assays to Aid Early Stage Discovery
• 2. Improved Prediction of Human Responses
• 3. Drug Development with Humanized Mouse Models
• 4. Genetically-Engineered Stem Cell Lines for Screening

C. Birth Defect Research

IV. MARKET SEGMENTS, BY END-USER

A. Basic Research: Understanding how micro-environmental cues modulate and guide stem cell differentiation and organization

B. Applied Research

• 1. Autologous & Allogeneic Cell Therapy
• 2. Toxicology Screening for Drug Discovery & Development

V. PRODUCT AREAS

A. Primary Antibodies

B. Bead-based Cell Separations Systems

C. Fluorescent-based Labeling and Detection

D. Protein Purification & Analysis Tools

• 1. Protein Purification
• 2. Stem Cell Protein Analysis
• 3. Quantitative Proteomics

E. DNA/RNA Based Characterization

• 1. Tools for DNA & RNA Based Characterization
• 2. Stem Cell HLA Typing
• 3. Stem Cell Nucleic Acid Extraction and Purification, & Associated PCR/RT-PCR Reagents

F. Isolation / Characterization Services

• 1. Stem Cell HLA Typing Services
• 2. Stem Cell Custom Services
• 3. Stem Cell Custom Antibodies

G. Stem Cell Culture Media & Reagents

H. Growth Factors & Cytokines

I. Stem Cell Gene Regulation

J. In vivo / In vitro Cell Tracking

K. Expansion / Differentiation Services

L. Stem Cell Lines

VI. MARKET ASSESSMENT (DATA-DRIVEN ANALYSIS)

A. Breakdown of Stem Cell Research Activity, by Cell Type

B. Breakdown of Stem Cell Research Activity, by Species

C. Sources of Funding

• 1. Federal
• 2. State
• 3. Private

D. Patent Analysis

E. Publication Rate Analysis

• 1. Overview of Stem Cell Publication Rates
• 2. Comparative Analysis of Stem Cell Publication Rates

F. Geographical Analysis: Domestic vs. International Status

VII. MARKET TRENDS (“PRIMARY” MARKET SURVEY)

A. Survey Overview

B. Characterization of Market Survey Respondents

• 1. Geographic Distribution of Respondents
• 2. Breakdown of Respondents by Industry Affiliation
• 3. Breakdown of Respondents by Duration of Stem Cell Activity

C. Breakdown of Stem Cell Research Activity, by Cell Type

D. Dominant Stem Cell Markers

E. Market Penetration of Stem Cell Markers

• 1. Mesenchymal Stem Cell (MSC) Markers
• 2. Human Embryonic Stem Cell (hESC) Markers
• 3. Neural Stem Cells (NSC) Markers
• 4. Hematopoietic Stem Cells (HSC) Markers

F. Most Frequently Utilized Providers of Stem Cell Antibodies

VIII. KEY MARKET COMPETITORS: Providers of Diverse Stem Cell Product Lines

A. Invitrogen

• 1. Products
  • a. “Isolation and Characterization” Stem Cell Products
  • b. “Expansion and Differentiation” Stem Cell Products
• 2. Collaborations
  • a. Invitrogen and Cellartis AB
  • b. Invitrogen and Novocell

B. BD Biosciences

• 1. Products
  • a. Isolation
  • b. Culturing
  • c. Analysis
• 2. Collaborations: BD Biosciences and Stem Cell Technologies

C. Comparison of Invitrogen and BD Biosciences Stem Cell Publication Rates

IX. MARKET SIZE

A. Definition of “Stem Cell Research Products”

B. Experimental Approach

C. Stem Cell Research Products, Market Size (in Millions)

D. Stem Cell Antibodies, Market Size (in Millions)

E. Stem Cell Therapies, Market Size (in Billions)

X. MARKET FORECASTS

A. Near-term (1-3yrs): Stem Cells as Tools for Drug Discovery

B. Short-term (3-5yrs): Therapeutics Involving Cord Blood & Adult Stem Cells

C. Long-Terms (10yrs): Therapeutics involving hESCs

XI. COMPETITIVE LANDSCAPE

A. Market Opportunities

B. Market Risks

XII. Communications Strategies for Accessing the Marketplace

A. Top Research Institutions Performing Stem Cell Research

• 1. University of Wisconsin
• 2. Johns Hopkins
• 3. NIH
• 4. California Institute for Regenerative Medicine

B. Events of Interest

C. Leads

• 1. NIH Funding Announcements by Institute
• 2. NIH Stem Cell Interest Group (SCIG)
• 3. NIH Stem Cell Program Staff: List of email and phone contacts

APPENDIX (Supplemental Documents)

• Table I. NIH-Supported Stem Cell Training Courses
• Table II. Additional Stem Cell Training Courses
• Table III. NIH Funding Announcement by Institute
• Table IV. Contact Information for the Stem Cell Interest Group (SCIG) Steering Committee
• Table V. Contact Information for the Stem Cell Interest Group (SCIG) Members
• Table VI. NIH Contacts for Heads of Stem Cell Institutes and Centers

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